KEGG   ORTHOLOGY: K04519
Entry
K04519                      KO                                     

Name
IL1B
Definition
interleukin 1 beta
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04064  NF-kappa B signaling pathway
ko04217  Necroptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04625  C-type lectin receptor signaling pathway
ko04640  Hematopoietic cell lineage
ko04657  IL-17 signaling pathway
ko04659  Th17 cell differentiation
ko04668  TNF signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04932  Non-alcoholic fatty liver disease
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04940  Type I diabetes mellitus
ko05010  Alzheimer disease
ko05020  Prion disease
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05133  Pertussis
ko05134  Legionellosis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05142  Chagas disease
ko05143  African trypanosomiasis
ko05144  Malaria
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05321  Inflammatory bowel disease
ko05323  Rheumatoid arthritis
ko05332  Graft-versus-host disease
ko05418  Fluid shear stress and atherosclerosis
Disease
H01492  Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04519  IL1B; interleukin 1 beta
   04064 NF-kappa B signaling pathway
    K04519  IL1B; interleukin 1 beta
   04668 TNF signaling pathway
    K04519  IL1B; interleukin 1 beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04519  IL1B; interleukin 1 beta
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04519  IL1B; interleukin 1 beta
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04519  IL1B; interleukin 1 beta
   04620 Toll-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04621 NOD-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04623 Cytosolic DNA-sensing pathway
    K04519  IL1B; interleukin 1 beta
   04625 C-type lectin receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04659 Th17 cell differentiation
    K04519  IL1B; interleukin 1 beta
   04657 IL-17 signaling pathway
    K04519  IL1B; interleukin 1 beta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04519  IL1B; interleukin 1 beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04519  IL1B; interleukin 1 beta
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04519  IL1B; interleukin 1 beta
   05321 Inflammatory bowel disease
    K04519  IL1B; interleukin 1 beta
   05332 Graft-versus-host disease
    K04519  IL1B; interleukin 1 beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04519  IL1B; interleukin 1 beta
   05020 Prion disease
    K04519  IL1B; interleukin 1 beta
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04519  IL1B; interleukin 1 beta
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04519  IL1B; interleukin 1 beta
   04932 Non-alcoholic fatty liver disease
    K04519  IL1B; interleukin 1 beta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04519  IL1B; interleukin 1 beta
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04519  IL1B; interleukin 1 beta
   05132 Salmonella infection
    K04519  IL1B; interleukin 1 beta
   05131 Shigellosis
    K04519  IL1B; interleukin 1 beta
   05135 Yersinia infection
    K04519  IL1B; interleukin 1 beta
   05133 Pertussis
    K04519  IL1B; interleukin 1 beta
   05134 Legionellosis
    K04519  IL1B; interleukin 1 beta
   05152 Tuberculosis
    K04519  IL1B; interleukin 1 beta
  09172 Infectious disease: viral
   05162 Measles
    K04519  IL1B; interleukin 1 beta
   05164 Influenza A
    K04519  IL1B; interleukin 1 beta
   05168 Herpes simplex virus 1 infection
    K04519  IL1B; interleukin 1 beta
   05163 Human cytomegalovirus infection
    K04519  IL1B; interleukin 1 beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04519  IL1B; interleukin 1 beta
   05144 Malaria
    K04519  IL1B; interleukin 1 beta
   05140 Leishmaniasis
    K04519  IL1B; interleukin 1 beta
   05142 Chagas disease
    K04519  IL1B; interleukin 1 beta
   05143 African trypanosomiasis
    K04519  IL1B; interleukin 1 beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04519  IL1B; interleukin 1 beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04519  IL1B; interleukin 1 beta
   00536 Glycosaminoglycan binding proteins
    K04519  IL1B; interleukin 1 beta
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K04519  IL1B; interleukin 1 beta
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Cytokines
   K04519  IL1B; interleukin 1 beta
Other DBs
GO: 0005149
Genes
HSA: 3553(IL1B)
PTR: 450200(IL1B)
PPS: 100993613(IL1B)
GGO: 101130571(IL1B)
PON: 100454379(IL1B)
NLE: 100587357(IL1B)
MCC: 704701(IL1B)
MCF: 102119749(IL1B)
CSAB: 103241278(IL1B)
RRO: 104672547(IL1B)
RBB: 108541809(IL1B)
CJC: 100406769(IL1B)
SBQ: 101033664(IL1B)
MMU: 16176(Il1b)
MCAL: 110290100(Il1b)
MPAH: 110319321(Il1b)
RNO: 24494(Il1b)
MUN: 110551400(Il1b)
CGE: 100775079(Il1b)
NGI: 103739899(Il1b)
HGL: 101704309(Il1b)
CCAN: 109701168(Il1b)
OCU: 100008990(IL1B)
TUP: 102475138(IL1B)
CFA: 403974(IL1B)
VVP: 112916797(IL1B)
AML: 100480874(IL1B)
UMR: 103671495(IL1B)
UAH: 113242506(IL1B)
ORO: 101383005(IL1B)
ELK: 111158456
FCA: 768274(IL1B)
PTG: 102951272(IL1B)
PPAD: 109264508(IL1B)
AJU: 106976013(IL1B)
BTA: 281251(IL1B)
BOM: 102282890(IL1B)
BIU: 109566133(IL1B)
BBUB: 102396262(IL1B)
CHX: 100860816(IL1B)
OAS: 443539(IL1B)
SSC: 396565(IL1B2) 397122(IL1B)
CFR: 102521979(IL1B)
CDK: 105093155(IL1B)
BACU: 103008438(IL1B)
LVE: 103090784(IL1B)
OOR: 101284892(IL1B)
DLE: 111187492(IL1B)
PCAD: 102994188(IL1B)
ECB: 100034237(IL1B) 100052414(IL1B) 111768185
EPZ: 103544835(IL1B)
EAI: 106838557(IL1B)
MYB: 102251576(IL1B)
MYD: 102769803(IL1B)
MNA: 107528631(IL1B)
HAI: 109393524(IL1B)
DRO: 112302944(IL1B)
PALE: 102893238(IL1B)
RAY: 107514900(IL1B)
MJV: 108393034(IL1B)
LAV: 100674746(IL1B)
TMU: 101359415(IL1B)
MDO: 100026024(IL1B)
SHR: 100922350(IL1B)
PCW: 110192539(IL1B)
OAA: 103165286(IL1B)
GGA: 395196(IL1B)
MGP: 100034741(IL1RN)
CJO: 107323637
NMEL: 110387108
TGU: 100227014(IL1B)
LSR: 110478285(IL1B)
SCAN: 103822662(IL1B)
GFR: 102041770(IL1B)
FAB: 101819115(IL1B)
PHI: 102108659(IL1B)
PMAJ: 107213896
CCAE: 111938925
CCW: 104683159
ETL: 114070272(IL1B)
FPG: 101924267
FCH: 102050776
CLV: 102090585(IL1B)
EGZ: 104132895(IL1RN)
NNI: 104022599
ACUN: 113488139
PADL: 103912923
ASN: 102369595 112547978
AMJ: 102570262(IL1B) 102575353
PSS: 102448244
CMY: 102933972 102936298
CPIC: 101943587(IL1B) 101949861
PVT: 110072197(IL1B)
PBI: 103055254(IL1B)
PMUR: 107283245(IL1B)
TSR: 106544675
PMUA: 114603303(IL1B)
GJA: 107118765
XLA: 108711577(il1b.L) 108711578 108712739 373606(il1b.S)
XTR: 100487038(il1b) 116409784
NPR: 108785587 108785600
DRE: 405770(il1b)
SRX: 107706800 107735843
SANH: 107658569 107682454
SGH: 107554524 107581079 107589025
CCAR: 109062938 109062992 109062994 109097442
IPU: 100304696(il1b) 100304697(il1b)
PHYP: 113544737
AMEX: 103026214 111194997
EEE: 113584063
TRU: 101080001(il1b)
LCO: 104923462
NCC: 104948030 104955090(il1b)
MZE: 101472948 101473431 101481848 101485031
ONL: 100693282 100707066 100707443
OLA: 101169209
XMA: 102231459 106700093 111610322
XCO: 114149066 114153988 114155120
PRET: 103470686 103473214
CVG: 107099154 107099476
NFU: 107386182
KMR: 108242738
ALIM: 106510763(il1b) 106522184
AOCE: 111580399 111583887
CSEM: 103389940 103396898 103397875
POV: 109626174 109641260
LCF: 108878374 108895307
SDU: 111227981 111227984 111239668
SLAL: 111659489 111660942 111660964 111666074
HCQ: 109513432
BPEC: 110166705 110172087(il1b)
MALB: 109951327 109953309
SASA: 100136449 106562915(IL-1b3) 106570815
OTW: 112219797 112230772 112248882
SALP: 111963800 111974578 112071295
ELS: 105007339 105009489
SFM: 108932396 108940319 114909774
PKI: 111848567 111851454
LCM: 102364535
CMK: 103187802
 » show all
Reference
PMID:6083565
  Authors
Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA
  Title
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
  Journal
Proc Natl Acad Sci U S A 81:7907-11 (1984)
DOI:10.1073/pnas.81.24.7907
  Sequence
[hsa:3553]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (80)   
   KEGG PATHWAY (80)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DRUG (4)   
Gene (200)   
   KEGG GENES (196)   
   RefGene (3)   
   OC (1)   
Protein sequence (85)   
   UniProt (76)   
   SWISS-PROT (9)   
Literature (1)   
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