KEGG ORTHOLOGY: K04526

ORTHOLOGY: K04526

Entry

K04526                      KO

Symbol

INS

Name

insulin

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04022

cGMP-PKG signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04114

Oocyte meiosis

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04213

Longevity regulating pathway - multiple species

map04810

Regulation of actin cytoskeleton

map04910

Insulin signaling pathway

map04911

Insulin secretion

map04913

Ovarian steroidogenesis

map04914

Progesterone-mediated oocyte maturation

map04917

Prolactin signaling pathway

map04923

Regulation of lipolysis in adipocytes

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map04940

Type I diabetes mellitus

map04950

Maturity onset diabetes of the young

map04960

Aldosterone-regulated sodium reabsorption

map05010

Alzheimer disease

map05215

Prostate cancer

map05415

Diabetic cardiomyopathy

Disease

H00408

Type 1 diabetes mellitus

H00410

Maturity onset diabetes of the young (MODY)

H00512

Permanent neonatal diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04526  INS; insulin
   04014 Ras signaling pathway
    K04526  INS; insulin
   04015 Rap1 signaling pathway
    K04526  INS; insulin
   04066 HIF-1 signaling pathway
    K04526  INS; insulin
   04068 FoxO signaling pathway
    K04526  INS; insulin
   04072 Phospholipase D signaling pathway
    K04526  INS; insulin
   04022 cGMP-PKG signaling pathway
    K04526  INS; insulin
   04151 PI3K-Akt signaling pathway
    K04526  INS; insulin
   04152 AMPK signaling pathway
    K04526  INS; insulin
   04150 mTOR signaling pathway
    K04526  INS; insulin
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04526  INS; insulin
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04526  INS; insulin
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04526  INS; insulin
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04526  INS; insulin
   04910 Insulin signaling pathway
    K04526  INS; insulin
   04923 Regulation of lipolysis in adipocytes
    K04526  INS; insulin
   04913 Ovarian steroidogenesis
    K04526  INS; insulin
   04914 Progesterone-mediated oocyte maturation
    K04526  INS; insulin
   04917 Prolactin signaling pathway
    K04526  INS; insulin
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04526  INS; insulin
  09149 Aging
   04211 Longevity regulating pathway
    K04526  INS; insulin
   04213 Longevity regulating pathway - multiple species
    K04526  INS; insulin
09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    K04526  INS; insulin
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04526  INS; insulin
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04526  INS; insulin
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04526  INS; insulin
   04940 Type I diabetes mellitus
    K04526  INS; insulin
   04950 Maturity onset diabetes of the young
    K04526  INS; insulin
   04932 Non-alcoholic fatty liver disease
    K04526  INS; insulin
   04931 Insulin resistance
    K04526  INS; insulin

Genes

HSA:

3630(INS)

PTR:	449570(INS)

PPS:	100969387(INS)

GGO:	101132604(INS)

PON:	100453978(INS)

NLE:	100586809(INS)

MCC:	704534(INS)

MCF:	102133184(INS)

MTHB:

126935873

MNI:	105469786(INS)

CSAB:

103239029(INS)

CATY:

105577261(INS)

PANU:

100997985(INS)

MLEU:

105545324(INS)

RRO:	104677102(INS)

RBB:	108539226(INS)

TFN:	117081143(INS)

PTEH:

111520623(INS)

CJC:	100393089(INS)

SBQ:	101038116(INS)

CIMI:

108288726(INS)

MMUR:

105859822(INS)

LCAT:

123642915(INS)

PCOQ:

105816531(INS)

OGA:	100958310(INS)

MMU:	16333(Ins1) 16334(Ins2)

MCAL:

110286053 110299132

MPAH:

110326410 110333420

RNO:	24505(Ins1) 24506(Ins2)

MCOC:

116101481

ANU:	117722990 117723507

MUN:

110547298

CGE:	100760716(Ins)

MAUA:

101823595(Ins)

PLEU:

114695174(Ins)

MORG:

121457317(Ins)

MFOT:

126498130

AAMP:

119805421(Ins)

NGI:	103738986(Ins)

HGL:	101719971(Ins)

CPOC:

100379579(Ins)

CCAN:

109689794

DORD:

105989171(Ins)

DSP:	122102073(Ins)

NCAR:

124960685

OPI:

101533865

TUP:	102481191(INS)

CFA:	483665(INS)

CLUD:

112663225(INS)

VVP:	112924140(INS)

VLG:	121471415(INS)

NPO:	129503213(INS)

AML:	100483432(INS)

UMR:

103671056

UAH:

113243960

UAR:	123775502(INS)

ELK:

111150279

LLV:

125079072

MPUF:

101684928(INS)

NVS:	122914590(INS)

ORO:	101383590(INS)

EJU:

114220406

ZCA:	113914580(INS)

MLX:	118015656(INS)

NSU:	110576080(INS)

LWW:	102747637(INS)

FCA:	493804(INS)

PYU:	121023965(INS)

PBG:	122484127(INS)

LRUF:

124527868

PPAD:

109259395(INS)

PUC:

125911602

AJU:

113595531

HHV:	120226896(INS)

BTA:	280829(INS)

BOM:	102274400(INS)

BIU:	109554336(INS)

BBUB:

102396436(INS)

CHX:	108634241(INS)

OAS:	114110121(INS)

BTAX:

128069208(INS)

ODA:	120874170(INS)

CCAD:

122430981(INS)

SSC:	397415(INS)

CFR:	116666555(INS)

CDK:	116152037(INS)

VPC:	116285510(INS)

BACU:

103021022(INS)

LVE:	103085742(INS)

OOR:	101278494(INS)

DLE:	111183606(INS)

PCAD:

112062628(INS)

PSIU:

116758168

NASI:

112402369(INS)

ECB:	111776000(INS)

EPZ:	103567614(INS)

MYB:

102254396

MYD:	102753598(INS)

MMYO:

118659596 118659608 118659612

MLF:	102430737(INS)

PKL:	118713982(INS)

HAI:	109395936(INS)

DRO:

112317432

SHON:

118988340(INS)

AJM:	119057541(INS)

PDIC:

114500824(INS)

PHAS:

123807354(INS)

MMF:	118628933(INS)

RFQ:	117030020(INS)

PALE:

102881117

PGIG:

120584612(INS)

RAY:	107513269(INS)

MJV:	108402614(INS)

TOD:	119249861(INS)

SARA:

101545195(INS) 101551461

LAV:	100661112(INS)

TMU:

101346705

ETF:	101641705(INS)

GAS:	123256044(INS)

AFZ:

127540738

PCW:	110197190(INS)

OAA:	114810063(INS)

GGA:	396145(INS-IGF2)

PCOC:

116242868(INS)

MGP:	100540225(INS)

CJO:	107314531(INS)

TPAI:

128086622(INS)

NMEL:

110400779(INS)

APLA:

101794427(INS)

ACYG:

106042601(INS)

AFUL:

116489355(INS)

TGU:	100231606(INS)

LSR:	110468670(INS)

SCAN:

103826754(INS)

PMOA:

120511419(INS)

OTC:	121341561(INS)

PRUF:

121361012(INS)

GFR:	102044590(INS)

FAB:	101812165(INS)

PHI:	102111203(INS)

PMAJ:

107205419(INS)

CCAE:

111930707(INS)

CCW:

104687554

CBRC:

103624930

ETL:	114059852(INS)

ZAB:	102072773(INS)

ACHL:

103802297(INS)

SVG:	106859791(INS)

FPG:	101915745(INS)

FCH:	102054961(INS)

CLV:	102092033(INS)

EGZ:

104124907

NNI:

104010412

PLET:

104617306(INS)

PCRI:

104029162(INS)

PCAO:

104047388(INS)

ACUN:

113481160

TALA:

104368806(INS)

PADL:

103920695(INS)

AFOR:

103906715(INS)

ACHC:

115352123

HALD:

104319005(INS)

HLE:	104829565(INS)

AGEN:

126047226

GCL:

127017343

CCRI:

104163519(INS)

CSTI:

104556073(INS)

EHS:	104516693(INS)

CMAC:

104484558(INS)

MUI:	104536216(INS)

BREG:

104639471(INS)

FGA:	104083782(INS)

GSTE:

104256001(INS)

LDI:	104339708(INS)

MNB:	103768524(INS)

OHA:	104330120(INS)

NNT:	104404955(INS)

SHAB:

115607484(INS)

DPUB:

104305807(INS)

PGUU:

104472141(INS)

ACAR:

104520874(INS)

CPEA:

104394306

AVIT:

104279700(INS)

CVF:	104292587(INS)

CUCA:

104068903

TEO:	104379612(INS)

BRHI:

104488944(INS)

AAM:	106497062(INS)

AROW:

112972450(INS)

NPD:	112945254(INS)

TGT:

104570706

DNE:	112978921(INS)

SCAM:

104143748(INS)

ASN:	102378642(INS)

AMJ:	102565762(INS)

CPOO:

109320953(INS)

GGN:	109299505(INS)

PSS:	102445198(INS)

CMY:	102935680(INS)

CPIC:

101937524(INS)

TST:	117876752(INS)

CABI:

116819349(INS)

MRV:	120404835(INS)

ACS:	100565615(ins)

PVT:	110076559(INS)

SUND:

121918950(INS)

PBI:	103061255(INS)

PMUR:

107294042(INS)

CTIG:

120311349

TSR:	106547000(INS)

PGUT:

117666068

PTEX:

113440221(INS)

NSS:	113412472(INS)

VKO:	123021294(INS)

PMUA:

114585088

ZVI:

118089274

HCG:	128323861(INS)

GJA:	107123376(INS)

STOW:

125426313 125426951(INS)

XLA:	108696734(XB5961731.L) 378695(ins.L) 378696(ins.S)

XTR:	100101718(ins)

NPR:	108792002(INS)

RTEM:

120917286(INS)

BBUF:

120980007(INS)

BGAR:

122920015(INS)

DRE:	100534937 30262(ins) 566735(insb)

SRX:	107707184 107729420 107730741 107734121 107736649 107746436

SANH:

107661260(ins) 107663421 107663422 107666601 107689667

SGH:	107554113 107561280 107596207 107599231 107600181

CCAR:

109051698 109085261 109085271 109094548

CAUA:

113047664 113049073 113073488 113077182 113114193

CGIB:

127953825 127957935 127971917 128004082 128027077

PTET:

122342085 122344767(ins) 122358096(insb)

LROH:

127163542 127164980(ins) 127176089(insb)

PPRM:

120460588(insb) 120461675(ins)

MAMB:

125259323(insb) 125266058(ins) 125277562

CIDE:

127508035 127512529 127525708

MASI:

127413002 127427992 127428010 127435195 127435203 127451533

IPU:	108259786 108259964 108280599

PHYP:

113525002 113531241(ins)

SMEO:

124379286(ins)

TFD:	113650955(ins)

AMEX:

103028544 103030099(ins) 103041971

CMAO:

118800533 118801651(ins) 118806420(insb)

EEE:	113591428(ins)

TRU:

101065226

TNG:	GSTEN00008749G001 GSTEN00014675G001

LCO:	104923900 104931882 109142434(ins)

NCC:	104961913(ins)

CGOB:

115014742 115018585(ins)

ELY:	117261385(insb) 117270452(ins)

EFO:	125894470(insb) 125898795(ins)

PLEP:

121938184(ins) 121948354(insb)

SLUC:

116052062(insb) 116060396 116061955(ins)

ECRA:

117951814(insb)

ESP:	116696869(ins)

PFLV:

114562468 114567209

GAT:	120822893(ins)

PPUG:

119215349(ins)

MSAM:

119888918(insb) 119894945(ins)

SCHU:

122880879(insb) 122888298(ins)

CUD:	121516567(insb) 121519113(ins)

ALAT:

119007595 119031601 119031607 119031608

MZE:	101468103(ins) 101469513

ONL:	100692120(ins) 100704156

OAU:	116315148(insb) 116335737(ins)

OLA:	100125446 101172253

OML:	112141334(ins) 112142690 112153519

XMA:	102225241(ins) 102229304

XCO:	114139621 114153755(ins)

XHE:	116714921 116728047(ins)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122837576(insb) 122845354(ins)

CVG:	107086316 107090300(ins)

CTUL:

119798134(ins)

GMU:	124860812(insb) 124875874(ins)

NFU:	107383905 107386784

KMR:	108237967(insb) 108238926 108250678(ins)

ALIM:

106525530 106529800 106536859

NWH:	119409113(insb) 119419923 119420379(ins)

AOCE:

111566177 111587296(ins) 111588046

MCEP:

125008716(insb) 125021226(ins)

CSEM:

103395680(ins)

POV:	109624754 109643669(ins) 109645588

SSEN:

122778685(insb) 122779138(ins)

HHIP:

117769264(insb) 117774639(ins)

HSP:	118112388 118122248(ins)

LCF:	108882783 108890171 108890250 108893384

SDU:	111221377(ins) 111226678 111234582

SLAL:

111653396(ins) 111664630 111672131

XGL:	120785499(insb) 120802773 120802802

HCQ:	109517881 109524473 109528912

SSCV:

125981728 125994063

BPEC:

110156469 110172772

MALB:

109952337 109955249 109959979 109968712

BSPL:

114864486(insb) 114869723 114869891(ins)

SASA:

106567474(INS) 106603941(INS) 106612054

STRU:

115148215 115153684 115190165

OTW:	112234673 112255913 112259393

OMY:	100136702 100136703 118946006

OGO:	123995144 124000570

ONE:	115104644 115124592 115129128

SALP:

111950763 111967220 111981304

SNH:	120044421 120046921 120056420 120062047

CCLU:

121533215 121574459 121580143

ELS:	105021727 105025960

SFM:	108934283(ins)

PKI:	111850821(ins)

AANG:

118216348 118235395 118235396 118235397

LOC:	102694874 102695073

PSPA:

121295106 121305882 121330389

ARUT:

117434440

PSEX:

120517688(ins) 120542969

LCM:	102348278(INS)

CMK:	103186003(ins)

RTP:	109921259(ins)

CPLA:

122558059

DME:	Dmel_CG14167(Ilp3) Dmel_CG14173(Ilp1) Dmel_CG33273(Ilp5) Dmel_CG6736(Ilp4) Dmel_CG8167(Ilp2)

DER:	6546016 6546017 6546018 6546019 6546022

DSE:	6605102 6605104 6605107

DSI:	Dsimw501_GD12890(Dsim_GD12890) Dsimw501_GD12891(Dsim_GD12891) Dsimw501_GD12892(Dsim_GD12892) Dsimw501_GD14217(Dsim_GD14217) Dsimw501_GD14218(Dsim_GD14218)

DYA:	Dyak_GE20299 Dyak_GE20300(Dyak_Ilp4) Dyak_GE20301 Dyak_GE21719 Dyak_GE21720

DSR:	110187335 110187345 110190564 110190613 110190614 110190615 110190725

DPO:	117185171 4813355 4813890 6900736 6900737

DPE:	113566445 6602817 6602822 6602823

DMN:	108152247 108152248 108152249 108152251 108152252

DWI:	26529296 6645318 6645319

DGR:	6556876 6556893 6556922 6556940 6556947 6557001

DMO:	Dmoj_GI12279 Dmoj_GI12280 Dmoj_GI12281 Dmoj_GI13033 Dmoj_GI13035

DAZ:	108613071 108613072 108613073 108613074 108613075

DNV:	108651278 108651279 108651280 108651282 108651283

DHE:	111598695 111598707 111598708 111598709 111598755

CCAT:

101450959 101462409 101462588 101463004 105665118 105665119 105665120

BOD:	106617457 106617580 106617597 106617598 106617599 106627622 106627642

MDE:	101889921 101893775 101893945 101894101 101894119 105262243 109612103 109612104 109613673

SCAC:

106086464 106088789 106094793 106094794 106094866 106094921 106095269

LCQ:	111675091 111675996

LSQ:	119602639 119602640 119602641 119602642 119602643 119613806

AGA:	AgaP_AGAP010600 AgaP_AGAP010601 AgaP_AGAP010602 AgaP_AGAP010603 AgaP_AGAP010604 AgaP_AGAP010605

ACOZ:

120958288 120959058 120960184

AARA:

120900028 120903604 120903606

AMER:

121598295 121599717 121600169

ASTE:

118506112 118506113 118506114

AALI:

118466994 118467312

AAG:	110679401 5567483 5567485 5567486

AALB:

109403160 109403183 109622174 115268336

CQU:	CpipJ_CPIJ018049 CpipJ_CPIJ018050 CpipJ_CPIJ018051 CpipJ_CPIJ018052

CPII:

120421839 120421843 120421844

CNS:

116340098

BCOO:

119066837 119069766 119074792

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:	105252710 105255165 105257206 112637902 112637903 112638354 112638377 112638378 112638379 112638381 112638382 112639387

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CCIN:

NPT:

NFB:

NLO:

TCA:

DPA:

SOY:	115875219 115885302

AGRG:

126733737

ATD:	109597751 109603602

CSET:

123309733 123309734 123317986

AGB:	108911986 108912000 108912816

LDC:	111503248 111517962 111517971

NVL:	108569818 108569829 108569830

APLN:

108741729 108741730

PPYR:

116169219 116174659 116174660 116174701

OTU:	111415302 111415305 111415878 111415883 111416716 111418959 111421582 111421720 111423319 111423355

BMOR:

100146109(Bbx-e1) 100146110(Bbx-f1) 100169657(Bbx-a4) 100169708(Bbx-a7) 100169712(Bbx-a3) 100169716(Bbx-b7) 100169719(Bbx-b1) 100169720(Bbx-b4) 100169723(Bbx-b6) 100169726(Bbx-g1) 100653512(BmILP) 101736783 101741759 110386649

BMAN:

114239790 114239809 114249637 114249638 114249639 114249640 114249643 114249645 114249646 114249648 114249649 114249650 114252200 114252201 114252205 114252555 114252556

MSEX:

115447806 115447807 115447808 115447809 115447810 115447811 115447813 115447814 115447816 115447817 115447818 115447819 115456422 115456431 119189397

DPL:	KGM_200042 KGM_202681 KGM_202682 KGM_206157

BANY:

112042917 112044938 112045526 112045735 112050564 112053796

PMAC:

106709220 106715286 106720292

PPOT:

106099949 106099950 106099951 106105649

PXU:	106113421 106126592

PRAP:

110992988 110999357

PNAP:

125048599

ZCE:	119830987 119833516 119838279 119838563 119840923

CCRC:

123696434

HAW:	110374203 110384007

HZE:

124632454

TNL:	113495219 113497725 113500591 113506709

SLIU:

111349683 111354087 111355654 111355766 111358241

OFU:	114357258 114361879 114362154 114363626 114363628

PXY:	105384156 105393888

API:	100161832 100568938 100570058 100574788 100575361

DNX:	107166147 107169120

AGS:	114120744 114127532

RMD:

113558495

BTAB:

109038562 109038563

DCI:	103505565 103505566

CLEC:

112127432

HHAL:

106683319

NLU:	111046284 111053537 111053538

FOC:

113208572

TPAL:

117650332 117650333

ZNE:	110829699 110832106 110832107 110832108

CSEC:

111861297 111862713

FCD:

110851216

DPX:	DAPPUDRAFT_300602

PCHN:

125038073

PTRU:

123506887

EAF:	111704221 111706369

PPOI:

119092352 119107572

ISC:	IscW_ISCW020331

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

111624064 111634212 111637650 111637652 111637654

PTEP:

107444576 107448965 107448973 107451234 107455901

SDM:	118185030 118185031 118196017 118196019 118197391

LPOL:

106457310 106457397 106459415 106469140 111083358

TSP:

Tsp_10902

LGI:	LOTGIDRAFT_232734

BGT:	106057571 106076723

GAE:	121369741 121372018

HRF:	124125324 124133455

HRJ:	124256453 124271354

CRG:	105319755 105347687

MMER:

OSN:

LAK:

EGL:

NVE:	116601477 116603593

ATEN:

116292330 116292360 116304936

AMIL:

PDAM:

SPIS:

HADH:

PHX:	KGNDJEFE_00269

» show all

Reference

PMID:11937037

Authors

Lizcano JM, Alessi DR

Title

The insulin signalling pathway.

Journal

Curr Biol 12:R236-8 (2002)
DOI:10.1016/S0960-9822(02)00777-7

Reference

PMID:2397023

Authors

Sawa T, Ohgaku S, Morioka H, Yano S

Title

Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.

Journal

J Mol Endocrinol 5:61-7 (1990)
DOI:10.1677/jme.0.0050061

Sequence

[mmu:16333 16334]

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