KEGG   ORTHOLOGY: K04575
Entry
K04575                      KO                                     

Name
ALS2
Definition
amyotrophic lateral sclerosis 2 protein
Pathway
ko05014  Amyotrophic lateral sclerosis
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00970  Juvenile primary lateral sclerosis
H01172  Infantile ascending hereditary spastic paralysis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04575  ALS2; amyotrophic lateral sclerosis 2 protein
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04575  ALS2; amyotrophic lateral sclerosis 2 protein
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04575  ALS2; amyotrophic lateral sclerosis 2 protein
Other DBs
GO: 0005087 0017112 0030676 0043539
Genes
HSA: 57679(ALS2)
PTR: 470613(ALS2)
PPS: 100982876(ALS2)
GGO: 101143307(ALS2)
PON: 100436721(ALS2)
NLE: 101177725(ALS2)
MCC: 703263(ALS2)
MCF: 101925534(ALS2)
CSAB: 103217652(ALS2)
RRO: 104655524(ALS2)
RBB: 108513034(ALS2)
CJC: 100398001(ALS2)
SBQ: 101040861(ALS2)
MMU: 74018(Als2)
MCAL: 110296120(Als2)
MPAH: 110322667(Als2)
RNO: 363235(Als2)
MUN: 110557655(Als2)
CGE: 100763641(Als2)
NGI: 103741649(Als2)
HGL: 101698373(Als2)
CCAN: 109683732(Als2)
OCU: 100345931(ALS2)
TUP: 102502263(ALS2)
CFA: 100856109(ALS2)
VVP: 112922867(ALS2)
AML: 100481919(ALS2)
UMR: 103659750(ALS2)
UAH: 113250585(ALS2)
ORO: 101363756(ALS2)
ELK: 111143863
FCA: 101094869(ALS2)
PTG: 102960190(ALS2)
PPAD: 109259194(ALS2)
AJU: 106978269(ALS2)
BTA: 535750(ALS2)
BOM: 102274317(ALS2)
BIU: 109569600(ALS2)
BBUB: 102395114(ALS2)
CHX: 102172771(ALS2)
OAS: 101109592(ALS2)
SSC: 100626864(ALS2)
CFR: 102506577(ALS2)
CDK: 105098965(ALS2)
BACU: 103007919(ALS2)
LVE: 103069433
OOR: 101278761(ALS2)
DLE: 111171735(ALS2)
PCAD: 102989704(ALS2)
ECB: 100066250(ALS2)
EPZ: 103560133(ALS2)
EAI: 106843147(ALS2)
MYB: 102250168(ALS2)
MYD: 102770825(ALS2)
MNA: 107533949(ALS2)
HAI: 109379242(ALS2)
PALE: 102879687(ALS2)
RAY: 107503166(ALS2)
MJV: 108394290(ALS2)
LAV: 100659508(ALS2)
TMU: 101346138
MDO: 100019560(ALS2)
SHR: 100924565(ALS2)
PCW: 110197039(ALS2)
OAA: 100088146(ALS2)
GGA: 424085(ALS2)
MGP: 100541821(ALS2)
CJO: 107316513(ALS2)
NMEL: 110399188(ALS2)
APLA: 101794599(ALS2)
ACYG: 106030102(ALS2)
TGU: 100228070(ALS2)
LSR: 110484619(ALS2)
SCAN: 103814502(ALS2)
GFR: 102043772(ALS2)
FAB: 101813166(ALS2)
PHI: 102102992(ALS2)
PMAJ: 107207462(ALS2)
CCAE: 111931992(ALS2)
CCW: 104693784(ALS2)
ETL: 114055721(ALS2)
FPG: 101913153(ALS2)
FCH: 102059164(ALS2)
CLV: 102086321(ALS2)
EGZ: 104130506(ALS2)
NNI: 104010200(ALS2)
ACUN: 113482530(ALS2)
PADL: 103923520(ALS2)
AAM: 106492450(ALS2)
ASN: 102371367(ALS2)
AMJ: 102566519(ALS2)
PSS: 102456896(ALS2)
CMY: 102930394(ALS2)
CPIC: 101931614(ALS2)
ACS: 100562313(als2)
PVT: 110090715(ALS2)
PBI: 103067234(ALS2)
PMUR: 107294762(ALS2) 107299145
PMUA: 114581415(ALS2)
GJA: 107113310(ALS2)
XLA: 108701459
XTR: 779575(als2)
NPR: 108785034(ALS2)
DRE: 100318899(als2b) 557014(als2a)
IPU: 108266741 108273198(als2)
PHYP: 113525238 113538409(als2)
AMEX: 103024024(als2) 103027455
EEE: 113578531 113584078(als2)
TRU: 101078293 677725(als2)
LCO: 104926237(als2) 104936975
NCC: 104949929(als2) 104956201
MZE: 101473430 101480076(als2)
ONL: 100690650(als2) 100694505
OLA: 101160203 101169837(als2)
XMA: 102219839 102233500(als2)
XCO: 114140461(als2) 114147672
PRET: 103461746 103473859(als2)
CVG: 107083525 107086449(als2)
KMR: 108240430 108249012(als2)
ALIM: 106512557(als2) 106519703
AOCE: 111581153(als2) 111584968
CSEM: 103389602(als2) 103392298
POV: 109631483 109644585(als2)
LCF: 108873054(als2) 108886906
SDU: 111218243 111232646(als2)
SLAL: 111652399 111670335(als2)
HCQ: 109523295 109528353(als2)
BPEC: 110156135 110175587(als2)
MALB: 109960543(als2) 109968298
SFM: 108918426(als2)
PKI: 111858356(als2)
LCM: 102357517(ALS2)
CMK: 103176840(als2)
SPU: 585159
APLC: 110973041
SKO: 102809689
DME: Dmel_CG7158(Als2)
DER: 6543990
DSE: 6616492
DSI: Dsimw501_GD12097(Dsim_GD12097)
DAN: 6507276
DSR: 110179817
DPE: 6595768
DMN: 108152902
DWI: 6639317
DAZ: 108614009
DNV: 108651549
DHE: 111600997
DVI: 6624244
MDE: 101889064
LCQ: 111691241
AAG: 5578118
AME: 413195
BIM: 100748788
BTER: 100652045
CCAL: 108632878
OBB: 114883153
SOC: 105194519
AEC: 105146341
ACEP: 105627904
PBAR: 105430582
VEM: 105562106
HST: 105190401
DQU: 106746585
CFO: 105257567
LHU: 105678892
OBO: 105278245
PCF: 106790517
NVI: 100117052
CSOL: 105363557
MDL: 103571455
TCA: 100142202
DPA: 109538616
NVL: 108560714
BMOR: 101740931
BMAN: 114249251
PMAC: 106714179
PRAP: 110994205
HAW: 110371117
TNL: 113501041
PXY: 105397918
CLEC: 106667928
ZNE: 110832883
CSCU: 111621426
TSP: Tsp_06444
PCAN: 112557000
CRG: 105327937
MYI: 110461627
OBI: 106867358
LAK: 106163905
NVE: 5515546
EPA: 110246385
AMIL: 114966855
PDAM: 113675738
SPIS: 111332559
DGT: 114517598
HMG: 100205079
AQU: 100640928
 » show all
Reference
  Authors
Millecamps S, Gentil BJ, Gros-Louis F, Rouleau G, Julien JP
  Title
Alsin is partially associated with centrosome in human cells.
  Journal
Biochim Biophys Acta 1745:84-100 (2005)
DOI:10.1016/j.bbamcr.2004.12.008
  Sequence
[hsa:57679] [mmu:74018]
Reference
  Authors
Jacquier A, Buhler E, Schafer MK, Bohl D, Blanchard S, Beclin C, Haase G
  Title
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons.
  Journal
Ann Neurol 60:105-17 (2006)
DOI:10.1002/ana.20886
  Sequence
[rno:363235]
Reference
  Authors
Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben-Hamida M, Pericak-Vance M, Hentati F, Siddique T.
  Title
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.
  Journal
Nat Genet 29:160-5 (2001)
DOI:10.1038/ng1001-160
  Sequence
[hsa:57679]

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