KEGG   ORTHOLOGY: K04662
Entry
K04662                      KO                                     

Name
BMP4
Definition
bone morphogenetic protein 4
Pathway
ko04013  MAPK signaling pathway - fly
ko04060  Cytokine-cytokine receptor interaction
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04919  Thyroid hormone signaling pathway
ko05200  Pathways in cancer
ko05217  Basal cell carcinoma
ko05418  Fluid shear stress and atherosclerosis
Disease
H00516  Cleft lip and/or cleft palate
H02170  Microphthalmia, syndromic
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04341 Hedgehog signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04350 TGF-beta signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
   04390 Hippo signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP4; bone morphogenetic protein 4
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP4; bone morphogenetic protein 4
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04662  BMP4; bone morphogenetic protein 4
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K04662  BMP4; bone morphogenetic protein 4
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04662  BMP4; bone morphogenetic protein 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04662  BMP4; bone morphogenetic protein 4
   00536 Glycosaminoglycan binding proteins
    K04662  BMP4; bone morphogenetic protein 4
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   K04662  BMP4; bone morphogenetic protein 4
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Morphogens
   K04662  BMP4; bone morphogenetic protein 4
Other DBs
GO: 0070700
Genes
HSA: 652(BMP4)
PTR: 107968170(BMP4)
PPS: 100987443(BMP4)
GGO: 101126138(BMP4)
PON: 100449444(BMP4)
NLE: 100586277(BMP4)
MCC: 694618(BMP4)
MCF: 102132568(BMP4)
CSAB: 103229007(BMP4)
RRO: 104669157(BMP4)
RBB: 108513693
CJC: 100398270(BMP4)
SBQ: 101038031(BMP4)
MMU: 12159(Bmp4)
MCAL: 110309274(Bmp4)
MPAH: 110325391(Bmp4)
RNO: 25296(Bmp4)
MUN: 110550958(Bmp4)
CGE: 100754303(Bmp4)
NGI: 103739231(Bmp4)
HGL: 101711207(Bmp4)
CCAN: 109701382(Bmp4)
OCU: 100009569(BMP4)
TUP: 102497487(BMP4)
CFA: 490695(BMP4)
VVP: 112921419(BMP4)
AML: 100477715(BMP4)
UMR: 103672975(BMP4)
UAH: 113242361(BMP4)
ORO: 101380696(BMP4)
ELK: 111162047
FCA: 101100311(BMP4)
PTG: 102950088(BMP4)
PPAD: 109268456(BMP4)
AJU: 106983046(BMP4)
BTA: 407216(BMP4)
BOM: 102266106(BMP4)
BIU: 109565174(BMP4)
BBUB: 102398788(BMP4)
CHX: 100860789(BMP4)
OAS: 443502(BMP4)
SSC: 100113425(BMP4)
CFR: 102509507(BMP4)
CDK: 105091431(BMP4)
BACU: 103010740(BMP4)
LVE: 103072786(BMP4)
OOR: 101278431(BMP4)
DLE: 111173145(BMP4)
PCAD: 102981535(BMP4)
ECB: 100034048(BMP4)
EPZ: 103558707(BMP4)
EAI: 106846123(BMP4)
MYB: 102262406(BMP4)
MYD: 102769625(BMP4) 102770741
MNA: 107525879(BMP4)
HAI: 109384420(BMP4)
DRO: 112311413(BMP4)
PALE: 102881920(BMP4)
RAY: 107509544(BMP4)
MJV: 108407678(BMP4)
LAV: 100654115(BMP4)
TMU: 101356019
MDO: 100010652(BMP4)
SHR: 100916609(BMP4)
PCW: 110199877(BMP4)
OAA: 100089255(BMP4)
GGA: 396165(BMP4)
MGP: 100544182(BMP4)
CJO: 107315532(BMP4)
NMEL: 110401682(BMP4)
APLA: 101803077(BMP4)
ACYG: 106044053(BMP4)
TGU: 100221891(BMP4)
LSR: 110474762(BMP4)
SCAN: 103826326(BMP4)
GFR: 102044724(BMP4)
FAB: 101816834(BMP4)
PHI: 102110411(BMP4)
PMAJ: 107205267(BMP4)
CCAE: 111929526(BMP4)
CCW: 104687658(BMP4)
ETL: 114067429(BMP4)
FPG: 101923141(BMP4)
FCH: 102047171(BMP4)
CLV: 102098788(BMP4)
EGZ: 104122989(BMP4)
NNI: 104019440(BMP4)
PADL: 103915984(BMP4)
AAM: 106494596(BMP4)
ASN: 102371622(BMP4)
AMJ: 102573848(BMP4)
PSS: 102459846(BMP4)
CMY: 102932745(BMP4)
CPIC: 101949490(BMP4)
ACS: 100567033(bmp4)
PVT: 110089746(BMP4)
PBI: 103054912(BMP4)
PMUR: 107293299(BMP4)
TSR: 106539867(BMP4)
PMUA: 114594877(BMP4)
GJA: 107118494(BMP4)
XLA: 397874(bmp4.L) 399322(bmp4.S)
XTR: 549788(bmp4)
NPR: 108788625(BMP4)
DRE: 30612(bmp4)
IPU: 108270422(bmp4)
PHYP: 113538966(bmp4)
AMEX: 103024384(bmp4)
EEE: 113572633(bmp4)
TRU: 101061931(bmp4)
LCO: 104922404(bmp4)
NCC: 104964390(bmp4)
MZE: 101478902(bmp4)
ONL: 100693424(bmp4)
OLA: 100049354(bmp4)
XMA: 102236800(bmp4)
XCO: 114134479(bmp4)
PRET: 103458754(bmp4)
CVG: 107096913(bmp4)
NFU: 107392164(bmp4)
KMR: 108232299(bmp4)
ALIM: 106518439(bmp4)
AOCE: 111573266(bmp4)
CSEM: 103378831(bmp4)
POV: 109646622(bmp4)
LCF: 108875064(bmp4)
SDU: 111225424(bmp4)
SLAL: 111651019(bmp4)
HCQ: 109509080 109517481(bmp4)
BPEC: 110153633(bmp4)
MALB: 109968000(bmp4)
SASA: 100194815(bmp4) 106611121
ELS: 105015523(bmp4)
PKI: 111859967(bmp4)
LCM: 102365184(BMP4)
CMK: 103175246(bmp4)
RTP: 109911221(bmp4) 109915190
BFO: 118427296
DME: Dmel_CG9885(dpp)
DER: 6542079
DSE: 6613103
DSI: Dsimw501_GD23157(Dsim_dpp)
DYA: Dyak_GE18157(Dyak_dpp)
DAN: 6503287
DSR: 110184975
DPO: Dpse_GA22099(Dpse_dpp)
DPE: 6596485
DMN: 108163475
DWI: 6641621
DAZ: 108611910
DNV: 108649930
DHE: 111599355
DVI: 6627524
MDE: 101892832
LCQ: 111679334
AAG: 5572653
AALB: 109401713
AME: 727101
BIM: 100748741
BTER: 100646366
CCAL: 108629683
OBB: 114873881
SOC: 105202003
MPHA: 105835632
AEC: 105148754
ACEP: 105627064
PBAR: 105427703
VEM: 105560857
HST: 105180468
DQU: 106741356
CFO: 105252168
LHU: 105672334
PGC: 109861453
OBO: 105284879
PCF: 106785345
NVI: 100123906
CSOL: 105363714
MDL: 103575692
TCA: 654513(Dpp)
BMOR: 100270781(Dpp)
BMAN: 114248672
PMAC: 106715051
PRAP: 111000988
HAW: 110370724
TNL: 113497790
CLEC: 106665529
ZNE: 110828339
FCD: 110858354
CSCU: 111612605
PTEP: 107442925
CEL: CELE_T25F10.2(dbl-1)
LAK: 106163298
 » show all
Reference
  Authors
Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T
  Title
Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
  Journal
Calcif Tissue Int 94:454-64 (2014)
DOI:10.1007/s00223-013-9828-1
Reference
  Authors
Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J
  Title
BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
  Journal
Development 134:1221-30 (2007)
DOI:10.1242/dev.000182
  Sequence
[mmu:12159]

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