KEGG   ORTHOLOGY: K04725
Entry
K04725                      KO                                     

Symbol
XIAP, BIRC4
Name
E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
Pathway
map01524  Platinum drug resistance
map04064  NF-kappa B signaling pathway
map04120  Ubiquitin mediated proteolysis
map04210  Apoptosis
map04214  Apoptosis - fly
map04215  Apoptosis - multiple species
map04217  Necroptosis
map04510  Focal adhesion
map04621  NOD-like receptor signaling pathway
map05145  Toxoplasmosis
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05222  Small cell lung cancer
Disease
H00107  Other well-defined immunodeficiency syndromes
H01969  X-linked lymphoproliferative syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04214 Apoptosis - fly
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04215 Apoptosis - multiple species
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04217 Necroptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   05207 Chemical carcinogenesis - receptor activation
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   03029 Mitochondrial biogenesis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Peptidases and inhibitors [BR:ko01002]
 Peptidase inhibitors
  Family I32: IAP family
   K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Retention of mitochondria
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Other DBs
GO: 0043027
Genes
HSA: 331(XIAP)
PTR: 473765(XIAP)
PPS: 100970113 100971253 100993738(XIAP)
GGO: 101133804(XIAP)
PON: 100449741(XIAP)
NLE: 100597865(XIAP)
MCC: 698057(XIAP)
MCF: 102131393(XIAP)
CSAB: 103247375(XIAP)
CATY: 105586304(XIAP) 105591186(BIRC8)
PANU: 100998457 101022825(XIAP)
RRO: 104655196(XIAP)
TFN: 117077500(XIAP)
PTEH: 111532918
CJC: 100402341(XIAP)
SBQ: 101031174(XIAP)
MMUR: 105860713(XIAP)
MMU: 11798(Xiap)
MCAL: 110286671(Xiap)
MPAH: 110313538(Xiap)
RNO: 63879(Xiap)
MCOC: 116079101(Xiap)
MUN: 110542115(Xiap)
CGE: 100689374(Xiap)
PLEU: 114701517
NGI: 103734850(Xiap)
HGL: 101715865(Xiap)
CPOC: 100715778(Xiap)
CCAN: 109700263(Xiap)
OCU: 100328700(XIAP)
OPI: 101530290
TUP: 102500839(XIAP)
CFA: 442989(XIAP)
VVP: 112934433(XIAP)
VLG: 121482906
AML: 100471203(XIAP)
UMR: 103680228(XIAP)
UAH: 113270927(XIAP)
ORO: 101367150(XIAP)
ELK: 111157209
MPUF: 101671154(XIAP)
EJU: 114223713(XIAP)
MLX: 118012582(XIAP)
FCA: 101090594(XIAP)
PYU: 121025478
PBG: 122477723
PTG: 102957920(XIAP)
PPAD: 109250719(XIAP)
AJU: 106972832(XIAP)
HHV: 120236173
BTA: 281647(XIAP)
BOM: 102275096(XIAP)
BBUB: 102404023(XIAP)
CHX: 102170035(XIAP)
OAS: 101116381(XIAP)
ODA: 120881497
CCAD: 122434599
SSC: 100037300(XIAP)
CFR: 102507842(XIAP)
CBAI: 105075942(XIAP)
CDK: 105098886(XIAP)
BACU: 103010212(XIAP)
LVE: 103085092(XIAP)
OOR: 101290359(XIAP)
DLE: 111168228(XIAP)
PCAD: 102978378(XIAP)
PSIU: 116747379(XIAP)
ECB: 100060870(XIAP)
EPZ: 103543512(XIAP)
EAI: 106829909
MYB: 102246972(XIAP)
MYD: 102755332(XIAP)
MMYO: 118653756
MLF: 102436922(XIAP)
MNA: 107524984(XIAP)
PKL: 118722006
HAI: 109390892(XIAP)
DRO: 112310530(XIAP)
SHON: 119001606
AJM: 119055846
PDIC: 114504538
MMF: 118635819
RFQ: 117021889(XIAP) 117029051
PALE: 102885349(XIAP)
PGIG: 120612220
RAY: 107497750(XIAP)
MJV: 108391115(XIAP)
TOD: 119245919
LAV: 100657657(XIAP)
TMU: 101346318
MDO: 100016651(XIAP)
GAS: 123253493
SHR: 100928240(XIAP)
PCW: 110200954(XIAP)
OAA: 100079889
GGA: 395280(XIAP)
PCOC: 116234903(XIAP)
MGP: 100542540(XIAP)
CJO: 107312953(XIAP)
NMEL: 110403244(XIAP)
APLA: 101796377(XIAP)
ACYG: 106038586(XIAP)
TGU: 100231359(XIAP)
LSR: 110480473(XIAP)
SCAN: 103816388(XIAP)
PMOA: 120506206
OTC: 121331766
PRUF: 121363028
GFR: 102039585(XIAP)
FAB: 101819741(XIAP)
PHI: 102101552(XIAP)
PMAJ: 107203935(XIAP)
CCAE: 111928676(XIAP)
CCW: 104694440
ETL: 114064797(XIAP)
FPG: 101916449(XIAP)
FCH: 102051757(XIAP)
CLV: 102088054(XIAP)
EGZ: 104124100(XIAP)
NNI: 104023425(XIAP)
ACUN: 113480037(XIAP)
PADL: 103922595(XIAP)
AAM: 106487581(XIAP)
AROW: 112977305(XIAP)
NPD: 112944519(XIAP)
DNE: 112997207(XIAP)
ASN: 102386593(XIAP)
AMJ: 102570735(XIAP)
CPOO: 109313567(XIAP)
GGN: 109300765(XIAP)
PSS: 102449987(XIAP)
CMY: 102939941
CPIC: 101937031
TST: 117882841(XIAP)
CABI: 116830438(XIAP)
MRV: 120372466
ACS: 100557644(xiap)
PVT: 110088616(XIAP)
SUND: 121936807
PBI: 103053668(XIAP)
PMUR: 107297409(XIAP)
PGUT: 117665131(XIAP)
VKO: 123022051
PMUA: 114589070(XIAP)
ZVI: 118084167(XIAP)
GJA: 107123686(XIAP)
XLA: 733235(xiap.L)
XTR: 594971(xiap)
NPR: 108788768(XIAP)
DRE: 373108(xiap)
SRX: 107751921(xiap)
IPU: 108269205(xiap) 108269206
PHYP: 113529366(xiap)
AMEX: 103037921(xiap)
EEE: 113581375(xiap)
TRU: 101067395
LCO: 104938662(xiap)
CGOB: 115014252(xiap)
ELY: 117260567(xiap)
PLEP: 121947947
SLUC: 116036580
ECRA: 117952036(xiap)
PFLV: 114563007(xiap)
GAT: 120818475
PPUG: 119210105
MSAM: 119889051
CUD: 121515941
MZE: 101472383
ONL: 100702537(xiap)
OAU: 116315168
OLA: 101166883
OML: 112153690
XMA: 102236946
XCO: 114139667
XHE: 116714306
PRET: 103470906(xiap)
GAF: 122837308
CTUL: 119790477
NFU: 107384738(xiap)
KMR: 108237932
AOCE: 111583181(xiap)
CSEM: 103391373
POV: 109647059(xiap)
SSEN: 122778630
HHIP: 117769083(xiap)
LCF: 108882775(xiap)
SDU: 111226606(xiap)
SLAL: 111646416(xiap)
XGL: 120785816
HCQ: 109524245
BPEC: 110158118(xiap)
MALB: 109955160 109957605(xiap)
SASA: 106604301 106612162(BIRC4)
OTW: 112236582(xiap) 112255900
ELS: 105024403(xiap)
SFM: 108925196
PKI: 111853545(xiap)
AANG: 118224103(xiap)
LOC: 102684651(xiap)
ARUT: 117430831
LCM: 102349446(XIAP)
CMK: 103178709
BBEL: 109485374
CIN: 100177446 100186811 778999(zf(ring)-22)
BVAN: 117155953
FEX: 115241113
PFUC: 122526293
API: 100159652
PJA: 122263241
EAF: 111699210
VDE: 111245273
VJA: 111269460
MYI: 110457948
LAK: 106161698
 » show all
Reference
PMID:8654366
  Authors
Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, Shiels H, Hardwick JM, Thompson CB
  Title
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
  Journal
EMBO J 15:2685-94 (1996)
DOI:10.1002/j.1460-2075.1996.tb00629.x
  Sequence
[hsa:331]
Reference
  Authors
MacFarlane M, Merrison W, Bratton SB, Cohen GM
  Title
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
  Journal
J Biol Chem 277:36611-6 (2002)
DOI:10.1074/jbc.M200317200
  Sequence
[hsa:331]

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