KEGG ORTHOLOGY: K04729

ORTHOLOGY: K04729

Entry

K04729                      KO

Symbol

MYD88

Name

myeloid differentiation primary response protein MyD88

Pathway

map04010

MAPK signaling pathway

map04064

NF-kappa B signaling pathway

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05133

Pertussis

map05134

Legionellosis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05145

Toxoplasmosis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

Disease

H00721

Pyogenic bacterial infections, recurrent, due to MYD88 deficiency

H02424

Primary central nervous system lymphoma

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   04064 NF-kappa B signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   04624 Toll and Imd signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   04621 NOD-like receptor signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05161 Hepatitis B
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05171 Coronavirus disease - COVID-19
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05164 Influenza A
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05162 Measles
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05168 Herpes simplex virus 1 infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05169 Epstein-Barr virus infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05132 Salmonella infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05131 Shigellosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05135 Yersinia infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05133 Pertussis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05134 Legionellosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05152 Tuberculosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09174 Infectious disease: parasitic
   05144 Malaria
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05145 Toxoplasmosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05140 Leishmaniasis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05142 Chagas disease
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05143 African trypanosomiasis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04729  MYD88; myeloid differentiation primary response protein MyD88

Genes

HSA:	4615(MYD88)

PTR:	460269(MYD88)

PPS:	100996159(MYD88)

GGO:	101141837(MYD88)

PON:	100460593(MYD88)

PPYG:

129032803(MYD88)

NLE:	100598173(MYD88)

HMH:	116473667(MYD88)

SSYN:

129484663(MYD88)

MCC:	696494(MYD88)

MCF:	101866832(MYD88)

MTHB:

126948486

MNI:	105480196(MYD88)

CSAB:

103221064(MYD88)

CATY:

105573904(MYD88)

PANU:

101005327(MYD88)

TGE:	112618384(MYD88)

MLEU:

105553429(MYD88)

RRO:	104657448(MYD88)

RBB:	108512239(MYD88)

TFN:	117083885(MYD88)

PTEH:

111523175(MYD88)

CANG:

105519819(MYD88)

CJC:	100413151(MYD88)

SBQ:	101052794(MYD88)

CIMI:

108289112(MYD88)

ANAN:

105719553(MYD88)

CSYR:

103270832(MYD88)

MMUR:

105866806(MYD88)

LCAT:

123627174(MYD88)

PCOQ:

105805211(MYD88)

OGA:	100948454(MYD88)

MMU:	17874(Myd88)

MCAL:

110301084(Myd88)

MPAH:

110327862(Myd88)

RNO:	301059(Myd88)

MCOC:

116073051(Myd88)

ANU:	117693388(Myd88)

MUN:	110555059(Myd88)

CGE:	100775060(Myd88)

MAUA:

101828578(Myd88)

PROB:

127235106(Myd88)

PLEU:

114682503(Myd88)

MORG:

121464317(Myd88)

MFOT:

126496436 126501081

AAMP:

119809015(Myd88)

NGI:	103744662(Myd88)

HGL:	101712637(Myd88)

CPOC:

100733381(Myd88)

CCAN:

109684529(Myd88)

DORD:

105996289(Myd88)

DSP:	122096770(Myd88)

PLOP:

125342411(Myd88) 125345116

NCAR:

124968831

MMMA:

107145496(Myd88)

OCU:

100340811

OPI:	101524248(MYD88)

TUP:	102499350(MYD88)

GVR:	103602129(MYD88)

CFA:	477024(MYD88)

CLUD:

112668882(MYD88)

VVP:	112921656(MYD88)

VLG:	121478665(MYD88)

NPO:	129506934(MYD88)

AML:	100479307(MYD88)

UMR:	103680724(MYD88)

UAH:	113253781(MYD88)

UAR:	123792836(MYD88)

ELK:

111159049

LLV:

125106441

MPUF:

101685422(MYD88)

MNP:	132011660(MYD88)

MLK:	131824370(MYD88)

NVS:	122909079(MYD88)

ORO:	101363951(MYD88)

EJU:	114212285(MYD88)

ZCA:	113916493(MYD88)

MLX:	118001922(MYD88)

NSU:	110569660(MYD88)

LWW:	102737954(MYD88)

FCA:	101087092(MYD88)

PYU:	121033462(MYD88)

PCOO:

112850482(MYD88)

PBG:	122492160(MYD88)

PVIV:

125174804(MYD88)

LRUF:

124526006

PTG:	102952059(MYD88)

PPAD:

109248749(MYD88)

PUC:

125921434

AJU:

106966692

HHV:	120235110(MYD88)

BTA:	444881(MYD88)

BOM:	102279944(MYD88)

BIU:	109576356(MYD88)

BBUB:

123465262(MYD88)

BBIS:

104985366(MYD88)

CHX:	102174883(MYD88)

OAS:	678682(MYD88)

BTAX:

128049046(MYD88)

ODA:	120867827(MYD88)

CCAD:

122424834(MYD88)

MBEZ:

129548144(MYD88)

SSC:	396646(MYD88)

CFR:	102506575(MYD88)

CBAI:

105061728(MYD88)

CDK:	105090692(MYD88)

VPC:	102538305(MYD88)

BACU:

103011989(MYD88)

BMUS:

118904029(MYD88)

LVE:	103088205(MYD88)

OOR:	101278425(MYD88)

DLE:	111164350(MYD88)

PCAD:

102974002(MYD88)

PSIU:

116761621(MYD88)

NASI:

112407416(MYD88)

ECB:	100053940(MYD88)

EPZ:	103557961(MYD88)

EAI:	106834265(MYD88)

MYB:	102247438(MYD88)

MYD:	107183283(MYD88)

MMYO:

118668344(MYD88)

MLF:	102425374(MYD88)

MDT:	132215714(MYD88)

PKL:	118715489(MYD88)

EFUS:

103298161(MYD88)

MNA:	107524328(MYD88)

DRO:	112309628(MYD88)

AJM:	119051446(MYD88)

PDIC:

114501591(MYD88)

PHAS:

123830839(MYD88)

MMF:	118633334(MYD88)

PPAM:

129088050(MYD88)

HAI:	109393491(MYD88)

RFQ:	117036629(MYD88)

PALE:

102890488(MYD88)

PGIG:

120586750(MYD88)

PVP:	105295639(MYD88)

RAY:	107499600(MYD88)

MJV:	108401029(MYD88)

TOD:	119258024(MYD88)

SETR:

125998189(MYD88)

LAV:	100659447(MYD88)

TMU:

101341326

ETF:	101644448(MYD88)

DNM:	101431630(MYD88)

GAS:

123254147

SHR:	100927751(MYD88)

AFZ:

127550351

PCW:	110197028(MYD88)

TVP:	118831332(MYD88)

OAA:	100077067(MYD88)

GGA:	420420(MYD88)

PCOC:

116238234(MYD88)

MGP:	100541304(MYD88)

CJO:	107308786(MYD88)

TPAI:

128086102(MYD88)

LMUT:

125696192(MYD88)

NMEL:

110394261(MYD88)

APLA:

101797621(MYD88)

ACYG:

106036798(MYD88)

CATA:

118251776(MYD88)

AFUL:

116486798(MYD88)

TGU:	100223638(MYD88)

LSR:	110484551(MYD88)

SCAN:

103813055(MYD88)

PMOA:

120510590(MYD88)

OTC:	121338173(MYD88)

PRUF:

121365519(MYD88)

GFR:	102044578(MYD88)

FAB:	101805645(MYD88)

OMA:	130249978(MYD88)

PHI:	102100550(MYD88)

PMAJ:

107200823(MYD88)

CCAE:

111925454(MYD88)

CCW:	104686502(MYD88)

CBRC:

103623979(MYD88)

ETL:	114065146(MYD88)

ZAB:	102073247(MYD88)

ZLE:	135443551(MYD88)

ACHL:

103811144(MYD88)

SVG:	106851574(MYD88)

MMEA:

130573168(MYD88)

HRT:	120762395(MYD88)

SATI:

136358106(MYD88)

FPG:	101922907(MYD88)

FCH:	102049997(MYD88)

CCRI:

104167671(MYD88)

NNT:	104410125(MYD88)

SHAB:

115609931(MYD88)

ACUN:

113476914(MYD88)

TALA:

104369214(MYD88)

ACHC:

115339371(MYD88)

HALD:

104312103(MYD88)

HLE:	104827827(MYD88)

AGEN:

126037734

GCL:

127012707

CSTI:

104563759(MYD88)

LDI:	104347571(MYD88)

DPUB:

104298988(MYD88)

AVIT:

104278766(MYD88)

EGZ:	104130985(MYD88)

NNI:	104021773(MYD88)

PCRI:

104026211(MYD88)

PCAO:

104045422(MYD88)

PADL:

103924746(MYD88)

AFOR:

103896185(MYD88)

FGA:	104071173(MYD88)

GSTE:

104252140(MYD88)

CLV:	102087774(MYD88)

MUI:	104545424(MYD88)

PGUU:

104459630(MYD88)

PLET:

104617900(MYD88)

CMAC:

104487033(MYD88)

CUCA:

104057017(MYD88)

TEO:	104382931(MYD88)

BREG:

104633883(MYD88)

OHA:	104337212(MYD88)

ACAR:

104528123(MYD88)

CPEA:

104396189(MYD88)

CVF:	104291270(MYD88)

RTD:	128905834(MYD88)

AAM:

106490262

AROW:

112978275(MYD88)

NPD:	112958106(MYD88)

TGT:	104578292(MYD88)

DNE:	112981549(MYD88)

SCAM:

104148783(MYD88)

ASN:	102372553(MYD88)

AMJ:	102560312(MYD88)

CPOO:

109320185(MYD88)

GGN:	109291074(MYD88)

PSS:	102454616(MYD88)

CMY:	102935478(MYD88)

CCAY:

125631189(MYD88)

DCC:	119851837(MYD88)

CPIC:

101944305(MYD88)

TST:	117871992(MYD88)

CABI:

116826962(MYD88)

MRV:	120397823(MYD88)

ACS:	100561767(myd88)

ASAO:

132769661 132779005(MYD88)

PVT:	110085835(MYD88)

SUND:

121935209(MYD88)

PBI:	103066844(MYD88)

PMUR:

107303333(MYD88)

CTIG:

120319633(MYD88) 120319898

TSR:	106539892(MYD88)

PGUT:

117654762(MYD88)

APRI:

131197807(MYD88)

PTEX:

113447969(MYD88)

NSS:	113419506(MYD88)

VKO:	123020809(MYD88)

PMUA:

114607585(MYD88)

PRAF:

128424222(MYD88)

ZVI:	118092232(MYD88)

HCG:	128331680(MYD88)

STOW:

125425446(MYD88)

EMC:	129337671(MYD88)

XLA:	394321(myd88.L) 734302(myd88.S)

XTR:	549591(myd88)

NPR:	108784626(MYD88)

RTEM:

120940125(MYD88)

BBUF:

121002337(MYD88)

BGAR:

122938267(MYD88)

MUO:	115466618(MYD88)

GSH:

117354356

DRE:	403145(myd88)

SRX:	107741019 107758293

SANH:

107678069(myd88) 107701636

SGH:	107584943 107591285(myd88)

CCAR:

109049860(myd88)

CAUA:

113066302 113099580

CGIB:

127946607 128013035

PTET:

122329857(myd88)

LROH:

127156015(myd88)

OMC:	131533057(myd88)

PPRM:

120476028(myd88)

RKG:	130083832(myd88)

MAMB:

125257785(myd88)

CIDE:

127506001

CERY:

137013841(myd88)

MASI:

127432067 127434787

TROS:

130547294(myd88)

TDW:	130413368(myd88)

MANU:

129425390(myd88)

IPU:	100305041(myd88)

IFU:	128599684(myd88)

PHYP:

113541356(myd88)

SMEO:

124375591(myd88)

TFD:	113662161(myd88)

TVC:	132840300(myd88)

TRN:	134300772(myd88)

AMEX:

103044166(myd88)

CMAO:

118798879(myd88)

EEE:	113585082(myd88)

CHAR:

105890158(myd88)

TRU:	100134853(myd88)

TFS:	130514275(myd88)

LCO:	104937116(myd88)

TBEN:

117494993(myd88)

CGOB:

115025518(myd88)

PGEO:

117465800(myd88)

GACU:

117549862

EMAC:

134883898(myd88)

ELY:	117264724(myd88)

EFO:	125881832(myd88)

PLEP:

121960534(myd88)

SLUC:

116037895(myd88)

ECRA:

117937605(myd88)

ESP:	116672056(myd88)

PFLV:

114549018(myd88)

GAT:	120811549 120811921(myd88)

PPUG:

119198435(myd88)

AFB:	129110486(myd88)

CLUM:

117749486(myd88)

PSWI:

130206432(myd88)

MSAM:

119910303(myd88)

SCHU:

122866653(myd88)

CUD:	121527123(myd88)

ALAT:

119008972(myd88)

MZE:	101476408(myd88)

ONL:	100700534(myd88)

OAU:	116314457(myd88)

OLA:	101168580(myd88)

OML:	112151085(myd88)

CSAI:

133423093(myd88)

XMA:	102234764(myd88)

XCO:	114136895(myd88)

XHE:	116712350(myd88)

PRET:

103456564(myd88)

PFOR:

103140404(myd88)

PLAI:

106948893(myd88)

PMEI:

106921037(myd88)

GAF:	122824582(myd88)

PPRL:

129364806(myd88)

CVG:	107100961(myd88)

CTUL:

119789066(myd88)

GMU:	124857967(myd88)

NFU:	107382819(myd88)

KMR:	108230293(myd88)

ALIM:

106513380(myd88)

NWH:	119426512(myd88)

AOCE:

111565947(myd88)

MCEP:

124995917(myd88)

CSEM:

103377208(myd88)

POV:	109629696(myd88)

SSEN:

122782449(myd88)

HHIP:

117754084(myd88)

HSP:	118098776(myd88)

PPLT:

128425491(myd88)

SMAU:

118290922(myd88)

LCF:

SDU:

SLAL:

XGL:

HCQ:	109514064(myd88)

SSCV:

125985752

SBIA:

133492794(myd88)

PEE:	133396375(myd88)

PTAO:

133470416(myd88)

BPEC:

110160924(myd88)

MALB:

109961464(myd88)

BSPL:

114854334(myd88)

SJO:	128382440(myd88)

SASA:

100169859(myd88)

STRU:

115195308(myd88)

OTW:	112227606(myd88)

OMY:	100136123(myd88)

OGO:	124039433(myd88)

ONE:	115126380(myd88)

OKI:	109881912(myd88)

OKE:	127916490(myd88)

SALP:

112079159(myd88)

SNH:	120050282(myd88)

CCLU:

121569950(myd88)

ELS:	105007691(myd88)

SFM:	108934019(myd88)

PKI:	111837820(myd88)

AANG:

118226080(myd88)

LOC:	102684939(myd88)

PSPA:

121307986 121309888 121314032(myd88)

ARUT:

117399595 117435484(myd88)

PSEX:

120529597(myd88)

LCM:	102348650(MYD88)

CMK:	103189851(myd88)

RTP:	109927021(myd88)

CPLA:

122548926(myd88)

HOC:	132815068(myd88)

LERI:

129715134(myd88)

PMRN:

116954645(MYD88)

LRJ:	133358203(MYD88)

BFO:	118403304 118429507

BBEL:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:	100373041(myd88)

DME:	Dmel_CG2078(Myd88)

DER:

6540756

DSE:

6608336

DSI:	Dsimw501_GD10085(Dsim_GD10085)

DYA:	Dyak_GE22390

DAN:

DSR:

DPO:

DPE:

DMN:	108160497 117193290

DWI:

6639863

DGR:

6560536

DMO:	Dmoj_GI19523

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106627244 106627312

BDR:	105227777 105227779

RZE:

108363774

AOQ:

129243910

TDA:	119683530 119684319

MDE:

101901307

SCAC:

106093182

LCQ:	111686209 124419352

LSQ:	119601143 119602303

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008547 CpipJ_CPIJ018307

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105677438 105677448

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:	124953888 124953979

NVI:

CSOL:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124219297 124219587

NFB:

124182640

NLO:

107220645

NVG:	124305028 124305288

TCA:	662213(Kra)

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205936

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:	114351323 114353912

ATRA:

GMW:

PXY:

PGW:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106685201(Myd88)

NLU:

111046615

HVI:

124366277

MQU:

129002993

PHU:	Phum_PHUM536290

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_305569

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136989387 136989389

PTEP:

107443819

ABRU:

129958467

UDV:	129218216 129225134

SDM:	118182029 118186311

LPOL:

106461068

LGI:	LOTGIDRAFT_203449

PVUL:

126820766 126830193

PCAN:

112556147

BGT:	106054887 106070923

GAE:	121385299 121385442 121385643

HRF:	124152910 124152912

HRJ:	124278595 124278596 124278598 124278601

CRG:	105323406 105342670(Myd88) 105347306 105347308

CANU:

128164183 128164223 128164235 128164305 128187983 128188009

CVN:	111115640 111129875 111137650 111137660

OED:	125645535 125647807 125683926 125683927 125683928

MYI:	110451498 110453522

PMAX:

117321504 117321505 117321976 117321977

MMER:

123542387 123559857 123559858 123560539 123560922

RPHI:

132725878 132725879 132740221 132742206 132758813

DPOL:

127853689 127859598 127860295 127861258

MAEA:

128234201 128235274 128235284

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124440841 124456533

RES:

135682894

AQU:	100616081(Myd88)

» show all

Reference

PMID:9013863

Authors

Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE

Title

The cloning and characterization of human MyD88: a member of an IL-1 receptor related family.

Journal

FEBS Lett 402:81-4 (1997)
DOI:10.1016/S0014-5793(96)01506-2

Sequence

[hsa:4615]

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