KEGG ORTHOLOGY: K04733

ORTHOLOGY: K04733

Entry

K04733                      KO

Symbol

IRAK4

Name

interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]

Pathway

map04010

MAPK signaling pathway

map04064

NF-kappa B signaling pathway

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04722

Neurotrophin signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05133

Pertussis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05145

Toxoplasmosis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05417

Lipid and atherosclerosis

Disease

H00096

Defects of toll-like receptor signaling

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04064 NF-kappa B signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04624 Toll and Imd signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04621 NOD-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05161 Hepatitis B
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05171 Coronavirus disease - COVID-19
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05164 Influenza A
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05162 Measles
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05168 Herpes simplex virus 1 infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05169 Epstein-Barr virus infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05132 Salmonella infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05135 Yersinia infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05133 Pertussis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05152 Tuberculosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05140 Leishmaniasis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05142 Chagas disease
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  IRAK family
   K04733  IRAK4; interleukin-1 receptor-associated kinase 4

Genes

HSA:	51135(IRAK4)

PTR:	466962(IRAK4)

PPS:	100968191(IRAK4)

GGO:	101141826(IRAK4)

PON:	100447243(IRAK4)

PPYG:

129009780(IRAK4)

NLE:	100602648(IRAK4)

HMH:	116481090(IRAK4)

SSYN:

129466354(IRAK4)

MCC:	700568(IRAK4)

MCF:	102140231(IRAK4)

MTHB:

126931312

MNI:	105470108(IRAK4)

CSAB:

103238180(IRAK4)

CATY:

105574390(IRAK4)

PANU:

101007351(IRAK4)

TGE:	112617260 112617282

MLEU:

105553446(IRAK4)

RRO:	104677388(IRAK4)

RBB:	108539989(IRAK4)

TFN:	117090258(IRAK4)

PTEH:

111520209(IRAK4)

CANG:

105507588(IRAK4)

CJC:	100402978(IRAK4)

SBQ:	101029005(IRAK4)

CIMI:

108305262(IRAK4)

ANAN:

105721850(IRAK4)

CSYR:

103276369(IRAK4)

MMUR:

105861650(IRAK4)

LCAT:

123639836(IRAK4)

PCOQ:

105805561(IRAK4)

OGA:	100956612(IRAK4)

MMU:	266632(Irak4)

MCAL:

110310638(Irak4)

MPAH:

110334455(Irak4)

RNO:	300177(Irak4)

MCOC:

116078433(Irak4)

ANU:	117718426(Irak4)

MUN:	110563636(Irak4)

CGE:	100751891(Irak4)

MAUA:

101824326(Irak4)

PROB:

127225991(Irak4)

PLEU:

114693067(Irak4)

MORG:

121441443(Irak4)

MFOT:

126492812

AAMP:

119822715(Irak4)

NGI:	103728592(Irak4)

HGL:	101698190(Irak4)

CPOC:

100729751(Irak4)

CCAN:

109684435

DORD:

105987554(Irak4)

DSP:	122106144(Irak4)

PLOP:

125365792(Irak4)

NCAR:

124983710

MMMA:

107148556(Irak4)

OCU:

100341605

OPI:	101526929(IRAK4)

TUP:	102490347(IRAK4)

GVR:	103595699(IRAK4)

CFA:	486601(IRAK4)

CLUD:

112678201(IRAK4)

VVP:	112921061(IRAK4)

VLG:	121479634(IRAK4)

NPO:	129505651(IRAK4)

AML:	100469127(IRAK4)

UMR:	103675405(IRAK4)

UAH:	113257718(IRAK4)

UAR:	123794834(IRAK4)

ELK:

111157836

LLV:

125106124

MPUF:

101670774(IRAK4)

MNP:	132019603(IRAK4)

MLK:	131838863(IRAK4)

NVS:	122891544(IRAK4)

ORO:	101380365(IRAK4)

EJU:	114224086(IRAK4)

ZCA:	113922141(IRAK4)

MLX:	118008943(IRAK4)

NSU:	110593539(IRAK4)

LWW:	102741856(IRAK4)

FCA:	101100225(IRAK4)

PYU:	121038701(IRAK4)

PCOO:

112867801(IRAK4)

PBG:	122473209(IRAK4)

PVIV:

125170096(IRAK4)

LRUF:

124501320

PTG:	102962570(IRAK4)

PPAD:

109248991(IRAK4)

PUC:

125918985

AJU:

106978292

HHV:	120246010(IRAK4)

BTA:	533692(IRAK4)

BOM:	102284148(IRAK4)

BIU:	109559201(IRAK4)

BBUB:

102402933(IRAK4)

BBIS:

105003529(IRAK4)

CHX:	102171575(IRAK4)

OAS:	100216438(IRAK4)

BTAX:

128048533(IRAK4)

ODA:	120857909(IRAK4) 120861265

CCAD:

122427504(IRAK4)

MBEZ:

129536594(IRAK4)

SSC:	100127166(IRAK4)

CFR:	102518467(IRAK4)

CBAI:

105081383(IRAK4)

CDK:	105097094(IRAK4)

VPC:	102544486(IRAK4)

BACU:

103013107(IRAK4)

BMUS:

118902731(IRAK4)

LVE:	103080704(IRAK4)

OOR:	101283238(IRAK4)

DLE:	111174096(IRAK4)

PCAD:

102982312(IRAK4)

PSIU:

116760732(IRAK4)

NASI:

112396652(IRAK4)

ECB:	100054848(IRAK4)

EPZ:	103547487(IRAK4)

EAI:	106828056(IRAK4)

MYB:	102262455(IRAK4)

MYD:	102754676(IRAK4)

MMYO:

118649743(IRAK4)

MLF:	102433848(IRAK4)

MDT:	132227478(IRAK4)

PKL:	118728234(IRAK4)

EFUS:

103285212(IRAK4)

MNA:	107528202(IRAK4)

DRO:	112318391(IRAK4)

SHON:

118997428(IRAK4)

AJM:	119061695(IRAK4)

PDIC:

114514079(IRAK4)

PHAS:

123812800(IRAK4)

MMF:	118624132(IRAK4)

PPAM:

129084910(IRAK4)

HAI:	109388403(IRAK4)

RFQ:	117028994(IRAK4)

PALE:

102880867(IRAK4)

PGIG:

120618259(IRAK4)

PVP:	105297485(IRAK4)

RAY:	107511752(IRAK4)

MJV:	108396677(IRAK4)

TOD:	119247577(IRAK4)

SARA:

101547526(IRAK4)

SETR:

126022862(IRAK4)

LAV:	100653528(IRAK4)

TMU:

101349224

ETF:	101643108(IRAK4)

DNM:	101411653(IRAK4)

MDO:	100019202(IRAK4)

GAS:	123248659(IRAK4)

SHR:	100934112(IRAK4)

AFZ:

127538287

PCW:	110199045(IRAK4)

TVP:	118850416(IRAK4)

OAA:	100093279(IRAK4)

GGA:	417796(IRAK4)

PCOC:

116226644(IRAK4)

MGP:	100538968(IRAK4)

CJO:	107309789(IRAK4)

TPAI:

128073080(IRAK4)

LMUT:

125688635(IRAK4)

NMEL:

110392685(IRAK4)

APLA:

101794110(IRAK4)

ACYG:

106047628(IRAK4)

CATA:

118246720(IRAK4)

AFUL:

116502253(IRAK4)

TGU:	100227974(IRAK4)

LSR:	110478580(IRAK4)

SCAN:

103820377(IRAK4)

PMOA:

120510675(IRAK4)

OTC:	121333037(IRAK4)

PRUF:

121352494(IRAK4)

GFR:	102032992(IRAK4)

FAB:	101816877(IRAK4)

OMA:	130262891(IRAK4)

PHI:	102100592(IRAK4)

PMAJ:

107204545(IRAK4)

CCAE:

111932046(IRAK4)

CCW:	104698327(IRAK4)

CBRC:

103614865(IRAK4)

ETL:	114061965(IRAK4)

ZAB:	102069806(IRAK4)

ZLE:	135442232(IRAK4)

ACHL:

103805791

SVG:	106850081(IRAK4)

MMEA:

130573609(IRAK4)

HRT:	120752462(IRAK4)

SATI:

136361266(IRAK4)

FPG:	101914647(IRAK4)

FCH:	102057320(IRAK4)

CCRI:

104163734(IRAK4)

NNT:	104399643(IRAK4)

SHAB:

115605130(IRAK4)

ACUN:

113475900(IRAK4)

TALA:

104362784(IRAK4)

ACHC:

115341041(IRAK4)

HALD:

104317714(IRAK4)

HLE:	104835850(IRAK4)

AGEN:

126044400

GCL:

127020686

CSTI:

104561036(IRAK4)

LDI:	104346349(IRAK4)

MNB:	103779660(IRAK4)

DPUB:

104299101(IRAK4)

AVIT:

104270762(IRAK4)

BRHI:

104489844(IRAK4)

EGZ:	104129331(IRAK4)

NNI:	104013612(IRAK4)

PCRI:

104024819(IRAK4)

PCAO:

104051466(IRAK4)

PADL:

103919991(IRAK4)

AFOR:

103904736(IRAK4)

FGA:	104077445(IRAK4)

GSTE:

104251131(IRAK4)

CLV:	102092630(IRAK4)

MUI:	104534214(IRAK4)

PGUU:

104461023

PLET:

104617998

EHS:	104512393(IRAK4)

CMAC:

104473787(IRAK4)

CUCA:

104062406(IRAK4)

TEO:

104375423

BREG:

104633553(IRAK4)

OHA:	104337513(IRAK4)

ACAR:

104530907(IRAK4)

CPEA:

104396455(IRAK4)

CVF:	104282729(IRAK4)

RTD:	128908840(IRAK4)

AAM:	106488895(IRAK4)

AROW:

112976393(IRAK4)

NPD:	112956803(IRAK4)

TGT:	104568625(IRAK4)

DNE:	112993775(IRAK4)

SCAM:

104153326(IRAK4)

ASN:	102375747(IRAK4)

AMJ:	102560034(IRAK4)

CPOO:

109315576(IRAK4)

GGN:	109295655(IRAK4)

PSS:	102445433(IRAK4)

CMY:	102940314(IRAK4)

CCAY:

125630290(IRAK4)

DCC:	119852920(IRAK4)

CPIC:

101931311(IRAK4)

TST:	117877089(IRAK4)

CABI:

116838906(IRAK4)

MRV:	120386280(IRAK4)

ACS:	100556834(irak4)

ASAO:

132776222(IRAK4)

PVT:	110079982(IRAK4)

SUND:

121931563(IRAK4)

PBI:	103053361(IRAK4)

PMUR:

107284404(IRAK3)

CTIG:

120306806(IRAK4)

TSR:

106556721

PGUT:

117660695 132712366

APRI:

131201839(IRAK4)

PTEX:

113447567(IRAK4)

NSS:	113412310(IRAK4)

VKO:	123019899(IRAK4)

PMUA:

114605640(IRAK4)

PRAF:

128422052(IRAK4)

ZVI:	118091266(IRAK4)

HCG:	128327130(IRAK4)

GJA:	107125917(IRAK4)

STOW:

125435860(IRAK4)

EMC:	129335648(IRAK4)

XLA:	108711122(irak4.L)

XTR:	733738(irak4)

NPR:	108789468(IRAK4)

RTEM:

120931918(IRAK4)

BBUF:

120981214(IRAK4)

BGAR:

122927975(IRAK4)

MUO:	115478559(IRAK4)

GSH:	117367136(IRAK4)

DRE:	393132(irak4)

SRX:	107710863(irak4)

SANH:

107695004(irak4)

SGH:	107564744(irak4)

CAUA:

113042977 113042987

CGIB:

128014660

PTET:

122330912(irak4)

LROH:

127156541(irak4)

OMC:	131534196(irak4)

PPRM:

120460430(irak4)

RKG:	130086517(irak4)

MAMB:

125247671(irak4)

CIDE:

127507772

CERY:

137015448(irak4)

MASI:

127437120

TROS:

130551555(irak4)

TDW:	130413857(irak4)

MANU:

129433142(irak4)

IPU:	100528915(irak4)

IFU:	128618080(irak4)

PHYP:

113529752(irak4)

SMEO:

124392333(irak4)

TFD:	113639159(irak4)

TVC:	132856689(irak4)

TRN:	134311313(irak4)

AMEX:

103046249(irak4)

CMAO:

118811803(irak4)

EEE:	113571874(irak4)

CHAR:

105908798(irak4)

TRU:	101066430(irak4)

TFS:	130536083(irak4)

TNG:	GSTEN00029683G001

LCO:	104933859(irak4)

NCC:	104950347(irak4)

TBEN:

117494946(irak4)

CGOB:

115009385(irak4)

PGEO:

117447743(irak4)

GACU:

117547837(irak4)

EMAC:

134876786(irak4)

ELY:	117262485(irak4)

EFO:	125886906(irak4)

PLEP:

121949826(irak4)

SLUC:

116038435(irak4)

ECRA:

117949437(irak4)

ESP:	116694099(irak4)

PFLV:

114559818(irak4)

GAT:	120809229(irak4)

PPUG:

119196184(irak4)

AFB:	129107767(irak4)

CLUM:

117731873(irak4)

PSWI:

130195457(irak4)

MSAM:

119893462(irak4)

SCHU:

122874968(irak4)

CUD:	121514729(irak4)

ALAT:

119024075(irak4)

MZE:	101482950(irak4)

ONL:	100707440(irak4)

OAU:	116332712(irak4)

OLA:	101158603(irak4)

OML:	112142118 112152049(irak4)

CSAI:

133443810(irak4)

XMA:	102235789(irak4)

XCO:	114158068(irak4)

XHE:	116736373(irak4)

PRET:

103465840(irak4)

PFOR:

103134441 103134442

PLAI:

106936712(irak4) 106965283

PMEI:

106909806 106933748(irak4)

GAF:	122835248(irak4)

PPRL:

129361730(irak4)

CVG:	107089506(irak4)

CTUL:

119780397(irak4)

GMU:	124884703(irak4)

NFU:	107388500(irak4)

KMR:	108246966(irak4)

ALIM:

106526262(irak4)

NWH:	119416399(irak4)

AOCE:

111569910(irak4)

MCEP:

125014830(irak4)

CSEM:

103380353(irak4)

POV:	109624486(irak4)

SSEN:

122776278(irak4)

HHIP:

117763078(irak4)

HSP:	118109649(irak4)

PPLT:

128443943(irak4)

SMAU:

118314984(irak4)

LCF:

108888551

SDU:	111229598(irak4)

SLAL:

111650410(irak4)

XGL:	120792990(irak4)

HCQ:	109529881(irak4)

SSCV:

125970831

SBIA:

133501732(irak4)

PEE:	133403261(irak4)

PTAO:

133478109(irak4)

BPEC:

110168058(irak4)

MALB:

109973145(irak4)

BSPL:

114857648(irak4)

SJO:	128358636(irak4)

SASA:

100196744(irak4)

STRU:

115196945(irak4)

OTW:

112218414

OMY:

110493646

OGO:

124038309

ONE:	115134409(irak4)

OKI:	109867657(irak4)

OKE:

118396543

SALP:

111962246(irak4)

SNH:

120066164

CCLU:

121531748

ELS:	105026619(irak4)

SFM:	108931599(irak4)

PKI:	111833297(irak4)

AANG:

118219282(irak4)

LOC:	102693125(irak4)

PSPA:

121319978(irak4)

ARUT:

117419673(irak4)

PSEX:

120533850(irak4)

LCM:	102365908(IRAK4)

CMK:	103186122(irak4)

RTP:

109935969

CPLA:

122559701(irak4)

HOC:

132824917

LERI:

129706494(irak4)

PMRN:

116947439(IRAK4)

LRJ:	133351591(IRAK4)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

SKO:

DME:	Dmel_CG10520(tub)

DER:

6552132

DSE:

6613818

DSI:	Dsimw501_GD19725(Dsim_tub)

DYA:	Dyak_GE25413(Dyak_tub)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10610

DAZ:

108619657

DNV:

108652303

DHE:

111602009

DVI:	116650256 6631033

CCAT:

101459242

BOD:

106624391

BDR:

105222917

TDA:	119683488 119683492

MDE:	101888716 131804142

SCAC:

LCQ:

LSQ:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ013746

CPII:

BCOO:

AME:

ACER:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105667498(tub)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

CCIN:

TCA:

DPA:

ATD:

CSET:

AGB:	108906727 108914341 111691831

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

DPL:	KGM_208945

BANY:

MJU:

VCD:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103522561 103523448

CLEC:

HHAL:

NLU:

HVI:

MQU:	129000968 129004641

PHU:	Phum_PHUM194370

FOC:	113206886 113210751

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_314397

DMK:	116928387 123466401

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DFR:

CVS:

PTEP:

ABRU:

129975272 129975273 129975786 129975795 129976361 129976457

UDV:

129217112

SDM:

118202301

LPOL:

106478740

LGI:	LOTGIDRAFT_114172

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

MYI:

PMAX:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:	106152888 106179261

LLON:

135491340

TAD:	TRIADDRAFT_56774

AQU:

100631706

» show all

Reference

PMID:11960013

Authors

Li S, Strelow A, Fontana EJ, Wesche H

Title

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.

Journal

Proc Natl Acad Sci U S A 99:5567-72 (2002)
DOI:10.1073/pnas.082100399

Sequence

[hsa:51135]

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