KEGG ORTHOLOGY: K04741

ORTHOLOGY: K04741

Entry

K04741                      KO

Symbol

CASP12

Name

caspase 12 [EC:3.4.22.-]

Pathway

map04141

Protein processing in endoplasmic reticulum

map04210

Apoptosis

map04621

NOD-like receptor signaling pathway

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05161

Hepatitis B

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04741  CASP12; caspase 12
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04741  CASP12; caspase 12
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K04741  CASP12; caspase 12
09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04741  CASP12; caspase 12
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04741  CASP12; caspase 12
   05014 Amyotrophic lateral sclerosis
    K04741  CASP12; caspase 12
   05020 Prion disease
    K04741  CASP12; caspase 12
   05022 Pathways of neurodegeneration - multiple diseases
    K04741  CASP12; caspase 12
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04741  CASP12; caspase 12
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C14: caspase family
   K04741  CASP12; caspase 12

Genes

HSA:	100506742(CASP12)

PTR:	466766(CASP12)

PPS:

100991705

GGO:

101137790

PON:	100436165 100938140

PPYG:

NLE:

HMH:

SSYN:

MCC:	724039(CASP12)

MCF:

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

105534151(CASP4)

RRO:

RBB:

PTEH:

CANG:

ANAN:

CSYR:

MMUR:

LCAT:

OGA:

MMU:	12364(Casp12)

MCAL:

110302047

MPAH:

110327565

RNO:	156117(Casp12)

MCOC:

116073421

ANU:

117699648

MUN:

110552937

CGE:	100759746(Casp4)

MAUA:

PROB:

PLEU:

HGL:

OCU:

TUP:

CFA:	479458(CASP12)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	100135767(CASP12)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

CCAD:

BACU:

103011794(CASP12)

BMUS:

LVE:

OOR:

NASI:

ECB:

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

SARA:

SETR:

LAV:	100657555 100657844

TMU:

101352646

ETF:

101653369

DNM:

101417090

MDO:	100032604 100032606

GAS:	123239005 123241351

SHR:	100913330 100913862

AFZ:

127554934

PCW:

110214950

TVP:	118837995 118840346

MMER:

123543279

» show all

Reference

PMID:10638761

Authors

Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J

Title

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.

Journal

Nature 403:98-103 (2000)
DOI:10.1038/47513

Reference

PMID:12054529

Authors

Fischer H, Koenig U, Eckhart L, Tschachler E

Title

Human caspase 12 has acquired deleterious mutations.

Journal

Biochem Biophys Res Commun 293:722-6 (2002)
DOI:10.1016/S0006-291X(02)00289-9

Sequence

[hsa:100506742]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (16)   
Gene (124)   
   KEGG GENES (123)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (144)   

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