Entry |
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Name |
isochorismate lyase;
salicylate biosynthesis protein pchB;
pyochelin biosynthetic protein PchB;
isochorismate pyruvate lyase
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Class |
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases
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Sysname |
isochorismate pyruvate-lyase (salicylate-forming)
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Reaction(IUBMB) |
isochorismate = salicylate + pyruvate [RN: R06602]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin.
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History |
EC 4.2.99.21 created 2010
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Pathway |
ec01053 | Biosynthesis of siderophore group nonribosomal peptides |
ec01110 | Biosynthesis of secondary metabolites |
ec01130 | Biosynthesis of antibiotics |
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Orthology |
K04782 | isochorismate pyruvate lyase |
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Genes |
» show all
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Reference |
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Authors |
Serino L, Reimmann C, Baur H, Beyeler M, Visca P, Haas D |
Title |
Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa. |
Journal |
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Sequence |
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Reference |
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Authors |
Kerbarh O, Ciulli A, Howard NI, Abell C |
Title |
Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 4.2.99.21 |
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