KEGG ORTHOLOGY: K04967

ORTHOLOGY: K04967

Entry

K04967                      KO

Symbol

TRPC4

Name

transient receptor potential cation channel subfamily C member 4

Pathway

map04360

Axon guidance

map04745

Phototransduction - fly

map04929

GnRH secretion

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    K04967  TRPC4; transient receptor potential cation channel subfamily C member 4
  09157 Sensory system
   04745 Phototransduction - fly
    K04967  TRPC4; transient receptor potential cation channel subfamily C member 4
  09158 Development and regeneration
   04360 Axon guidance
    K04967  TRPC4; transient receptor potential cation channel subfamily C member 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04967  TRPC4; transient receptor potential cation channel subfamily C member 4
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   K04967  TRPC4; transient receptor potential cation channel subfamily C member 4

Other DBs

GO:

0015279

TC:	1.A.4.1.1 1.A.4.1.9 1.A.4.1.10 1.A.4.1.12

Genes

HSA:	7223(TRPC4)

PTR:	452544(TRPC4)

PPS:	100989868(TRPC4)

GGO:	101145891(TRPC4)

PON:	100453863(TRPC4)

NLE:	100588408(TRPC4)

HMH:	116467069(TRPC4)

MCC:	695636(TRPC4)

MCF:	102143736(TRPC4)

MTHB:

126940854

MNI:	105486048(TRPC4)

CSAB:

103214299(TRPC4)

CATY:

105587850(TRPC4)

PANU:

101011273(TRPC4)

TGE:	112610795(TRPC4)

MLEU:

105548787(TRPC4)

RRO:	104677928(TRPC4)

RBB:	108516605(TRPC4)

TFN:	117097101(TRPC4)

PTEH:

111540409(TRPC4)

CANG:

105512528(TRPC4)

CJC:	100408892(TRPC4)

SBQ:	101033814(TRPC4)

CIMI:

108310837(TRPC4)

CSYR:

103275733(TRPC4)

MMUR:

105862084(TRPC4)

LCAT:

123649469(TRPC4)

PCOQ:

105809922(TRPC4)

OGA:	100957571(TRPC4)

MMU:	22066(Trpc4)

MCAL:

110290650(Trpc4)

MPAH:

110319800(Trpc4)

RNO:	84494(Trpc4)

MCOC:

116092867(Trpc4)

ANU:	117706893(Trpc4)

MUN:	110542368(Trpc4) 110561501

CGE:	100770387(Trpc4)

MAUA:

101824804(Trpc4)

PROB:

127216326(Trpc4)

PLEU:

114695867(Trpc4)

MORG:

121452864(Trpc4)

MFOT:

126499313

AAMP:

119826578(Trpc4)

NGI:	103747064(Trpc4)

HGL:	101712632(Trpc4)

CPOC:

100233224(Trpc4)

CCAN:

109674852(Trpc4)

DORD:

105997142(Trpc4)

DSP:	122112711(Trpc4)

NCAR:

124984917

OCU:

100353818

OPI:	101523649(TRPC4)

TUP:	102498780(TRPC4)

GVR:	103603412(TRPC4)

CFA:	486004(TRPC4)

CLUD:

112669382(TRPC4)

VVP:	112918694(TRPC4)

VLG:	121497143(TRPC4)

AML:	100481526(TRPC4)

UMR:	103664381(TRPC4)

UAH:	113251267(TRPC4)

UAR:	123791901(TRPC4)

ELK:

111158553

LLV:

125096338

MPUF:

101675620(TRPC4)

NVS:	122907034(TRPC4)

ORO:	101365793(TRPC4)

EJU:	114211324(TRPC4)

ZCA:	113919669(TRPC4)

MLX:	118009494(TRPC4)

NSU:	110570313(TRPC4)

LWW:	102730948(TRPC4)

FCA:	101087035(TRPC4)

PYU:	121012872(TRPC4)

PBG:	122481714(TRPC4)

LRUF:

124510242

PTG:	102951356(TRPC4)

PPAD:

109266028(TRPC4)

PUC:

125933727

AJU:	106973836(TRPC4)

HHV:	120246212(TRPC4)

BTA:	282102(TRPC4)

BOM:	102267732(TRPC4)

BIU:	109566764(TRPC4)

BBUB:

102407365(TRPC4)

BBIS:

104985456(TRPC4)

CHX:	102172166(TRPC4)

OAS:	101102401(TRPC4)

ODA:	120883101(TRPC4)

CCAD:

122447058(TRPC4)

SSC:	100157635(TRPC4)

CFR:	102512848(TRPC4)

CBAI:

105066197(TRPC4)

CDK:	105091013(TRPC4)

VPC:	102530549(TRPC4)

BACU:

103018549(TRPC4)

LVE:	103083164(TRPC4)

OOR:	101283119(TRPC4)

DLE:	111175248(TRPC4)

PCAD:

102996674(TRPC4)

PSIU:

116743095(TRPC4)

NASI:

112406576(TRPC4)

ECB:	100062641(TRPC4)

EPZ:	103555287(TRPC4)

EAI:	106844934(TRPC4)

MYB:	102252171(TRPC4)

MYD:

102754540

MMYO:

118650517(TRPC4)

MLF:	102431226(TRPC4)

MNA:	107533976(TRPC4)

PKL:	118728448(TRPC4)

HAI:	109391271(TRPC4)

DRO:	112310558(TRPC4)

SHON:

118994868(TRPC4)

AJM:	119044394(TRPC4)

PDIC:

114508663(TRPC4)

PHAS:

123818825(TRPC4)

MMF:	118622716(TRPC4)

RFQ:	117021074(TRPC4)

PALE:

102884419(TRPC4)

PGIG:

120610599(TRPC4)

PVP:	105293300(TRPC4)

RAY:	107499368(TRPC4)

MJV:	108390823(TRPC4)

TOD:	119258852(TRPC4)

SARA:

101553557(TRPC4)

LAV:	100674242(TRPC4)

TMU:

101342560

ETF:	101651194(TRPC4)

DNM:

101437108

MDO:	100021320(TRPC4)

GAS:	123238843(TRPC4)

SHR:	100924385(TRPC4)

AFZ:

127555237

PCW:	110196645(TRPC4)

OAA:	100078427(TRPC4)

GGA:	418895(TRPC4)

PCOC:

116244210(TRPC4)

MGP:	100538928 104917567

CJO:	107308209(TRPC4)

NMEL:

110388264(TRPC4)

APLA:

101798377(TRPC4)

ACYG:

106043253(TRPC4)

AFUL:

116502394(TRPC4)

TGU:	100229157(TRPC4)

LSR:	110476721(TRPC4)

SCAN:

103827372(TRPC4)

PMOA:

120496317(TRPC4)

OTC:	121337336(TRPC4)

PRUF:

121353331(TRPC4)

GFR:	102032831(TRPC4)

FAB:	101811033(TRPC4)

PHI:	102114334(TRPC4)

PMAJ:

107211492(TRPC4)

CCAE:

111945800(TRPC4)

CCW:	104689932(TRPC4)

CBRC:

103613605(TRPC4)

ETL:	114061881(TRPC4)

ZAB:	102075398(TRPC4)

ACHL:

103804467

SVG:	106848766(TRPC4)

FPG:	101914694(TRPC4)

FCH:	102048452(TRPC4)

CLV:	102094524(TRPC4)

EGZ:	104131496(TRPC4)

NNI:	104010870(TRPC4)

PCRI:

104036197

ACUN:

113483259(TRPC4)

TALA:

104361772(TRPC4)

PADL:

103913469

AFOR:

103907930(TRPC4)

ACHC:

115353543(TRPC4)

HLE:	104835006(TRPC4)

AGEN:

126048396

GCL:

127029697

CSTI:

104553205(TRPC4)

EHS:	104507479(TRPC4)

CMAC:

104481070

MUI:	104537610(TRPC4)

OHA:	104336896(TRPC4)

SHAB:

115604188(TRPC4)

DPUB:

104302325(TRPC4)

PGUU:

104459304

CPEA:

104389352(TRPC4)

AVIT:

104274359(TRPC4)

CVF:	104289463(TRPC4)

CUCA:

104066128(TRPC4)

TEO:

104372267

BRHI:

104488871(TRPC4)

AAM:	106489207(TRPC4)

AROW:

112973448(TRPC4)

NPD:	112942892(TRPC4)

TGT:	104574366(TRPC4)

DNE:	112988112(TRPC4)

SCAM:

104151550(TRPC4)

ASN:	102385690(TRPC4)

AMJ:	106736678(TRPC4)

CPOO:

109306576(TRPC4)

GGN:	109303161(TRPC4)

PSS:	102451117(TRPC4)

CMY:	102942118(TRPC4)

CPIC:

101944186 101945686(TRPC4)

TST:	117871022(TRPC4)

CABI:

116823751(TRPC4)

MRV:	120395980(TRPC4)

ACS:	100559243(trpc4)

PVT:	110090023(TRPC4)

SUND:

121924377(TRPC4)

PBI:

103064976

PMUR:

107292285(TRPC4)

CTIG:

120297597(TRPC4)

TSR:	106553099(TRPC4)

PGUT:

117677560

VKO:	123017765(TRPC4)

PMUA:

114587653(TRPC4) 114589839

ZVI:	118075435(TRPC4)

GJA:	107113469(TRPC4)

XLA:	108708683 108709012

XTR:	100485338(trpc4)

NPR:	108790003(TRPC4)

RTEM:

120929132(TRPC4)

BBUF:

120993977(TRPC4)

BGAR:

122931238(TRPC4)

DRE:	102725536(trpc4b) 102725537(trpc4a)

SRX:	107718778 107720578 107730855 107752869

SANH:

107683445 107693894 107701104 107704724

SGH:	107555142 107557214 107582253 107588262

CCAR:

109064960 109076317 109112668

CAUA:

113054299 113054304 113058652 113073968 113109848 113114787

CGIB:

127966606 127972207 128021183 128028602

PPRM:

120476437(trpc4a) 120478737(trpc4b)

MAMB:

125248877(trpc4b) 125260504(trpc4a)

CIDE:

127494962 127521818

MASI:

127422056 127430099 127432286 127433849

IPU:	108276614(trpc4a) 108277864(trpc4b)

PHYP:

113539241 113543433(trpc4)

SMEO:

124393555(trpc4a) 124394551(trpc4b)

TFD:	113651678(trpc4b) 113659098(trpc4a)

AMEX:

103035222 103045092

EEE:	113571742(trpc4) 113582277

TRU:

101076517

TNG:	GSTEN00018875G001 GSTEN00030182G001

LCO:	104923310 104936460

NCC:	104950572(trpc4) 104960489

CGOB:

115017903 115019000(trpc4)

ELY:	117259614(trpc4b) 117272767

EFO:	125888764(trpc4b) 125897875(trpc4a)

PLEP:

121943244(trpc4b) 121952136

SLUC:

116036997(trpc4a) 116048359(trpc4b)

ECRA:

117941329(trpc4b) 117955399(trpc4a)

ESP:	116671272 116700352(trpc4)

PFLV:

114553286 114567131(trpc4)

GAT:	120822375 120829014(trpc4b)

PPUG:

119215893 119216493(trpc4b)

MSAM:

119882986(trpc4b) 119896001(trpc4a)

CUD:	121516145(trpc4b) 121518830

ALAT:

119009001(trpc4b) 119031409

MZE:	101467992(trpc4)

ONL:	100692457 100695568

OAU:	116310846(trpc4b) 116323461

OLA:	101170611(trpc4)

OML:

112139414

XMA:	102219416(trpc4)

XCO:	114153552(trpc4) 114161828

XHE:	116728694(trpc4)

PRET:

103474979 103475553(trpc4)

PFOR:

103140219

PLAI:

106951415(trpc4)

PMEI:

106915934

GAF:

122844495

CVG:	107088254(trpc4) 107095577

CTUL:

119779227

GMU:

124875849

NFU:	107380230 107386938

KMR:	108235966(trpc4b) 108237049(trpc4a)

ALIM:

106514151(trpc4) 106521534

NWH:	119411346(trpc4b) 119420545

AOCE:

111563673 111565880(trpc4)

MCEP:

125013025(trpc4b) 125021766

CSEM:

103378000 103395493(trpc4)

POV:	109629990 109635706(trpc4)

SSEN:

122772943 122780146

HHIP:

117773134(trpc4b) 117774565(trpc4a)

HSP:	118106133(trpc4b) 118122689

LCF:	108876021 108893986

SDU:	111217071(trpc4) 111224433

SLAL:

111657805 111662632(trpc4)

XGL:	120792391(trpc4b) 120802225(trpc4a)

HCQ:	109513659 109516929(trpc4) 109525637

SSCV:

125972721 125982288

BPEC:

110158552(trpc4) 110162887

MALB:

109967497 109971893(trpc4)

BSPL:

114868544(trpc4b) 114869059

SASA:

106563868 106563872 106581007 106612758

STRU:

115163313 115204646(trpc4) 115206808

OTW:	112247577 112265447 112267006

OMY:	110503831 110507665 110509467(trpc4a)

OGO:	123993946 124004915 124006910

ONE:	115137782 115141272

SALP:

111949821 111956826

SNH:	120018575 120021168(trpc4a) 120029200

CCLU:

121541363 121568367 123485099

ELS:	105010890 105011169(trpc4)

SFM:	108936015(trpc4) 108941081

PKI:	111840457(trpc4) 111851269

AANG:

118208978 118235253(trpc4a)

LOC:	102691071(trpc4)

PSPA:

121320913

ARUT:

117406695 117972651(trpc4b)

PSEX:

120524017(trpc4b)

LCM:	102349424(TRPC4)

CMK:	103177185(trpc4b)

RTP:

109912753

CPLA:

122550814(trpc4b)

BFO:	118412792 118415209 118415864 118416178 118416200 118416338 118419311 118419817 118419995 118425535 118425539

BBEL:

109466341 109466352 109472092 109476741 109487654 109487655 109487755

CIN:	100179145 100184758 100186220 100186522 101243108 104266085

SCLV:

120326109 120326531 120345753

SPU:	583250 584852 586872 594022

APLC:

110973787 110976139 110976301 110976316 110987534 110990784

SKO:	100371165 100378311 102810113

DME:	Dmel_CG5996(Trpgamma) Dmel_CG7875(trp)

DER:	6547500 6554434

DSE:	6612774 6614396

DSI:	Dsimw501_GD11966(Dsim_GD11966) Dsimw501_GD17578(Dsim_GD17578)

DYA:	Dyak_GE10412 Dyak_GE13177

DAN:	6498681 6499020

DSR:	110181159 110190092

DPO:	4800281 4817504

DPE:	6588881 6595004

DMN:	108157470 108164170

DWI:	6651153 6651846

DGR:	6568468 6570234

DMO:	Dmoj_GI10448 Dmoj_GI13792

DAZ:	108608792 108612133

DNV:	108649345 108659720

DHE:	111596372 111597842 115482739

DVI:	6627567 6633024

CCAT:

101450455 101455538

BOD:	106616737 106620520

RZE:	108368701 108370407 108376911 108382969

MDE:	101887708 101890597

SCAC:

106082776 106087184 106087191

LCQ:	111680958 111686428

LSQ:	119602220 119611137

HIS:	119652724 119659975

AGA:	AgaP_AGAP000348 AgaP_AGAP008435

ACOZ:

120954864 120955060

AARA:

120904801 120906387

ASTE:

118512622 118517379

AAG:	5565862 5566497

AALB:

109407024 109410160 109427440 115254485 115262060 115262241 115269152

CQU:	CpipJ_CPIJ001522 CpipJ_CPIJ018599

CPII:

120417027 120420517

CNS:	116338345 116345955

BCOO:

119070453 119082579

AME:	410823 724608

ACER:

108001544 108003337

ALAB:

122715317 122718514

BIM:	100740218 100740768 100743147

BBIF:

117205753 117206755 117211153

BVK:	117230560 117236799 117238520

BVAN:

117155667 117157381 117160288

BTER:

100647530 100651056 105666600

BPYO:

122574774 122577344

CCAL:

108625028 108627324 108628714

OBB:	114877128 114881914

MGEN:

117225002 117227365

NMEA:

116423863 116425630 116430144

CGIG:

122395609 122397624

SOC:	105195295 105195362 105198528

MPHA:

105832795 105835077 105838785

AEC:	105146953 105147352

ACEP:

105619980 105625710 105627050

PBAR:

105422471 105423018

VEM:	105560968 105562120

HST:	105182632 105183332 105185238

DQU:	106746708 106749788 106751813

CFO:	105257707 105258619

FEX:	115235686 115242430

LHU:	105669094 105669468

PGC:	109857144 109858136

OBO:	105284167 105285066

PCF:	106791441 106791574

PFUC:

122517433 122517960

VPS:	122629259 122635383

NVI:	100120998 100121718

CSOL:

105364627 105366727

TPRE:

106652968 106654087

MDL:	103570845 103573089 103580341

CGLO:

123266947 123271824

FAS:	105263860 105274031

DAM:	107043936 107047366 107048750

AGIF:

122852269 122856671

CINS:

118066066 118071694

LHT:	122499747 122512482

CCIN:

107266925 107268588

TCA:	657097(TRP) 663398(TRPL)

DPA:	109536143 109537030 109544981 125505330

SOY:	115874611 115876407

ATD:	109596133 109597265 109598186 109607034

CSET:

123309346 123309465

AGB:	108910300 111691760

LDC:	111503221 111508869 111510927

NVL:	108561527 108561781 108567750 108568078

APLN:

108736661 108738494

PPYR:

116169370 116169576

OTU:	111413293 111423725 111427901

BMOR:

101736324 101740441

BMAN:

114241206 114252755

MSEX:

115441838 115445467 115450003

DPL:	KGM_213792 KGM_216017

BANY:

112051187 112055305

NIQ:	126776744 126781603

PMAC:

106709557 106712436

PPOT:

106104945 106105331

PXU:	106120782 106123250

PRAP:

110993116 110998365

PBX:	123712292 123712612

PNAP:

125056659 125057690

ZCE:	119833577 119837481

CCRC:

123691724 123701261

HAW:	110375205 110380830 110384028

HZE:	124632658 124635863

TNL:	113492598 113500048

SLIU:

111354360 111358422

OFU:	114364995 114365971

PXY:

105393020

CFEL:

113371012

API:

100571950

DNX:	107162342 107168708 107168790

AGS:	114120546 114125497 114129985

RMD:	113558597 113559196

BTAB:

109032310 109036537

CLEC:

106661285 106668059 106669848

HHAL:

106684104 106688246 106689816

NLU:	111051570 111061806

PHU:	Phum_PHUM055080 Phum_PHUM086850

FOC:	113206994 113207296

TPAL:

117648395 117650803

ZNE:	110826465 110828770 110829563 110838040 110838488

CSEC:

111862256 111870895 111870942

SGRE:

126282063 126354208

FCD:	110842888 110850913

DPX:	DAPPUDRAFT_309057(TRPC) DAPPUDRAFT_323725(TRPG)

DMK:	116921960 116931644 123477502

DPZ:	124335807 124350540

PVM:	113804536 113804993 113805723 113827410

PJA:	122242540 122244301 122250003 122256307

PCHN:

125034424 125036256 125044795 125048345

PMOO:

119589312 119597482 119599515

HAME:

121859413 121864119 121874988 121876675

PCLA:

123745335 123745556 123766196 123773929

PTRU:

123499394 123512666 123513189 123514084

ESN:	126985045 126985496 127009065 127010432

HAZT:

108667124 108670128 108673878

EAF:	111697349 111703933 111707945 111710037

LSM:	121114400 121116765 121116903

PPOI:

119092738 119107303 119107997 119107998 119114490

ISC:	IscW_ISCW016812

DSV:	119449396 119450236 119456896

RSAN:

119381054 119381715 119383283

RMP:	119162586 119169579

VDE:

111245614

VJA:

111271765

TUT:	107365698 107368113

DPTE:

113795072

DFR:

124493185

CSCU:

111612817 111620290 111620705 111626203 111634685 111634686 111634687 111635530 111636969 111637278 111638598 111638600 111640003

PTEP:

107437390 107445755 107446622 107450089 107454480

SDM:	118183513 118185692 118187745 118188311 118196742 118201402 118203440 118206073

CEL:	CELE_R06B10.4(trp-2) CELE_ZC21.2(trp-1)

CBR:	CBG_15139(Cbr-trp-2) CBG_18103(Cbr-trp-1)

BMY:	BM_BM5246(Bma-trp-2)

LOA:	LOAG_10859

NAI:	NECAME_15371 NECAME_15723

TSP:	Tsp_00950 Tsp_01428

HRO:	HELRODRAFT_63393 HELRODRAFT_66730

LGI:	LOTGIDRAFT_177244

PCAN:

112558564 112560581

BGT:	106056780 106074945

GAE:	121374204 121374365

HRF:	124132657 124151391

HRJ:	124260511 124275216

CRG:	105333397 105333583

MYI:	110445790 110465385

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:	115218635 115222574

LAK:	106156195 106156216 106168419 106177384 106181868

SMM:	Smp_147860 Smp_151880

OVI:	T265_03003 T265_09033

EGL:	EGR_00433 EGR_07656 EGR_08665

NVE:	116618328 5517341

EPA:	110244721 110244725 110247702

ATEN:

116290433

ADF:	107329762 107333747 107341655 107343456 107344643 107356706 107356707 107356708

AMIL:

114950509 114954985 114956244 114956800 114976086

PDAM:

113668190 113668208 113677259 113677413 113681324 113683261

SPIS:

111328870 111328892 111329278 111329289 111329297 111342250

DGT:

114530569

XEN:

124438702

CRE:	CHLRE_10g452950v5

MBR:	MONBRDRAFT_27307

SRE:	PTSG_10078

» show all

Reference

PMID:19996314

Authors

Graziani A, Poteser M, Heupel WM, Schleifer H, Krenn M, Drenckhahn D, Romanin C, Baumgartner W, Groschner K

Title

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

Journal

J Biol Chem 285:4213-23 (2010)
DOI:10.1074/jbc.M109.060301

Sequence

[hsa:7223]

Reference

PMID:11042129

Authors

McKay RR, Szymeczek-Seay CL, Lievremont JP, Bird GS, Zitt C, Jungling E, Luckhoff A, Putney JW Jr

Title

Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3.

Journal

Biochem J 351 Pt 3:735-46 (2000)
DOI:10.1042/bj3510735

Sequence

[hsa:7223]

Reference

PMID:10896160

Authors

Xu XZ, Chien F, Butler A, Salkoff L, Montell C

Title

TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL.

Journal

Neuron 26:647-57 (2000)
DOI:10.1016/S0896-6273(00)81201-5

Sequence

[dme:Dmel_CG5996]

Reference

PMID:1314617

Authors

Hardie RC, Minke B

Title

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors.

Journal

Neuron 8:643-51 (1992)
DOI:10.1016/0896-6273(92)90086-S

Sequence

[dme:Dmel_CG7875]

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Ontology (7)   
   KEGG BRITE (2)   
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   TC (4)   
Pathway (6)   
   KEGG PATHWAY (6)   
Gene (3145)   
   KEGG GENES (918)   
   KEGG MGENES (319)   
   RefGene (1899)   
   OC (9)   
Literature (4)   
   PubMed (4)   
All databases (3162)   

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