KEGG ORTHOLOGY: K05121

ORTHOLOGY: K05121

Entry

K05121                      KO

Symbol

TEK, TIE2, CD202

Name

endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04066

HIF-1 signaling pathway

map04151

PI3K-Akt signaling pathway

map05323

Rheumatoid arthritis

Disease

H00531

Venous malformations

H01203

Primary congenital glaucoma

H02044

Cutaneous and mucosal venous malformation

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04014 Ras signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04015 Rap1 signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04066 HIF-1 signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04151 PI3K-Akt signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  TIE family
   K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
CD molecules [BR:ko04090]
Proteins
  K05121  CD202b, TEK; TEK tyrosine kinase, endothelial

Genes

HSA:

7010(TEK)

PTR:	465028(TEK)

PPS:	100980629(TEK)

GGO:	101153987(TEK)

PON:	100174302(TEK)

PPYG:

129044353(TEK)

NLE:	100606897(TEK)

HMH:	116458259(TEK)

SSYN:

129490279(TEK)

MCC:	707455(TEK)

MCF:	102122204(TEK)

MTHB:

126937984

MNI:	105493864(TEK)

CSAB:

103219338(TEK)

CATY:

105591300(TEK)

PANU:

101004283(TEK)

TGE:	112608598(TEK)

MLEU:

105549728(TEK)

RRO:	104679005(TEK)

RBB:	108527847(TEK)

TFN:	117098682(TEK)

PTEH:

111537223(TEK)

CANG:

105523238

CJC:	103793489(TEK)

SBQ:	101039223(TEK)

CIMI:

108289419(TEK)

ANAN:

105718767(TEK)

CSYR:

103257533(TEK)

MMUR:

105871174(TEK)

LCAT:

123645784(TEK)

PCOQ:

105812103(TEK)

OGA:	100966523(TEK)

MMU:	21687(Tek)

MCAL:

110293136(Tek)

MPAH:

110322884(Tek)

RNO:	89804(Tek)

MCOC:

116096241(Tek)

ANU:	117709160(Tek)

MUN:	110552526(Tek)

CGE:	100764854(Tek)

MAUA:

101840374(Tek)

PROB:

127224949(Tek)

PLEU:

114693771(Tek)

MORG:

121448096(Tek)

MFOT:

126497972

AAMP:

119817629(Tek)

NGI:	103730679(Tek)

HGL:	101710501(Tek)

CPOC:

100713324(Tek)

CCAN:

109686627(Tek)

DORD:

105989026(Tek)

DSP:	122121294(Tek)

PLOP:

125361448(Tek)

NCAR:

124964747

MMMA:

107147869(Tek)

OCU:

100356675

OPI:	101525496(TEK)

TUP:	102498017(TEK)

GVR:	103588261(TEK)

CFA:	403714(TEK)

CLUD:

112650526(TEK)

VVP:	112927571(TEK)

VLG:	121494752(TEK)

NPO:	129494846(TEK)

AML:	100474998(TEK)

UMR:	103667004(TEK)

UAH:	113260555(TEK)

UAR:	123781314(TEK)

ELK:

111159847

LLV:

125083337

MPUF:

101690484(TEK)

MNP:	132024682(TEK)

MLK:	131813238(TEK)

NVS:	122917546(TEK)

ORO:	101367636(TEK)

EJU:	114218235(TEK)

ZCA:	113934126(TEK)

MLX:	118018047(TEK)

NSU:	110572635(TEK)

LWW:	102737690(TEK)

FCA:	101091977(TEK)

PYU:	121034541(TEK)

PCOO:

112856283(TEK)

PBG:	122475108(TEK)

PVIV:

125150336(TEK)

LRUF:

124501143

PTG:	102954161(TEK)

PPAD:

109252069(TEK)

PUC:

125916653

AJU:

106977825

HHV:	120223605(TEK)

BTA:	280939(TEK)

BOM:	102283049(TEK)

BIU:	109562825(TEK)

BBUB:

102395572(TEK)

BBIS:

104998255(TEK)

CHX:	102169100(TEK)

OAS:	497272(TEK)

BTAX:

128052138(TEK)

ODA:	120862020(TEK)

CCAD:

122452906(TEK)

MBEZ:

129557527(TEK)

SSC:	396729(TEK)

CFR:	102510021(TEK)

CBAI:

105071266(TEK)

CDK:	105093613(TEK)

VPC:	102536292(TEK)

BACU:

103016789(TEK)

BMUS:

118897062(TEK)

LVE:	103068442(TEK)

OOR:	101280154(TEK)

DLE:	111163124(TEK)

PCAD:

102994335(TEK)

PSIU:

116755617(TEK)

NASI:

112406011(TEK)

ECB:	100066963(TEK)

EPZ:	103550275(TEK)

EAI:	106838956(TEK)

MYB:	102241735(TEK)

MYD:	102773744(TEK)

MMYO:

118667603(TEK)

MLF:	102429943(TEK)

MDT:	132211847(TEK)

PKL:	118716646(TEK)

EFUS:

103297376(TEK)

MNA:	107543094(TEK)

DRO:	112302877(TEK)

SHON:

118996978(TEK)

AJM:	119046176(TEK)

PDIC:

114498561(TEK)

PHAS:

123820012(TEK)

MMF:	118629453(TEK)

PPAM:

129082381(TEK)

HAI:	109388180(TEK)

RFQ:	117032285(TEK)

PALE:

102894883(TEK)

PGIG:

120617099(TEK)

PVP:	105308731(TEK)

RAY:	107516483(TEK)

MJV:	108399089(TEK)

TOD:	119231355(TEK)

SARA:

101554614(TEK)

SETR:

126004527(TEK)

LAV:	100656674(TEK)

TMU:

101351895

ETF:	101658503(TEK)

DNM:	101417906(TEK)

MDO:	100023250(TEK)

GAS:	123234658(TEK)

SHR:	100926118(TEK)

AFZ:

127537989

PCW:	110196671(TEK)

TVP:	118830988(TEK)

OAA:	100074264(TEK)

GGA:	427368(TEK)

PCOC:

116234640(TEK)

MGP:	100542149(TEK)

CJO:	107306600(TEK)

TPAI:

128089435(TEK)

LMUT:

125686609(TEK)

NMEL:

110390338(TEK)

APLA:

101789714(TEK)

ACYG:

106043732(TEK)

CATA:

118256250(TEK)

AFUL:

116501135(TEK)

TGU:	100225537(TEK)

LSR:	110473416(TEK)

SCAN:

103821834(TEK)

PMOA:

120513649(TEK)

OTC:	121334200(TEK)

PRUF:

121363708(TEK)

GFR:	102042810(TEK)

FAB:	101812140(TEK)

OMA:	130265629(TEK)

PHI:	102104127(TEK)

PMAJ:

107216128(TEK)

CCAE:

111941340(TEK)

CCW:	104690490(TEK)

CBRC:

103611659(TEK)

ETL:	114056113(TEK)

ZAB:	102062909(TEK)

ZLE:	135459869(TEK)

ACHL:

103803817(TEK)

SVG:	106857795(TEK)

MMEA:

130572928(TEK)

HRT:	120765245(TEK)

SATI:

136373840(TEK)

FPG:	101910639(TEK)

FCH:	102048724(TEK)

CCRI:

104166134(TEK)

NNT:	104406784(TEK)

SHAB:

115600625(TEK)

ACUN:

113490318(TEK)

TALA:

104366012(TEK)

ACHC:

115337108(TEK)

HALD:

104325795(TEK)

HLE:	104838400(TEK)

AGEN:

126035865

GCL:

127027523

CSTI:

104558134(TEK)

LDI:	104344138(TEK)

MNB:	103770589 103781482

DPUB:

104304183(TEK)

AVIT:

104270152(TEK)

BRHI:

104495735(TEK)

EGZ:	104123038(TEK)

NNI:	104013668(TEK)

PCRI:

104028562(TEK)

PCAO:

104043700(TEK)

PADL:

103921046(TEK)

AFOR:

103904724(TEK)

FGA:	104079541(TEK)

GSTE:

104257177(TEK)

CLV:	102086382(TEK)

MUI:	104547958(TEK)

PGUU:

104466815(TEK)

PLET:

104616754

EHS:	104513388(TEK)

CMAC:

104481822(TEK)

CUCA:

104059654(TEK)

TEO:	104375632(TEK)

BREG:

104635551(TEK)

OHA:	104326744(TEK)

ACAR:

104518098(TEK)

CPEA:

104391702(TEK)

CVF:	104296058(TEK)

RTD:	128902621(TEK)

AAM:	106486993 106487885(TEK)

AROW:

112972336(TEK)

NPD:	112953948(TEK)

TGT:	104575421(TEK)

DNE:	112992614(TEK)

SCAM:

104147419(TEK)

ASN:	102376701(TEK)

AMJ:	102559179(TEK)

CPOO:

109323582(TEK)

GGN:	109297335(TEK)

PSS:	102457133(TEK)

CMY:	102934200(TEK)

CCAY:

125636425(TEK)

DCC:

119855619

CPIC:

101949487(TEK)

TST:	117879039(TEK)

CABI:

116826873(TEK)

MRV:	120408416(TEK)

ACS:	100558197(tek)

ASAO:

132767449(TEK)

PVT:	110080357(TEK)

SUND:

121924049(TEK)

PMUR:

107290679(TEK)

CTIG:

120309994(TEK)

TSR:	106545353(TEK)

PGUT:

117661554(TEK)

APRI:

131191946(TEK)

PTEX:

113444605(TEK)

NSS:	113415052(TEK)

VKO:	123022419(TEK)

PMUA:

114588053(TEK)

PRAF:

128405457(TEK)

ZVI:	118097807(TEK)

HCG:	128347983(TEK)

GJA:	107116257(TEK)

STOW:

125437286(TEK)

EMC:	129334866(TEK)

XLA:	108713943(tek.L) 398263(tek.S)

XTR:	100492432(tek)

NPR:	108787082(TEK)

RTEM:

120944847(TEK)

BBUF:

120989219(TEK)

BGAR:

122921671(TEK)

MUO:	115463548(TEK)

GSH:	117347909(TEK)

DRE:	30747(tek)

SRX:	107717338 107721039

SANH:

107656940 107687250

SGH:	107558058 107563393

CCAR:

109058312 109096567

CAUA:

113070658(tek)

CGIB:

127957319

PTET:

122344957(tek)

LROH:

127165311(tek)

OMC:	131540544(tek)

PPRM:

120471683(tek)

RKG:	130076952(tek)

MAMB:

125266198(tek)

CIDE:

127512113

CERY:

137034052(tek)

MASI:

127423155

TROS:

130564115(tek)

TDW:	130418863(tek)

MANU:

129439453(tek)

IPU:

108260272

IFU:	128603483(tek)

PHYP:

113531282(tek)

SMEO:

124379069(tek)

TFD:	113641618(tek)

TVC:	132840926(tek)

TRN:	134303137(tek)

AMEX:

103021852(tek)

CMAO:

118814883(tek)

EEE:	113582828(tek)

CHAR:

105902491(tek)

SASA:

106568558(tek)

STRU:

115149540 115160173

OTW:	112259477(tek)

OMY:	110536771(tek)

OGO:	123999465(tek)

ONE:

115121464

OKI:	109884910(tek)

OKE:	118381796(tek)

SALP:

112070363 112072193

SNH:	120026142 120036876(tek)

CCLU:

121573364(tek) 121581828

ELS:	105020503(tek)

PKI:	111842012(tek)

AANG:

118213247(tek) 118237185

LOC:	102688555(tek)

PSPA:

121303549 121314515

ARUT:

117408563 117421531

PSEX:

120533066(tek)

LCM:	102358253(TEK)

CMK:	103178069(tek)

RTP:	109915196(tek)

CPLA:

122563494(tek)

HOC:	132824960(tek)

PMRN:

116948979(TIE1)

LRJ:	133351972(TIE1)

BFO:

118408000

BBEL:

109469109 109473275 109476127 109482325 109486050

SCLV:

120335191

SPU:	105446745 587243

APLC:

110975479 110982839 110990853

ARUN:

TCA:

ATD:

NVL:

API:	100161662 100163240 100570133

AGS:

114121036

RMD:	113555747 113560410

DCI:

103504836

FOC:

113209189

TPAL:

117644927 117645782 117647041

HAZT:

108666740

LAK:

106156959

EPA:	110240224 110244087 110244535

ATEN:

116295098 116295631 116298177 116302251 116304929

AMIL:

114960955 114976684

PDAM:

113673325 113673673 113674889 113681282

SPIS:

111324192 111327747 111327748 111327753 111327754

DGT:	114515639 114515640 114538605 114539527 114540931 114543360 114544793

XEN:

124442858

» show all

Reference

PMID:8382358

Authors

Ziegler SF, Bird TA, Schneringer JA, Schooley KA, Baum PR

Title

Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.

Journal

Oncogene 8:663-70 (1993)

Sequence

[hsa:7010]

Reference

PMID:14530387

Authors

Puri MC, Bernstein A

Title

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.

Journal

Proc Natl Acad Sci U S A 100:12753-8 (2003)
DOI:10.1073/pnas.2133552100

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (857)   
   KEGG GENES (397)   
   KEGG MGENES (235)   
   RefGene (217)   
   OC (8)   
Literature (2)   
   PubMed (2)   
All databases (885)   

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