KEGG   ORTHOLOGY: K05296Help
Entry
K05296                      KO                                     

Name
E1.1.1.51
Definition
3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51]
Pathway
ko00140  Steroid hormone biosynthesis
ko00984  Steroid degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K05296  E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K05296  E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     K05296  E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase
BRITE hierarchy
Other DBs
RN: R01836 R01838 R02352 R02353 R03406 R03407 R09956 R09957
GO: 0030283
Genes
RGL: CS053_01735
PRE: PCA10_43660
PPUU: PputUW4_01679
PKC: PKB_4320
PFZ: AV641_10575
PPSY: AOC04_07875
PSET: THL1_4408
PSIL: PMA3_11580
SPL: Spea_2173
SHL: Shal_2144
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
BCT: GEM_4149
BCON: NL30_04370
BTEI: WS51_05535
BFN: OI25_4612
CTES: O987_11065
GME: Gmet_2217
NAR: Saro_3532
SPHD: HY78_14230
SPHR: BSY17_3924
SINB: SIDU_16905
 » show all
TaxonomyKoalaUniProt
Reference
PMID:193845
  Authors
Schultz RM, Groman EV, Engel LL
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J Biol Chem 252:3775-83 (1977)
Reference
  Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
  Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
  Journal
J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002

KEGG   ENZYME: 1.1.1.51Help
Entry
EC 1.1.1.51                 Enzyme                                 

Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3)
PPS: 100986388(AKR1C3)
GGO: 101144878
PON: 100174617(AKR1C3)
NLE: 100604844
MCC: 711440
MCF: 102142023(HSD17B5)
RBB: 108532990
SBQ: 101041594
MUN: 110560700
CFA: 497070(AKR1C3)
FCA: 100510801(AKR1C3)
PTG: 102963188
PPAD: 109273789
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884 785762
BOM: 102269337
BIU: 109568087
BBUB: 102395293
SSC: 733634(AKR1C1)
LVE: 103069218
PCAD: 102978533
ECB: 100070616
MYB: 102255491
MYD: 102751586
TMU: 101342771
OAA: 100085065
PSS: 102446010
PVT: 110088827
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 105946859 779627(akr1c3)
PKC: PKB_4320
PSET: THL1_4408
PSIL: PMA3_11580
SPL: Spea_2173
SHL: Shal_2144
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
BCT: GEM_4149
BCON: NL30_04370
BTEI: WS51_05535
BFN: OI25_4612
CTES: O987_11065
GME: Gmet_2217
NAR: Saro_3532
SPHD: HY78_14230
SPHR: BSY17_3924
SINB: SIDU_16905
 » show all
Taxonomy
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe Seylers Z Physiol Chem 336:63-8 (1964)
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J Biol Chem 232:1015-30 (1958)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL.
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J Biol Chem 252:3775-83 (1977)
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J Biol Chem 205:823-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0

KEGG   REACTION: R01836Help
Entry
R01836                      Reaction                               

Name
testosterone:NAD+ 17-oxidoreductase
Definition
Testosterone + NAD+ <=> Androstenedione + NADH + H+
Equation
Comment
NADP+ (see R01838)
Reaction class
RC00001  C00003_C00004
RC00127  C00280_C00535
Enzyme
1.1.1.51        1.1.1.239
Pathway
rn00140  Steroid hormone biosynthesis
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K05296  3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51]
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.239]
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
K13370  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239]
Other DBs
RHEA: 14932

KEGG   REACTION: R01838Help
Entry
R01838                      Reaction                               

Name
testosterone:NADP+ 17-oxidoreductase
Definition
Testosterone + NADP+ <=> Androstenedione + NADPH + H+
Equation
Comment
NAD+ (see R01836)
Reaction class
RC00001  C00005_C00006
RC00127  C00280_C00535
Enzyme
1.1.1.51        1.1.1.64
Pathway
rn00140  Steroid hormone biosynthesis
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K05296  3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51]
K10207  testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64]
Other DBs
RHEA: 14984

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