PMID:8415746

Nakajima K, Hashimoto T, Yamada Y

Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.

Proc Natl Acad Sci U S A 90:9591-5 (1993)
DOI:10.1073/pnas.90.20.9591

[ag:AAA33282]

PMID:11855731

Keiner R, Kaiser H, Nakajima K, Hashimoto T, Drager B

Molecular cloning, expression and characterization of tropinone reductase II, an enzyme of the SDR family in Solanum tuberosum (L.).

Plant Mol Biol 48:299-308 (2002)
DOI:10.1023/A:1013315110746

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

pseudotropine:NADP+ 3-oxidoreductase

pseudotropine + NADP+ = tropinone + NADPH + H+ [RN:R06734]

R06734
Reaction

pseudotropine [CPD:C02066];
NADP+ [CPD:C00006]

This enzyme along with EC 1.1.1.206, tropine dehydrogenase, represents a branch point in tropane alkaloid metabolism [3]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [3]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [2].

EC 1.1.1.236 created 1992, modified 2007

1

Drager, B., Hashimoto, T. and Yamada, Y.

Purification and characterization of pseudotropine forming tropinone reductase from Hyoscyamus niger root cultures.

Agric Biol Chem 52:2663-2667 (1988)

2

Couladis, M.M, Friesen, J.B., Landgrebe, M.E. and Leete, E.

Enzymes catalysing the reduction of tropinone to tropine and psi-tropine isolated from the roots of Datura innoxia.

Pytochemistry 30:801-805 (1991)

3  [PMID:8415746]

Nakajima K, Hashimoto T, Yamada Y.

Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.

Proc Natl Acad Sci U S A 90:9591-5 (1993)
DOI:10.1073/pnas.90.20.9591

[ag:AAA33282]

4  [PMID:16426652]

Drager B.

Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism.

Phytochemistry 67:327-37 (2006)
DOI:10.1016/j.phytochem.2005.12.001