KEGG   ORTHOLOGY: K05406
Entry
K05406                      KO                                     
Symbol
IL12A
Name
interleukin 12A
Pathway
map04060  Cytokine-cytokine receptor interaction
map04620  Toll-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05133  Pertussis
map05134  Legionellosis
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05321  Inflammatory bowel disease
map05330  Allograft rejection
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05406  IL12A; interleukin 12A
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05406  IL12A; interleukin 12A
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04622 RIG-I-like receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04625 C-type lectin receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04658 Th1 and Th2 cell differentiation
    K05406  IL12A; interleukin 12A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05406  IL12A; interleukin 12A
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05406  IL12A; interleukin 12A
   05164 Influenza A
    K05406  IL12A; interleukin 12A
   05162 Measles
    K05406  IL12A; interleukin 12A
   05168 Herpes simplex virus 1 infection
    K05406  IL12A; interleukin 12A
  09171 Infectious disease: bacterial
   05133 Pertussis
    K05406  IL12A; interleukin 12A
   05134 Legionellosis
    K05406  IL12A; interleukin 12A
   05152 Tuberculosis
    K05406  IL12A; interleukin 12A
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05406  IL12A; interleukin 12A
   05144 Malaria
    K05406  IL12A; interleukin 12A
   05145 Toxoplasmosis
    K05406  IL12A; interleukin 12A
   05140 Leishmaniasis
    K05406  IL12A; interleukin 12A
   05142 Chagas disease
    K05406  IL12A; interleukin 12A
   05143 African trypanosomiasis
    K05406  IL12A; interleukin 12A
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05406  IL12A; interleukin 12A
   05330 Allograft rejection
    K05406  IL12A; interleukin 12A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05406  IL12A; interleukin 12A
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05406  IL12A; interleukin 12A
   04936 Alcoholic liver disease
    K05406  IL12A; interleukin 12A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05406  IL12A; interleukin 12A
   00536 Glycosaminoglycan binding proteins
    K05406  IL12A; interleukin 12A
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05406  IL12A; interleukin 12A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K05406  IL12A; interleukin 12A
Other DBs
GO: 0005143
Genes
HSA: 3592(IL12A)
PTR: 460816(IL12A)
PPS: 100979574(IL12A)
GGO: 101150677(IL12A)
PON: 100444807(IL12A)
PPYG: 129033150(IL12A)
NLE: 100603245(IL12A)
HMH: 116463392 116463424
SSYN: 134732931(IL12A)
MCC: 703205(IL12A)
MCF: 102115316(IL12A)
MTHB: 126949358
MNI: 105488536(IL12A)
CSAB: 103241402(IL12A)
CATY: 105598171(IL12A)
PANU: 100126719(IL12A)
TGE: 112619066(IL12A)
MLEU: 105552064(IL12A)
RRO: 104665012(IL12A)
RBB: 108514790(IL12A)
TFN: 117079203(IL12A)
PTEH: 111550126(IL12A)
CANG: 105523976(IL12A)
CJC: 100406669(IL12A)
SBQ: 101044358(IL12A)
CIMI: 108284144(IL12A)
ANAN: 105713571(IL12A)
CSYR: 103258245(IL12A)
MMUR: 105881187(IL12A)
LCAT: 123646097(IL12A)
PCOQ: 105809128(IL12A)
OGA: 100959043(IL12A)
MMU: 16159(Il12a)
MCAL: 110291699(Il12a)
MPAH: 110320680(Il12a)
RNO: 84405(Il12a)
MCOC: 116094048(Il12a)
ANU: 117707571(Il12a)
MUN: 110557307(Il12a)
CGE: 100760602(Il12a)
MAUA: 101844248(Il12a)
PROB: 127232891(Il12a)
PLEU: 114691738(Il12a)
MORG: 121452968(Il12a)
MFOT: 126504946
AAMP: 119826750(Il12a)
NGI: 103745345(Il12a)
HGL: 101701392(Il12a)
CPOC: 100379543(Il12a)
CCAN: 109692199(Il12a)
DORD: 105985549(Il12a)
DSP: 122112737(Il12a)
PLOP: 125351136(Il12a)
NCAR: 124993138
MMMA: 107143551(Il12a)
OCU: 100349007
OPI: 101518190(IL12A)
TUP: 102493627(IL12A)
GVR: 103605130(IL12A)
CFA: 403977(IL12A)
CLUD: 112645861(IL12A)
VVP: 112933314(IL12A)
VLG: 121477529(IL12A)
NPO: 129498700(IL12A)
AML: 100470471(IL12A)
UMR: 103681335(IL12A)
UAH: 113254130(IL12A)
UAR: 123801580(IL12A)
ELK: 111150468
LLV: 125099687
MPUF: 101689314(IL12A)
MNP: 132012091(IL12A)
MLK: 131824928(IL12A)
NVS: 122910459(IL12A)
ORO: 101367178(IL12A)
EJU: 114209150(IL12A)
ZCA: 113916510(IL12A)
MLX: 118005789(IL12A)
NSU: 110591738(IL12A)
LWW: 102738603(IL12A)
FCA: 493741(IL12A)
PYU: 121033922(IL12A)
PCOO: 112849717(IL12A)
PBG: 122491789(IL12A)
PVIV: 125175189(IL12A)
LRUF: 124526682
PTG: 102971802(IL12A)
PPAD: 109262066(IL12A)
PUC: 125921200
AJU: 106969467
HHV: 120238298(IL12A)
BTA: 281856(IL12A)
BOM: 102276398(IL12A)
BIU: 109564477(IL12A)
BBUB: 102406980(IL12A)
BBIS: 104988502(IL12A)
CHX: 100861293(IL12A)
OAS: 443064(IL12A)
BTAX: 128050368(IL12A)
ODA: 120881582(IL12A)
CCAD: 122444988(IL12A)
MBEZ: 129551055(IL12A)
SSC: 397053(IL12A)
CFR: 102507202(IL12A)
CBAI: 105066646(IL12A)
CDK: 105094260(IL12A)
VPC: 102530946(IL12A)
BACU: 103003516(IL12A)
BMUS: 118894377(IL12A)
LVE: 103079299(IL12A)
OOR: 101279088(IL12A)
DLE: 111174517(IL12A)
PCAD: 102982335(IL12A)
PSIU: 116753024(IL12A)
NASI: 112406240(IL12A)
ECB: 100034215(IL12A)
EPZ: 103562911(IL12A)
EAI: 106824114(IL12A)
MYB: 102251395(IL12A)
MYD: 102753538(IL12A)
MMYO: 118675787(IL12A)
MLF: 102431058(IL12A)
MDT: 132229142(IL12A)
PKL: 118722291(IL12A)
EFUS: 103286786(IL12A)
MNA: 107539273(IL12A)
DRO: 112304655(IL12A)
SHON: 118987454(IL12A)
PDIC: 114491057(IL12A)
PHAS: 123827188(IL12A)
MMF: 118617678(IL12A)
PPAM: 129073129(IL12A)
HAI: 109373148(IL12A)
RFQ: 117036506(IL12A)
PALE: 102887571(IL12A)
PGIG: 120598918(IL12A)
PVP: 105305876(IL12A)
RAY: 107512954(IL12A)
MJV: 108409113(IL12A)
TOD: 119256979(IL12A)
SARA: 101539403(IL12A)
SETR: 126026256(IL12A)
LAV: 100665137(IL12A)
TMU: 101353752
ETF: 101641618(IL12A)
DNM: 101425226(IL12A)
MDO: 100018516(IL12A)
GAS: 123242043(IL12A)
SHR: 100914201(IL12A)
AFZ: 127557721
PCW: 110210080(IL12A)
TVP: 118848889(IL12A)
OAA: 100086041(IL12A)
GGA: 407090(IL12A)
PCOC: 116235488(IL12A)
MGP: 100542954(IL12A)
CJO: 107318422(IL12A)
TPAI: 128082460(IL12A)
LMUT: 125697669(IL12A)
NMEL: 110397416(IL12A)
APLA: 113844483(IL12A)
ACYG: 106043510(IL12A)
CATA: 118258017(IL12A)
AFUL: 116492528(IL12A)
LSR: 110476606(IL12A)
OTC: 121336701
PRUF: 121353830
FAB: 101809609(IL12A)
OMA: 130256960(IL12A)
CCW: 104688158(IL12A)
CBRC: 103615719(IL12A)
ETL: 114062930(IL12A)
ZLE: 135451810(IL12A)
ACHL: 103802304(IL12A)
SATI: 136365769(IL12A)
FPG: 101915475(IL12A)
FCH: 102047690(IL12A)
CCRI: 104157671(IL12A)
NNT: 104412611(IL12A)
SHAB: 115612199(IL12A)
ACUN: 113483415(IL12A)
TALA: 104361192(IL12A)
ACHC: 115347215(IL12A)
HALD: 104312900(IL12A)
HLE: 104842575(IL12A)
AGEN: 126039801
GCL: 127020209
CSTI: 104552433(IL12A)
LDI: 104341792(IL12A)
MNB: 103777763(IL12A)
DPUB: 104301678(IL12A)
AVIT: 104275833(IL12A)
BRHI: 104497158(IL12A)
EGZ: 104122263(IL12A)
NNI: 104011599(IL12A)
PCRI: 104026598(IL12A)
PCAO: 104042903(IL12A)
PADL: 103925294(IL12A)
AFOR: 103899051(IL12A)
FGA: 104082263(IL12A)
CLV: 102091031(IL12A)
PGUU: 104471462(IL12A)
PLET: 104622095(IL12A)
EHS: 104505612(IL12A)
TEO: 104372701(IL12A)
BREG: 104635022(IL12A)
OHA: 104334437(IL12A)
CPEA: 104387039(IL12A)
CVF: 104285963(IL12A)
RTD: 128911046(IL12A)
AAM: 106495099(IL12A)
AROW: 112961972(IL12A)
NPD: 112952373(IL12A)
TGT: 104581103(IL12A)
DNE: 112981307(IL12A)
SCAM: 104140049(IL12A)
ASN: 102368752(IL12A)
AMJ: 102576541(IL12A)
GGN: 109287816(IL12A)
PSS: 102457029(IL12A)
CMY: 102945506(IL12A)
CCAY: 125642736(IL12A)
DCC: 119861806(IL12A)
CPIC: 101945519(IL12A)
TST: 117882372(IL12A)
CABI: 116815969(IL12A)
MRV: 120372381(IL12A)
HCG: 128352498(IL12A)
XTR: 101734580
DRE: 100004358(zmp:0000001127) 445410(il12a)
SGH: 107551286
PTET: 122326874 122358897(il12a)
LROH: 127152832 127177348(il12a)
OMC: 131520808(il12a) 131521563
RKG: 130101545(zmp:0000001127) 130102084(il12a)
MAMB: 125249020(il12a) 125251788
CERY: 137003712(zmp:0000001127) 137004468(il12a)
TROS: 130554909 130565029(il12a)
TDW: 130418244 130428341(il12a)
MANU: 129437567(il12a) 129442597
IPU: 108267859(zmp:0000001127) 108280274(il12a)
IFU: 128609727 128624558(il12a)
SMEO: 124387956(zmp:0000001127) 124403349(il12a)
TFD: 113646835(il12a) 113649170(zmp:0000001127)
TVC: 132840637(il12a) 132847843(zmp:0000001127)
TRN: 134302828(il12a)
AMEX: 103025849(il12a) 107197652(zmp:0000001127)
CMAO: 118797489(il12a) 118825427
EEE: 113588304
TFS: 130534565(il12a) 130539546(zmp:0000001127)
LCO: 104936631
TBEN: 117470545(il12a) 117488965
CGOB: 115018081
PGEO: 117456860(il12a) 117461720
GACU: 117538330 117554846(il12a)
EMAC: 134865471(zmp:0000001127) 134880048(il12a)
ELY: 117260285(il12a)
EFO: 125888559(il12a)
PLEP: 121943813(il12a)
SLUC: 116037408 116050803(il12a)
ECRA: 117942332(il12a) 117954544
PFLV: 114553224 114565169(il12a)
GAT: 120816383 120824284(il12a)
PPUG: 119215541(il12a)
AFB: 129089316 129096969(il12a)
CLUM: 117741747(il12a) 117746853
PSWI: 130198075(zmp:0000001127) 130210467(il12a)
MSAM: 119883275(il12a) 119902142
SCHU: 122878743(il12a)
CUD: 121520201 121526300(il12a)
ALAT: 119008508(il12a) 119011350
OAU: 116323590(il12a) 116332858
OML: 112139606 112149667(il12a)
CSAI: 133442533(il12a)
XMA: 111612051
XCO: 114161440
PRET: 103474728
GAF: 122832580(il12a) 122840819
PPRL: 129362234 129369906(il12a)
CVG: 107081893
CTUL: 119786140 119797295(il12a)
GMU: 124869262(zmp:0000001127) 124884050(il12a)
NFU: 107380562
KMR: 108239606 108240891(il12a)
NWH: 119410891(il12a)
AOCE: 111572772
MCEP: 125011367 125013840(il12a)
CSEM: 103378499
SSEN: 122763998 122773547(il12a)
HHIP: 117772855(il12a) 117777965
HSP: 118106541(il12a) 118117381
PPLT: 128440722(il12a) 128454546
SMAU: 118299177(il12a) 118311396(zmp:0000001127)
LCF: 108883223
XGL: 120792403(il12a) 120799320
HCQ: 109518416
SSCV: 125971856
SBIA: 133504974(il12a)
PEE: 133405317(il12a)
PTAO: 133482325(il12a)
BPEC: 110159295
MALB: 109957731
BSPL: 114844910(zmp:0000001127) 114867871(il12a)
SASA: 106580951
ELS: 109616205
PKI: 111841504(il12a) 111847694
AANG: 118210312(il12a) 118229324
LOC: 107079109(il12a)
PSPA: 121326368
CMK: 103176349(il12a)
CPLA: 122556360(zmp:0000001127)
HOC: 132821556(zmp:0000001127)
LERI: 129703696(il12a)
 » show all
Reference
PMID:1673147
  Authors
Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM, et al.
  Title
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
  Journal
J Immunol 146:3074-81 (1991)
  Sequence
[hsa:3592]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242

KEGG   ORTHOLOGY: K05492
Entry
K05492                      KO                                     
Symbol
IL17D, IL27
Name
interleukin 17D
Pathway
map04060  Cytokine-cytokine receptor interaction
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05492  IL17D, IL27; interleukin 17D
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K05492  IL17D, IL27; interleukin 17D
   04657 IL-17 signaling pathway
    K05492  IL17D, IL27; interleukin 17D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05492  IL17D, IL27; interleukin 17D
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05492  IL17D, IL27; interleukin 17D
Genes
HSA: 53342(IL17D)
PTR: 467221(IL17D)
GGO: 101125278(IL17D)
PON: 100448961(IL17D)
PPYG: 129011887(IL17D)
NLE: 100593537(IL17D)
HMH: 116467179(IL17D)
SSYN: 129463565(IL17D)
MCC: 721163(IL17D)
MCF: 123569746(IL17D)
MTHB: 126940699
MNI: 105490302(IL17D)
CSAB: 103248958(IL17D)
CATY: 105591946(IL17D)
PANU: 101000353(IL17D)
TGE: 112611109(IL17D)
MLEU: 105537062(IL17D)
RRO: 104668275(IL17D)
TFN: 117063332(IL17D)
PTEH: 111525320(IL17D) 113224801
CJC: 100412953(IL17D)
SBQ: 101053421(IL17D)
CIMI: 108317573(IL17D)
ANAN: 135273829(IL17D)
CSYR: 103270483(IL17D)
MMUR: 105878805(IL17D)
LCAT: 123649487(IL17D)
PCOQ: 105808166(IL17D)
OGA: 100959364(IL17D)
MMU: 239114(Il17d)
MCAL: 110309861(Il17d)
MPAH: 110325617(Il17d)
RNO: 691799(Il17d)
MCOC: 116084923(Il17d)
ANU: 117706302(Il17d)
MUN: 110549752(Il17d)
CGE: 100763580(Il17d)
MAUA: 101840280(Il17d)
PROB: 127230336(Il17d)
PLEU: 114693855(Il17d)
MORG: 121435129(Il17d)
MFOT: 126507678
AAMP: 119799719(Il17d)
NGI: 103726719(Il17d)
HGL: 101707249(Il17d)
CPOC: 100715454(Il17d)
CCAN: 109689011(Il17d)
DORD: 105998941(Il17d)
DSP: 122112791(Il17d)
PLOP: 125348444(Il17d)
NCAR: 124985936
MMMA: 107153755(Il17d)
OCU: 103349030
OPI: 101517695(IL17D)
TUP: 102482171(IL17D)
GVR: 103591250(IL17D)
CFA: 102156421(IL17D)
CLUD: 112669552(IL17D)
VVP: 112918513(IL17D)
VLG: 121497687
NPO: 129504488(IL17D)
AML: 105240206(IL17D)
UMR: 103664391(IL17D)
UAH: 113251173(IL17D)
UAR: 123791987(IL17D)
ELK: 111159932
LLV: 125096160
MPUF: 101672410(IL17D)
MNP: 132002730(IL17D)
MLK: 131813871(IL17D)
NVS: 122906909(IL17D)
ORO: 101384335(IL17D)
EJU: 114209451(IL17D)
ZCA: 113920012(IL17D)
MLX: 118009601(IL17D)
NSU: 110570238(IL17D)
LWW: 102728170(IL17D)
FCA: 101093070(IL17D)
PYU: 121012718(IL17D)
PCOO: 112860874(IL17D)
PBG: 122480427(IL17D)
PVIV: 125160849(IL17D)
LRUF: 124510902
PTG: 102961536(IL17D)
PPAD: 109265827(IL17D)
PUC: 125934211
AJU: 106979791
HHV: 120247526(IL17D)
BTA: 614982(IL17D)
BOM: 102277364(IL17D)
BIU: 109567051(IL17D)
BBUB: 102406982(IL17D)
BBIS: 104996853(IL17D)
CHX: 106502702(IL17D)
OAS: 114116619(IL17D)
BTAX: 128057655(IL17D)
CCAD: 122447170(IL17D)
MBEZ: 129556400(IL17D)
SSC: 100738902(IL17D)
CFR: 102509374(IL17D)
CBAI: 105066277(IL17D)
CDK: 105096396(IL17D)
VPC: 102545869(IL17D)
BMUS: 118884351(IL17D)
LVE: 103073060
OOR: 117197461(IL17D)
DLE: 111175147(IL17D)
PCAD: 112065399(IL17D)
EAI: 106828567(IL17D)
MYB: 102255538(IL17D)
MYD: 107184378(IL17D)
MMYO: 118650932(IL17D)
MLF: 102423354(IL17D)
MDT: 132228205(IL17D)
PKL: 118730406(IL17D)
EFUS: 103301252(IL17D)
MNA: 107529936(IL17D)
DRO: 112323164(IL17D)
SHON: 118980442(IL17D)
PDIC: 118498386(IL17D)
PHAS: 123822696(IL17D)
MMF: 118623855(IL17D)
PPAM: 129082313(IL17D)
HAI: 109388028(IL17D)
RFQ: 117021238(IL17D)
PGIG: 120602861(IL17D)
RAY: 107497727(IL17D)
MJV: 108403291(IL17D)
TOD: 119258542(IL17D)
SARA: 101558678(IL17D)
SETR: 126015703(IL17D)
LAV: 100660403(IL17D)
TMU: 101344915
ETF: 101653828(IL17D)
DNM: 101420286(IL17D)
MDO: 100023643(IL17D)
GAS: 123238887(IL17D)
SHR: 100918625(IL17D)
AFZ: 127554764
PCW: 110195858(IL17D)
TVP: 118839593(IL17D)
OAA: 100089487(IL17D)
PCOC: 116244107(IL17D)
CJO: 107308325(IL17D)
TPAI: 128074875(IL17D)
LMUT: 125687984(IL17D)
NMEL: 110389381(IL17D)
APLA: 101793918(IL17D)
ACYG: 106040400(IL17D)
CATA: 118246007(IL17D)
AFUL: 116501792(IL17D)
TGU: 100229170(IL17D)
LSR: 110475650(IL17D)
SCAN: 103827311(IL17D)
PMOA: 120506761(IL17D)
OTC: 121342015(IL17D)
PRUF: 121364244(IL17D)
GFR: 102042389(IL17D)
OMA: 130248683(IL17D)
PHI: 102110810(IL17D)
PMAJ: 107200298(IL17D)
CCAE: 111923768(IL17D)
CCW: 120411253(IL17D)
ETL: 114058082(IL17D)
ZAB: 102061265(IL17D)
ZLE: 135450025(IL17D)
ACHL: 103804679(IL17D)
SVG: 106853990(IL17D)
MMEA: 130574970(IL17D)
HRT: 120748619(IL17D)
SATI: 136374159(IL17D)
CCRI: 104157158(IL17D)
NNT: 104406896(IL17D)
SHAB: 115604395(IL17D)
TALA: 122153458(IL17D)
ACHC: 115353541(IL17D)
HALD: 104319449(IL17D)
AGEN: 126048194
GCL: 127028607
CSTI: 104552090(IL17D)
LDI: 104354100(IL17D)
MNB: 103770457(IL17D)
DPUB: 104303386(IL17D)
AVIT: 104271761(IL17D)
BRHI: 104497934(IL17D)
EGZ: 104134732(IL17D)
PCRI: 104026436(IL17D)
PCAO: 104040675(IL17D)
PADL: 103920116(IL17D)
FGA: 104079295(IL17D)
GSTE: 104254457(IL17D)
CLV: 110358055(IL17D)
MUI: 104535549(IL17D)
PGUU: 104460498(IL17D)
PLET: 104615930(IL17D)
EHS: 104509900(IL17D)
CMAC: 104482236(IL17D)
CUCA: 104055320(IL17D)
TEO: 104375749(IL17D)
BREG: 104636220(IL17D)
OHA: 104337318(IL17D)
CPEA: 104390331(IL17D)
CVF: 104291397(IL17D)
RTD: 128902730(IL17D)
AROW: 112977972(IL17D)
NPD: 112943767(IL17D)
DNE: 112988423(IL17D)
SCAM: 104151624(IL17D)
ASN: 102377557
AMJ: 102575791(IL17D) 109281816(IL17D)
CPOO: 109305533(IL17D)
PSS: 102457933(IL17D)
CMY: 102939057(IL17D)
CCAY: 125634541(IL17D)
DCC: 119850224(IL17D)
CPIC: 101944488(IL17D) 101954010
TST: 117871121(IL17D)
CABI: 116816475(IL17D)
MRV: 120399263(IL17D)
ACS: 100564316(il17d)
ASAO: 132770061(IL17D)
PVT: 110083531(IL17D)
SUND: 121925763(IL17D)
PBI: 103061985(IL17D)
PMUR: 107286121(IL17D)
CTIG: 120311690(IL17D)
TSR: 106551497(IL17D)
PGUT: 117661368(IL17D)
APRI: 131199517(IL17D)
PTEX: 113441716(IL17D)
NSS: 113416879(IL17D)
VKO: 123029454(IL17D)
PMUA: 114595715(IL17D)
PRAF: 128412651(IL17D)
ZVI: 118085472(IL17D)
HCG: 128351071(IL17D)
GJA: 107125993(IL17D)
STOW: 125432134(IL17D)
EMC: 129326480(IL17D)
XLA: 108707761(il17d.L) 108709971(il17d.S)
XTR: 100135708(il17d)
NPR: 108800071(IL17D)
RTEM: 120929239(IL17D)
BBUF: 120996353(IL17D)
BGAR: 122932722(IL17D)
MUO: 115468520(IL17D)
GSH: 117362557(IL17D)
DRE: 553961(il17d)
SANH: 107658252
SGH: 107597382
PTET: 122351366(il17d)
LROH: 127170810(il17d)
OMC: 131547510(il17d)
PPRM: 120467046(il17d)
RKG: 130076315(il17d)
MAMB: 125270527(il17d)
CIDE: 127518663
CERY: 137035818(il17d)
TROS: 130555563(il17d)
TDW: 130427126(il17d)
MANU: 129451524(il17d)
IPU: 108267044
IFU: 128609131(il17d)
PHYP: 113526093(il17d)
SMEO: 124380734(il17d)
TFD: 113654288(il17d)
TVC: 132850060(il17d)
TRN: 134324335(il17d)
AMEX: 103023846(il17d)
CMAO: 118799053(il17d)
EEE: 113588653(il17d)
CHAR: 105913240(il17d)
TRU: 101068517(il17d)
TFS: 130529307(il17d)
LCO: 104934846(il17d)
NCC: 104964956(il17d)
TBEN: 117495141(il17d)
PGEO: 117467125(il17d)
GACU: 117536537(il17d)
EMAC: 134867318(il17d)
ELY: 117251170(il17d)
EFO: 125900219(il17d)
PLEP: 121949531(il17d)
SLUC: 116062465(il17d)
ECRA: 117953290(il17d)
ESP: 116698184(il17d)
PFLV: 114564409(il17d)
GAT: 120826770 120833954(il17d)
PPUG: 119229348(il17d)
AFB: 129105145(il17d)
CLUM: 117750670(il17d)
PSWI: 130207355(il17d)
MSAM: 119904478(il17d)
SCHU: 122885355(il17d)
ALAT: 119025313(il17d)
MZE: 101464592(il17d)
ONL: 100696484(il17d)
OAU: 116332580(il17d)
OLA: 100533505(il17d)
OML: 112155570(il17d)
CSAI: 133445717(il17d)
XMA: 102231184(il17d)
XCO: 114148012(il17d)
XHE: 116723629(il17d)
PRET: 103478095(il17d)
PFOR: 103156377(il17d)
PLAI: 106935262(il17d)
PMEI: 106903601(il17d)
GAF: 122839858(il17d)
PPRL: 129360914(il17d)
CVG: 107087362(il17d)
CTUL: 119772902(il17d)
GMU: 124871082(il17d)
NFU: 107395219
KMR: 108244212(il17d)
ALIM: 106524934(il17d)
NWH: 119429399(il17d)
AOCE: 111584736(il17d)
MCEP: 125017793(il17d)
CSEM: 103391956(il17d)
POV: 109637970(il17d)
SSEN: 122765235(il17d)
HHIP: 117754640(il17d)
HSP: 118120143(il17d)
PPLT: 128455456(il17d)
SMAU: 118320425(il17d)
LCF: 108897034
SDU: 111218179(il17d)
SLAL: 111652892(il17d)
XGL: 120801049(il17d)
HCQ: 109522056(il17d)
SSCV: 125974249
SBIA: 133511892(il17d)
PEE: 133410414(il17d)
PTAO: 133486807(il17d)
BPEC: 110162070(il17d)
MALB: 109970946(il17d)
BSPL: 114846916(il17d)
SJO: 128368065(il17d)
SASA: 100195864(il17d)
STRU: 115155756(il17d)
OTW: 112225489(il17d)
OMY: 100136099(il17d)
OGO: 124024920(il17d)
ONE: 115131078
OKI: 109871422
OKE: 118386255(il17d)
SALP: 111959756
SNH: 120063712(il17d)
CCLU: 121571697
ELS: 105016419(il17d)
PKI: 111837180(il17d)
AANG: 118223592
LOC: 102684564(il17d)
PSPA: 121320539
ARUT: 117406462(il17d)
PSEX: 120523055(il17d)
LCM: 102364219(IL17D)
CPLA: 122549589
HOC: 132815188
BFO: 118420904
BBEL: 109484733
CIN: 100170006(il-17-2) 101243009
APLC: 110978870
ARUN: 117304877
SKO: 102807043
GAE: 121382193
 » show all
Reference
  Authors
Starnes T, Broxmeyer HE, Robertson MJ, Hromas R
  Title
Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.
  Journal
J Immunol 169:642-6 (2002)
DOI:10.4049/jimmunol.169.2.642
  Sequence
[hsa:53342]

KEGG   ORTHOLOGY: K05425
Entry
K05425                      KO                                     
Symbol
IL12B
Name
interleukin 12B
Pathway
map04060  Cytokine-cytokine receptor interaction
map04620  Toll-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05133  Pertussis
map05134  Legionellosis
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05321  Inflammatory bowel disease
map05330  Allograft rejection
map05417  Lipid and atherosclerosis
Disease
H00089  IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05425  IL12B; interleukin 12B
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05425  IL12B; interleukin 12B
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04622 RIG-I-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04625 C-type lectin receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04658 Th1 and Th2 cell differentiation
    K05425  IL12B; interleukin 12B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05425  IL12B; interleukin 12B
   05205 Proteoglycans in cancer
    K05425  IL12B; interleukin 12B
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05425  IL12B; interleukin 12B
   05164 Influenza A
    K05425  IL12B; interleukin 12B
   05162 Measles
    K05425  IL12B; interleukin 12B
   05168 Herpes simplex virus 1 infection
    K05425  IL12B; interleukin 12B
  09171 Infectious disease: bacterial
   05133 Pertussis
    K05425  IL12B; interleukin 12B
   05134 Legionellosis
    K05425  IL12B; interleukin 12B
   05152 Tuberculosis
    K05425  IL12B; interleukin 12B
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05425  IL12B; interleukin 12B
   05145 Toxoplasmosis
    K05425  IL12B; interleukin 12B
   05140 Leishmaniasis
    K05425  IL12B; interleukin 12B
   05142 Chagas disease
    K05425  IL12B; interleukin 12B
   05143 African trypanosomiasis
    K05425  IL12B; interleukin 12B
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05425  IL12B; interleukin 12B
   05330 Allograft rejection
    K05425  IL12B; interleukin 12B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05425  IL12B; interleukin 12B
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05425  IL12B; interleukin 12B
   04936 Alcoholic liver disease
    K05425  IL12B; interleukin 12B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05425  IL12B; interleukin 12B
   00536 Glycosaminoglycan binding proteins
    K05425  IL12B; interleukin 12B
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05425  IL12B; interleukin 12B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K05425  IL12B; interleukin 12B
Other DBs
GO: 0005143
Genes
HSA: 3593(IL12B)
PTR: 471723(IL12B)
PPS: 100989950(IL12B)
GGO: 101141274(IL12B)
PON: 100435254(IL12B)
PPYG: 129036747(IL12B)
NLE: 100579267 115837257
HMH: 116471783(IL12B)
SSYN: 129486083(IL12B)
MCC: 694747(IL12B)
MCF: 102124858(IL12B)
MTHB: 126957215
MNI: 105482347(IL12B)
CSAB: 103244892(IL12B)
CATY: 105581574(IL12B)
PANU: 100126717(IL12B)
TGE: 112626411(IL12B)
MLEU: 105529523(IL12B)
RRO: 104669104(IL12B)
RBB: 108537933(IL12B)
TFN: 117065537(IL12B)
PTEH: 111547191(IL12B)
CANG: 105515783(IL12B)
CJC: 100395403(IL12B)
SBQ: 101049311(IL12B)
CIMI: 108285116(IL12B)
ANAN: 105723180(IL12B)
CSYR: 103265030(IL12B)
MMUR: 105871571(IL12B)
LCAT: 123638007(IL12B)
PCOQ: 105810764(IL12B)
OGA: 100962204(IL12B)
MMU: 16160(Il12b)
MCAL: 110304465(Il12b)
MPAH: 110332403(Il12b)
RNO: 64546(Il12b)
MCOC: 116077653(Il12b)
ANU: 117711474(Il12b)
MUN: 110548438(Il12b)
CGE: 100764758(Il12b)
MAUA: 101843678(Il12b)
PROB: 127219792(Il12b)
PLEU: 114689882(Il12b)
MORG: 121464009(Il12b)
MFOT: 126499523
AAMP: 119811033(Il12b)
NGI: 103724546(Il12b)
HGL: 101701309(Il12b)
CPOC: 100135554(Il12b)
CCAN: 109677112(Il12b)
DORD: 106001299(Il12b)
DSP: 122125036(Il12b)
PLOP: 125342078(Il12b)
NCAR: 124987404
MMMA: 107148164(Il12b)
OCU: 100354852
OPI: 101520638 101523854(IL12B)
TUP: 102499876(IL12B)
GVR: 103607235(IL12B)
CFA: 403976(IL12B)
CLUD: 112651834(IL12B)
VVP: 112928651(IL12B)
VLG: 121486324(IL12B)
NPO: 129509743(IL12B)
AML: 100477772(IL12B)
UMR: 103664531(IL12B)
UAH: 113263879(IL12B)
UAR: 123788629(IL12B)
ELK: 111141150
LLV: 125101014
MPUF: 101676232(IL12B)
MNP: 132027813(IL12B)
MLK: 131831849(IL12B)
NVS: 122901988(IL12B)
ORO: 101372789(IL12B)
EJU: 114211944(IL12B)
ZCA: 113929340(IL12B)
MLX: 118016150(IL12B)
NSU: 110587628(IL12B)
LWW: 102740807(IL12B)
FCA: 768273(IL12B)
PYU: 121010131(IL12B)
PCOO: 112861083(IL12B)
PBG: 122493041(IL12B)
PVIV: 125148412(IL12B)
LRUF: 124520689
PTG: 102959546(IL12B)
PPAD: 109257574(IL12B)
PUC: 125934482
AJU: 106967679
HHV: 120240593(IL12B)
BTA: 281857(IL12B)
BOM: 102283689(IL12B)
BIU: 109561305(IL12B)
BBUB: 102409559(IL12B)
BBIS: 104999734(IL12B)
CHX: 100860845(IL12B)
OAS: 443472(IL12B)
BTAX: 128051514(IL12B)
ODA: 120863361(IL12B)
CCAD: 122439617(IL12B)
MBEZ: 129558692(IL12B)
SSC: 397076(IL12B)
CFR: 102515488(IL12B)
CBAI: 105065241(IL12B)
CDK: 105099900(IL12B)
VPC: 102543998(IL12B)
BACU: 103007028(IL12B)
BMUS: 118893547(IL12B)
LVE: 103083704(IL12B)
OOR: 101272835(IL12B)
DLE: 111170635(IL12B)
PCAD: 102980587(IL12B)
PSIU: 116751765(IL12B)
NASI: 112415192(IL12B)
ECB: 100034222(IL12B)
EPZ: 103547779(IL12B)
EAI: 106832166(IL12B)
MYB: 102253394(IL12B)
MYD: 102756968(IL12B)
MMYO: 118659025(IL12B)
MLF: 102435627(IL12B)
MDT: 132234353(IL12B)
PKL: 118710699(IL12B)
EFUS: 103291598(IL12B)
MNA: 107537877(IL12B)
DRO: 112319648(IL12B)
SHON: 118984138(IL12B)
AJM: 119054378(IL12B)
PDIC: 114510060(IL12B)
PHAS: 123811597(IL12B)
MMF: 118615760(IL12B)
PPAM: 129066360(IL12B)
HAI: 109388897(IL12B)
RFQ: 117016848(IL12B)
PALE: 102884214(IL12B)
PGIG: 120614142(IL12B)
PVP: 105289903(IL12B)
RAY: 107521891(IL12B)
MJV: 108409190(IL12B)
TOD: 119235953(IL12B)
SARA: 101542768(IL12B)
SETR: 126011600(IL12B)
LAV: 100657211(IL12B)
TMU: 101344352
ETF: 101650484(IL12B)
DNM: 101432053(IL12B)
MDO: 100030276(IL12B)
GAS: 123235575(IL12B)
SHR: 100932486(IL12B)
AFZ: 127546715
PCW: 110212378(IL12B)
TVP: 118842089(IL12B)
OAA: 100074930(IL12B)
GGA: 404671(IL12B)
PCOC: 116225955 116231896(IL12B)
MGP: 100303696(IL12B)
CJO: 107306820 107320334(IL12B)
TPAI: 128081483(IL12B)
LMUT: 125700445(IL12B)
NMEL: 110390927 110405552(IL12B)
APLA: 101800211(IL12B)
ACYG: 106034345(IL12B) 106043190
CATA: 118256742(IL12B)
AFUL: 116494936(IL12B)
TGU: 100217488(IL12B) 115494797
LSR: 110468736 110479711(IL12B)
SCAN: 103817383(IL12B) 103823110
PMOA: 120498678(IL12B) 120509207
OTC: 121332435(IL12B)
PRUF: 121365592(IL12B)
GFR: 102044384(IL12B)
FAB: 101814108(IL12B)
OMA: 130258777(IL12B)
PHI: 102100519 102100856(IL12B)
PMAJ: 107202840 107210594(IL12B)
CCAE: 111935760(IL12B)
CCW: 104689490(IL12B) 104690841
CBRC: 103611483(IL12B)
ETL: 114067346(IL12B) 114068872
ZAB: 102064202(IL12B)
ZLE: 135453730(IL12B)
ACHL: 103806855(IL12B)
SVG: 106860454(IL12B)
MMEA: 130583417(IL12B)
HRT: 120759324(IL12B)
SATI: 136367319(IL12B)
FPG: 101920686(IL12B)
FCH: 102046968(IL12B) 114014855
CCRI: 104162398(IL12B)
NNT: 104407355(IL12B)
SHAB: 115615709(IL12B)
ACUN: 113485246(IL12B)
TALA: 104362597(IL12B)
ACHC: 115334335(IL12B)
HALD: 104316525(IL12B)
HLE: 104839011(IL12B)
AGEN: 126050806
GCL: 127022112
CSTI: 104550175(IL12B)
LDI: 104340042(IL12B)
MNB: 103769572(IL12B)
DPUB: 104304030(IL12B)
AVIT: 104269152(IL12B)
BRHI: 104501251(IL12B)
EGZ: 104133653(IL12B)
NNI: 104019032(IL12B)
PCRI: 104024355(IL12B)
PCAO: 104053283(IL12B)
PADL: 103912251(IL12B)
AFOR: 103904300(IL12B)
FGA: 104069678(IL12B)
GSTE: 104260245(IL12B)
CLV: 102097579(IL12B)
MUI: 104542091(IL12B)
PGUU: 104465780(IL12B)
PLET: 104619834(IL12B)
EHS: 104509798(IL12B)
CMAC: 104482775(IL12B)
CUCA: 104062908(IL12B)
TEO: 104382108(IL12B)
BREG: 104641614(IL12B)
OHA: 104330549(IL12B)
ACAR: 104518036(IL12B)
CPEA: 104392549(IL12B)
CVF: 104283845(IL12B)
RTD: 128916376(IL12B)
AAM: 106493613(IL12B)
AROW: 112978176(IL12B)
NPD: 112954426(IL12B)
TGT: 104578175(IL12B)
DNE: 112994363(IL12B)
SCAM: 104151047(IL12B)
ASN: 102379831(IL12B)
AMJ: 102568125(IL12B) 106737635
CPOO: 109310277(IL12B)
GGN: 109290116(IL12B)
PSS: 102449025(IL12B)
CMY: 102939116(IL12B)
CCAY: 125641222(IL12B)
DCC: 119860616(IL12B)
CPIC: 101948692(IL12B)
TST: 117881164(IL12B)
CABI: 116833140(IL12B)
MRV: 120370753(IL12B)
ACS: 103277860(il12b) 103282245
ASAO: 132765564(IL12B)
PVT: 110072310(IL12B)
SUND: 121920389
PMUR: 107292495
CTIG: 120311467
TSR: 106538833(IL12B)
PGUT: 117657780
APRI: 131191152
NSS: 113423754
PMUA: 114592861
PRAF: 128409598
ZVI: 118076513(IL12B)
HCG: 128344008(IL12B)
STOW: 125430087(IL12B)
EMC: 129327588(IL12B)
XLA: 108712268(il12b.S)
XTR: 100493914 116409688(il12b)
NPR: 108803420
RTEM: 120930493(IL12B)
BBUF: 121007691(IL12B)
BGAR: 122926526(IL12B)
MUO: 115476413(IL12B)
GSH: 117351829(IL12B)
DRE: 445373(il12ba)
CCAR: 109069813
PTET: 122357160(il12ba)
LROH: 127176354(il12ba)
OMC: 131552864(il12ba)
PPRM: 120474357(il12ba)
RKG: 130095193(il12ba)
MAMB: 125258949(il12ba)
CIDE: 127494824
CERY: 137013992(il12ba)
TROS: 130564021(il12ba)
TDW: 130437751(il12ba)
MANU: 129422536(il12ba)
IPU: 108264170(si:dkey-88e18.2) 108278485(il12bb)
SMEO: 124386286(il12ba)
TFD: 113636009(il12ba)
TVC: 132856116(il12ba)
TRN: 134318680(il12ba)
AMEX: 103028022(si:dkey-88e18.2) 103036896(il12bb) 103041682(il12ba)
CMAO: 118806450(il12ba)
TRU: 101066952 101077588 445913(IL-12_p40)
TFS: 130525906(il12b2) 130531080(il12ba) 130537568(il12bb)
TBEN: 117472651(si:dkey-88e18.2) 117475162(il12ba) 117490406(il12bb)
PGEO: 117452273(si:dkey-88e18.2) 117454236(il12ba) 117458894(il12bb)
GACU: 117540244(il12bb) 117545217(il12ba) 117560348(si:dkey-88e18.2)
EMAC: 134859849(il12ba) 134871663(il12bb) 134874216(il12b2)
ELY: 117253185(si:dkey-88e18.2) 117260978(il12ba) 117272368(il12bb)
EFO: 125890339(si:dkey-88e18.2) 125894593(il12ba) 125898296
PLEP: 121944600(si:dkey-88e18.2) 121947757(il12ba) 121953039(il12bb)
SLUC: 116036907(il12bb) 116052081(il12ba) 116054264(si:dkey-88e18.2)
ECRA: 117945492(si:dkey-88e18.2) 117951870(il12ba) 117956129(il12bb)
GAT: 120816901(il12ba) 120821794(il12bb) 120830416(si:dkey-88e18.2)
PPUG: 119210060(il12ba) 119215092(il12bb) 119225100(si:dkey-88e18.2)
AFB: 129090530(il12ba) 129100825(si:dkey-88e18.2) 129113850(il12bb)
CLUM: 117735756(si:dkey-88e18.2) 117737664(il12ba) 117742683(il12bb)
PSWI: 130191715(il12bb) 130196829(il12b2)
SCHU: 122875711(si:dkey-88e18.2) 122880857(il12ba) 122888396(il12bb)
CUD: 121509815(si:dkey-88e18.2) 121516183(il12ba) 121519111(il12bb)
ALAT: 119007358(il12ba) 119020042(si:dkey-88e18.2) 119031730(il12bb)
OAU: 116310975(si:dkey-88e18.2) 116319695(il12bb) 116324586(il12ba)
OML: 112142961(il12bb) 112148544(si:dkey-88e18.2) 112153451(il12ba)
CSAI: 133447505(il12ba) 133451121(il12b2) 133460219(il12bb)
GAF: 122828041(si:dkey-88e18.2) 122837553(il12ba) 122844571(il12bb)
PPRL: 129362619(il12ba) 129366135(si:dkey-88e18.2) 129373487(il12bb)
CTUL: 119778201(si:dkey-88e18.2) 119780972(il12ba) 119792692(il12bb)
GMU: 124860173(il12ba) 124876947(il12bb) 124877456(si:dkey-88e18.2)
KMR: 108233659(si:dkey-88e18.2) 108238912(il12bb) 108245805(il12ba)
NWH: 119409099(il12ba) 119413863(si:dkey-88e18.2) 119420855
MCEP: 125007734(il12ba) 125012641(si:dkey-88e18.2) 125021783(il12bb)
SSEN: 122769935(si:dkey-88e18.2) 122778289(il12ba) 122779594
HHIP: 117767964(si:dkey-88e18.2) 117769247(il12ba) 117774863(il12bb)
HSP: 118112354(il12ba) 118115660(si:dkey-88e18.2) 118122246
PPLT: 128445893(il12ba) 128457252(il12bb)
SMAU: 118301647(il12bb) 118314177(si:dkey-88e18.2) 118319527(il12ba)
LCF: 108881460(si:dkey-88e18.2) 108882723(il12ba) 108893814(il12bb)
XGL: 120785554(il12ba) 120802827(il12bb) 120805575(si:dkey-88e18.2)
HCQ: 109524222(il12b) 109527235
SSCV: 125988535 125994686(si:dkey-88e18.2)
SBIA: 133499642(il12b2) 133508724(il12ba)
PEE: 133400601(il12b2) 133407780(il12ba)
PTAO: 133475123(il12b2) 133485149(il12ba)
BSPL: 114862735(il12b2) 114865013(il12ba) 114869364(il12bb)
SJO: 128363354(il12ba) 128364895(si:dkey-88e18.2) 128370876(il12bb)
OTW: 112228305 112235243 112235249 112235857(si:dkey-88e18.2) 112258298(il12bb)
OMY: 100136086(si:dkey-88e18.2) 110489482 110504616 110533322 110537792(il12bb)
AANG: 118222641(il12ba) 118236355 118237126(si:dkey-88e18.2)
LOC: 102697617(il12b) 102699198
ARUT: 117403858(si:dkey-88e18.2) 117412916 117431159
LCM: 102348110(IL12B)
RTP: 109917876(il12ba) 125484189
CPLA: 122556860(il12ba) 122560228
HOC: 132823534(il12ba)
 » show all
Reference
PMID:1674604
  Authors
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.
  Title
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
  Journal
Proc Natl Acad Sci U S A 88:4143-7 (1991)
DOI:10.1073/pnas.88.10.4143
  Sequence
[hsa:3593]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242

KEGG   ORTHOLOGY: K05415
Entry
K05415                      KO                                     
Symbol
IFNB
Name
interferon beta
Pathway
map04060  Cytokine-cytokine receptor interaction
map04151  PI3K-Akt signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04668  TNF signaling pathway
map04936  Alcoholic liver disease
map05131  Shigellosis
map05135  Yersinia infection
map05142  Chagas disease
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05415  IFNB; interferon beta
   04668 TNF signaling pathway
    K05415  IFNB; interferon beta
   04151 PI3K-Akt signaling pathway
    K05415  IFNB; interferon beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05415  IFNB; interferon beta
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K05415  IFNB; interferon beta
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04621 NOD-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04622 RIG-I-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04623 Cytosolic DNA-sensing pathway
    K05415  IFNB; interferon beta
   04650 Natural killer cell mediated cytotoxicity
    K05415  IFNB; interferon beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05415  IFNB; interferon beta
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05415  IFNB; interferon beta
   05161 Hepatitis B
    K05415  IFNB; interferon beta
   05160 Hepatitis C
    K05415  IFNB; interferon beta
   05171 Coronavirus disease - COVID-19
    K05415  IFNB; interferon beta
   05164 Influenza A
    K05415  IFNB; interferon beta
   05162 Measles
    K05415  IFNB; interferon beta
   05168 Herpes simplex virus 1 infection
    K05415  IFNB; interferon beta
   05163 Human cytomegalovirus infection
    K05415  IFNB; interferon beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05415  IFNB; interferon beta
   05169 Epstein-Barr virus infection
    K05415  IFNB; interferon beta
   05165 Human papillomavirus infection
    K05415  IFNB; interferon beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05415  IFNB; interferon beta
   05135 Yersinia infection
    K05415  IFNB; interferon beta
   05152 Tuberculosis
    K05415  IFNB; interferon beta
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K05415  IFNB; interferon beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05415  IFNB; interferon beta
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05415  IFNB; interferon beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05415  IFNB; interferon beta
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interferons
   K05415  IFNB; interferon beta
Other DBs
GO: 0005132
Genes
HSA: 3456(IFNB1)
PTR: 473183(IFNB1)
PPS: 100995851(IFNB1)
GGO: 101137136(IFNB1)
PON: 100441074(IFNB1)
PPYG: 129044486(IFNB1)
NLE: 100598986(IFNB1)
HMH: 116458843(IFNB1)
SSYN: 129490755(IFNB1)
MCC: 711414(IFNB1)
MCF: 102115670(IFNB1)
MTHB: 126937702
MNI: 105465886(IFNB1)
CSAB: 103219383(IFNB1)
CATY: 105584002(IFNB1)
PANU: 101024523(IFNB1)
TGE: 112608413(IFNB1)
MLEU: 105545746(IFNB1)
RRO: 104670295(IFNB1)
RBB: 108538565(IFNB1)
TFN: 117098642(IFNB1)
PTEH: 111526147(IFNB1)
CANG: 105503452(IFNB1)
CJC: 100388391(IFNB1)
SBQ: 101035681(IFNB1)
CIMI: 108296169(IFNB1)
ANAN: 105715622(IFNB1)
CSYR: 103260915(IFNB1)
MMUR: 105874210(IFNB1)
LCAT: 123646249(IFNB1)
PCOQ: 105827006(IFNB1)
OGA: 100959385(IFNB1)
MMU: 15977(Ifnb1)
MCAL: 110293791(Ifnb1)
MPAH: 110323346(Ifnb1)
RNO: 24481(Ifnb1)
MCOC: 116095400(Ifnb1)
ANU: 117709633(Ifnb1)
MUN: 110541303(Ifnb1)
CGE: 103160615(Ifnb1)
MAUA: 121144026(Ifnb1)
PROB: 127224840(Ifnb1)
PLEU: 114685139(Ifnb1)
MORG: 121447990(Ifnb1)
MFOT: 126510741
AAMP: 119816165(Ifnb1) 119817276
NGI: 103743951(Ifnb1) 103746144
HGL: 101699042(Ifnb1) 101723869
DORD: 105988975(Ifnb1)
DSP: 122118962(Ifnb1)
PLOP: 125352673(Ifnb1)
MMMA: 107156465 107156489(Ifnb1)
OCU: 100342931
OPI: 101533318(IFNB1)
TUP: 102493858(IFNB1)
CFA: 481558(IFNB1)
CLUD: 112650215(IFNB1)
VVP: 112921940(IFNB1)
VLG: 121494639(IFNB1)
NPO: 129494739(IFNB1)
AML: 100476556(IFNB1)
UMR: 103662150(IFNB1)
UAH: 113260295(IFNB1)
UAR: 123781031(IFNB1)
ELK: 111156577
LLV: 125083789
MPUF: 101679100(IFNB1)
MNP: 132025125(IFNB1)
MLK: 131813182(IFNB1)
NVS: 122916938(IFNB1)
ORO: 101374900(IFNB1)
EJU: 114212404(IFNB1)
ZCA: 113934419(IFNB1)
MLX: 117998994(IFNB1)
NSU: 110587130(IFNB1)
LWW: 102748842(IFNB1)
FCA: 493849(IFNB1)
PYU: 121034394
PCOO: 112849621(IFNB1)
PBG: 122474874(IFNB1)
PVIV: 125150775
LRUF: 124525672
PTG: 102960421(IFNB1)
PPAD: 109247124(IFNB1)
PUC: 125925944
AJU: 106971145
HHV: 120239877(IFNB1)
SSC: 445459(IFNB1)
CFR: 102513411(IFNB1)
CBAI: 105061881(IFNB1)
CDK: 105095933(IFNB1)
VPC: 102540243(IFNB1)
BACU: 103011926
BMUS: 118897323(IFNB1)
LVE: 103073772
OOR: 101289058(IFNB1)
DLE: 111174560(IFNB1)
PCAD: 102990155(IFNB1)
PSIU: 116755914(IFNB1)
NASI: 112407026(IFNB1)
MYB: 102261905(IFNB1)
MYD: 102765800(IFNB1)
MMYO: 118666805(IFNB1)
MLF: 102417209(IFNB1)
MDT: 132212752(IFNB1)
PKL: 118716770(IFNB1)
EFUS: 103289195(IFNB1)
MNA: 107531433(IFNB1)
DRO: 112300024(IFNB1)
AJM: 119055662(IFNB1)
PDIC: 114512515(IFNB1)
PHAS: 123820149 123820232(IFNB1)
MMF: 118629329(IFNB1)
PPAM: 129078454(IFNB1)
HAI: 109396418(IFNB1)
RFQ: 117032413(IFNB1)
PALE: 102890512(IFNB1)
PGIG: 120605473(IFNB1)
PVP: 105309141(IFNB1)
RAY: 107518589(IFNB1)
MJV: 108402531(IFNB1)
TOD: 119231101(IFNB1)
SARA: 101548268(IFNB1)
SETR: 126002675(IFNB1)
LAV: 100666438(IFNB1)
TMU: 101349610
ETF: 101650550(IFNB1)
DNM: 101410923(IFNB1)
MDO: 100021258(IFNB1)
GAS: 123250431
SHR: 100914443
AFZ: 127552925
OAA: 100082925(IFNB1)
GGA: 554219(IFNW1)
MGP: 109363864
TPAI: 128074649
LMUT: 125687310
NMEL: 110390553
LSR: 110484216
SCAN: 108962800
OTC: 121345277
CBRC: 108449705
ZAB: 102066024
ACHL: 103802741
SVG: 106865001
FPG: 101921672
NNT: 104400091
TALA: 122153561
HLE: 104827847
LDI: 104350945
MNB: 103781025
NNI: 104017595
PCAO: 104050721
AFOR: 109279355
FGA: 104078379
MUI: 104542485
EHS: 104511443
CMAC: 104475033
CUCA: 128850512
ACAR: 104520009
CVF: 104287685
RTD: 128902806
AROW: 112976152
SCAM: 104152576
TVC: 132837626
 » show all
Reference
  Authors
Ohno S, Taniguchi T
  Title
Structure of a chromosomal gene for human interferon beta.
  Journal
Proc Natl Acad Sci U S A 78:5305-9 (1981)
DOI:10.1073/pnas.78.9.5305
  Sequence
[hsa:3456]

KEGG   ORTHOLOGY: K05440
Entry
K05440                      KO                                     
Symbol
IFNW
Name
interferon omega
Pathway
map04060  Cytokine-cytokine receptor interaction
map04622  RIG-I-like receptor signaling pathway
map04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05440  IFNW; interferon omega
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05440  IFNW; interferon omega
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K05440  IFNW; interferon omega
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05440  IFNW; interferon omega
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interferons
   K05440  IFNW; interferon omega
Other DBs
GO: 0005132
Genes
HSA: 3467(IFNW1)
PTR: 473184(IFNW1)
PPS: 100996206
GGO: 101137485
PON: 100440345
PPYG: 129044558
NLE: 100598653(IFNW1)
HMH: 116459314(IFNW1)
SSYN: 129490325(IFNW1)
MCC: 114675730 711329
MCF: 102114910(IFNW1)
MTHB: 126937597
MNI: 105465887(IFNW1) 105498427
CSAB: 103219382(IFNW1)
CATY: 105584001(IFNW1)
PANU: 101024175(IFNW1)
TGE: 112608624(IFNW1)
MLEU: 105545736
RBB: 108538561
TFN: 117098644(IFNW1) 117099356
PTEH: 111526146(IFNW1) 111537202
CJC: 100388753(IFNW1)
SBQ: 101035047(IFNW1)
ANAN: 105715623(IFNW1) 105715630
PCOQ: 105827007 105827008(IFNW1)
NGI: 103734248
OPI: 101532360
MPUF: 101686395
MNP: 132024135
MLK: 131812132
NVS: 122916736
ORO: 101379383
EJU: 114218198
MLX: 118018166
NSU: 110587134
LWW: 102728156
FCA: 101088699 105259601 751853(IFNW8) 751856(IFNW11) 751857(IFNW12)
PCOO: 112857094
PTG: 102956175 102956457(IFNW1)
HHV: 120239880
SSC: 100152132(IFN-OMEGA-3) 100154098(IFN-OMEGA-5)
TMU: 101350376
IFU: 128600504
TFD: 125140174
 » show all
Reference
  Authors
Fensterl V, Sen GC
  Title
Interferons and viral infections.
  Journal
Biofactors 35:14-20 (2009)
DOI:10.1002/biof.6

KEGG   ORTHOLOGY: K05447
Entry
K05447                      KO                                     
Symbol
IFNL1, IL29
Name
interferon lambda 1
Pathway
map04060  Cytokine-cytokine receptor interaction
map04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05447  IFNL1, IL29; interferon lambda 1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05447  IFNL1, IL29; interferon lambda 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05447  IFNL1, IL29; interferon lambda 1
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interferons
   K05447  IFNL1, IL29; interferon lambda 1
Other DBs
GO: 0032003
Genes
HSA: 282618(IFNL1)
PTR: 100609679(IFNL1)
PPS: 100976419
GGO: 101154093
PON: 100460595
PPYG: 129019654
NLE: 100596098(IFNL1)
HMH: 116480185(IFNL1)
MCC: 697161(IFNL1)
MCF: 102139603(IFNL1)
MTHB: 126942095
MNI: 105495377(IFNL1)
CSAB: 103234663(IFNL1)
CATY: 105594190(IFNL1)
PANU: 101003843(IFNL1)
TGE: 112613144(IFNL1)
MLEU: 105534602(IFNL1)
RRO: 104676155(IFNL1)
RBB: 108527168
TFN: 117092507(IFNL1)
PTEH: 111554094(IFNL1)
CANG: 105519150(IFNL1)
CJC: 100395801(IFNL1)
SBQ: 101032182(IFNL1)
CIMI: 108285720(IFNL1)
ANAN: 105707787(IFNL1) 105723092
MMUR: 105877016
LCAT: 123624351
OGA: 100941323(IFNL1)
MPAH: 110330418(Ifnl1)
MCOC: 116100323
PLEU: 114684655
NGI: 103750791(Ifnl1)
OCU: 100341420
OPI: 101521992
GVR: 103598107(IFNL1)
CFA: 611377(IL29L) 612539(IFNL1)
NPO: 129500129(IFNL1) 129521721
UMR: 103661020
ELK: 111161574
MPUF: 101674696(IFNL1) 101681310
MNP: 132005287(IFNL1) 132022788
ORO: 101381320 101383268(IFNL1)
FCA: 101091490 692347(IL-29)
PTG: 102965761(IFNL1)
PPAD: 109256563(IFNL1)
HHV: 120230438 120244378(IFNL1)
BOM: 102271031(IFNL1)
SSC: 100217388(IL29)
CFR: 102518151
CBAI: 105071859
CDK: 105087870
VPC: 102536256
BACU: 103003207(IFNL1)
BMUS: 118881803
LVE: 103069528(IFNL1)
PSIU: 116740656
NASI: 112403081
ECB: 100071430 100146825(IL28B)
EPZ: 103540302(IFNL1) 103546142
MNA: 107534165(IFNL1)
DRO: 112320025
SHON: 118988117(IFNL1)
AJM: 119039941
MMF: 118639483
PPAM: 129076700(IFNL1)
PALE: 102894035(IFNL1)
PGIG: 120595123(IFNL1)
PVP: 105310596
RAY: 107521777
SARA: 101558405
TMU: 101355653
DNM: 101438474
PGUT: 117677613
APRI: 131204859
NSS: 113426464
STOW: 125435570
MUO: 115458811
BFO: 118417796
 » show all
Reference
  Authors
Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM
  Title
IL-28, IL-29 and their class II cytokine receptor IL-28R.
  Journal
Nat Immunol 4:63-8 (2003)
DOI:10.1038/ni873
  Sequence
[hsa:282618]

KEGG   ORTHOLOGY: K22669
Entry
K22669                      KO                                     
Symbol
IFNL2_3, IL28
Name
interferon lambda 2/3
Pathway
map04060  Cytokine-cytokine receptor interaction
map04630  JAK-STAT signaling pathway
Disease
H00413  Hepatitis C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K22669  IFNL2_3, IL28; interferon lambda 2/3
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K22669  IFNL2_3, IL28; interferon lambda 2/3
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K22669  IFNL2_3, IL28; interferon lambda 2/3
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interferons
   K22669  IFNL2_3, IL28; interferon lambda 2/3
Other DBs
GO: 0032003
Genes
HSA: 282616(IFNL2) 282617(IFNL3)
PTR: 112206397 735838(IFNL3)
PPS: 100975561(IFNL3) 100976754
GGO: 101153729 109024085 115931638
PON: 100458631 100459981
PPYG: 129019655 129019656
NLE: 100596435 100596769
HMH: 116480691
MCC: 695997(IFNL3) 696117
MCF: 102130733 102137836 102138968
MNI: 105495378
PANU: 101003144
RBB: 108524754 108539007(IFNL3)
CJC: 100395444(IFNL3) 118150216
SBQ: 101034825(IFNL3)
CIMI: 108285721
ANAN: 105707808(IFNL3)
MMUR: 105877017
LCAT: 123624229
PCOQ: 105820524
MMU: 330496(Ifnl2) 338374(Ifnl3)
MPAH: 110330430
RNO: 100911249(Ifnl1) 685840(Ifnl3)
ANU: 117693258 117695561(Ifnl3)
PROB: 127238921
PLEU: 114684616
CCAN: 109681986
DORD: 105993072(Ifnl3) 106000891
DSP: 122097353
PLOP: 125338936
MMMA: 107135041 107151650(Ifnl3)
TUP: 102477775(IFNL2) 102478212(IFNL1)
GVR: 103599266
CFA: 119870346(IFNL3)
CLUD: 112643716
VLG: 121479123
NPO: 129500131
AML: 100466034(IFNL3)
UMR: 103661082
UAR: 123798668(IFNL3)
ELK: 111161564
LLV: 125089580
MPUF: 101672127(IFNL3)
MNP: 132005940(IFNL3)
MLK: 131817635
NVS: 122913838
ORO: 101363775
EJU: 114198997
ZCA: 113936478
MLX: 118022908
NSU: 110590306
LWW: 102735097(IFNL3)
FCA: 101091743
PYU: 121011337
PBG: 122494292
AJU: 106988318
HHV: 120242850
BTA: 100620067(IFNL3) 112441453
BBUB: 102395794 102402216(IFNL3)
BBIS: 104995334
CCAD: 122421613(IFNL3)
SSC: 100310828(IL28B) 110255217
VPC: 102533820
BACU: 103012028 103012509(IFNL3)
LVE: 103068971 103080330(IFNL3)
PCAD: 102988439
MYD: 102768489(IFNL3) 102774772
DNM: 101437604
MDO: 103098387(IFNL3)
GAS: 123240890(IFNL3)
AFZ: 127556139
PCW: 110198176
TVP: 118836327(IFNL3)
GGA: 101751261(IFNL3L) 112532795 770778(IFNL3A)
PCOC: 116236055
MGP: 100550136
CJO: 107316488
TPAI: 128076824
LMUT: 125696794
NMEL: 110399993
APLA: 101795406
ACYG: 106034587
CATA: 118243083
AFUL: 116490456
TGU: 115495912
LSR: 110473502
SCAN: 115484344
GFR: 102038979
FAB: 101807582
OMA: 130255289
PHI: 102112572
PMAJ: 107207297(IFNL1)
CCAE: 111931691
CCW: 104694550
ETL: 114060662
ZAB: 102063945
ZLE: 135450348
ACHL: 103801762
SVG: 106856548
MMEA: 130588848
HRT: 120755473
SATI: 136363796
FPG: 101922324
FCH: 102053225
CCRI: 104165106
ACUN: 113482083
TALA: 116965807
ACHC: 115342765
HLE: 104838248
AGEN: 126039274
CSTI: 104560717
LDI: 104353411
MNB: 103770266
DPUB: 104300550
AVIT: 104275149
BRHI: 104490996
EGZ: 104123245
NNI: 104010164
PADL: 103921639
AFOR: 103903838
CLV: 102094032
MUI: 104541469
PGUU: 104465187
PLET: 104618467
CMAC: 104481749
CUCA: 104067396
OHA: 104327809
ACAR: 104527194
CVF: 104288737
RTD: 128912873
AAM: 106492747
AROW: 112976546
NPD: 112955207
DNE: 112979495
AMJ: 106737492
CCAY: 125644972 125645233(IFNL3)
TST: 117888460
CABI: 116839413
ACS: 107983691(IFNL)
ASAO: 132780532
SUND: 121915561
PMUR: 107291643
HCG: 128332546
XTR: 100329162(il28b.1) 100329164(ifnl3) 100329165(ifnl3) 101734074 101734966
GSH: 117364478 117366184(IFNL3)
 » show all
Reference
  Authors
Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM
  Title
IL-28, IL-29 and their class II cytokine receptor IL-28R.
  Journal
Nat Immunol 4:63-8 (2003)
DOI:10.1038/ni873
  Sequence

KEGG   ORTHOLOGY: K05432
Entry
K05432                      KO                                     
Symbol
IL9
Name
interleukin 9
Pathway
map04060  Cytokine-cytokine receptor interaction
map04630  JAK-STAT signaling pathway
map05310  Asthma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05432  IL9; interleukin 9
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05432  IL9; interleukin 9
 09160 Human Diseases
  09163 Immune disease
   05310 Asthma
    K05432  IL9; interleukin 9
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05432  IL9; interleukin 9
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05432  IL9; interleukin 9
Other DBs
GO: 0005140
Genes
HSA: 3578(IL9)
PTR: 745517(IL9)
PPS: 100972565(IL9)
GGO: 101135761(IL9)
PON: 100440198(IL9)
PPYG: 129036798(IL9)
NLE: 100579257(IL9)
HMH: 116470466(IL9)
SSYN: 129493424(IL9)
MCC: 712292(IL9)
MCF: 102131911(IL9)
MTHB: 126956024
MNI: 105467115(IL9)
CSAB: 103244581(IL9)
CATY: 105599805(IL9)
PANU: 101002587(IL9)
TGE: 112626566(IL9)
MLEU: 105531300(IL9)
RRO: 104659785(IL9)
RBB: 108517038(IL9)
TFN: 117064601(IL9)
PTEH: 111527521(IL9)
CANG: 105506949(IL9)
CJC: 100396248(IL9)
SBQ: 101047729(IL9)
CIMI: 108307015(IL9)
ANAN: 105715638(IL9)
CSYR: 103269203(IL9)
MMUR: 105869999(IL9)
LCAT: 123638848(IL9)
PCOQ: 105811988(IL9)
OGA: 100941297(IL9)
MMU: 16198(Il9)
MCAL: 110308717(Il9)
MPAH: 110334313(Il9)
RNO: 116558(Il9)
MCOC: 116081439(Il9)
ANU: 117714392(Il9)
MUN: 110557059(Il9)
CGE: 100755564(Il9)
MAUA: 101831415(Il9)
PROB: 127229066(Il9)
PLEU: 114688884(Il9)
MORG: 121444926 121453143(Il9)
MFOT: 126502467
AAMP: 119817135(Il9)
NGI: 103746598(Il9)
HGL: 101713016(Il9)
CPOC: 100716466(Il9)
CCAN: 109701907(Il9)
DORD: 105985451(Il9)
DSP: 122100929(Il9)
PLOP: 125341778(Il9)
NCAR: 124986404
MMMA: 107144908(Il9)
OCU: 100340820
OPI: 101518469(IL9)
TUP: 102472404(IL9)
GVR: 103609419(IL9)
CFA: 100682918(IL9)
CLUD: 112650504(IL9)
VVP: 112916990(IL9)
VLG: 121495488(IL9)
NPO: 129494616(IL9)
AML: 105237562(IL9)
UMR: 103663953(IL9)
UAH: 113261494(IL9)
UAR: 123790532(IL9)
ELK: 111141057
LLV: 125101163
MPUF: 101682245(IL9)
MNP: 132027542(IL9)
MLK: 131831141(IL9)
NVS: 122891438(IL9)
ORO: 101383492(IL9)
EJU: 114209419(IL9)
ZCA: 113929956(IL9)
MLX: 118017102(IL9)
NSU: 110591212(IL9)
LWW: 102745909(IL9)
FCA: 101088458(IL9)
PYU: 121010733(IL9)
PCOO: 112861454(IL9)
PBG: 122487640(IL9)
PVIV: 125174967(IL9)
LRUF: 124524479
PTG: 102971669(IL9)
PPAD: 109250827(IL9)
PUC: 125935136
AJU: 106989142
HHV: 120238493(IL9)
BTA: 613392(IL9)
BOM: 102269055(IL9)
BIU: 109561070(IL9)
BBUB: 102393062(IL9)
BBIS: 104991928(IL9)
CHX: 102179848(IL9)
OAS: 101105494(IL9)
BTAX: 128050264(IL9)
ODA: 120863634(IL9)
CCAD: 122440837(IL9)
MBEZ: 129558500(IL9)
SSC: 100144594(IL9)
CFR: 102516621(IL9)
CBAI: 105082142(IL9)
CDK: 105090427(IL9)
VPC: 102532303(IL9)
BACU: 103004652(IL9)
BMUS: 118893519(IL9)
LVE: 103081336(IL9)
OOR: 101283367(IL9)
DLE: 111182469(IL9)
PCAD: 102989038(IL9)
PSIU: 116752120(IL9)
NASI: 112404458(IL9)
ECB: 100062710(IL9)
EPZ: 103543483(IL9)
EAI: 106822973(IL9)
MYB: 102248126(IL9)
MYD: 102760095(IL9)
MMYO: 118657901(IL9)
MLF: 102420845(IL9)
MDT: 132236153(IL9)
PKL: 118711263(IL9)
EFUS: 103289988(IL9)
MNA: 107525410(IL9)
DRO: 112317978(IL9)
SHON: 118996212(IL9)
AJM: 119044156(IL9)
PDIC: 114510338(IL9)
PHAS: 123812862(IL9)
MMF: 118643740(IL9)
PPAM: 129066432(IL9)
HAI: 109382566(IL9)
RFQ: 117017084(IL9)
PALE: 102894278(IL9)
PGIG: 120581152(IL9)
PVP: 105293649(IL9)
RAY: 107506790(IL9)
MJV: 108391238(IL9)
TOD: 119242914(IL9)
SARA: 101543306(IL9)
SETR: 126028357(IL9)
LAV: 100666698(IL9)
TMU: 101361292
ETF: 101640724(IL9)
DNM: 101436435(IL9)
MDO: 103105574(IL9)
GAS: 123236631(IL9)
SHR: 105749159(IL9)
PCW: 110211673(IL9)
TVP: 118844004(IL9)
GGA: 416307(IL9)
LSR: 110481057
PMOA: 120498628
OTC: 121332423
GFR: 102038106
CCW: 104689706(IL9)
CBRC: 103614684(IL9)
ZAB: 102062348
ACHL: 103802768
HRT: 120759361
FCH: 114016258
ACUN: 113485145
TALA: 104363094
ACHC: 115334331
HALD: 104325953
HLE: 104839079
LDI: 104347706
DPUB: 104310226(IL9)
FGA: 104077493
GSTE: 104263758
MUI: 104538797
PLET: 104615308
CUCA: 104059792
BREG: 104630802
AROW: 112964921
TGT: 104571748
ASN: 112549152(IL9)
AMJ: 109280876
MRV: 120369985(IL9)
XTR: 100335029(il9)
 » show all
Reference
  Authors
Liao W, Lin JX, Leonard WJ
  Title
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.
  Journal
Curr Opin Immunol 23:598-604 (2011)
DOI:10.1016/j.coi.2011.08.003

KEGG   ORTHOLOGY: K05435
Entry
K05435                      KO                                     
Symbol
IL13
Name
interleukin 13
Pathway
map04060  Cytokine-cytokine receptor interaction
map04630  JAK-STAT signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04664  Fc epsilon RI signaling pathway
map05200  Pathways in cancer
map05310  Asthma
map05321  Inflammatory bowel disease
Disease
H00079  Asthma
H00084  Graft-versus-host disease
H01360  Allergic rhinitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05435  IL13; interleukin 13
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05435  IL13; interleukin 13
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05435  IL13; interleukin 13
   04657 IL-17 signaling pathway
    K05435  IL13; interleukin 13
   04664 Fc epsilon RI signaling pathway
    K05435  IL13; interleukin 13
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05435  IL13; interleukin 13
  09163 Immune disease
   05310 Asthma
    K05435  IL13; interleukin 13
   05321 Inflammatory bowel disease
    K05435  IL13; interleukin 13
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05435  IL13; interleukin 13
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05435  IL13; interleukin 13
Other DBs
GO: 0005144
Genes
HSA: 3596(IL13)
PTR: 449564(IL13)
PPS: 100989787(IL13)
GGO: 101139192(IL13)
PON: 100451066(IL13)
PPYG: 129036372(IL13)
NLE: 100598534(IL13)
HMH: 116470838(IL13)
SSYN: 129493357(IL13)
MCC: 574325(IL13)
MCF: 102125887(IL13)
MTHB: 126956018
MNI: 105467171(IL13)
CSAB: 103244518(IL13)
CATY: 105599745(IL13)
PANU: 100137221(IL13)
TGE: 112626443(IL13)
MLEU: 105531346(IL13)
RRO: 104659835(IL13)
RBB: 108529535(IL13)
TFN: 117065886(IL13)
PTEH: 111529504(IL13)
CANG: 105518192(IL13)
CJC: 100406899(IL13)
SBQ: 101038789(IL13)
CIMI: 108307167(IL13)
ANAN: 105716196(IL13)
CSYR: 103259256(IL13)
MMUR: 105869952(IL13)
LCAT: 123638705(IL13)
PCOQ: 105816022(IL13)
OGA: 100946348(IL13)
MMU: 16163(Il13)
MCAL: 110306320(Il13)
MPAH: 110332737(Il13)
RNO: 116553(Il13)
MCOC: 116078552(Il13)
ANU: 117711969(Il13)
MUN: 110548783(Il13)
CGE: 100762597(Il13)
MAUA: 101843388(Il13)
PROB: 127219301(Il13)
MORG: 121445652 121456365(Il13)
MFOT: 126510962
AAMP: 119811061(Il13)
NGI: 103747046(Il13)
HGL: 101718152(Il13)
CPOC: 100720118(Il13)
CCAN: 109694188(Il13)
DORD: 105996761(Il13)
DSP: 122115499(Il13)
PLOP: 125341804(Il13)
NCAR: 124986687
MMMA: 107148000(Il13)
OCU: 100358676
OPI: 101536584(IL13)
TUP: 102484173(IL13)
GVR: 103589625(IL13)
CFA: 442990(IL13)
CLUD: 112649805(IL13)
VVP: 112917155(IL13)
VLG: 121495939(IL13)
NPO: 129494904(IL13)
AML: 100474520(IL13)
UMR: 103663833(IL13)
UAR: 123790538(IL13)
ELK: 111141294
LLV: 125100488
MPUF: 101686707(IL13)
MNP: 132027868(IL13)
MLK: 131831368(IL13)
NVS: 122901617(IL13)
ORO: 101365728(IL13)
EJU: 114209610(IL13)
ZCA: 113928605(IL13)
MLX: 118017098(IL13)
NSU: 110591204(IL13)
LWW: 102728526(IL13)
FCA: 101084678(IL13)
PYU: 121010681(IL13)
PCOO: 112860679(IL13)
PBG: 122487255(IL13)
PVIV: 125171790(IL13)
LRUF: 124523786
PTG: 102963390(IL13)
PPAD: 109250888(IL13)
PUC: 125935482
AJU: 106970699
HHV: 120223315(IL13)
BTA: 281247(IL13)
BOM: 102272332(IL13)
BIU: 109561215(IL13)
BBUB: 102397453(IL13)
BBIS: 105005563(IL13)
CHX: 102187477(IL13)
OAS: 664707(IL13)
BTAX: 128051691(IL13)
ODA: 120864748(IL13)
CCAD: 122440157(IL13)
MBEZ: 129558703(IL13)
SSC: 396721(IL13)
CFR: 102515236(IL13)
CBAI: 105082106(IL13)
CDK: 105090128(IL13)
VPC: 102541757(IL13)
BACU: 103009740(IL13)
BMUS: 118892465(IL13)
LVE: 103068731(IL13) 103083537
OOR: 101290079(IL13)
DLE: 111182419(IL13)
PCAD: 102989542(IL13)
PSIU: 116751685(IL13)
NASI: 112401385(IL13)
ECB: 100034113(IL13)
EPZ: 103563182(IL13)
EAI: 106841033(IL13)
MYB: 102243347(IL13)
MYD: 102774264(IL13)
MMYO: 118659168(IL13)
MLF: 102437628(IL13)
MDT: 132234320(IL13)
PKL: 118711270(IL13)
EFUS: 103290112(IL13)
MNA: 107525052(IL13)
DRO: 112318059(IL13)
SHON: 118990130(IL13)
AJM: 119037706(IL13)
PDIC: 114510342(IL13)
PHAS: 123812450(IL13)
MMF: 118616327(IL13)
PPAM: 129066442(IL13)
HAI: 109382572(IL13)
RFQ: 117016403(IL13)
PALE: 102890275(IL13)
PVP: 105293549(IL13)
RAY: 107497023(IL13)
MJV: 108390063(IL13)
TOD: 119242735(IL13)
SARA: 101539069(IL13)
SETR: 126028369(IL13)
LAV: 100674770(IL13)
TMU: 101341264
MDO: 103103487(IL13)
GAS: 123233890(IL13)
SHR: 111720829(IL13)
PCW: 110211655(IL13)
OAA: 103166612
 » show all
Reference
PMID:8096327
  Authors
Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, Labit C, Leplatois P, Liauzun P, Miloux B, et al.
  Title
Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses.
  Journal
Nature 362:248-50 (1993)
DOI:10.1038/362248a0
  Sequence
[hsa:3596]
Reference
  Authors
Geskin LJ, Viragova S, Stolz DB, Fuschiotti P
  Title
Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.
  Journal
Blood 125:2798-805 (2015)
DOI:10.1182/blood-2014-07-590398
  Sequence
[hsa:3596]

KEGG   ORTHOLOGY: K05444
Entry
K05444                      KO                                     
Symbol
IL19
Name
interleukin 19
Pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05444  IL19; interleukin 19
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05444  IL19; interleukin 19
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05444  IL19; interleukin 19
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05444  IL19; interleukin 19
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05444  IL19; interleukin 19
Other DBs
GO: 0045516
Genes
HSA: 29949(IL19)
PTR: 744162(IL19)
PPS: 100990188(IL19)
GGO: 101130815(IL19)
PON: 100445757(IL19)
PPYG: 129031978(IL19)
NLE: 100580750(IL19)
HMH: 116457673(IL19)
SSYN: 129458181(IL19)
MCC: 694806(IL19)
MCF: 102133068(IL19)
MTHB: 126949393
MNI: 105484853(IL19)
CSAB: 103230191(IL19)
CATY: 105576730(IL19)
PANU: 101023678(IL19)
TGE: 112605730(IL19)
MLEU: 105529835(IL19)
RRO: 104661741(IL19)
RBB: 108535117(IL19)
TFN: 117076748(IL19)
PTEH: 111522812(IL19)
CANG: 105508601(IL19)
CJC: 100386502(IL19)
SBQ: 101051941(IL19)
CIMI: 108301977(IL19)
ANAN: 105722000(IL19)
CSYR: 103257992(IL19)
MMUR: 105869320(IL19)
LCAT: 123627139(IL19)
PCOQ: 105805863(IL19)
OGA: 100966142(IL19)
MMU: 329244(Il19)
MCAL: 110305002(Il19)
MPAH: 110322622(Il19)
RNO: 681145(Il19)
MCOC: 116070123(Il19)
ANU: 117716562(Il19)
MUN: 110550306(Il19)
CGE: 100774163(Il19)
MAUA: 101824985(Il19)
PROB: 127236355(Il19)
PLEU: 114698037(Il19)
MORG: 121444343(Il19)
MFOT: 126505134
AAMP: 119827008(Il19)
NGI: 103725972(Il19)
HGL: 101725985(Il19)
CPOC: 100715337(Il19)
CCAN: 109688369(Il19)
DORD: 105986432(Il19)
DSP: 122109695(Il19)
PLOP: 125359917(Il19)
NCAR: 124962368
MMMA: 107140377(Il19)
OCU: 100353950
OPI: 101529339(IL19)
TUP: 102485096(IL19)
GVR: 103609266(IL19)
CFA: 490265(IL19)
CLUD: 112648336(IL19)
VVP: 112910975(IL19)
VLG: 121471431(IL19)
NPO: 129506028(IL19)
AML: 100483678(IL19)
UMR: 103657672(IL19)
UAH: 113242440(IL19)
UAR: 123785866(IL19)
ELK: 111151192
LLV: 125086388
MPUF: 101671841(IL19)
MNP: 132026139(IL19)
MLK: 131815255(IL19)
NVS: 122918165(IL19)
ORO: 101382882(IL19)
EJU: 114221911(IL19)
ZCA: 113933459(IL19)
MLX: 118013694(IL19)
NSU: 110573886(IL19)
LWW: 102743704(IL19)
FCA: 101090582(IL19)
PYU: 121022434(IL19)
PCOO: 112857869(IL19)
PBG: 122476115(IL19)
PVIV: 125155762(IL19)
LRUF: 124509899
PTG: 102957863(IL19)
PPAD: 109250660(IL19)
PUC: 125925353
AJU: 106981773
HHV: 120245600(IL19)
BTA: 527634(IL19)
BOM: 102274357(IL19)
BIU: 109570244(IL19)
BBUB: 102402621(IL19)
BBIS: 104998877(IL19)
CHX: 102176445(IL19)
OAS: 101112663(IL19)
BTAX: 128061793(IL19)
ODA: 120879936(IL19)
MBEZ: 129551123(IL19)
SSC: 100038024(IL19)
CFR: 102508518(IL19)
CBAI: 105075458(IL19)
CDK: 105098662(IL19)
VPC: 102529537(IL19)
BACU: 102998394(IL19)
BMUS: 118888188(IL19)
LVE: 103083294(IL19)
OOR: 101271645(IL19)
DLE: 111184612(IL19)
PCAD: 102973875(IL19)
PSIU: 116741507(IL19)
NASI: 112403582(IL19)
ECB: 100055588(IL19)
EAI: 106823324(IL19)
MYB: 102261466(IL19)
MYD: 102759997(IL19)
MMYO: 118673540(IL19)
MLF: 102442477(IL19)
MDT: 132221253(IL19)
PKL: 118721323(IL19)
EFUS: 103297557(IL19)
MNA: 107539452(IL19)
DRO: 112315930(IL19)
SHON: 119001718(IL19)
AJM: 119056787(IL19)
PDIC: 114512176(IL19)
PHAS: 123820682(IL19)
MMF: 118637919(IL19)
PPAM: 129062236(IL19)
HAI: 109374505(IL19)
RFQ: 117015370(IL19)
PALE: 102887033(IL19)
PGIG: 120617930(IL19)
PVP: 105308923(IL19)
RAY: 107502234(IL19)
MJV: 108403018(IL19)
TOD: 119233944(IL19)
SARA: 101541347(IL19)
SETR: 126004562(IL19)
LAV: 100658487(IL19)
TMU: 101360403
ETF: 101650725(IL19)
DNM: 101418254(IL19)
MDO: 100019862(IL19)
GAS: 123245975(IL19)
SHR: 100918216(IL19)
AFZ: 127559939
PCW: 110219595
TVP: 118845316(IL19)
OAA: 100091362(IL19)
 » show all
Reference
  Authors
Gallagher G, Dickensheets H, Eskdale J, Izotova LS, Mirochnitchenko OV, Peat JD, Vazquez N, Pestka S, Donnelly RP, Kotenko SV
  Title
Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10).
  Journal
Genes Immun 1:442-50 (2000)
DOI:10.1038/sj.gene.6363714
  Sequence
[hsa:29949]

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