KEGG ORTHOLOGY: K05411

ORTHOLOGY: K05411

Entry

K05411                      KO

Symbol

IRF3

Name

interferon regulatory factor 3

Pathway

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04936

Alcoholic liver disease

map05131

Shigellosis

map05133

Pertussis

map05135

Yersinia infection

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05203

Viral carcinogenesis

map05417

Lipid and atherosclerosis

Disease

H02536

Infection-induced acute encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05411  IRF3; interferon regulatory factor 3
   04621 NOD-like receptor signaling pathway
    K05411  IRF3; interferon regulatory factor 3
   04622 RIG-I-like receptor signaling pathway
    K05411  IRF3; interferon regulatory factor 3
   04623 Cytosolic DNA-sensing pathway
    K05411  IRF3; interferon regulatory factor 3
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05411  IRF3; interferon regulatory factor 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05411  IRF3; interferon regulatory factor 3
   05161 Hepatitis B
    K05411  IRF3; interferon regulatory factor 3
   05160 Hepatitis C
    K05411  IRF3; interferon regulatory factor 3
   05171 Coronavirus disease - COVID-19
    K05411  IRF3; interferon regulatory factor 3
   05164 Influenza A
    K05411  IRF3; interferon regulatory factor 3
   05162 Measles
    K05411  IRF3; interferon regulatory factor 3
   05168 Herpes simplex virus 1 infection
    K05411  IRF3; interferon regulatory factor 3
   05163 Human cytomegalovirus infection
    K05411  IRF3; interferon regulatory factor 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05411  IRF3; interferon regulatory factor 3
   05169 Epstein-Barr virus infection
    K05411  IRF3; interferon regulatory factor 3
   05165 Human papillomavirus infection
    K05411  IRF3; interferon regulatory factor 3
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05411  IRF3; interferon regulatory factor 3
   05135 Yersinia infection
    K05411  IRF3; interferon regulatory factor 3
   05133 Pertussis
    K05411  IRF3; interferon regulatory factor 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05411  IRF3; interferon regulatory factor 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05411  IRF3; interferon regulatory factor 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05411  IRF3; interferon regulatory factor 3
   04131 Membrane trafficking
    K05411  IRF3; interferon regulatory factor 3
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Tryptophan clusters interferon-regulating factors
    K05411  IRF3; interferon regulatory factor 3
Membrane trafficking [BR:ko04131]
Autophagy
  Other autophagy associated proteins
   TRIM-directed selective autophagy
    K05411  IRF3; interferon regulatory factor 3

Genes

HSA:	3661(IRF3)

PTR:	747565(IRF3)

PPS:	100977114(IRF3)

GGO:	101144709(IRF3)

PON:	100441280(IRF3)

PPYG:

129019711(IRF3)

NLE:	100603099(IRF3)

HMH:	116478197(IRF3)

SSYN:

129459934(IRF3)

MCC:	718970(IRF3)

MCF:	102132745(IRF3)

MTHB:

126943112

MNI:	105497189(IRF3)

CSAB:

103235050(IRF3)

CATY:

105595300(IRF3)

PANU:

101013579(IRF3)

TGE:	112612899(IRF3)

MLEU:

105528977(IRF3)

RRO:	104667206(IRF3)

RBB:	108535826(IRF3)

TFN:	117091591(IRF3)

PTEH:

111519959(IRF3)

CANG:

105514764(IRF3)

CJC:	100414132(IRF3)

SBQ:	101033122(IRF3)

CIMI:

108298392(IRF3)

ANAN:

105723007(IRF3)

CSYR:

103249777(IRF3)

MMUR:

105865644(IRF3)

LCAT:

123623813(IRF3)

PCOQ:

105809375(IRF3)

OGA:	100943304(IRF3)

MMU:	54131(Irf3)

MCAL:

110298322(Irf3)

MPAH:

110332836(Irf3)

RNO:	292892(Irf3)

MCOC:

116102161(Irf3)

ANU:	117708685(Irf3)

MUN:	110546826(Irf3)

CGE:	100765676(Irf3)

MAUA:

101827541(Irf3)

PROB:

127213691(Irf3)

PLEU:

114687156(Irf3)

MORG:

121451666(Irf3)

MFOT:

126488203

AAMP:

119802528(Irf3)

NGI:	103743674(Irf3)

HGL:	101722762(Irf3)

CPOC:

100724910(Irf3)

CCAN:

109683903(Irf3)

DORD:

105994272(Irf3)

DSP:	122125825(Irf3)

PLOP:

125338811(Irf3)

NCAR:

124967322

MMMA:

107151239(Irf3)

OCU:

103346571

OPI:	101528748(IRF3)

TUP:	102489835(IRF3)

GVR:	103592597(IRF3)

CFA:	476412(IRF3)

CLUD:

112645138(IRF3)

VVP:	112931284(IRF3)

VLG:	121483963(IRF3)

NPO:	129499930(IRF3)

AML:	100471184(IRF3)

UMR:	103657131(IRF3)

UAH:	113243290(IRF3)

UAR:	123776252(IRF3)

ELK:

111160645

LLV:

125088511

MPUF:

101693423(IRF3)

MNP:	132005020(IRF3)

MLK:	131817460(IRF3)

NVS:	122911811(IRF3)

ORO:	101386524(IRF3)

EJU:	114199531(IRF3)

ZCA:	113936398(IRF3)

MLX:	117998287(IRF3)

NSU:	110572882(IRF3)

LWW:	102732139(IRF3)

FCA:	101095934(IRF3)

PYU:	121018789(IRF3)

PCOO:

112851074(IRF3)

PBG:	122493856(IRF3)

PVIV:

125153270(IRF3)

LRUF:

124510901

PTG:	102956602(IRF3)

PPAD:

109253050(IRF3)

PUC:

125915966

AJU:

106983140

HHV:	120244065(IRF3)

BTA:	516979(IRF3)

BOM:	102279593(IRF3)

BIU:	109572224(IRF3)

BBUB:

102396674(IRF3)

BBIS:

104995732(IRF3)

CHX:	102171811(IRF3)

OAS:	780485(IRF3)

BTAX:

128062922(IRF3)

ODA:	120872121(IRF3)

CCAD:

122421010(IRF3)

MBEZ:

129546536(IRF3)

SSC:	396656(IRF3)

CFR:	102506077(IRF3)

CBAI:

105062642(IRF3)

CDK:	105100198(IRF3)

VPC:	102536109(IRF3)

BACU:

103004904(IRF3)

BMUS:

118884995(IRF3)

LVE:	103070943(IRF3)

OOR:	101272168(IRF3)

DLE:	111180609(IRF3)

PCAD:

102986279(IRF3)

PSIU:

116744395(IRF3)

NASI:

112415465(IRF3)

ECB:	100055868(IRF3)

EPZ:	103541756(IRF3)

EAI:	106824161(IRF3)

MYB:	102241188(IRF3)

MYD:	102760165(IRF3)

MMYO:

118655420(IRF3)

MLF:	102422872(IRF3)

MDT:	132216202(IRF3)

PKL:	118712200(IRF3)

EFUS:

103297623(IRF3)

MNA:	107531880(IRF3)

DRO:	112310089(IRF3)

AJM:	119045996(IRF3)

PDIC:

114511489(IRF3)

PHAS:

123830327(IRF3)

MMF:	118639395(IRF3)

PPAM:

129082940(IRF3)

HAI:	109391076(IRF3)

RFQ:	117035039(IRF3)

PALE:

102878862(IRF3)

PGIG:

120615538(IRF3)

PVP:	105301733(IRF3)

RAY:	107498821(IRF3)

MJV:	108400317(IRF3)

TOD:	119249593(IRF3)

SARA:

101542890(IRF3)

SETR:

126027203(IRF3)

LAV:	100667571(IRF3)

TMU:

101348880

ETF:	101651495(IRF3)

DNM:	101415954(IRF3)

MDO:	100030239(IRF3)

GAS:	123256113(IRF3)

SHR:

100933650

AFZ:

127556561

PCW:	110219913(IRF3)

TVP:	118835489(IRF3)

OAA:	114814621(IRF3)

ASN:	102368478(IRF3)

AMJ:	102560503(IRF3)

CMY:	114019695(IRF3)

CCAY:

125628494(IRF3)

DCC:	119847218(IRF3)

CPIC:

101938664(IRF3)

CABI:

116818009(IRF3)

MRV:	120388286(IRF3)

ACS:	100561376(irf3)

ASAO:

132778114(IRF3)

PVT:	110079174(IRF3)

SUND:

121932898(IRF3)

PBI:	103059405(IRF3)

PMUR:

107282419(IRF3)

CTIG:

120313686(IRF3)

TSR:	106553402(IRF3)

PGUT:

117664473(IRF3)

APRI:

131196585(IRF3)

PTEX:

113442936(IRF3)

NSS:	113413424(IRF3)

VKO:	123030475(IRF3)

PMUA:

114582063(IRF3)

PRAF:

128400358(IRF3)

ZVI:	118095336(IRF3)

HCG:	128328730(IRF3)

GJA:	107108113(IRF3)

STOW:

125444651(IRF3)

EMC:	129338317(IRF3)

XLA:	108695903 108697781(irf3.S) 379275(irf3.L)

XTR:	101734275(irf3)

NPR:	108797511 108797512

RTEM:

120916504(IRF3) 120916505

BBUF:

121002490(IRF3)

BGAR:

122926675(IRF3)

MUO:	115466632(IRF3)

GSH:	117367565(IRF3)

DRE:	564854(irf3)

SRX:	107708951 107732163

SANH:

107654019 107664612

SGH:	107557350 107598585

CCAR:

109068023 109087794

CAUA:

113056391 113111984

CGIB:

127968762 128025045

PTET:

122355691(irf3)

LROH:

127173842(irf3)

OMC:	131551463(irf3)

PPRM:

120470441(irf3)

RKG:	130080583(irf3)

MAMB:

125255661(irf3)

CIDE:

127523422

CERY:

137007874(irf3)

MASI:

127423260

TROS:

130569629(irf3)

TDW:	130438614(irf3)

MANU:

129421187(irf3)

IPU:	108273898(irf3)

IFU:	128617059(irf3)

PHYP:

113527080

SMEO:

124389156(irf3)

TFD:	113653598(irf3)

TVC:	132841563(irf3)

TRN:	134321090(irf3)

AMEX:

103032028(irf3)

CMAO:

118809735(irf3)

EEE:

113590849

CHAR:

105891192(irf3)

TRU:

101071639

TFS:	130523895(irf3)

TNG:	GSTEN00028285G001

LCO:	104935901(irf3)

NCC:

104948891

TBEN:

117473779(irf3)

CGOB:

115024497

PGEO:

117464722(irf3)

GACU:

117545135(irf3)

EMAC:

134870924(irf3)

ELY:	117247071(irf3)

EFO:	125881062(irf3)

PLEP:

121958671(irf3)

SLUC:

116061477(irf3)

ECRA:

117937301(irf3)

ESP:

116671420

PFLV:

114547777

GAT:	120819100(irf3)

PPUG:

119212633(irf3)

AFB:	129091070(irf3)

CLUM:

117749101(irf3)

PSWI:

130203491(irf3)

MSAM:

119915748(irf3)

SCHU:

122868143(irf3)

CUD:	121528801(irf3)

ALAT:

119009595(irf3)

MZE:

101466323

ONL:

100702954

OAU:	116319913(irf3)

OLA:

101158892

OML:	112154159(irf3)

CSAI:

133418955(irf3)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122823590(irf3)

PPRL:

129377822(irf3)

CVG:

107097205

CTUL:

119777604(irf3)

GMU:	124875664(irf3)

NFU:

107387991

KMR:	108237204(irf3)

ALIM:

106517444

NWH:	119423589(irf3)

AOCE:

111584600

MCEP:

125022331(irf3)

CSEM:

103382011

POV:

109642328

SSEN:

122759291(irf3)

HHIP:

117753319(irf3)

HSP:	118100461(irf3)

PPLT:

128426373(irf3)

SMAU:

118286990(irf3)

LCF:	108884442(irf3)

SDU:

111219805

SLAL:

111658714

XGL:	120794262(irf3)

HCQ:

109523980

SSCV:

125990919

SBIA:

133495601(irf3)

PEE:	133395243(irf3)

PTAO:

133469821(irf3)

BPEC:

110159564

MALB:

109963625

BSPL:

114845285(irf3)

SJO:	128381200(irf3)

SASA:

100337625(irf-3)

STRU:

115162648

OTW:	112235560(irf3)

OMY:	100750229(irf3)

OGO:	124048534(irf3)

ONE:

115106747

OKI:

109865630

OKE:	118363689(irf3)

SALP:

111978255

SNH:	120046426(irf3)

CCLU:

121572029(irf3)

ELS:

105026239

SFM:	108925144(irf3)

PKI:	111851276(irf3)

AANG:

118220990 118220991

LOC:	107075358(irf3)

PSPA:

121305885

LCM:	102348631(IRF3)

CMK:	103173446(irf3)

CPLA:

HOC:

RMP:

Reference

PMID:8524823

Authors

Au WC, Moore PA, Lowther W, Juang YT, Pitha PM

Title

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

Journal

Proc Natl Acad Sci U S A 92:11657-61 (1995)
DOI:10.1073/pnas.92.25.11657

Sequence

[hsa:3661]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (42)   
   KEGG PATHWAY (42)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (339)   
   KEGG GENES (324)   
   KEGG MGENES (13)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (386)   

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