KEGG ORTHOLOGY: K05460

ORTHOLOGY: K05460

Entry

K05460                      KO

Symbol

HGF

Name

hepatocyte growth factor

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map05144

Malaria

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05211

Renal cell carcinoma

map05218

Melanoma

map05223

Non-small cell lung cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Disease

H00048

Hepatocellular carcinoma

H00605

Deafness, autosomal recessive

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05460  HGF; hepatocyte growth factor
   04014 Ras signaling pathway
    K05460  HGF; hepatocyte growth factor
   04015 Rap1 signaling pathway
    K05460  HGF; hepatocyte growth factor
   04020 Calcium signaling pathway
    K05460  HGF; hepatocyte growth factor
   04151 PI3K-Akt signaling pathway
    K05460  HGF; hepatocyte growth factor
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05460  HGF; hepatocyte growth factor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05460  HGF; hepatocyte growth factor
   05205 Proteoglycans in cancer
    K05460  HGF; hepatocyte growth factor
   05208 Chemical carcinogenesis - reactive oxygen species
    K05460  HGF; hepatocyte growth factor
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05460  HGF; hepatocyte growth factor
   05226 Gastric cancer
    K05460  HGF; hepatocyte growth factor
   05218 Melanoma
    K05460  HGF; hepatocyte growth factor
   05211 Renal cell carcinoma
    K05460  HGF; hepatocyte growth factor
   05223 Non-small cell lung cancer
    K05460  HGF; hepatocyte growth factor
  09174 Infectious disease: parasitic
   05144 Malaria
    K05460  HGF; hepatocyte growth factor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05460  HGF; hepatocyte growth factor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05460  HGF; hepatocyte growth factor
   00536 Glycosaminoglycan binding proteins
    K05460  HGF; hepatocyte growth factor
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K05460  HGF; hepatocyte growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K05460  HGF; hepatocyte growth factor

Other DBs

GO:

0005171

Genes

HSA:

3082(HGF)

PPS:	100983117(HGF)

GGO:	101127877(HGF)

PON:	100462115(HGF)

PPYG:

129041077(HGF)

NLE:	100586296(HGF)

SSYN:

129484810(HGF)

MCC:	708316(HGF)

MCF:	102133907(HGF)

MTHB:

126949900

MNI:	105475398(HGF)

CSAB:

103226643(HGF)

CATY:

105583213(HGF)

PANU:

101018541(HGF)

TGE:	112620515(HGF)

MLEU:

105543916(HGF)

RRO:	104681576(HGF)

RBB:	108536940(HGF)

TFN:	117072632(HGF)

PTEH:

111552446(HGF)

CANG:

105501675(HGF)

CJC:	100385966(HGF)

SBQ:	101045517(HGF)

CIMI:

108300342(HGF)

ANAN:

105726653(HGF)

CSYR:

103249922(HGF)

MMUR:

105879346(HGF)

LCAT:

123647201(HGF)

PCOQ:

105811016(HGF)

OGA:	100963467(HGF)

MMU:	15234(Hgf)

MCAL:

110294216(Hgf)

MPAH:

110316234(Hgf)

RNO:	24446(Hgf)

MCOC:

116097489(Hgf)

ANU:	117720586(Hgf)

ASYL:

127678287(Hgf)

MUN:	110565312(Hgf)

CGE:	100764472(Hgf)

MAUA:

101829822(Hgf)

PROB:

127214533(Hgf)

PLEU:

114687327(Hgf)

MORG:

121434777 121459077

MFOT:

126500116

AAMP:

119803884(Hgf)

NGI:	103730723(Hgf)

HGL:	101707056(Hgf)

CPOC:

100730730(Hgf)

DORD:

105992969(Hgf)

DSP:	122111940(Hgf)

DMER:

138809623(Hgf)

PLOP:

125346953(Hgf)

NCAR:

124991665

MMMA:

107144587(Hgf)

ITI:	101977507(Hgf)

OCU:	100316908(HGF)

OPI:	101536351(HGF)

TUP:	102483689(HGF)

GVR:	103587362(HGF)

CFA:	403441(HGF)

CLUD:

112661349(HGF)

VVP:	112925397(HGF)

VLG:	121471954(HGF)

NPO:	129494407(HGF)

AML:	100463560(HGF)

UMR:	103658669(HGF)

UAH:	113259246(HGF)

UAR:	123789349(HGF)

ELK:

111155271

LLV:

125081138

MPUF:

101677610(HGF)

MNP:	132015990(HGF)

MLK:	131829310(HGF)

NVS:	122904762(HGF)

ORO:	101373766(HGF)

EJU:	114221299(HGF)

ZCA:	113911759(HGF)

MLX:	118020685(HGF)

NSU:	110580160(HGF)

LWW:	102740930(HGF)

FCA:	493705(HGF)

PYU:	121028796(HGF)

PCOO:

112866583(HGF)

PBG:	122487823(HGF)

PVIV:

125160804(HGF)

LRUF:

124523080

LGF:	123606383(HGF)

AJU:

106975661

PTG:	102952318(HGF)

PPAD:

109268152(HGF)

PUC:

125929849

PLEZ:

122206900(HGF)

HHV:	120221164 120245413(HGF)

BTA:	282879(HGF)

BOM:	102267837(HGF)

BIU:	109557878(HGF)

BBUB:

102406209(HGF)

BBIS:

104994516(HGF)

CHX:	102183288(HGF)

OAS:	443075(HGF)

BTAX:

128046678(HGF)

CSUM:

138080368(HGF)

ODA:	120878117(HGF)

CCAD:

122438250(HGF)

MREE:

136170686(HGF)

OVR:	110126741(HGF)

MBEZ:

129552336(HGF)

SSC:	100525120(HGF)

CFR:	102515749(HGF)

CBAI:

105062379(HGF)

CDK:	105100369(HGF)

VPC:	102532383(HGF)

BACU:

102997605

BMUS:

118900811(HGF)

LVE:	103079072(HGF)

OOR:	101273491(HGF)

LALB:

132524306(HGF)

GMF:	115840849(HGF)

DDP:	132430960(HGF)

DLE:	111164604(HGF)

PCAD:

102992196(HGF)

PSIU:

116759711(HGF)

PPHC:

136128547(HGF)

NASI:

112404733(HGF)

ECB:	100049848(HGF)

EPZ:	103563173(HGF)

EAI:	106840178(HGF)

MYB:	102259449(HGF)

MYD:	102765945(HGF)

MMYO:

118666274(HGF)

MLF:	102441297(HGF)

MDT:	132242888(HGF)

MYUM:

139016932(HGF)

PKL:	118714360(HGF)

EFUS:

103293251(HGF)

MNA:	107527167(HGF)

DRO:	112301961(HGF)

SHON:

119000987(HGF)

AJM:	119044937(HGF)

PDIC:

114507737(HGF)

PHAS:

123811490(HGF)

MMF:	118620202(HGF)

PPAM:

129063396(HGF)

HAI:	109392334(HGF)

RFQ:	117012542(HGF)

PALE:

102884470(HGF)

PGIG:

120591565(HGF)

PVP:	105295521(HGF)

RAY:	107501285(HGF)

MJV:	108399212(HGF)

TOD:	119244822(HGF)

SARA:

101546946(HGF)

SFUM:

130027741(HGF)

SETR:

126008496(HGF)

LAV:	100665493(HGF)

TMU:

101344799

ETF:	101659919(HGF)

DNM:	101445147(HGF)

MDO:	100016122(HGF)

GAS:	123249991(HGF)

SHR:	100915696(HGF)

PCW:	110206952(HGF)

TVP:	118850729(HGF)

PBRV:

138175875 138176026

MLAO:

141493126(HGF)

OAA:	100074892(HGF)

TACU:

119920951(HGF)

GGA:	395941(HGF)

PCOC:

116228074(HGF)

MGP:	100542153(HGF)

CJO:	107321440(HGF)

TPAI:

128079558(HGF)

LMUT:

125687996(HGF)

NMEL:

110392449(HGF)

APLA:

101793664(HGF)

ACYG:

106035566(HGF)

CATA:

118249402(HGF)

AFUL:

116497145(HGF)

TGU:	100218784(HGF)

LSR:	110469773(HGF)

SCAN:

103813737(HGF)

PMOA:

120509314(HGF)

OTC:	121336301(HGF)

PRUF:

121357407(HGF)

ATRC:

139588525(HGF)

GFR:	102042539(HGF)

FAB:	101810717(HGF)

OMA:	130267089(HGF)

PHI:	102106058(HGF)

PMAJ:

107205229(HGF)

CCAE:

111923284 111923285(HGF)

CCW:	104686934(HGF)

CBRC:

103612073(HGF)

ACOE:

138121758(HGF)

ETL:	114058724(HGF)

ZAB:	102069950(HGF)

ZLE:	135458074(HGF)

SVG:	106857395(HGF)

MMEA:

130579835(HGF)

HRT:	120751911(HGF)

SATI:

136361067(HGF)

CCIC:

134043370(HGF)

FPG:	101917184(HGF)

FCH:	102052167(HGF)

CCRI:

104155142(HGF)

NNT:

104409459

SHAB:

115605685(HGF)

ACUN:

113491250(HGF)

TALA:

104359062(HGF)

ACHC:

115341991(HGF)

HALD:

104320775(HGF)

HLE:	104840279(HGF)

AGEN:

126044501

HHAR:

128143192(HGF)

GCL:

127022227

CSTI:

104552859

LDI:	104349387(HGF)

MNB:	103773603(HGF)

DPUB:

104299860(HGF)

PPUS:

135174907(HGF)

AVIT:

104271212(HGF)

BRHI:

104495806(HGF)

EGZ:	104132389(HGF)

NNI:	104010752(HGF)

PCRI:

104032357

PCAO:

104045700

PADL:

103920599(HGF)

AFOR:

103904147(HGF)

FGA:	104083389(HGF)

GSTE:

104250295(HGF)

CBOY:

140650329(HGF)

CLV:	102084988(HGF)

CNIC:

135984436(HGF)

PGUU:

104459084(HGF)

PLET:

104618081

EHS:	104508841(HGF)

CMAC:

104480767(HGF)

CUCA:

104066036(HGF)

TEO:	104379562(HGF)

BREG:

104640421(HGF)

OHA:	104337639(HGF)

ACAR:

104520451(HGF)

CPEA:

104392409(HGF)

CVF:	104284639(HGF)

RTD:	128904147(HGF)

CRID:

134510349(HGF)

AAM:	106485602(HGF)

AROW:

112967578(HGF)

NPD:	112958373(HGF)

TGT:	104574728(HGF)

DNE:	112980299(HGF)

SCAM:

104144707(HGF)

ASN:	102385607(HGF)

AMJ:	102564574(HGF)

CPOO:

109315770(HGF)

GGN:	109292183(HGF)

PSS:	102451409(HGF)

CMY:	102929769(HGF)

CCAY:

125630483(HGF)

DCC:	119860386(HGF)

CPIC:

101946945(HGF)

TST:	117874925(HGF)

CABI:

116836199(HGF)

MRV:	120394336(HGF)

ACS:	100566618(hgf)

ASAO:

132776534(HGF)

PVT:	110077194(HGF)

SUND:

121930396(HGF)

PBI:

103063662

PMUR:

107297173

CTIG:

120312565(HGF)

TSR:

106554702

PGUT:

117675803(HGF)

PCAE:

139319266(HGF)

APRI:

131202315(HGF)

PTEX:

113436578(HGF)

NSS:	113412333(HGF)

VKO:	123020075(HGF)

PMUA:

114605154(HGF)

PRAF:

128421897(HGF)

ZVI:	118091334(HGF)

HCG:	128327973(HGF)

GJA:	107110492(HGF)

STOW:

125435141(HGF)

EMC:	129335365(HGF)

XLA:	108711206(hgf.L) 108713062(hgf.S)

XTR:	100495840(hgf)

NPR:	108792728(HGF)

RTEM:

120931733(HGF)

ACAT:

141131833(HGF)

BBUF:

120983011(HGF)

BGAR:

122927846(HGF)

DTC:	141054089(HGF)

PWL:	138287819(HGF)

MUO:	115479221(HGF)

GSH:	117367300(HGF)

DRE:	100334116(hgfb) 493781(hgfa)

SRX:	107723941 107732993 107738418 107738831

SANH:

107672595 107673134 107695871 107699067

SGH:	107557293 107559839 107563412 107591310

CCAR:

109071169 109081813 109108309 109108837

CAUA:

113048114 113073052 113079826 113118204

CGIB:

127933779 127956216 127974348 127974416 127977266

PTET:

122323126 122343515(hgfa)

LROH:

127163750(hgfa) 127180854

GRF:	141333312(hgfa) 141345648(hgfb)

OMC:	131523876(hgfb) 131539107(hgfa)

PPRM:

120462047 120476523(hgfa)

RKG:	130072301(hgfa) 130094859

MAMB:

125245538(hgfa) 125254287

CIDE:

127500203 127511019

CERY:

137023247(hgfb) 137023946(hgfa)

MASI:

127417070 127434838 127436761 127456213

TROS:

130548183(hgfa) 130563268

TDW:	130420926(hgfa) 130435850

MANU:

129419279(hgfb) 129431742(hgfa)

PDAB:

135750483(hgfa) 135773760(hgfb)

IPU:

108264660

IFU:

128606939

PHYP:

113534821(hgf)

SMEO:

124396193

TFD:

113652610

TVC:	132851377(hgfb)

CGAR:

128528235

NGRA:

132887874(hgfb)

TRN:	134322879(hgfb) 134324313(hgfa)

AMEX:

103033838 103045938(hgfa)

CMAO:

118812079(hgfa) 118817902

EEE:	113577168 113588284

CHAR:

105904094(hgfa) 105910388

SPIL:

134094536(hgfb)

TRU:	101064315 101078862

TFS:	130519430(hgfa) 130536520

TNG:	GSTEN00020823G001 GSTEN00035532G001

LCO:	104918123(hgf) 104918795

NCC:	104952156(hgf) 104958230

TBEN:

117485078(hgfa) 117491207

CGOB:

115009747(hgf) 115028611

PGEO:

117447549(hgfb) 117468338(hgfa)

GACU:

117537320 117545684

EMAC:

134858429(hgfb) 134878889(hgfa)

ELY:	117249132(hgfa) 117261655

EFO:	125883075(hgfa) 125887218

PLEP:

121950574 121961520(hgfa)

SLUC:

116045660 116060187(hgfa)

ECRA:

117938959(hgfa) 117948721

ESP:	116673226 116694689(hgf)

PFLV:

114550128 114560350

GAT:	120808778 120812715 120818299(hgfa)

PPUG:

119196459(hgfb) 119210907(hgfa)

AFB:	129108117 129112829(hgfa)

CLUM:

117726245(hgfa) 117732827

PSWI:

130195735 130200604(hgfa)

CANA:

137791624(hgfa) 137804041(hgfb)

CVE:	137877060(hgfa) 137881580(hgfb)

MSAM:

119893453 119918297(hgfa)

SCHU:

122871483 122875530

CUD:	121505193(hgfa) 121515535

SPUL:

138599475 138612758(hgfb)

LMIX:

132956416(hgfa) 132972398(hgfb)

ALAT:

119025110 119032739(hgfa)

ASTR:

137589303 137594492(hgfb)

MZE:	101470516(hgf) 101486965

ONL:	100704765(hgf) 100704875

OAU:	116318304 116335108(hgfa)

OLA:	101156453 101167035(hgf)

OML:	112152912 112158396

CSAI:

133424112(hgfa) 133444304(hgfb)

XMA:	102226489(hgf) 102232629

XCO:	114136644(hgf) 114161125

XHE:	116711743(hgf) 116736982

PRET:

103459222 103466001(hgf)

PFOR:

103133768(hgf) 103146203

PLAI:

106944865 106964833(hgf)

PMEI:

106904919(hgf) 106915078

GAF:	122826592(hgfa) 122835771

PPRL:

129359042 129375657

CVG:	107085972 107089218

CTUL:

119773623 119789721(hgfa)

GMU:	124857843 124882706(hgfa)

NFU:	107385652 107388871(hgf)

KMR:	108229905 108235047(hgfa)

ALIM:

106514764 106520334(hgf)

NWH:	119415687 119428491

AOCE:

111563989(hgfa) 111564882

EJA:	138206580(hgfb) 138207476(hgfa)

BFRE:

138621864 138628243(hgfb)

MCEP:

124999725(hgfA) 125015538

CSEM:

103380100(hgf) 103382777

POV:	109624365(hgf) 109632742

SSEN:

122765767(hgfa) 122776532

SSOE:

131455744(hgfa) 131470557(hgfb)

HHIP:

117757219(hgfa) 117762738

HSP:	118101930(hgfa) 118110071

PPLT:

128429094(hgfa) 128444373

SMAU:

118291790 118315498

LCF:	108875155 108879648(hgfa)

SDU:	111224573 111228480(hgf)

SLAL:

111653388(hgf) 111671911

XGL:	120793382 120801084(hgfa)

HCQ:	109523797 109526843(hgf)

SSCV:

125970635(hgfb) 125992037

SBIA:

133493674(hgfa) 133502148(hgfb)

PEE:	133397395(hgfa) 133403145(hgfb)

PTAO:

133472086(hgfa) 133477888(hgfb)

BPEC:

110161457 110166846

ENY:	140349386(hgfb) 140367328(hgfa)

MALB:

109959804 109967266(hgf)

BSPL:

114857737 114862956(hgfa)

SJO:	128353263 128358843

SSCO:

133982100(hgfb) 134004589(hgfa)

GMH:	115532538 115550795

SASA:

106561209 106573447 106576483 106609646

STRU:

115152048 115180143 115196709 115199105

OTW:	112214996(hgfa) 112219242 112245248

OMY:	110496163 110501011 110521571 118938825(hgfa)

OGO:	124001538 124005113 124013546(hgfa)

ONE:	115109462 115123754 115134744

OKI:	109867793 109879074 109886393 109889405

OKE:	118377125(hgfa) 118396152 118401177

OMM:	135509303 135515698 135524343

OCLA:

139372677 139392823 139405954

SALP:

111962524 112075847

SNH:	120031931 120050076(hgfa) 120053977 120066298

CCLU:

121531952 121543415 121549714 121576578

ELS:	105018431 105020379

OEP:	134021187(hgfb) 134037870

SFM:	108921145(hgf) 108936428

PKI:	111833314 111846155(hgf)

AANG:

118219269 118230988

AROT:

135245434 135259151

CCOG:

133118837 133135449(hgfb)

LOC:	102698086(hgf)

PSPA:

121318191 121319908

ARUT:

117415028 117420010

PSEX:

120534137

LCM:	102354206(HGF)

CMK:

RTP:

CPLA:

HOC:

LERI:

HAKA:

BBEL:

Reference

PMID:2528952

Authors

Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, et al.

Title

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.

Journal

Biochem Biophys Res Commun 163:967-73 (1989)
DOI:10.1016/0006-291X(89)92316-4

Sequence

[hsa:3082]

All links

Ontology (1)   
   GO (1)   
Gene (1166)   
   MGENES (241)   
   RefGene (920)   
   OC (5)   
All databases (1167)   

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