KEGG ORTHOLOGY: K05482

ORTHOLOGY: K05482

Entry

K05482                      KO

Symbol

IL18, IL1F4

Name

interleukin 18

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04621

NOD-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05134

Legionellosis

map05135

Yersinia infection

map05143

African trypanosomiasis

map05144

Malaria

map05152

Tuberculosis

map05164

Influenza A

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05482  IL18, IL1F4; interleukin 18
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05482  IL18, IL1F4; interleukin 18
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K05482  IL18, IL1F4; interleukin 18
   04623 Cytosolic DNA-sensing pathway
    K05482  IL18, IL1F4; interleukin 18
09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K05482  IL18, IL1F4; interleukin 18
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05482  IL18, IL1F4; interleukin 18
   05132 Salmonella infection
    K05482  IL18, IL1F4; interleukin 18
   05131 Shigellosis
    K05482  IL18, IL1F4; interleukin 18
   05135 Yersinia infection
    K05482  IL18, IL1F4; interleukin 18
   05134 Legionellosis
    K05482  IL18, IL1F4; interleukin 18
   05152 Tuberculosis
    K05482  IL18, IL1F4; interleukin 18
  09174 Infectious disease: parasitic
   05144 Malaria
    K05482  IL18, IL1F4; interleukin 18
   05143 African trypanosomiasis
    K05482  IL18, IL1F4; interleukin 18
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05482  IL18, IL1F4; interleukin 18
   05321 Inflammatory bowel disease
    K05482  IL18, IL1F4; interleukin 18
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05482  IL18, IL1F4; interleukin 18
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05482  IL18, IL1F4; interleukin 18
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05482  IL18, IL1F4; interleukin 18

Other DBs

GO:

0045515

Genes

HSA:	3606(IL18)

PTR:	739011(IL18)

PPS:	100971499(IL18)

GGO:	101138403(IL18)

PON:	100433564(IL18)

PPYG:

129008260(IL18)

NLE:	100585066(IL18)

HMH:	116476942(IL18)

SSYN:

129479656(IL18)

MCC:	574151(IL18)

MCF:	102135101(IL18)

MTHB:

126935802

MNI:	105493609(IL18)

CSAB:

103248464(IL18)

CATY:

105588688(IL18)

PANU:

101011371(IL18)

TGE:	112605580(IL18)

MLEU:

105537411(IL18)

RRO:	104677356(IL18)

RBB:	108536445(IL18)

PTEH:

111540136(IL18)

CANG:

105501023(IL18)

CJC:	100396804(IL18)

SBQ:	101027404(IL18)

CIMI:

108300504(IL18)

ANAN:

105729612(IL18)

CSYR:

103268016(IL18)

MMUR:

105862932(IL18)

LCAT:

123641690(IL18)

OGA:	100964386(IL18)

MMU:	16173(Il18)

MCAL:

110301583(Il18)

MPAH:

110328200(Il18)

RNO:	29197(Il18)

MCOC:

116072916(Il18)

ANU:	117699278(Il18)

MUN:	110562014(Il18)

CGE:	100750469(Il18)

MAUA:

101836016(Il18)

PROB:

127231713(Il18)

PLEU:

114690242(Il18)

MORG:

121438195 121438394

MFOT:

126509990

AAMP:

119810589 119810590

NGI:	103733877(Il18)

HGL:	101702804(Il18)

CPOC:

100734451(Il18)

CCAN:

109699439(Il18)

DORD:

105980688(Il18)

DSP:	122110254(Il18)

PLOP:

125348036(Il18)

NCAR:

124959757

MMMA:

107145853(Il18)

OCU:	100144338(IL18)

OPI:	101536496(IL18)

TUP:	102488248(IL18)

GVR:	103596331(IL18)

CFA:	403796(IL18)

CLUD:

112671334(IL18)

VVP:	112925988(IL18)

VLG:	121499279(IL18)

NPO:	129497319(IL18)

AML:	100484109(IL18)

UMR:	103662382(IL18)

UAH:	113260053(IL18)

UAR:	123792571(IL18)

ELK:

111153900

LLV:

125110334

MPUF:

101670212(IL18)

MNP:	132002682 132028277(IL18)

MLK:	131813672 131835948(IL18)

NVS:	122893710 122912284(IL18)

ORO:	101368106(IL18)

EJU:	114211321(IL18)

ZCA:	113913830(IL18)

MLX:	118013235(IL18)

NSU:	110586386(IL18)

LWW:	102742078(IL18)

FCA:	493688(IL18)

PYU:	121035384(IL18)

PCOO:

112866102(IL18)

PBG:	122482962(IL18)

PVIV:

125176286(IL18)

LRUF:

124504879

PTG:	102952004(IL18)

PPAD:

109278654(IL18)

PUC:

125909813

AJU:

106986372

HHV:	120229883(IL18)

BTA:	281249(IL18)

BOM:	102281355(IL18)

BIU:	109569934(IL18)

BBUB:

102401432(IL18)

BBIS:

104981315(IL18)

CHX:	100861190(IL18)

OAS:	443206(IL18)

BTAX:

128060832(IL18)

ODA:	120876254(IL18)

CCAD:

122449941(IL18)

MBEZ:

129554333(IL18)

SSC:	397057(IL18)

CFR:	102520544(IL18)

CBAI:

105080059(IL18)

CDK:	105094167(IL18)

VPC:	102540203(IL18)

BACU:

103002074(IL18)

BMUS:

118900268(IL18)

LVE:	103087219(IL18)

OOR:	101271274(IL18)

DLE:	111166897(IL18)

PCAD:

102976313(IL18)

PSIU:

116758597(IL18)

NASI:

112405739(IL18)

ECB:	100034216(IL18)

EPZ:	103565880(IL18)

EAI:	106840220(IL18)

MYB:	102260649(IL18)

MYD:	102761769(IL18)

MMYO:

118664355(IL18)

MLF:	102436271(IL18)

MDT:	132240553(IL18)

PKL:	118712991(IL18)

EFUS:

103293786(IL18)

MNA:	107531295(IL18)

DRO:	112314192(IL18)

SHON:

119000535(IL18)

AJM:	119056534(IL18)

PDIC:

114500941(IL18)

PHAS:

123819718(IL18)

MMF:	118628149(IL18)

PPAM:

129085975(IL18)

HAI:	109388707(IL18)

RFQ:	117030974(IL18)

PALE:

102885001(IL18)

PGIG:

120621996(IL18)

PVP:	105295631(IL18)

RAY:	107512960(IL18)

MJV:	108401553(IL18)

TOD:	119240673(IL18)

SARA:

101559035(IL18)

SETR:

126015838(IL18)

LAV:	100668369(IL18)

TMU:

101348624

ETF:	105978242(IL18)

DNM:	101427328(IL18)

MDO:	103101192 103101367 103102395

GAS:	123239045 123240473 123241363

SHR:	100919934 100920716(IL18) 111719790

AFZ:	127554992 127557357

PCW:	110210675(IL18) 110210730 110210731

TVP:	118836756 118836758 118838947(IL18)

OAA:	100083773(IL18)

GGA:	395312(IL18)

PCOC:

116233212(IL18)

MGP:	100303691(IL18)

CJO:	107324129(IL18)

TPAI:

128087490(IL18)

LMUT:

125703550(IL18)

NMEL:

110387565(IL18)

APLA:

101802715(IL18)

CATA:

118252395(IL18)

AFUL:

116497843(IL18)

TGU:	100217637(IL18)

LSR:	110470467(IL18)

SCAN:

103822985(IL18)

PMOA:

120508363(IL18)

OTC:	121340883(IL18)

PRUF:

121355739(IL18)

GFR:	102041240(IL18)

FAB:	101819906(IL18)

OMA:

PHI:

PMAJ:

CCAE:

CCW:	104692079(IL18)

CBRC:

103618509(IL18)

ETL:	114065628(IL18)

ZAB:	102065493(IL18)

ZLE:	135457466(IL18)

ACHL:

103810559(IL18)

SVG:	106858172(IL18)

MMEA:

130585571(IL18)

HRT:	120762619(IL18)

SATI:

136370938(IL18)

FPG:	101910930(IL18)

FCH:	102054449(IL18)

CCRI:

104156327(IL18)

NNT:	104411799(IL18)

SHAB:

115616293(IL18)

ACUN:

113488534(IL18)

TALA:

104368658(IL18)

ACHC:

115345010(IL18)

HALD:

104311772(IL18)

HLE:	104836409(IL18)

AGEN:

126038210

GCL:

127025925

CSTI:

104553432(IL18)

LDI:	104352779(IL18)

MNB:	103779936(IL18)

DPUB:

104302568(IL18)

AVIT:

104268833(IL18)

BRHI:

104496434(IL18)

EGZ:	104125907(IL18)

NNI:	104019045(IL18)

PCRI:

104025896(IL18)

PCAO:

104040362(IL18)

PADL:

103921543(IL18)

AFOR:

103895889(IL18)

FGA:	104071435(IL18)

GSTE:

104252302(IL18)

CLV:	102093971(IL18)

MUI:	104546623(IL18)

PGUU:

104459607(IL18)

PLET:

104615404(IL18)

EHS:	104504622(IL18)

CMAC:

104474761(IL18)

CUCA:

104067218(IL18)

TEO:	104384226(IL18)

BREG:

104630922(IL18)

OHA:	104338587(IL18)

ACAR:

104519255(IL18)

CPEA:

104388544(IL18)

CVF:	104284161(IL18)

RTD:

128918685

AAM:	106496023(IL18)

AROW:

112967461(IL18)

NPD:	112948749(IL18)

TGT:	104572264(IL18)

DNE:	112986542(IL18)

SCAM:

104141092(IL18)

ASN:	102369831(IL18)

AMJ:	102569730(IL18)

CPOO:

109318085(IL18)

GGN:	109292958(IL18)

PSS:	102463679(IL18)

CMY:	102933793(IL18)

CCAY:

125625437(IL18)

DCC:

119846635

CPIC:

101931104(IL18)

TST:	117868530(IL18)

CABI:

116829290(IL18)

MRV:	120375607(IL18)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:	129342730(IL18)

XLA:	108697611 108697612

XTR:	100496716 108648098(il18)

NPR:

RTEM:

BBUF:

BGAR:

MUO:	115481940 115482005

GSH:	117347793 117347918

XMA:	102222709(il18)

PRET:

103474370(il18)

CVG:

107103272

NFU:

107380752

KMR:

108247699

SASA:

100196379(il18)

OMY:	100136640(il-18)

SALP:

ELS:

SFM:

PKI:

AANG:

PSPA:

ARUT:

LCM:	102356354(IL18)

CMK:	103191153 103191155 103191156

RTP:

109919113

CPLA:

122540506 122540580

HOC:	132829623 132829672

LERI:

129712263 129712265

» show all

Reference

PMID:8666798

Authors

Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fujii M, Torigoe K, Tanimoto T, Fukuda S, Ikeda M, Okamura H, Kurimoto M

Title

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

Journal

J Immunol 156:4274-9 (1996)

Sequence

[hsa:3606]

Reference

PMID:15326478

Authors

Gaggero A, De Ambrosis A, Mezzanzanica D, Piazza T, Rubartelli A, Figini M, Canevari S, Ferrini S

Title

A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

Journal

Oncogene 23:7552-60 (2004)
DOI:10.1038/sj.onc.1208036

Sequence

[hsa:3606]

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (32)   
   KEGG PATHWAY (32)   
Drug (1)   
   KEGG DRUG (1)   
Gene (319)   
   KEGG GENES (315)   
   KEGG MGENES (3)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (357)   

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