KEGG ORTHOLOGY: K05505

ORTHOLOGY: K05505

Entry

K05505                      KO

Symbol

CXCL1_2_3, GRO

Name

C-X-C motif chemokine 1/2/3

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04621

NOD-like receptor signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05134

Legionellosis

map05146

Amoebiasis

map05167

Kaposi sarcoma-associated herpesvirus infection

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04668 TNF signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04657 IL-17 signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04062 Chemokine signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   05134 Legionellosis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Chemokines
   K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3

Genes

HSA:	2919(CXCL1) 2920(CXCL2) 2921(CXCL3)

PTR:	461255(CXCL3) 740567(CXCL1)

PPS:	100975544(CXCL3) 100976904

GGO:	101131798(CXCL1) 101133388 101134092

PON:	100438959(CXCL1) 100440799 100441532(CXCL2)

PPYG:

129035073 129035198 129035701

NLE:	100588392(CXCL3) 100591876(CXCL1) 100592551(CXCL2)

HMH:	116466971 116475080 116475085(CXCL1)

SSYN:

129491725(CXCL1) 129492252 129492254

MCC:	100424064 574222(CXCL1) 574223(CXCL3) 702067 703390

MCF:	102117979 102123272 102123657 102126138(CXCL1)

MTHB:

126954905 126954911 126954917 126955314

MNI:	105471157 105477288(CXCL2) 105477292 105477297(CXCL1) 105477387

CSAB:

103235789(CXCL1) 103235792 103235798(CXCL3) 103236682

CATY:

105576876(CXCL2) 105576880 105596235(CXCL1) 105596237 105596241

PANU:

101022800 101024554 101026663(CXCL1) 103884403

TGE:	112616891 112624653 112624697 112625022 112625248

MLEU:

105531125 105531126 105531130 105531132(CXCL1)

RRO:	104654807 104658876(CXCL1) 104658882 104658884

RBB:	108513563 108515821 108523516 108539234 108539235

TFN:	117085487 117085490 117085495

PTEH:

111524574 111528185 111531279 111531286(CXCL1)

CANG:

105501289(CXCL1) 105501293 105501298

CJC:	100389870(CXCL2) 100400489 100401955(CXCL1)

SBQ:

101048540

CIMI:

108292194 108292198

ANAN:

105725360(CXCL2) 105725378 105725381

CSYR:

103261912(CXCL1)

MMUR:

105860455

LCAT:

123624110 123624714 123624715

OGA:	100950823 100952509 100952827

MMU:	14825(Cxcl1) 20310(Cxcl2) 330122(Cxcl3)

MCAL:

110294442 110294443 110295209

MPAH:

110330904 110330924 110330950

RNO:	114105(Cxcl2) 171551(Cxcl3) 81503(Cxcl1)

MCOC:

116070642 116070643 116070644

ANU:	117712876 117712987 117713027

MUN:	110560483 110560489 110560490

CGE:	100689059(Cxcl1) 100689100(Cxcl3)

MAUA:

101827575 101834882 121140874

PROB:

127232100 127232102 127232104

PLEU:

114701719 114701735 114701736

MORG:

121460847 121460848(Cxcl3) 121460941

MFOT:

126506338 126506591 126506592

AAMP:

119816212 119816216

NGI:	103742468 103742470

HGL:	101705558(Cxcl1)

CPOC:

100135510(Cxcl1)

CCAN:

109691926 109700067

DORD:

105988528 105988529

DSP:	122106718 122106721

PLOP:

125364454 125365000

NCAR:

124994036 124994608

MMMA:

107158780 107158783

OCU:	100009245(GRO-A) 100328583(GRO-B)

OPI:	101521831 101534748 101534993

TUP:	102467686 102472622

GVR:	103590267 103591375 103600597 103600599 103600600

CFA:	119874472 119876918

CLUD:

112652148 112652150

VLG:	121472712 121473468 121473470

NPO:	129519109 129520159 129520255

AML:	100463732 100466241 100471490

UMR:	103665312 103665390

UAH:	113249943 113263276 125280957

UAR:	123787104 123789130 123789142

ELK:	111148819 111149266

LLV:	125093820 125093821 125093822

MPUF:

101672378 101672663

MNP:	132015959 132015978

MLK:	131823163 131823170 131823183

NVS:	122919245 122919267 122919268

ORO:	101365347 101377249

EJU:	114203885 114206733 114206753

ZCA:	113924854 113924855 118356741

NSU:	110591461 110591463 110591473

LWW:	102742158 102742576

FCA:	102901432 111560177 111560178

PYU:	121034414 121034424 121034449

PCOO:

112858315

PBG:	122478797 122478798 122478800

PVIV:

125163274 125164606 125164607

LRUF:

124520379 124520698 124520932

PPAD:

109277737

PUC:	125922824 125922825

AJU:	106981761 113599163 113599166

HHV:	120231058 120231111 120231112

BTA:	281212(GRO1) 281214(CXCL2) 613667(CXCL3)

BOM:

102269246

BIU:	109560573 109560578 109560579

BBUB:

102415247 102415899 102416225

BBIS:

104987311 104987339

CHX:	102182115 102182395 102182683

OAS:	101104661 114108665 443380(CXCL1)

BTAX:

128049546 128049610 128049611

ODA:	120861435 120861436 120861437

CCAD:

122428192 122428375 122428376

MBEZ:

129561737 129562028 129562061

SSC:	100525396 414904(CXCL2)

CFR:	102511405 116657068 116657069

CBAI:

105080430 105080431

CDK:	105091368 116158243 116158247

VPC:	102538005 107034385 116285036

BACU:

103005635 103005920 103006206

BMUS:

118895157 118895677 118895684

LVE:	103071404 103071675 103071959

OOR:	101277391 101285237 101285495

DLE:	111187576 111187591 111187662

PCAD:

102981375 102982314 112062060

PSIU:

116753842 116754232 116754241

NASI:

112392000 112405603 112405635 112405641

ECB:	100034121(CXCL1) 100056258(MIP-2BETA) 100233237(CXCL2)

EPZ:	103565789 103565792

EAI:	106829714 106829728 106829729

MYB:	102241767 102242280 102242586

MYD:

102760182

MMYO:

118669814 118669825 118669830

MLF:	102427247 102427544 102427867

MDT:	132218030 132218046(CXCL2)

PKL:

118705328

EFUS:

103288017 103288018 129151883

MNA:

107534487

DRO:	112319915(CXCL1) 112320502

SHON:

118999084(CXCL1) 118999119

AJM:	119052818 119059310

PDIC:

114491878 114491880 114492883

PHAS:

123831057 123831207 123831238 123831243

MMF:	118626364 118643206 118643274

PPAM:

129083870 129083875 129083885

HAI:	109371834 109371836 109394813

RFQ:	117022318 117022320 117022321

PALE:

102886142 102886385 102893266

PGIG:

120588200 120588202 120588203

PVP:

105292342

RAY:	107515315 107515316

MJV:	108397673 118969284

TOD:	119260635 119260855 119260938

SARA:

101544994 101545791

SETR:

126032263 126032541

LAV:	100665129 104846264(CXCL1)

TMU:	101346678 101357988

ETF:	101647727 101648039

DNM:	101442965 101443410

MDO:	100023783(CXCL1)

GAS:

123251660

SHR:

100915440

AFZ:	127540718 127540719

PCW:	110209790 110209791

TVP:

OAA:

TGU:

LSR:

SCAN:

PHI:

CCAE:

CLV:

ASN:	112549131 112549464

PSS:

PBI:

NSS:

PMUA:

ZVI:

XTR:

TRU:

TFS:

ELY:

ECRA:

ONL:

OML:	112141026 112156372 118597875

XCO:	114139301 114157834

XHE:	116732162 116732171 116732208

PRET:

103475946

PMEI:

106917624

GAF:

122820361

CVG:	107085231 107085241

CTUL:

119773350 119773413 119773414 119773427

GMU:	124881141 124881203

XGL:

SASA:

ONE:

SNH:

ELS:

PKI:

PSPA:

CMK:

Reference

PMID:10028286

Authors

Modi WS, Yoshimura T

Title

Isolation of novel GRO genes and a phylogenetic analysis of the CXC chemokine subfamily in mammals.

Journal

Mol Biol Evol 16:180-93 (1999)
DOI:10.1093/oxfordjournals.molbev.a026101

Reference

PMID:2970963

Authors

Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R

Title

Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

Journal

EMBO J 7:2025-33 (1988)
DOI:10.1002/j.1460-2075.1988.tb03042.x

Sequence

[hsa:2919]

Reference

PMID:2078213

Authors

Iida N, Grotendorst GR

Title

Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.

Journal

Mol Cell Biol 10:5596-9 (1990)
DOI:10.1128/MCB.10.10.5596

Sequence

[hsa:2920]

Reference

PMID:2217207

Authors

Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P, Sager R

Title

Identification of three related human GRO genes encoding cytokine functions.

Journal

Proc Natl Acad Sci U S A 87:7732-6 (1990)
DOI:10.1073/pnas.87.19.7732

Sequence

[hsa:2921]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (28)   
   KEGG PATHWAY (28)   
Gene (452)   
   KEGG GENES (442)   
   KEGG MGENES (1)   
   RefGene (4)   
   OC (5)   
Literature (4)   
   PubMed (4)   
All databases (486)   

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