KEGG   ORTHOLOGY: K05523
Entry
K05523                      KO                                     

Name
hchA
Definition
D-lactate dehydratase / protein deglycase [EC:4.2.1.130 3.5.1.124]
Pathway
ko00620  Pyruvate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K05523  hchA; D-lactate dehydratase / protein deglycase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K05523  hchA; D-lactate dehydratase / protein deglycase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.124  protein deglycase
     K05523  hchA; D-lactate dehydratase / protein deglycase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.130  D-lactate dehydratase
     K05523  hchA; D-lactate dehydratase / protein deglycase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C56: PfpI endopeptidase family
   K05523  hchA; D-lactate dehydratase / protein deglycase
Other DBs
RN: R09796
COG: COG0693
GO: 0019172 0036524
Genes
ECO: b1967(hchA)
ECJ: JW1950(hchA)
ECD: ECDH10B_2110(hchA)
EBW: BWG_1768(hchA)
ECOK: ECMDS42_1594(hchA)
ECE: Z3059(yedU)
ECS: ECs2705
ECF: ECH74115_2746(hchA)
ETW: ECSP_2573(hchA)
ELX: CDCO157_2499
EOI: ECO111_2546(hchA)
EOH: ECO103_2215(hchA)
ECOO: ECRM13514_2522(yedU)
ECOH: ECRM13516_2449(yedU)
ESL: O3K_09775
ESO: O3O_15850
ESM: O3M_09740
ECK: EC55989_2193(hchA)
ECG: E2348C_2078(hchA)
EOK: G2583_2417(hchA)
ELH: ETEC_2067
ECW: EcE24377A_2198(hchA)
ECP: ECP_1900
ENA: ECNA114_1913(yedU)
ECOS: EC958_2231(hchA)
ECV: APECO1_1002(hchA)
ECX: EcHS_A2068(hchA)
ECM: EcSMS35_1218(hchA)
ECY: ECSE_2196
ECR: ECIAI1_2047(hchA)
ECQ: ECED1_2232(hchA)
EUM: ECUMN_2258(hchA)
ECT: ECIAI39_1090(hchA)
EOC: CE10_2245(hchA)
EBR: ECB_01882(yedU)
EBL: ECD_01882(hchA)
EBD: ECBD_1680
ECI: UTI89_C2166(hchA)
EIH: ECOK1_2080(hchA)
ECZ: ECS88_2019(hchA)
ECC: c2385(yedU)
ELO: EC042_2123(hchA)
ESE: ECSF_1816
EKF: KO11_12890(hchA)
EAB: ECABU_c22250(hchA)
EDJ: ECDH1ME8569_1907(hchA)
ELW: ECW_m2139(hchA)
ELL: WFL_10490(hchA)
ELC: i14_2198(yedU)
ELD: i02_2198(yedU)
ELP: P12B_c1056(hchA)
ELF: LF82_0965(hchA)
ECOI: ECOPMV1_02055(hchA)
ECOJ: P423_10675
EFE: EFER_1951(hchA)
EAL: EAKF1_ch4074c(hchA)
ESZ: FEM44_24790(hchA)
SFL: SF2014(yedU)
SFX: S2111(yedU)
SFV: SFV_2012(yedU)
SFE: SFxv_2246(hchA)
SFN: SFy_2882
SFS: SFyv_2948
SFT: NCTC1_02190(yedU)
SSN: SSON_2023(yedU)
SBC: SbBS512_E0916(hchA)
EAE: EAE_21665
EAR: CCG29602
YRE: HEC60_06150(hchA)
SMAR: SM39_2702
SMW: SMWW4_v1c32350(hchA)
SMAF: D781_2748
SERF: L085_12445
EAM: EAMY_3249(yedU)
EAY: EAM_0353(hchA)
ETA: ETA_30440(hchA)
EPY: EpC_32470(hchA)
EPR: EPYR_03495(yedU)
ERJ: EJP617_07320(yedU)
PAM: PANA_1765(hchA)
PLF: PANA5342_2437(hchA)
PAJ: PAJ_1107(hchA)
PCOL: F1325_07900(hchA)
ETR: ETAE_2048(hchA)
ETD: ETAF_1847(hchA)
ETE: ETEE_0036(hchA)
PSHI: SAMEA2665130_1829(hchA)
ASEG: NCTC10977_00014(hchA)
APAG: EIA51_03490(hchA)
AVT: NCTC3438_00989(hchA)
RPNE: NCTC8284_03882(hchA)
RHEY: FEE42_06700(hchA)
SML: Smlt1840
SMT: Smal_1576
SMZ: SMD_1773(hchA)
VTA: B1336(hchA)
PAE: PA1135
PAEV: N297_1175(hchA)
PAEI: N296_1175(hchA)
PAU: PA14_49710(yedU)
PNC: NCGM2_2007(yedU)
PAEB: NCGM1900_1460(yedU)
PAEP: PA1S_20210
PAEM: U769_20085
PAEL: T223_21385
PAEG: AI22_13740
PAEC: M802_1171(hchA)
PAEO: M801_1175(hchA)
PMK: MDS_2717
PFO: Pfl01_2246(yedU)
PEN: PSEEN2870
PSEM: TO66_13415
PSEC: CCOS191_3061(hchA)
PSYA: AOT82_1858
ACB: A1S_2765
ABY: ABAYE0719(hchA)
ABN: AB57_3265
ABB: ABBFA_00703(hchA_1)
ABX: ABK1_3067
ABZ: ABZJ_03197(hchA)
ABD: ABTW07_3236(hchA)
ABH: M3Q_3245
ABAD: ABD1_27110(hchA)
ABAZ: P795_3320
ABAA: IX88_16995
ACC: BDGL_002217(hchA)
ACI: ACIAD1164(hchA)
AGU: AS4_33930(hchA)
ADS: FPL17_04795(hchA)
SWD: Swoo_2968
AHA: AHA_3120(hchA)
REH: H16_B1347(h16_B1347)
BCN: Bcen_5029
BCJ: BCAM0131(hchA)
BCEW: DM40_3483(hchA)
BCEO: I35_4112(hchA)
BCT: GEM_5453
BCED: DM42_5050(hchA)
BLAT: WK25_19845
BSTG: WT74_24065
DAC: Daci_2046
SHZ: shn_04630
LNE: FZC33_14180(hchA)
BID: Bind_2506
PAMN: JCM7685_0332(hchA)
SPAU: DRN02_015890(hchA)
GXY: GLX_23440
KEU: S101446_03111(hchA)
AOY: EOV40_007355(hchA)
SAU: SA0509
SAV: SAV0551
SAW: SAHV_0549
SAM: MW0506
SAS: SAS0509
SAR: SAR0556
SAC: SACOL0597
SAE: NWMN_0513
SAD: SAAV_0514
SUU: M013TW_0538(hchA)
SUE: SAOV_0586
SUC: ECTR2_505
SUZ: MS7_0541
SUG: SAPIG0626
SAUA: SAAG_00969
SAUE: RSAU_000503(hchA)
SAUS: SA40_0491
SAUU: SA957_0506
SAUG: SA268_0504
SAUT: SAI1T1_2004220(hchA)
SAUJ: SAI2T2_1004220(hchA)
SAUK: SAI3T3_1004220(hchA)
SAUQ: SAI4T8_1004220(hchA)
SAUV: SAI7S6_1004210(hchA)
SAUW: SAI5S5_1004190(hchA)
SAUX: SAI6T6_1004200(hchA)
SAUY: SAI8T7_1004210(hchA)
SAUF: X998_0592
SAB: SAB0502
SAUB: C248_0626
SAUM: BN843_5440
SAUC: CA347_567
SAUR: SABB_00602(hchA)
SAUI: AZ30_02790
SAUD: CH52_03000
SAMS: NI36_02740
SPAS: STP1_1532(hchA)
GHA: NCTC10459_00603(hchA)
DPM: FNV33_01550(hchA)
AIN: Acin_1683
MFJ: MFLOJ_00940(hchA)
MAB: MAB_1932c
MABB: MASS_1920
MCHE: BB28_10055
MSTE: MSTE_01869
SALS: SLNWT_1739
DAY: FV141_02565(hchA)
SERJ: SGUI_2126
PSEE: FRP1_13125
PSEH: XF36_09380
PAUT: Pdca_36460(hchA)
EKE: EK0264_05750(hchA)
FLL: EI427_16705(hchA)
RAI: RA0C_1004
RAR: RIA_1482
RAG: B739_1117
RAE: G148_0856
RAT: M949_1586
WIN: WPG_2158
EBV: F0358_13370(hchA)
FBU: UJ101_01147(hchA)
 » show all
Reference
  Authors
Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS
  Title
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.
  Journal
J Biol Chem 278:44552-9 (2003)
DOI:10.1074/jbc.M304517200
Reference
  Authors
Subedi KP, Choi D, Kim I, Min B, Park C
  Title
Hsp31 of Escherichia coli K-12 is glyoxalase III.
  Journal
Mol Microbiol 81:926-36 (2011)
DOI:10.1111/j.1365-2958.2011.07736.x
  Sequence
[eco:b1967]
Reference
  Authors
Malki A, Caldas T, Abdallah J, Kern R, Eckey V, Kim SJ, Cha SS, Mori H, Richarme G
  Title
Peptidase activity of the Escherichia coli Hsp31 chaperone.
  Journal
J Biol Chem 280:14420-6 (2005)
DOI:10.1074/jbc.M408296200

KEGG   ORTHOLOGY: K18881
Entry
K18881                      KO                                     

Name
DJ1D
Definition
D-lactate dehydratase [EC:4.2.1.130]
Pathway
ko00620  Pyruvate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K18881  DJ1D; D-lactate dehydratase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K18881  DJ1D; D-lactate dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.130  D-lactate dehydratase
     K18881  DJ1D; D-lactate dehydratase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C56: PfpI endopeptidase family
   K18881  DJ1D; D-lactate dehydratase
Other DBs
RN: R09796
GO: 0019172
Genes
ATH: AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY: 9312329 9317686 9318316
CRB: 17887335 17890045 17893619
CSAT: 104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUS: EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP: 103829987 103864103 103870900
BNA: 106352871 106410448 106446299 106453221
BOE: 106300197 106336900 106343236
RSZ: 108814118 108829307 108834072 108861274
THJ: 104802426 104824175 104824176
CIT: 102624325
VRA: 106776237
VAR: 108340996
VUN: 114187101
CCAJ: 109799212
CAM: 101494485
LJA: Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
CSV: 101208672
CMO: 103494789
MCHA: 111013252
CMAX: 111492880
CMOS: 111452219
CPEP: 111788975
QSU: 112040100
VVI: 100247956
SLY: 101263864
SPEN: 107011681
SOT: 102591897
CANN: 107859656
NSY: 104230336
NTO: 104106699
NAU: 109226966
INI: 109167578
SIND: 105175971
HAN: 110912749
CCAV: 112515269
SOE: 110798222
DOSA: Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
OBR: 102700620
BDI: 100841497
ATS: 109758946(LOC109758946) 109776890(LOC109776890)
ZMA: 100280536
PDA: 103717548
MUS: 103978686
DCT: 110107083
PEQ: 110033908
ATR: 18437741
PPP: 112287601
 » show all
Reference
  Authors
Kwon K, Choi D, Hyun JK, Jung HS, Baek K, Park C
  Title
Novel glyoxalases from Arabidopsis thaliana.
  Journal
FEBS J 280:3328-39 (2013)
DOI:10.1111/febs.12321
  Sequence
[ath:AT3G02720]

KEGG   ORTHOLOGY: K22211
Entry
K22211                      KO                                     

Name
GLX3, HSP31
Definition
D-lactate dehydratase [EC:4.2.1.130]
Pathway
ko00620  Pyruvate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K22211  GLX3, HSP31; D-lactate dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.130  D-lactate dehydratase
     K22211  GLX3, HSP31; D-lactate dehydratase
Other DBs
RN: R09796
COG: COG0693
GO: 0019172
Genes
APRO: F751_5969
SCE: YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
KLA: KLLA0_D00682g KLLA0_D00704g
KMX: KLMA_80019(HSP31)
VPO: Kpol_1058p1 Kpol_196p3
CGR: CAGL0C00275g
TBL: TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDL: TDEL_0F00110(TDEL0F00110)
KAF: KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
DHA: DEHA2D00880g DEHA2E03762g DEHA2E17270g DEHA2G01474g
CAL: CAALFM_C302610CA(GLX3)
SLB: AWJ20_5029(HSP31)
SSCK: SPSK_04538
ANG: ANI_1_1122094(An11g08940)
PBN: PADG_11179(PADG_00973)
ABE: ARB_05407
TVE: TRV_03863
TASA: A1Q1_00757
MGL: MGL_4192
 » show all
Reference
  Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
  Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
  Journal
J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784
  Sequence

KEGG   ENZYME: 4.2.1.130
Entry
EC 4.2.1.130                Enzyme                                 

Name
D-lactate dehydratase;
glyoxylase III;
GLO3
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(R)-lactate hydro-lyase
Reaction(IUBMB)
(R)-lactate = 2-oxopropanal + H2O [RN:R09796]
Reaction(KEGG)
R09796
Substrate
(R)-lactate [CPD:C00256]
Product
2-oxopropanal [CPD:C00546];
H2O [CPD:C00001]
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
History
EC 4.2.1.130 created 2011
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05523  D-lactate dehydratase / protein deglycase
K18881  D-lactate dehydratase
K22211  D-lactate dehydratase
Genes
ATH: AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY: 9312329 9317686 9318316
CRB: 17887335 17890045 17893619
CSAT: 104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUS: EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP: 103829987 103864103 103870900
BNA: 106352871 106410448 106446299 106453221
BOE: 106300197 106336900 106343236
RSZ: 108814118 108829307 108834072 108861274
THJ: 104802426 104824175 104824176
CIT: 102624325
VRA: 106776237
VAR: 108340996
VUN: 114187101
CCAJ: 109799212
CAM: 101494485
LJA: Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
CSV: 101208672
CMO: 103494789
MCHA: 111013252
CMAX: 111492880
CMOS: 111452219
CPEP: 111788975
QSU: 112040100
VVI: 100247956
SLY: 101263864
SPEN: 107011681
SOT: 102591897
CANN: 107859656
NSY: 104230336
NTO: 104106699
NAU: 109226966
INI: 109167578
SIND: 105175971
HAN: 110912749
CCAV: 112515269
SOE: 110798222
DOSA: Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
OBR: 102700620
BDI: 100841497
ATS: 109758946(LOC109758946) 109776890(LOC109776890)
ZMA: 100280536
PDA: 103717548
MUS: 103978686
DCT: 110107083
PEQ: 110033908
ATR: 18437741
PPP: 112287601
APRO: F751_5969
SCE: YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
KMX: KLMA_80019(HSP31)
TBL: TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDL: TDEL_0F00110(TDEL0F00110)
KAF: KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
CAL: CAALFM_C302610CA(GLX3)
SLB: AWJ20_5029(HSP31)
SSCK: SPSK_04538
ANG: ANI_1_1122094(An11g08940)
PBN: PADG_11179(PADG_00973)
ABE: ARB_05407
TVE: TRV_03863
TASA: A1Q1_00757
MGL: MGL_4192
ECO: b1967(hchA)
ECJ: JW1950(hchA)
ECD: ECDH10B_2110(hchA)
EBW: BWG_1768(hchA)
ECOK: ECMDS42_1594(hchA)
ECE: Z3059(yedU)
ECS: ECs2705
ECF: ECH74115_2746(hchA)
ETW: ECSP_2573(hchA)
EOI: ECO111_2546(hchA)
EOH: ECO103_2215(hchA)
ECOO: ECRM13514_2522(yedU)
ECOH: ECRM13516_2449(yedU)
ESL: O3K_09775
ESO: O3O_15850
ESM: O3M_09740
ECK: EC55989_2193(hchA)
ECG: E2348C_2078(hchA)
EOK: G2583_2417(hchA)
ELH: ETEC_2067
ECW: EcE24377A_2198(hchA)
ECP: ECP_1900
ENA: ECNA114_1913(yedU)
ECOS: EC958_2231(hchA)
ECV: APECO1_1002(hchA)
ECX: EcHS_A2068(hchA)
ECM: EcSMS35_1218(hchA)
ECY: ECSE_2196
ECR: ECIAI1_2047(hchA)
ECQ: ECED1_2232(hchA)
EUM: ECUMN_2258(hchA)
ECT: ECIAI39_1090(hchA)
EOC: CE10_2245(hchA)
EBR: ECB_01882(yedU)
EBL: ECD_01882(hchA)
EBD: ECBD_1680
ECI: UTI89_C2166(hchA)
EIH: ECOK1_2080(hchA)
ECZ: ECS88_2019(hchA)
ECC: c2385(yedU)
ELO: EC042_2123(hchA)
ESE: ECSF_1816
EKF: KO11_12890(hchA)
EAB: ECABU_c22250(hchA)
EDJ: ECDH1ME8569_1907(hchA)
ELW: ECW_m2139(hchA)
ELL: WFL_10490(hchA)
ELC: i14_2198(yedU)
ELD: i02_2198(yedU)
ELP: P12B_c1056(hchA)
ELF: LF82_0965(hchA)
ECOI: ECOPMV1_02055(hchA)
ECOJ: P423_10675
EFE: EFER_1951(hchA)
EAL: EAKF1_ch4074c(hchA)
ESZ: FEM44_24790(hchA)
SFL: SF2014(yedU)
SFX: S2111(yedU)
SFV: SFV_2012(yedU)
SFE: SFxv_2246(hchA)
SFN: SFy_2882
SFS: SFyv_2948
SFT: NCTC1_02190(yedU)
SSN: SSON_2023(yedU)
SBC: SbBS512_E0916(hchA)
EAE: EAE_21665
EAR: CCG29602
YRE: HEC60_06150(hchA)
SMAR: SM39_2702
SMW: SMWW4_v1c32350(hchA)
SMAF: D781_2748
SERF: L085_12445
EAM: EAMY_3249(yedU)
EAY: EAM_0353(hchA)
ETA: ETA_30440(hchA)
EPY: EpC_32470(hchA)
EPR: EPYR_03495(yedU)
ERJ: EJP617_07320(yedU)
PAM: PANA_1765(hchA)
PLF: PANA5342_2437(hchA)
PAJ: PAJ_1107(hchA)
PCOL: F1325_07900(hchA)
ETR: ETAE_2048(hchA)
ETD: ETAF_1847(hchA)
ETE: ETEE_0036(hchA)
PSHI: SAMEA2665130_1829(hchA)
ASEG: NCTC10977_00014(hchA)
APAG: EIA51_03490(hchA)
AVT: NCTC3438_00989(hchA)
RPNE: NCTC8284_03882(hchA)
RHEY: FEE42_06700(hchA)
SML: Smlt1840
SMT: Smal_1576
SMZ: SMD_1773(hchA)
VTA: B1336(hchA)
PAE: PA1135
PAEV: N297_1175(hchA)
PAEI: N296_1175(hchA)
PAU: PA14_49710(yedU)
PNC: NCGM2_2007(yedU)
PAEB: NCGM1900_1460(yedU)
PAEP: PA1S_20210
PAEM: U769_20085
PAEL: T223_21385
PAEG: AI22_13740
PAEC: M802_1171(hchA)
PAEO: M801_1175(hchA)
PMK: MDS_2717
PFO: Pfl01_2246(yedU)
PEN: PSEEN2870
PSEM: TO66_13415
PSEC: CCOS191_3061(hchA)
PSYA: AOT82_1858
ACB: A1S_2765
ABY: ABAYE0719(hchA)
ABN: AB57_3265
ABB: ABBFA_00703(hchA_1)
ABX: ABK1_3067
ABZ: ABZJ_03197(hchA)
ABD: ABTW07_3236(hchA)
ABH: M3Q_3245
ABAD: ABD1_27110(hchA)
ABAZ: P795_3320
ABAA: IX88_16995
ACC: BDGL_002217(hchA)
ACI: ACIAD1164(hchA)
AGU: AS4_33930(hchA)
ADS: FPL17_04795(hchA)
SWD: Swoo_2968
AHA: AHA_3120(hchA)
REH: H16_B1347(h16_B1347)
BCN: Bcen_5029
BCJ: BCAM0131(hchA)
BCEW: DM40_3483(hchA)
BCEO: I35_4112(hchA)
BCT: GEM_5453
BCED: DM42_5050(hchA)
BLAT: WK25_19845
BSTG: WT74_24065
DAC: Daci_2046
SHZ: shn_04630
LNE: FZC33_14180(hchA)
BID: Bind_2506
PAMN: JCM7685_0332(hchA)
SPAU: DRN02_015890(hchA)
GXY: GLX_23440
KEU: S101446_03111(hchA)
AOY: EOV40_007355(hchA)
SAU: SA0509
SAV: SAV0551
SAW: SAHV_0549
SAM: MW0506
SAS: SAS0509
SAR: SAR0556
SAC: SACOL0597
SAE: NWMN_0513
SAD: SAAV_0514
SUU: M013TW_0538(hchA)
SUE: SAOV_0586
SUC: ECTR2_505
SUZ: MS7_0541
SUG: SAPIG0626
SAUA: SAAG_00969
SAUE: RSAU_000503(hchA)
SAUS: SA40_0491
SAUU: SA957_0506
SAUG: SA268_0504
SAUT: SAI1T1_2004220(hchA)
SAUJ: SAI2T2_1004220(hchA)
SAUK: SAI3T3_1004220(hchA)
SAUQ: SAI4T8_1004220(hchA)
SAUV: SAI7S6_1004210(hchA)
SAUW: SAI5S5_1004190(hchA)
SAUX: SAI6T6_1004200(hchA)
SAUY: SAI8T7_1004210(hchA)
SAUF: X998_0592
SAB: SAB0502
SAUB: C248_0626
SAUM: BN843_5440
SAUC: CA347_567
SAUR: SABB_00602(hchA)
SAUI: AZ30_02790
SAUD: CH52_03000
SAMS: NI36_02740
SPAS: STP1_1532(hchA)
GHA: NCTC10459_00603(hchA)
DPM: FNV33_01550(hchA)
AIN: Acin_1683
MFJ: MFLOJ_00940(hchA)
MAB: MAB_1932c
MABB: MASS_1920
MCHE: BB28_10055
MSTE: MSTE_01869
SALS: SLNWT_1739
DAY: FV141_02565(hchA)
SERJ: SGUI_2126
PSEE: FRP1_13125
PSEH: XF36_09380
PAUT: Pdca_36460(hchA)
EKE: EK0264_05750(hchA)
FLL: EI427_16705(hchA)
RAI: RA0C_1004
RAR: RIA_1482
RAG: B739_1117
RAE: G148_0856
RAT: M949_1586
WIN: WPG_2158
EBV: F0358_13370(hchA)
FBU: UJ101_01147(hchA)
 » show all
Reference
1  [PMID:24302734]
  Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
  Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
  Journal
J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784
  Sequence
Reference
2  [PMID:24758716]
  Authors
Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y
  Title
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
  Journal
BMC Evol Biol 14:86 (2014)
DOI:10.1186/1471-2148-14-86
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.130
IUBMB Enzyme Nomenclature: 4.2.1.130
ExPASy - ENZYME nomenclature database: 4.2.1.130
BRENDA, the Enzyme Database: 4.2.1.130

KEGG   REACTION: R09796
Entry
R09796                      Reaction                               

Name
(R)-lactate hydro-lyase
Definition
(R)-Lactate <=> Methylglyoxal + H2O
Equation
Reaction class
RC02658  C00256_C00546
Enzyme
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K05523  D-lactate dehydratase / protein deglycase [EC:4.2.1.130 3.5.1.124]
K18881  D-lactate dehydratase [EC:4.2.1.130]
K22211  D-lactate dehydratase [EC:4.2.1.130]
Other DBs
RHEA: 27757

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