KEGG   ORTHOLOGY: K05551Help
Entry
K05551                      KO                                     

Name
actI1, oxyA, tcmK, snoa1, aknB, mtmP
Definition
minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
   00253 Tetracycline biosynthesis
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
   01008 Polyketide biosynthesis proteins
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
    2.3.1.260  tetracycline polyketide synthase
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
    2.3.1.-  
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
BRITE hierarchy
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
MBD: MEBOL_003040
ABF: AMK58_25510
SPAE: E2C16_10950
MSAO: MYCSP_12700
MSAL: DSM43276_02543
NBR: O3I_007445 O3I_015110
NNO: NONO_c10810
NTP: CRH09_08670
NOZ: DMB37_03470
SCO: SCO5087(actIORF1)
SMA: SAVERM_2376(pks9-4)
SSX: SACTE_5202 SACTE_6346
SFA: Sfla_5318
SBH: SBI_06844
SHY: SHJG_1189
SHO: SHJGH_1024
SVE: SVEN_5977 SVEN_5980
SDV: BN159_2471 BN159_2515(tcmK)
SALS: SLNWT_5121
STRP: F750_1305(whiE-KS)
SFI: SFUL_4002 SFUL_6285
SCI: B446_13320
SALU: DC74_6590
SALL: SAZ_34270
SLV: SLIV_12950
SGU: SGLAU_26355(tcmK) SGLAU_28980
SVT: SVTN_18780 SVTN_28595
STRE: GZL_p00214
SCW: TU94_31825
SLD: T261_0018 T261_6830
SXI: SXIM_35610
STRC: AA958_14835 AA958_30255
SAMB: SAM23877_0196(alpA) SAM23877_0208(alpR) SAM23877_7465(alpR) SAM23877_7477(alpA)
SPRI: SPRI_0266 SPRI_0280 SPRI_7073 SPRI_7087
SCZ: ABE83_16245
SCX: AS200_01095
SRW: TUE45_01297 TUE45_01570
STRF: ASR50_01175 ASR50_34265
SPAV: Spa2297_32720
SGS: AVL59_46045
SLS: SLINC_6895
STRD: NI25_18955
SVU: B1H20_09640
SPUN: BFF78_19350
SLAU: SLA_3074
SALJ: SMD11_0675(actI1) SMD11_6044(actI1)
SLX: SLAV_40245 SLAV_40510
SNZ: DC008_13180
SGE: DWG14_07360
KAB: B7C62_31265
KAU: B6264_18490
KIT: CFP65_4148
LMOI: VV02_05815
TFU: Tfu_1218
TCU: Tcur_2773
SRO: Sros_4150
NOA: BKM31_22830
FRA: Francci3_4101
FRI: FraEuI1c_1317
SVI: Svir_33690
AMD: AMED_5435(fabF)
AMN: RAM_27705
AMM: AMES_5370(fabF)
AMZ: B737_5370(fabF)
PSEQ: AD006_30020
PECQ: AD017_31230
PHH: AFB00_31125
SESP: BN6_40990 BN6_54860
KAL: KALB_7831
KPHY: AOZ06_32115
LED: BBK82_02455
AHM: TL08_10465
ACTI: UA75_11090
ACAD: UA74_11000
AHG: AHOG_10345
ACTA: C1701_02400
ALO: CRK55091
PMAD: BAY61_07810
STP: Strop_2223
MAU: Micau_4019
MIL: ML5_4402
MICH: FJK98_03840
VMA: VAB18032_18175
AMS: AMIS_50430 AMIS_50640
ACTN: L083_3109
PLK: CIK06_11005
CAI: Caci_3546 Caci_6485
AG: AAA65206(dpsA) AAF70106(aknB) AAG30189(zhuB) AAZ78325(oxyA) CAA12017(snoa1) CAA61989(mtmP)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5087]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
  Sequence
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (20)   
   KEGG ENZYME (2)   
   KEGG REACTION (10)   
   KEGG RCLASS (8)   
Gene (140)   
   KEGG GENES (115)   
   KEGG MGENES (14)   
   RefGene (7)   
   OC (4)   
Protein sequence (99)   
   UniProt (98)   
   SWISS-PROT (1)   
Literature (6)   
   PubMed (6)   
All databases (278)   

Download RDF
KEGG   ORTHOLOGY: K05552Help
Entry
K05552                      KO                                     

Name
actI2, oxyB, tcmL, snoa2, aknC, mtmK
Definition
minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
   00253 Tetracycline biosynthesis
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
   01008 Polyketide biosynthesis proteins
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    2.3.1.260  tetracycline polyketide synthase
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    2.3.1.-  
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
BRITE hierarchy
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
MBD: MEBOL_003041
MSAO: MYCSP_12695
MSAL: DSM43276_02542
NBR: O3I_007450 O3I_015115
NNO: NONO_c10800
NTP: CRH09_08675
NOZ: DMB37_03465
SCO: SCO5088(actIORF2)
SMA: SAVERM_2375(pks9-3)
SSX: SACTE_5203 SACTE_6347
SFA: Sfla_5317
SBH: SBI_06845
SHY: SHJG_1188
SHO: SHJGH_1023
SVE: SVEN_5981
SDV: BN159_2470 BN159_2514(tcmL)
SALS: SLNWT_5122
STRP: F750_1306(whiE-CLF)
SFI: SFUL_4003
SCI: B446_13325
SALU: DC74_6591
SALL: SAZ_34275
SLV: SLIV_12945
SGU: SGLAU_26360(tcmL) SGLAU_28975
SVT: SVTN_18775 SVTN_28600
STRE: GZL_p00215
SCW: TU94_31830
SLD: T261_0019 T261_6831
SXI: SXIM_35600
STRM: M444_36340
STRC: AA958_14840 AA958_30260
SAMB: SAM23877_0195(alpB) SAM23877_0207(alpQ) SAM23877_7466(alpQ) SAM23877_7478(alpB)
SPRI: SPRI_0267 SPRI_0278 SPRI_7075 SPRI_7086
SCZ: ABE83_16240
SCX: AS200_01090
SRW: TUE45_01296 TUE45_01569
STRF: ASR50_01170 ASR50_34270
SPAV: Spa2297_32725
SGS: AVL59_46040
SLS: SLINC_6894
STRD: NI25_18960
SVU: B1H20_09645
SPUN: BFF78_19355
SLAU: SLA_3073
SALJ: SMD11_0676(actI2) SMD11_1144(actI2) SMD11_6045(actI2)
SLX: SLAV_40240 SLAV_40515
SNZ: DC008_13175
SGE: DWG14_07359
KAB: B7C62_31270
KAU: B6264_18495
KIT: CFP65_4149
LMOI: VV02_05820
PACD: EGX94_12535
TFU: Tfu_1219
TCU: Tcur_2772
SRO: Sros_4151
NOA: BKM31_22870
FRA: Francci3_4100 Francci3_4148
FRI: FraEuI1c_1318
SVI: Svir_33700
AMD: AMED_5434(fabF)
AMN: RAM_27700
AMM: AMES_5369(fabF)
AMZ: B737_5369(fabF)
PSEQ: AD006_30015
PECQ: AD017_31235
PHH: AFB00_31130
SESP: BN6_54870
KAL: KALB_7830
KPHY: AOZ06_32110
LED: BBK82_02450
AHM: TL08_10470
ACTI: UA75_11095
ACAD: UA74_11005
AHG: AHOG_10350
ACTA: C1701_02395
ALO: CRK55092
PMAD: BAY61_07805
STP: Strop_2224
MAU: Micau_4018
MIL: ML5_4403
MICH: FJK98_03845
VMA: VAB18032_18170
AMS: AMIS_50420 AMIS_50650
ACTN: L083_3108
PLK: CIK06_11010
CAI: Caci_3547 Caci_6486
AG: AAA65207(dpsB) AAF70107(aknC) AAG30188(zhuA) AAZ78326(oxyB) CAA12018(snoa2) CAA61990(mtmK)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5088]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
  Sequence
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (20)   
   KEGG ENZYME (2)   
   KEGG REACTION (10)   
   KEGG RCLASS (8)   
Gene (133)   
   KEGG GENES (114)   
   KEGG MGENES (11)   
   RefGene (6)   
   OC (2)   
Protein sequence (99)   
   UniProt (98)   
   SWISS-PROT (1)   
Literature (6)   
   PubMed (6)   
All databases (271)   

Download RDF
KEGG   ORTHOLOGY: K05553Help
Entry
K05553                      KO                                     

Name
actI3, oxyC, tcmM, snoa3, aknD, mtmS
Definition
minimal PKS acyl carrier protein
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   00253 Tetracycline biosynthesis
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   01008 Polyketide biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
BRITE hierarchy
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
MBD: MEBOL_003042
MSAO: MYCSP_12690
MSAL: DSM43276_02541
NBR: O3I_007455 O3I_010615 O3I_015120
NNO: NONO_c10790
NTP: CRH09_08680
NOZ: DMB37_03460
SCO: SCO5089(actIORF3)
SMA: SAVERM_2373(pks9-1)
SSX: SACTE_5205 SACTE_6348
SFA: Sfla_5316
SBH: SBI_06846
SHY: SHJG_1187
SHO: SHJGH_1022
SVE: SVEN_5982
SDV: BN159_2492 BN159_2513
SALS: SLNWT_5123
STRP: F750_1307
SFI: SFUL_4004
SCI: B446_13330
SALU: DC74_6592
SALL: SAZ_34280
SLV: SLIV_12940 SLIV_31430
SGU: SGLAU_26365(tcmM)
SVT: SVTN_18770 SVTN_28605
STRE: GZL_p00216
SCW: TU94_31835
SLD: T261_0020 T261_6832
SXI: SXIM_35580 SXIM_35680
STRC: AA958_14845 AA958_30265
SAMB: SAM23877_0194(alpC) SAM23877_7479(alpC)
SPRI: SPRI_0265 SPRI_0277 SPRI_7076 SPRI_7088
SCZ: ABE83_16235
SCX: AS200_01425
SRW: TUE45_01110 TUE45_01317 TUE45_01568
STRF: ASR50_01165 ASR50_34275
SPAV: Spa2297_32730
SGS: AVL59_46035
SLS: SLINC_6893
STRD: NI25_18965
SVU: B1H20_09515
SPUN: BFF78_19345
SLAU: SLA_3072
SALJ: SMD11_0677(actI3) SMD11_1145(actI3) SMD11_6046(actI3)
SLX: SLAV_40235 SLAV_40285
SNZ: DC008_13170
SGE: DWG14_07358
KSK: KSE_58090
KAB: B7C62_31275
KAU: B6264_18500
KIT: CFP65_4142
LMOI: VV02_05825
PACD: EGX94_11640
TFU: Tfu_1220
TCU: Tcur_2794
SRO: Sros_4152
NOA: BKM31_22705
FRA: Francci3_4099 Francci3_4147
FRI: FraEuI1c_1319
SVI: Svir_33710
AMD: AMED_5433(actI)
AMN: RAM_27695
AMM: AMES_5368(actI)
AMZ: B737_5368(actI)
PSEQ: AD006_30010
PECQ: AD017_31240
PHH: AFB00_31135
SESP: BN6_54880(acp5)
KAL: KALB_7829
KPHY: AOZ06_32105
LED: BBK82_02475
AHM: TL08_10475
ACTI: UA75_11100
ACAD: UA74_11010
AHG: AHOG_10355
ACTA: C1701_02390
ALO: CRK55093
PMAD: BAY61_07800
STP: Strop_2225
MAU: Micau_4017
MIL: ML5_4404
MICH: FJK98_03855
VMA: VAB18032_18165
AMS: AMIS_50440
PLK: CIK06_11015
CAI: Caci_3548 Caci_6487
AG: AAD04718(dpsG) AAF70108(aknD) AAG30201(zhuN) AAZ78327(oxyC) CAA12019(snoa3) CAA61991(mtmS)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5089]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
  Sequence
Reference
PMID:1592832
  Authors
Shen B, Summers RG, Gramajo H, Bibb MJ, Hutchinson CR
  Title
Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase.
  Journal
J Bacteriol 174:3818-21 (1992)
DOI:10.1128/JB.174.11.3818-3821.1992
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (18)   
   KEGG REACTION (10)   
   KEGG RCLASS (8)   
Gene (128)   
   KEGG GENES (113)   
   KEGG MGENES (3)   
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   OC (4)   
Protein sequence (100)   
   UniProt (98)   
   SWISS-PROT (2)   
Literature (7)   
   PubMed (7)   
All databases (265)   

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KEGG   ENZYME: 2.3.1.235Help
Entry
EC 2.3.1.235                Enzyme                                 

Name
tetracenomycin F2 synthase;
TCM PKS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:acetate malonyltransferase (tetracenomycin F2 forming)
Reaction(IUBMB)
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O [RN:R10960]
Reaction(KEGG)
R10960;
(other) R06643 R09269
Show
Substrate
malonyl-CoA [CPD:C00083]
Product
tetracenomycin F2 [CPD:C12366];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules.
History
EC 2.3.1.235 created 2014
Pathway
ec01056  Biosynthesis of type II polyketide backbone
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K05551  minimal PKS ketosynthase (KS/KS alpha)
K05552  minimal PKS chain-length factor (CLF/KS beta)
K15886  multifunctional cyclase / dehydratase / O-methyltransferase
Genes
MBD: MEBOL_003040 MEBOL_003041
ABF: AMK58_25510
SPAE: E2C16_10950
MSAO: MYCSP_12695 MYCSP_12700
MSAL: DSM43276_02542 DSM43276_02543
NBR: O3I_007445 O3I_007450 O3I_015110 O3I_015115
NNO: NONO_c10800 NONO_c10810
NTP: CRH09_08670 CRH09_08675
NOZ: DMB37_03465 DMB37_03470
SCO: SCO5087(actIORF1) SCO5088(actIORF2)
SMA: SAVERM_2375(pks9-3) SAVERM_2376(pks9-4)
SSX: SACTE_5202 SACTE_5203 SACTE_6346 SACTE_6347
SFA: Sfla_5317 Sfla_5318
SBH: SBI_06844 SBI_06845
SHY: SHJG_1188 SHJG_1189
SHO: SHJGH_1023 SHJGH_1024
SVE: SVEN_5977 SVEN_5980 SVEN_5981
SDV: BN159_2470 BN159_2471 BN159_2514(tcmL) BN159_2515(tcmK)
SALS: SLNWT_5121 SLNWT_5122
STRP: F750_1305(whiE-KS) F750_1306(whiE-CLF)
SFI: SFUL_4002 SFUL_4003 SFUL_6285
SCI: B446_13320 B446_13325
SALU: DC74_6590 DC74_6591
SALL: SAZ_34270 SAZ_34275
SLV: SLIV_12945 SLIV_12950
SGU: SGLAU_26355(tcmK) SGLAU_26360(tcmL) SGLAU_26370(tcmN) SGLAU_28975 SGLAU_28980
SVT: SVTN_18775 SVTN_18780 SVTN_28595 SVTN_28600
STRE: GZL_p00214 GZL_p00215
SCW: TU94_31825 TU94_31830
SLD: T261_0018 T261_0019 T261_6830 T261_6831
SXI: SXIM_35600 SXIM_35610
STRM: M444_36340
STRC: AA958_14835 AA958_14840 AA958_30255 AA958_30260
SAMB: SAM23877_0195(alpB) SAM23877_0196(alpA) SAM23877_0207(alpQ) SAM23877_0208(alpR) SAM23877_7465(alpR) SAM23877_7466(alpQ) SAM23877_7477(alpA) SAM23877_7478(alpB)
SPRI: SPRI_0266 SPRI_0267 SPRI_0278 SPRI_0280 SPRI_7073 SPRI_7075 SPRI_7086 SPRI_7087
SCZ: ABE83_16240 ABE83_16245
SCX: AS200_01090 AS200_01095
SRW: TUE45_01296 TUE45_01297 TUE45_01569 TUE45_01570
STRF: ASR50_01170 ASR50_01175 ASR50_34265 ASR50_34270
SPAV: Spa2297_32720 Spa2297_32725
SGS: AVL59_46040 AVL59_46045
SLS: SLINC_6894 SLINC_6895
STRD: NI25_18955 NI25_18960
SVU: B1H20_09640 B1H20_09645
SPUN: BFF78_19350 BFF78_19355
SLAU: SLA_3073 SLA_3074
SALJ: SMD11_0675(actI1) SMD11_0676(actI2) SMD11_1144(actI2) SMD11_6044(actI1) SMD11_6045(actI2)
SLX: SLAV_40240 SLAV_40245 SLAV_40510 SLAV_40515
SNZ: DC008_13175 DC008_13180
SGE: DWG14_07359 DWG14_07360
KAB: B7C62_31265 B7C62_31270
KAU: B6264_18490 B6264_18495
KIT: CFP65_4148 CFP65_4149
LMOI: VV02_05815 VV02_05820
PACD: EGX94_12535
TFU: Tfu_1218 Tfu_1219
TCU: Tcur_2772 Tcur_2773
SRO: Sros_4150 Sros_4151
NOA: BKM31_22830 BKM31_22870
FRA: Francci3_4100 Francci3_4101 Francci3_4148
FRI: FraEuI1c_1317 FraEuI1c_1318
SVI: Svir_33690 Svir_33700
AMD: AMED_5434(fabF) AMED_5435(fabF)
AMN: RAM_27700 RAM_27705
AMM: AMES_5369(fabF) AMES_5370(fabF)
AMZ: B737_5369(fabF) B737_5370(fabF)
PSEQ: AD006_30015 AD006_30020
PECQ: AD017_31230 AD017_31235
PHH: AFB00_31125 AFB00_31130
SESP: BN6_40990 BN6_54860 BN6_54870
KAL: KALB_7830 KALB_7831
KPHY: AOZ06_32110 AOZ06_32115
LED: BBK82_02450 BBK82_02455
AHM: TL08_10465 TL08_10470
ACTI: UA75_11090 UA75_11095
ACAD: UA74_11000 UA74_11005
AHG: AHOG_10345 AHOG_10350
ACTA: C1701_02395 C1701_02400
ALO: CRK55091 CRK55092
PMAD: BAY61_07805 BAY61_07810
STP: Strop_2223 Strop_2224
MAU: Micau_4018 Micau_4019
MIL: ML5_4402 ML5_4403
MICH: FJK98_03840 FJK98_03845
VMA: VAB18032_18170 VAB18032_18175
AMS: AMIS_50420 AMIS_50430 AMIS_50640 AMIS_50650
ACTN: L083_3108 L083_3109
PLK: CIK06_11005 CIK06_11010
CAI: Caci_3546 Caci_3547 Caci_6485 Caci_6486
 » show all
Taxonomy
Reference
1  [PMID:9609708]
  Authors
Bao W, Wendt-Pienkowski E, Hutchinson CR
  Title
Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis.
  Journal
Biochemistry 37:8132-8 (1998)
DOI:10.1021/bi980466i
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.235
IUBMB Enzyme Nomenclature: 2.3.1.235
ExPASy - ENZYME nomenclature database: 2.3.1.235
BRENDA, the Enzyme Database: 2.3.1.235

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Pathway (8)   
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Chemical substance (8)   
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Chemical reaction (9)   
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Gene (273)   
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   KEGG GENES (230)   
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   RefGene (13)   
Protein sequence (1)   
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DNA sequence (2)   
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All databases (301)   

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KEGG   REACTION: R06643Help
Entry
R06643                      Reaction                               

Definition
10 Malonyl-CoA + Acyl-carrier protein <=> 3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] + 10 CO2 + 10 CoA
Equation
10 C00083 + C00229 <=> C12354 + 10 C00011 + 10 C00010
Comment
minimal PKS, sno1+sno2+sno3, tcmKLM, mtmPKS
Reaction class
RC00004  C00010_C00083
RC00039  C00229_C12354
RC02931  C00083_C12354
RC02932  C00083_C12354
RC02947  C00083_C12354
Enzyme
2.3.1.235       2.3.1.-
Pathway
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K05551  minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05552  minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05553  minimal PKS acyl carrier protein

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG RCLASS (5)   
Gene (345)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (342)   
All databases (364)   

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