KEGG ORTHOLOGY: K05553

ORTHOLOGY: K05553

Entry

K05553                      KO

Symbol

actI3, oxyC, tcmM, snoa3, aknD, mtmS

Name

minimal PKS acyl carrier protein

Pathway

map00253

Tetracycline biosynthesis

map01056

Biosynthesis of type II polyketide backbone

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00778

Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   00253 Tetracycline biosynthesis
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   01008 Polyketide biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Lipid biosynthesis proteins [BR:ko01004]
Polyketide synthase
  Component type
   K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Octaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
    Nonaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
    Decaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein

Other DBs

RN:	R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516

Genes

MBD:	MEBOL_003042

MSAO:

MYCSP_12690

MSAL:

DSM43276_02541

NBR:	O3I_007455 O3I_015120

NNO:	NONO_c10790

NTP:	CRH09_08680

NOZ:	DMB37_03460

NAH:	F5544_10725 F5544_17030 F5544_31055

NAD:	NCTC11293_03460

NWL:	NWFMUON74_57140

NIE:	KV110_14180

NTC:	KHQ06_30025

NYA:	LTV02_09620

NGP:	LTT66_26665

SCO:	SCO1272(2SCG18.19c) SCO5089(actIORF3)

SMA:	SAVERM_2373(pks9-1)

SSX:	SACTE_5205 SACTE_6348

SHY:

SHJG_1187

SHO:	SHJGH_1022

SFA:

Sfla_5316

SBH:

SBI_06846

SVE:

SVEN_5982

SDV:	BN159_2492 BN159_2513

SALS:

SLNWT_5123

STRP:

F750_1307

SFI:

SFUL_4004

SCI:	B446_13330

SLV:	SLIV_12940 SLIV_31430

SGU:	SGLAU_26365(tcmM)

SVT:	SVTN_18770 SVTN_28605

STRE:

GZL_p00216

SCW:	TU94_31835

SLD:	T261_0020 T261_6832

SXI:	SXIM_35580 SXIM_35680

STRC:

AA958_14845 AA958_30265

SAMB:

SAM23877_0194(alpC) SAM23877_7479(alpC)

SPRI:

SPRI_0265 SPRI_0277 SPRI_7076 SPRI_7088

SCZ:	ABE83_16235

SCX:	AS200_01425

SRW:	TUE45_01110 TUE45_01317 TUE45_01568

STRF:

ASR50_01165 ASR50_34275

SPAV:

Spa2297_32730

SGS:	AVL59_46035

SGM:	GCM10017557_73770

SPHW:

NFX46_12160 NFX46_24975

SLS:	SLINC_6893

SALU:

DC74_6592

SALL:

SAZ_34280

STRD:

NI25_18965

SVU:	B1H20_09515

SPUN:

BFF78_19345

SLAU:

SLA_3072

SALJ:

SMD11_0677(actI3) SMD11_1145(actI3) SMD11_6046(actI3)

SLX:	SLAV_40235 SLAV_40285

SNZ:	DC008_13170

SGE:	DWG14_07358

SLK:	SLUN_33505

SDX:	C4B68_09605

SGD:	ELQ87_00825 ELQ87_08180

SCYA:

EJ357_29975 EJ357_34770

SNQ:	CP978_29740

STIR:

DDW44_27915

SKA:	CP970_02730 CP970_39685

SGZ:	C0216_31860

SNK:	CP967_10250

SHAW:

CEB94_23580

SRK:	FGW37_04265 FGW37_16275

SFIC:

EIZ62_03840

SGAL:

CP966_29080

SSPO:

DDQ41_07360

SVR:	CP971_23925

SFY:	GFH48_20445

SAQU:

EJC51_31365

SGF:	HEP81_07941

SCAV:

CVT27_18220

SRIM:

CP984_02385

SCIN:

CP977_27935

SPAC:

B1H29_00830 B1H29_36230

STSU:

B7R87_21965

SCHA:

CP983_03640 CP983_27900

SGX:	H4W23_11630 H4W23_11715

SCOE:

CP976_32955

SBAT:

G4Z16_23880

SSPB:

CP982_18995

SNF:	JYK04_04014 JYK04_04602

SPLA:

CP981_11510 CP981_34520

STUI:

SCHF:

SHUN:

SHAR:

SCYG:

SFEU:

SLIA:

SDW:	K7C20_32770

SCAL:

SAUH:

SMOB:

SPEU:

SROI:

IAG44_09650 IAG44_37975 IAG44_41440

SXN:	IAG42_35935 IAG42_36725

SHK:	J2N69_31110

SANU:

K7396_04300

SDD:	D9753_08535

SACT:

SMAO:

SGOB:

SINE:

SLF:	JEQ17_32800 JEQ17_32820

SDEC:

SYAN:

STAA:

SNIG:

SSPN:

SCIR:

STRCI_006080 STRCI_006102

SLON:

LGI35_31860

SDRZ:

NEH16_30125 NEH16_32485

KSK:

KSE_58090

KAB:	B7C62_31275

KAU:	B6264_18500

KIT:	CFP65_4142

KIS:	HUT16_23695

YIA:	LO772_34325 LO772_34340

STRH:

GXP74_03135

ABRY:

NYE86_15460 NYE86_15945

LMOI:

VV02_05825

PACD:

EGX94_11640

TFU:

Tfu_1220

TALX:

FOF52_07525 FOF52_07535

TCU:

Tcur_2794

AGRA:

AGRA3207_004548

SRO:

Sros_4152

NOA:	BKM31_22705

NCX:	Nocox_12785

NGN:	LCN96_42550

FRA:	Francci3_4099 Francci3_4147

FRI:	FraEuI1c_1319

SVI:	Svir_33710

AMD:	AMED_5433(actI)

AMN:

RAM_27695

AMM:	AMES_5368(actI)

AMZ:	B737_5368(actI)

AMYY:

YIM_23710

AORI:

SD37_09335 SD37_34250

APRT:

MUY14_22555

PSEQ:

AD006_30010

PECQ:

AD017_31240

PHH:	AFB00_31135

SESP:

BN6_54880(acp5)

SSYI:

EKG83_16310 EKG83_32210

KAL:

KALB_7829

KUT:	JJ691_15670

KPHY:

AOZ06_32105

LED:	BBK82_02475

AHM:	TL08_10475

ACTI:

UA75_11100

ACAD:

UA74_11010

AHG:	AHOG_10355

ACTA:

ALO:

PMAD:

ACTU:

STP:	Strop_2225

MAU:	Micau_4017

MIL:

ML5_4404

MICH:

FJK98_03855

MSAG:

GCM10017556_44970

VMA:	VAB18032_18165

VER:	HUT12_05330

MENO:

Jiend_53200

AMS:	AMIS_50440

AIH:	Aiant_86580

ACTL:

L3i22_085330

PLK:	CIK06_11015

CATI:

CS0771_73140

DVC:	Dvina_17830 Dvina_17855

DFU:	Dfulv_18400

DROS:

Drose_14690 Drose_24325

DAUR:

Daura_28640 Daura_37920

NHY:	JQS43_06225

CCAZ:

COUCH_16065

CAI:	Caci_3548 Caci_6487

AG:	AAD04718(dpsG) AAF70108(aknD) AAG30201(zhuN) AAZ78327(oxyC) CAA12019(snoa3) CAA61991(mtmS)

» show all

Reference

PMID:1527048

Authors

Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F

Title

Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.

Journal

J Biol Chem 267:19278-90 (1992)

Sequence

[sco:SCO5089]

Reference

PMID:16597959

Authors

Zhang W, Ames BD, Tsai SC, Tang Y

Title

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Journal

Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006

Sequence

[ag:AAZ78327]

Reference

PMID:20522541

Authors

Pickens LB, Tang Y

Title

Oxytetracycline biosynthesis.

Journal

J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419

Reference

PMID:2684656

Authors

Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR

Title

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

Journal

EMBO J 8:2727-36 (1989)
DOI:10.1002/j.1460-2075.1989.tb08414.x

Sequence

[sgu:SGLAU_26365]

Reference

PMID:1592832

Authors

Shen B, Summers RG, Gramajo H, Bibb MJ, Hutchinson CR

Title

Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase.

Journal

J Bacteriol 174:3818-21 (1992)
DOI:10.1128/JB.174.11.3818-3821.1992

Reference

PMID:8668120

Authors

Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P

Title

A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.

Journal

Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908

Sequence

[ag:CAA12019]

Reference

PMID:8654997

Authors

Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA

Title

Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.

Journal

Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7

Sequence

[ag:CAA61991]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (18)   
   KEGG REACTION (10)   
   KEGG RCLASS (8)   
Gene (246)   
   KEGG GENES (231)   
   KEGG MGENES (3)   
   RefGene (8)   
   OC (4)   
Literature (7)   
   PubMed (7)   
All databases (283)   

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