KEGG   ORTHOLOGY: K05554Help
Entry
K05554                      KO                                     

Name
actVII
Definition
aromatase [EC:4.2.1.-]
Pathway
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05554  actVII; aromatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05554  actVII; aromatase
   01008 Polyketide biosynthesis proteins
    K05554  actVII; aromatase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-  
     K05554  actVII; aromatase
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05554  actVII; aromatase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05554  actVII; aromatase
BRITE hierarchy
Other DBs
RN: R09265
Genes
PLU: plu4187
PLUM: A4R40_20765
HOE: IMCC20628_03255
ABF: AMK58_25500
MANA: MAMMFC1_01621
MSAO: MYCSP_12685
MSAL: DSM43276_02540
NBR: O3I_007465
NNO: NONO_c10770
NTP: CRH09_08655 CRH09_08685
SCO: SCO5090(actVII)
SFA: Sfla_5325
SBH: SBI_06853
SHY: SHJG_1197
SVE: SVEN_5984
SALS: SLNWT_5125
STRP: F750_1298
SFI: SFUL_4006
SALU: DC74_6594
SALL: SAZ_34290
STRE: GZL_p00218
SLD: T261_6834
SLE: sle_03410(sle_03410)
STRD: NI25_18975
SLAU: SLA_3088
SALJ: SMD11_0678(actVII) SMD11_1146(actVII) SMD11_6048(actVII)
LMOI: VV02_05835
TFU: Tfu_1222
TCU: Tcur_2780
SESP: BN6_54900
KAL: KALB_7824
MIL: ML5_4410
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5090]
Reference
PMID:7868592
  Authors
Kim ES, Cramer KD, Shreve AL, Sherman DH
  Title
Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species.
  Journal
J Bacteriol 177:1202-7 (1995)
DOI:10.1128/JB.177.5.1202-1207.1995

KEGG   REACTION: R09265Help
Entry
R09265                      Reaction                               

Definition
7,9,12-Octaketide intermediate 2 <=> 7,9,12-Octaketide intermediate 3 + 2 H2O
Equation
Reaction class
RC02546  C18328_C18329
Enzyme
4.2.1.-
Pathway
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K05554  aromatase [EC:4.2.1.-]

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