KEGG   ORTHOLOGY: K05556Help
Entry
K05556                      KO                                     

Name
actVI1, RED1
Definition
ketoreductase RED1 [EC:1.1.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K05556  actVI1, RED1; ketoreductase RED1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K05556  actVI1, RED1; ketoreductase RED1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K05556  actVI1, RED1; ketoreductase RED1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Ketoreductase
   K05556  actVI1, RED1; ketoreductase RED1
BRITE hierarchy
Other DBs
RN: R09306 R09307 R09308
Genes
MBAH: HYN46_09100
BUI: AX768_31340
VGO: GJW-30_1_03969(lcdH_3)
PAEK: D3873_11650
PANC: E2636_01580
MSA: Mycsm_04371
MAB: MAB_0761c
MMV: MYCMA_0403
MABB: MASS_0730
MABL: MMASJCM_0753
MCHE: BB28_03670
MSTE: MSTE_00722
SCO: SCO5072(SCBAC20F6.15)
SMA: SAVERM_1348(fadC7)
SALJ: SMD11_6827
SLX: SLAV_40105(lcdH)
SGE: DWG14_01130(lcdH)
BLIN: BLSMQ_3179
SEN: SACE_5408
AMD: AMED_6369
AMN: RAM_32655
AMM: AMES_6278
AMZ: B737_6278
AOI: AORI_2196
PSEH: XF36_09650
KAL: KALB_2690
FMR: Fuma_01191(lcdH)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Itoh T, Taguchi T, Kimberley MR, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Ichinose K
  Title
Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase.
  Journal
Biochemistry 46:8181-8 (2007)
DOI:10.1021/bi700190p

KEGG   ORTHOLOGY: K14626Help
Entry
K14626                      KO                                     

Name
actVIA
Definition
actinorhodin biosynthesis protein ActVIA
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14626  actVIA; actinorhodin biosynthesis protein ActVIA
BRITE hierarchy
Other DBs
RN: R09308
Genes
MMI: MMAR_1563
MLI: MULP_01694
SCO: SCO5071(SCBAC20F6.14c)
SLV: SLIV_13030
SVT: SVTN_18755
TCU: Tcur_2764
FRA: Francci3_4104
FRI: FraEuI1c_1316
AMS: AMIS_50520
CAI: Caci_6494
TaxonomyKoalaUniProt
Reference
  Authors
Taguchi T, Okamoto S, Lezhava A, Li A, Ochi K, Ebizuka Y, Ichinose K
  Title
Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis.
  Journal
FEMS Microbiol Lett 269:234-9 (2007)
DOI:10.1111/j.1574-6968.2007.00627.x

KEGG   ORTHOLOGY: K14627Help
Entry
K14627                      KO                                     

Name
actVI3
Definition
dehydratase [EC:4.2.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14627  actVI3; dehydratase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14627  actVI3; dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-  
     K14627  actVI3; dehydratase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K14627  actVI3; dehydratase
BRITE hierarchy
Other DBs
RN: R09308
Genes
MNE: D174_01030
NBR: O3I_022830
NNO: NONO_c18340
SCO: SCO5074(SCBAC20F6.17)
SLV: SLIV_13015
SVT: SVTN_18850
KFL: Kfla_1381
SEN: SACE_5375
AMD: AMED_6664
AMN: RAM_34190
AMM: AMES_6565
AMZ: B737_6565
AOI: AORI_2036
AMI: Amir_2388
KAL: KALB_1674
SAQ: Sare_1524
CAI: Caci_6481
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7929165
  Authors
Fernandez-Moreno MA, Martinez E, Caballero JL, Ichinose K, Hopwood DA, Malpartida F
  Title
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).
  Journal
J Biol Chem 269:24854-63 (1994)

KEGG   REACTION: R09308Help
Entry
R09308                      Reaction                               

Definition
(S)-Hemiketal <=> (S)-DNPA + H2O
Equation
Reaction class
RC02485  C12434_C18356
Enzyme
4.2.1.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Orthology
K05556  ketoreductase RED1 [EC:1.1.1.-]
K14626  actinorhodin biosynthesis protein ActVIA
K14627  dehydratase [EC:4.2.1.-]

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