KEGG   ORTHOLOGY: K05556Help
Entry
K05556                      KO                                     

Name
actVI1, RED1
Definition
ketoreductase RED1 [EC:1.1.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K05556  actVI1, RED1; ketoreductase RED1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K05556  actVI1, RED1; ketoreductase RED1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K05556  actVI1, RED1; ketoreductase RED1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Ketoreductase
   K05556  actVI1, RED1; ketoreductase RED1
BRITE hierarchy
Other DBs
RN: R09306 R09307 R09308
Genes
MBAH: HYN46_09100
BUI: AX768_31340
VGO: GJW-30_1_03969(lcdH_3)
PAEK: D3873_11650
PANC: E2636_01580
MSA: Mycsm_04371
MAB: MAB_0761c
MMV: MYCMA_0403
MABB: MASS_0730
MABL: MMASJCM_0753
MCHE: BB28_03670
MSTE: MSTE_00722
SCO: SCO5072(SCBAC20F6.15)
SMA: SAVERM_1348(fadC7)
SALJ: SMD11_6827
SLX: SLAV_40105(lcdH)
SGE: DWG14_01130(lcdH)
BLIN: BLSMQ_3179
SEN: SACE_5408
AMD: AMED_6369
AMN: RAM_32655
AMM: AMES_6278
AMZ: B737_6278
AOI: AORI_2196
PSEH: XF36_09650
KAL: KALB_2690
FMR: Fuma_01191(lcdH)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Itoh T, Taguchi T, Kimberley MR, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Ichinose K
  Title
Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase.
  Journal
Biochemistry 46:8181-8 (2007)
DOI:10.1021/bi700190p

KEGG   REACTION: R09306Help
Entry
R09306                      Reaction                               

Definition
Octaketide bicyclic intermediate + NADPH + H+ <=> (S)-Chiral alcohol + NADP+
Equation
Reaction class
RC00001  C00005_C00006
Enzyme
1.1.1.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Orthology
K05556  ketoreductase RED1 [EC:1.1.1.-]

DBGET integrated database retrieval system