KEGG ORTHOLOGY: K05633

ORTHOLOGY: K05633

Entry

K05633                      KO

Symbol

WWP1, AIP5

Name

NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]

Pathway

map04120

Ubiquitin mediated proteolysis

map04144

Endocytosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1
   04121 Ubiquitin system
    K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  HECT type E3
   K05633  WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1

Genes

HSA:	11059(WWP1)

PTR:	464269(WWP1)

PPS:	100990521(WWP1)

GGO:	101148212(WWP1)

PON:	100442298(WWP1)

PPYG:

129034226 129043163(WWP1)

NLE:	100580729(WWP1)

HMH:	116813379(WWP1)

SSYN:

129486569(WWP1)

MCC:	694098(WWP1)

MCF:	101865249(WWP1)

MTHB:

126961167

MNI:	105477150(WWP1)

CSAB:

103237079(WWP1)

CATY:

105572885(WWP1)

PANU:

100998869(WWP1)

TGE:	112629884(WWP1)

MLEU:

105530488(WWP1)

RRO:	104674278(WWP1)

RBB:	108531641(WWP1)

TFN:	117079140(WWP1) 117083614

PTEH:

111549658(WWP1)

CANG:

105501632 105508251(WWP1)

CJC:	100400473(WWP1)

SBQ:	101053807(WWP1)

CIMI:

108299476(WWP1)

ANAN:

105730000(WWP1)

CSYR:

103257175(WWP1)

MMUR:

105876567(WWP1)

LCAT:

123645044(WWP1)

PCOQ:

105809711(WWP1)

OGA:	100957479(WWP1)

MMU:	107568(Wwp1)

MCAL:

110292851(Wwp1)

MPAH:

110338628(Wwp1)

RNO:	297930(Wwp1)

MCOC:

116088033(Wwp1)

ANU:	117698587(Wwp1)

ASYL:

127680578(Wwp1)

MUN:	110565189(Wwp1)

CGE:	100757929(Wwp1)

MAUA:

101843456(Wwp1)

PROB:

127232370(Wwp1)

PLEU:

114704115(Wwp1)

MORG:

121451494(Wwp1)

MFOT:

126486751

AAMP:

119826118(Wwp1)

NGI:	103731153(Wwp1)

HGL:	101725489(Wwp1)

CPOC:

100715948(Wwp1)

CCAN:

109696210(Wwp1)

DORD:

105982819(Wwp1) 105989874

DSP:	122096724(Wwp1)

PLOP:

125343816 125360678(Wwp1)

NCAR:

124980297

MMMA:

107142482(Wwp1)

ITI:	101977750(Wwp1)

OCU:

100350478

OPI:	101521435(WWP1)

TUP:	102483029(WWP1)

GVR:	103590373(WWP1)

CFA:	100856769(WWP1)

CLUD:

112650774(WWP1)

VVP:	112930774(WWP1)

VLG:	121498535(WWP1)

NPO:	129495696(WWP1)

AML:	100475461(WWP1)

UMR:	103661400(WWP1)

UAH:	113252973(WWP1)

UAR:	123797909(WWP1)

ELK:

111146529

LLV:

125097785

MPUF:

101682164(WWP1)

MNP:	132002985 132014134(WWP1)

MLK:	131826635(WWP1)

NVS:	122904466(WWP1)

ORO:	101374742(WWP1)

EJU:	114216475(WWP1)

ZCA:	113915511(WWP1)

MLX:	118014986(WWP1)

NSU:	110579123(WWP1)

LWW:	102737427(WWP1)

FCA:	101095882(WWP1)

PYU:	121038026(WWP1)

PCOO:

112859260(WWP1)

PBG:	122495559(WWP1)

PVIV:

125156104(WWP1)

LRUF:

124507750

LGF:	123585902(WWP1)

AJU:

106977247

PTG:	102969670(WWP1)

PPAD:

109269443(WWP1)

PUC:

125924570

PLEZ:

122210451(WWP1)

HHV:	120225202(WWP1)

BTA:	513789(WWP1)

BOM:	102271307(WWP1)

BBUB:

102404172(WWP1)

BBIS:

104993110(WWP1)

CHX:	102171442(WWP1)

OAS:	101117426(WWP1) 101122347

BTAX:

128059672(WWP1)

CSUM:

138088210(WWP1)

ODA:	120878521(WWP1)

CCAD:

122451170(WWP1)

MREE:

136144846(WWP1)

OVR:	110152138(WWP1)

MBEZ:

129559950(WWP1)

SSC:	100157283(WWP1)

CFR:	102509478(WWP1)

CBAI:

105066617(WWP1)

CDK:	105088497(WWP1)

VPC:	102525102(WWP1)

BACU:

103009404(WWP1)

BMUS:

118883325(WWP1)

LVE:	103076297(WWP1)

OOR:	101288239(WWP1)

LALB:

132508430(WWP1)

DLE:	111164981(WWP1)

PCAD:

102990840(WWP1)

PSIU:

116742480(WWP1)

NASI:

112390495(WWP1)

ECB:	100055725(WWP1)

EPZ:	103541679(WWP1)

EAI:	106829847(WWP1)

MYB:	102261539(WWP1)

MYD:	102764292(WWP1)

MMYO:

118670456(WWP1)

MLF:	102442500(WWP1)

MDT:	132219658(WWP1)

MYUM:

138993544(WWP1)

PKL:	118718496(WWP1) 118722439

EFUS:

103303366(WWP1)

MNA:	107526470(WWP1)

DRO:	112320867(WWP1)

SHON:

118989867(WWP1)

AJM:	119046362(WWP1)

PDIC:

114501274(WWP1)

PHAS:

123825753(WWP1)

MMF:	118631398(WWP1)

PPAM:

129075724 129088286(WWP1)

HAI:	109387583(WWP1)

RFQ:	117034130(WWP1)

PALE:

102896487(WWP1)

PGIG:

120585575(WWP1)

PVP:	105302743(WWP1)

RAY:	107514922(WWP1)

MJV:	108406620(WWP1)

TOD:	119240057(WWP1)

SARA:

101549431(WWP1)

SFUM:

130019599(WWP1)

SETR:

126020641(WWP1)

LAV:	100662373(WWP1)

TMU:

101348915

ETF:	101662385(WWP1)

DNM:	101429327(WWP1)

MDO:	100029107(WWP1)

GAS:	123240600(WWP1)

SHR:	100919125(WWP1)

AFZ:

127544255

PCW:	110196723(WWP1)

TVP:	118845204(WWP1)

PBRV:

138173572(WWP1)

OAA:	100075459(WWP1)

TACU:

119927270(WWP1)

GGA:	420212(WWP1)

PCOC:

116227584(WWP1)

CJO:	107310303(WWP1)

TPAI:

128091495(WWP1)

LMUT:

125690405(WWP1)

NMEL:

110394777(WWP1)

APLA:

101801705(WWP1)

ACYG:

106030549(WWP1)

CATA:

118247998(WWP1)

AFUL:

116485505(WWP1)

TGU:	100219204(WWP1)

LSR:	110477418(WWP1)

SCAN:

103813369(WWP1)

PMOA:

120495768(WWP1)

OTC:	121340090(WWP1)

PRUF:

121351908(WWP1)

ATRC:

139587377(WWP1)

GFR:	102038961(WWP1)

FAB:	101818641(WWP1)

OMA:	130249994(WWP1)

PHI:	102101936(WWP1)

PMAJ:

107199517(WWP1)

CCAE:

111924578(WWP1)

CCW:	104692771(WWP1)

CBRC:

103613438(WWP1)

ACOE:

138105279(WWP1)

ETL:	114065895(WWP1)

ZAB:	102063929(WWP1)

ZLE:	135444615(WWP1)

ACHL:

103806311(WWP1)

SVG:	106849856(WWP1)

MMEA:

130576433(WWP1)

HRT:	120764692(WWP1)

SATI:

136369869(WWP1)

CCIC:

134042521(WWP1)

FPG:	101914676(WWP1)

FCH:	102050477(WWP1)

CCRI:

104161216(WWP1)

NNT:	104399892(WWP1)

SHAB:

115617541(WWP1)

ACUN:

113476997(WWP1)

TALA:

104360915(WWP1)

ACHC:

115340104(WWP1)

HALD:

104324567(WWP1)

HLE:	104832148(WWP1)

AGEN:

126046534

HHAR:

128141708(WWP1)

GCL:

127013757

CSTI:

104555534(WWP1)

LDI:	104347370(WWP1)

MNB:	103777964(WWP1)

DPUB:

104309200(WWP1)

PPUS:

135181395(WWP1)

AVIT:

104267854(WWP1)

BRHI:

104493223(WWP1)

EGZ:	104123325(WWP1)

NNI:	104022786(WWP1)

PCRI:

104024808(WWP1)

PCAO:

104047244(WWP1)

PADL:

103924064(WWP1)

AFOR:

103896236(WWP1)

FGA:	104075606(WWP1)

CLV:	102084568(WWP1)

MUI:	104534070(WWP1)

PGUU:

104471928(WWP1)

PLET:

104618113(WWP1)

EHS:	104514548(WWP1)

CUCA:

104056760(WWP1)

TEO:	104377060(WWP1)

BREG:

104643726(WWP1)

OHA:	104339434(WWP1)

ACAR:

104521374(WWP1)

CPEA:

104396562(WWP1)

CVF:	104292472(WWP1)

RTD:	128905187(WWP1)

CRID:

134512095(WWP1)

AAM:	106496263(WWP1)

AROW:

112973025(WWP1)

NPD:	112960316(WWP1)

DNE:	112982979(WWP1)

SCAM:

104143936(WWP1)

ASN:	102377089(WWP1)

AMJ:	102576998(WWP1)

CPOO:

109320063(WWP1)

GGN:	109305007(WWP1)

PSS:	102448686(WWP1)

CMY:	102941009(WWP1)

CCAY:

125632613(WWP1)

DCC:	119850483(WWP1)

CPIC:

101937468(WWP1)

TST:	117873633(WWP1)

CABI:

116828260(WWP1)

MRV:	120396623(WWP1)

ACS:	100558141(wwp1)

ASAO:

132774961(WWP1)

PVT:	110085122(WWP1)

SUND:

121928360(WWP1)

PBI:	103062713(WWP1)

PMUR:

107284961(WWP1)

CTIG:

120308857(WWP1)

TSR:	106551170(WWP1)

PGUT:

117668474(WWP1)

APRI:

131195395(WWP1)

PTEX:

113439929(WWP1)

NSS:	113426440(WWP1)

VKO:	123020495(WWP1)

PMUA:

114600452(WWP1)

PRAF:

128417289(WWP1)

ZVI:	118089829(WWP1)

HCG:	128322910(WWP1)

GJA:	107119005(WWP1)

STOW:

125438808(WWP1)

EMC:	129333105(WWP1)

XLA:	108695372(wwp1.S) 108719322(wwp1.L)

XTR:	100038255(wwp1)

NPR:	108786471(WWP1)

RTEM:

120941260(WWP1)

BBUF:

121002349(WWP1)

BGAR:

122937799(WWP1)

PWL:	138282642(WWP1)

MUO:	115478665(WWP1)

GSH:	117355147(WWP1)

DRE:

103909792

SRX:	107729941 107756866

SANH:

107668154 107678480

SGH:	107572619(wwp1) 107573294

CCAR:

109066183

CAUA:

113042666 113068786(wwp1)

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CERY:

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:

IFU:

PHYP:

113545425(wwp1)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113579398(wwp1)

CHAR:

105897247

SPIL:

134065722

TRU:	101068611 115248323

TFS:

130513418

TNG:	GSTEN00016645G001

LCO:

104924707

NCC:	104951727(wwp1)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114549454(wwp1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:	101467964(wwp1)

ONL:

100701023

OAU:

116311299

OLA:	101169496(wwp1)

OML:

112151160

CSAI:

133422965

XMA:	102223052(wwp1)

XCO:	114136982(wwp1)

XHE:	116711598(wwp1)

PRET:

103482265(wwp1)

PFOR:

103143359(wwp1)

PLAI:

106955650(wwp1)

PMEI:

106914573(wwp1)

GAF:

122824308

PPRL:

129364726

CVG:	107084904 107084905

CTUL:

119771491 119787934

GMU:

124857835

NFU:	107382627(wwp1)

KMR:

108248254

ALIM:

106533496(wwp1)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103377056(wwp1)

POV:	109629755(wwp1)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111228237(wwp1)

SLAL:

111659839(wwp1)

XGL:

120789816

HCQ:	109507829(wwp1)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110158668(wwp1)

ENY:

140364381

MALB:

109965105(wwp1)

BSPL:

114852989

SJO:

128382069

SSCO:

134001959

GMH:	115536982(wwp1)

SASA:

106578528(wwp1)

STRU:

115153498(wwp1)

OTW:

112215571

OMY:

110535527

OGO:

123991159

ONE:	115105084(wwp1)

OKI:	109909997(wwp1)

OKE:

118361588

OMM:

135522657

OCLA:

139420396

SALP:

111973057(wwp1)

SNH:

120028139

CCLU:

121549935

ELS:	105031534(wwp1)

OEP:

134035284

SFM:	108927653 108938297

PKI:	111835152 111846204

AANG:

118225467 118234169

AROT:

135253893 135260765

CCOG:

133126350 133136262

LOC:	102695344(wwp1)

PSPA:

121312708 121314160

ARUT:

117394648 117400357

PSEX:

120530119

LCM:	102360416(WWP1)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133350957 133355784

BFO:

BBEL:

CIN:

SCLV:

SPU:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

PFLL:

DME:	Dmel_CG4244(Su(dx))

DER:

6542319

DSE:

6617446

DSI:	Dsimw501_GD23128(Dsim_GD23128)

DYA:	Dyak_GE17900

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18245

DAZ:

108611157

DNV:

108649950

DHE:

111594789

DVI:	6628204(Su(dx))

CCAT:

101458764

BOD:

106627603

BDR:

105230772

RZE:	108366925 108374233

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135952525(Su(dx))

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004171

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139107889(Su(dx))

TLN:	139819476(Su(dx))

HST:

DQU:

CFO:

FEX:

PMEC:

138935377(Su(dx))

LHU:	105673973(Su(dx))

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124211269(Su(dx))

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138130836(Su(dx))

DPA:

109538604

ESIM:

136416790(Su(dx))

EFOR:

136350902(Su(dx))

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

135796654(Su(dx))

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214205

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137922088(Su(dx))

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

CSTB:

CFEL:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106680234(Su(dx))

NLU:

111049833

HVI:

124364282

MQU:	128999457 129004622

PHU:	Phum_PHUM249630

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139691525(Su(dx))

FCD:

110842235

DPX:	DAPPUDRAFT_207722

DMK:

116919979

DPZ:

124336910

AFRA:

136034775 136040058

PVM:	113824435(Su(dx))

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123765049(Su(dx))

CQD:	128692036(Su(dx))

PTRU:

123518520

ESN:

126998868

MNZ:

135196363

MRJ:	136840747(Su(dx))

PORN:

139760538(Su(dx))

HAZT:

108674622

EAF:

111707930

LSM:	121114541(Su(dx))

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136990305(Su(dx))

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106458870 106464188 106471579 106478416

PMEO:

129590452

CEL:	CELE_Y65B4BR.4(wwp-1)

CBR:	CBG_05115(Cbr-wwp-1)

CRQ:	GCK72_001361

NAI:	NECAME_14860

BMY:	BM_BM6975(Bma-wwp-1)

LOA:	LOAG_18030

HRO:	HELRODRAFT_107622 HELRODRAFT_62284 HELRODRAFT_94814

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_123180 Smp_165260

SHX:	MS3_00003518(WWP1_1) MS3_00008785(WWP1_3)

OVI:	T265_00947 T265_09141

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

RES:

TAD:	TRIADDRAFT_23972

AQU:

100636847

MBR:	MONBRDRAFT_18151

» show all

Reference

PMID:20209166

Authors

Chen CS, Bellier A, Kao CY, Yang YL, Chen HD, Los FC, Aroian RV

Title

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.

Journal

PLoS One 5:e9494 (2010)
DOI:10.1371/journal.pone.0009494

Sequence

[cel:CELE_Y65B4BR.4]

Reference

PMID:15221015

Authors

Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K

Title

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

Journal

Oncogene 23:6914-23 (2004)
DOI:10.1038/sj.onc.1207885

Sequence

[hsa:11059]

All links

Gene (3556)   
   MGENES (361)   
   RefGene (3191)   
   OC (4)   
All databases (3556)   

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