KEGG ORTHOLOGY: K05702

ORTHOLOGY: K05702

Entry

K05702                      KO

Symbol

AF6, MLLT4

Name

afadin

Pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04520

Adherens junction

map04530

Tight junction

map04670

Leukocyte transendothelial migration

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05702  AF6, MLLT4; afadin
   04015 Rap1 signaling pathway
    K05702  AF6, MLLT4; afadin
   04024 cAMP signaling pathway
    K05702  AF6, MLLT4; afadin
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05702  AF6, MLLT4; afadin
   04530 Tight junction
    K05702  AF6, MLLT4; afadin
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K05702  AF6, MLLT4; afadin

Genes

HSA:	4301(AFDN)

PTR:	463135(AFDN)

PPS:	100994843(AFDN)

GGO:	101145438(AFDN)

PON:	100460020(AFDN)

PPYG:

129037959(AFDN)

NLE:	100592208(AFDN)

HMH:	116473818(AFDN)

SSYN:

129476726(AFDN)

MCC:	693560(AFDN)

MCF:	102124166(AFDN)

MTHB:

126952445

MNI:	105487581(AFDN)

CSAB:

103240945(AFDN)

CATY:

105597489(MLLT4)

PANU:

100998712(AFDN)

TGE:	112622839(AFDN)

MLEU:

105553513(MLLT4)

RRO:	104678498(AFDN)

RBB:	108544169(AFDN)

TFN:	117096874(AFDN)

PTEH:

111550284(AFDN)

CANG:

105506696(MLLT4)

CJC:	100398334(AFDN)

SBQ:	101044596(MLLT4)

CIMI:

108288644(AFDN)

ANAN:

105725966(AFDN)

CSYR:

103261011(AFDN)

MMUR:

105877867(AFDN)

LCAT:

123633458(AFDN)

PCOQ:

105822030(MLLT4)

OGA:	100944943(AFDN)

MMU:	17356(Afdn)

MCAL:

110284326(Afdn)

MPAH:

110338407(Afdn)

RNO:	26955(Afdn)

MCOC:

116078310(Afdn)

ANU:	117700252(Afdn)

ASYL:

127673587(Afdn)

MUN:	110552572(Afdn)

CGE:	100751158(Afdn)

MAUA:

101823227(Afdn)

PROB:

127237707(Afdn)

PLEU:

114691342(Afdn)

MORG:

121466553(Afdn)

MFOT:

126497826

AAMP:

119820228(Afdn)

NGI:	103729802(Afdn)

HGL:	101702949(Afdn)

CPOC:

100720687(Afdn)

DORD:

105991835(Mllt4)

DSP:	122101899(Afdn)

PLOP:

125357493(Afdn)

NCAR:

124989634

MMMA:

107153096(Afdn)

ITI:	101969560(Afdn)

OCU:

100346256

OPI:	101527677(AFDN)

TUP:	102477954(AFDN)

CFA:	431695(AFDN)

CLUD:

112644441(AFDN)

VVP:	112932947(AFDN)

VLG:	121485222(AFDN)

NPO:	129499893(AFDN)

AML:	100483095(AFDN)

UMR:	103660799(AFDN)

UAH:	113247099(AFDN)

UAR:	123775438(AFDN)

ELK:

111158727

LLV:

125102582

MPUF:

101688441(MLLT4)

MNP:	132018466(AFDN)

MLK:	131833346(AFDN)

NVS:	122902557(AFDN)

ORO:	101377207(MLLT4)

EJU:	114209343(AFDN)

ZCA:	113927317(AFDN)

MLX:	118001767 118001899

NSU:	110583198(AFDN)

FCA:	101081386(AFDN)

PYU:	121013486(AFDN)

PCOO:

112849252(AFDN)

PBG:	122490187(AFDN)

PVIV:

125166191(AFDN)

LRUF:

124522007

LGF:	123609302(AFDN)

AJU:

106978645

PTG:	102949607(AFDN)

PPAD:

109245430(AFDN)

PUC:

125939064

PLEZ:

122220605(AFDN)

HHV:	120248697(AFDN)

BTA:	504856(AFDN)

BOM:	102276101(AFDN)

BIU:	109564121(AFDN)

BBUB:

102408009(AFDN)

BBIS:

105002229(MLLT4)

CHX:	106502495(AFDN)

OAS:	101115800(AFDN)

BTAX:

128053365(AFDN)

CSUM:

138089855(AFDN)

ODA:	120863003(AFDN)

CCAD:

122434206(AFDN)

MREE:

136165074(AFDN)

OVR:	110148101(AFDN)

MBEZ:

129560977(AFDN)

SSC:	100514741(AFDN)

CFR:	102514304(AFDN)

CBAI:

105077655(MLLT4)

CDK:	105091826(AFDN)

VPC:	102524829(AFDN)

BMUS:

118905165(AFDN)

LVE:	103080521(MLLT4)

OOR:	101272883(AFDN)

LALB:

132530836(AFDN)

DLE:	111167806(AFDN)

PCAD:

102990362(AFDN)

PSIU:

116763385(AFDN)

NASI:

112399640(AFDN)

ECB:	100054846(AFDN)

EPZ:	103547082(AFDN)

EAI:	106842071(AFDN)

MYB:	102243870(AFDN)

MYD:	102761358(AFDN)

MMYO:

118660054(AFDN)

MLF:	102439095(AFDN)

MDT:	132236697(AFDN)

MYUM:

139012028(AFDN)

PKL:	118712105(AFDN)

EFUS:

103299839(AFDN)

MNA:	107537017(MLLT4)

DRO:	112297167(AFDN)

SHON:

118998349(AFDN)

AJM:	119034921(AFDN)

PDIC:

114490093(AFDN)

PHAS:

123821913(AFDN)

MMF:	118621052(AFDN)

PPAM:

129088138(AFDN)

HAI:	109391697(AFDN)

RFQ:	117019071(AFDN)

PALE:

102891465(AFDN)

PGIG:

120617844(AFDN)

PVP:	105303711(AFDN)

RAY:	107518106(MLLT4)

MJV:	108386819(AFDN)

TOD:	119253045(AFDN)

SARA:

101550464(MLLT4)

SFUM:

130033270(AFDN)

SETR:

126024707(AFDN)

LAV:	100669420(AFDN)

TMU:

101361049

ETF:	101651254(AFDN)

DNM:	101444408(AFDN)

MDO:	100032641(AFDN)

GAS:	123243794(AFDN)

SHR:	100934446(AFDN)

AFZ:

127562421

PCW:	110196912(AFDN)

TVP:	118858427(AFDN)

PBRV:

138147824(AFDN)

OAA:	100074808(AFDN)

TACU:

119944740(AFDN)

GGA:	421564(AFDN)

PCOC:

116242372(AFDN)

MGP:	100546394(AFDN)

CJO:	107311463(AFDN)

TPAI:

128087027(AFDN)

LMUT:

125688687(AFDN)

NMEL:

110395656(AFDN)

APLA:

101799402(AFDN)

ACYG:

106044558(AFDN)

CATA:

118243985(AFDN)

AFUL:

116488354(AFDN)

TGU:	100227101(AFDN)

LSR:	110477937(AFDN)

SCAN:

103818483(AFDN)

PMOA:

120501125(AFDN)

OTC:	121334707(AFDN)

PRUF:

121353955(AFDN)

ATRC:

139591796(AFDN)

GFR:	102044501(AFDN)

FAB:	101818644(AFDN)

OMA:	130250672(AFDN)

PHI:	102106095(MLLT4)

PMAJ:

107201865(AFDN)

CCAE:

111926920(AFDN)

CCW:	104684336(AFDN)

CBRC:

103624113(AFDN)

ACOE:

138108063(AFDN)

ETL:	114060003(AFDN)

ZAB:	102070772(AFDN)

ZLE:	135445712(AFDN)

ACHL:

103810081(MLLT4)

SVG:	106852839(MLLT4)

MMEA:

130582488(AFDN)

HRT:	120750882(AFDN)

SATI:

136359309(AFDN)

CCIC:

134042604(AFDN)

FPG:	101922639(AFDN)

FCH:	102058790(AFDN)

CCRI:

104163023(MLLT4)

NNT:	104401776(MLLT4)

SHAB:

115613626(AFDN)

ACUN:

113478737(AFDN)

TALA:

104364053(AFDN)

ACHC:

115349874(AFDN)

HALD:

104315036(MLLT4)

HLE:	104828783(MLLT4)

AGEN:

126051563

HHAR:

128149920(AFDN)

GCL:

127015270

CSTI:

104563481(MLLT4)

MNB:	103775722(MLLT4)

DPUB:

104305475(MLLT4)

PPUS:

135183438(AFDN)

BRHI:

104493593(MLLT4)

EGZ:	104121923(AFDN)

NNI:	104017942(MLLT4)

PCRI:

104027983(MLLT4)

PADL:

103921260(MLLT4)

AFOR:

103900957(AFDN)

FGA:	104069192(MLLT4)

CLV:	102087170(AFDN)

MUI:	104546637(MLLT4)

PGUU:

104457483(MLLT4)

PLET:

104616703(MLLT4)

EHS:	104506929(MLLT4)

CMAC:

104473582(MLLT4)

CUCA:

104056495(AFDN)

TEO:

104370401

BREG:

104637077(MLLT4)

OHA:	104338103(MLLT4)

ACAR:

104525681(AFDN)

CPEA:

104395575(MLLT4)

CVF:	104292127(MLLT4)

RTD:	128906767(AFDN)

CRID:

134513074(AFDN)

AAM:	106487335(AFDN)

AROW:

112975266(AFDN)

NPD:	112945714(AFDN)

TGT:	104566879(MLLT4)

DNE:	112993526(AFDN)

SCAM:

104151461(MLLT4)

ASN:	102370691(AFDN)

AMJ:	102575036(AFDN)

CPOO:

109320029(AFDN)

GGN:	109304398(AFDN)

PSS:	102454221(AFDN)

CMY:	102929950(AFDN)

CCAY:

125633954(AFDN)

DCC:	119852842(AFDN)

CPIC:

101950909(AFDN)

TST:	117874760(AFDN)

CABI:

116825252(AFDN)

MRV:	120400404(AFDN)

ACS:	100564963(afdn)

ASAO:

132761130(AFDN)

PVT:	110086962(AFDN)

SUND:

121925042(AFDN)

PBI:	103056666(AFDN) 103063837

PMUR:

107289612(AFDN)

CTIG:

120310962(AFDN)

TSR:

106542759

PGUT:

117672050(AFDN)

APRI:

131190394(AFDN)

PTEX:

113439307(AFDN)

NSS:	113417080(AFDN)

VKO:	123018777(AFDN)

PMUA:

114594338(AFDN)

PRAF:

128410755(AFDN)

ZVI:	118081932(AFDN)

HCG:	128345134(AFDN)

GJA:	107119630(AFDN)

STOW:

125427647(AFDN)

EMC:	129325968(AFDN)

XLA:	496308(afdn.L) 496335(afdn.S)

XTR:	100493083(afdn)

NPR:	108787997(AFDN)

RTEM:

120937428(AFDN)

BBUF:

120998659(AFDN)

BGAR:

122934286(AFDN)

PWL:	138296089(AFDN)

MUO:	115465455(AFDN)

GSH:	117357559(AFDN)

DRE:	558359(afdna)

SRX:	107726731 107743316

SANH:

107653728 107678828 107697133

SGH:	107549673 107552029 107603070

CAUA:

113037883 113037884 113092595 113116906

CGIB:

127939077 127983763

PTET:

122325560(afdna)

LROH:

127151826(afdna)

OMC:	131526872(afdna)

PPRM:

120493963(afdna)

RKG:	130103242(afdna)

MAMB:

125278389(afdna)

CIDE:

127502311

CERY:

137019171(afdna)

MASI:

127409839 127415974

TROS:

130566266(afdna)

TDW:	130434654(afdna)

MANU:

129429773(afdna)

PDAB:

135738303(afdna)

IPU:	108257749(afdna)

IFU:	128601241(afdna)

PHYP:

113531916(afdn)

SMEO:

124377279(afdna)

TFD:	113648263(afdna)

TVC:	132843082(afdna)

CGAR:

128515241(afdna)

NGRA:

132883144(afdna)

TRN:	134320792(afdna)

AMEX:

103033004(afdna) 103046279

CMAO:

118815731(afdna)

EEE:	113570299(afdn)

CHAR:

105897055(afdna)

SPIL:

134098502(afdna)

TRU:	101063677(afdn) 101078746

TFS:	130513021 130516275(afdna)

TNG:	GSTEN00035441G001

LCO:	104934235(afdn) 104937233

TBEN:

117487642(afdna)

CGOB:

115006102 115028887

PGEO:

117439766(afdna) 117467970

GACU:

117532975

EMAC:

134876658

ELY:	117267032 117270713(afdna)

EFO:	125897575(afdna) 125900603

PLEP:

121953873 121955347(afdna)

SLUC:

116057291 116066295(afdna)

ECRA:

117935742 117961822(afdna)

ESP:	116670334 116706300(afdn)

PFLV:

114547161 114572754(afdn)

GAT:	120807656(afdna) 120833024

PPUG:

119195123(afdna) 119227347

AFB:	129103697 129107485(afdna)

CLUM:

117727106(afdna) 117751606

PSWI:

130202911(afdna)

CANA:

137785614(afdna) 137787598

CVE:	137870981 137880305

MSAM:

119908611(afdna) 119910799

SCHU:

122861812 122862991(afdna)

CUD:	121521095(afdna) 121526675

SPUL:

138585085(afdna) 138591162

LMIX:

132984703(afdna) 132993639

ALAT:

119004544 119012557(afdna)

ASTR:

137610778 137613792(afdna)

MZE:	101467084(afdn) 101477882

ONL:	100701319(afdn) 100703154

OAU:	116318142 116333126(afdna)

OLA:	101167331 101169758(afdn)

OML:	112148162 112160254(afdna)

CSAI:

133462191 133464626(afdna)

XMA:	102226767(afdn) 102235553

XCO:	114134438 114158731(afdn)

XHE:	116709245 116734354(afdn)

PRET:

103457240(mllt4) 103458481

PFOR:

103144794 103152698(mllt4)

PLAI:

106935365 106946965

PMEI:

106904767 106931496(mllt4)

GAF:	122825223(afdna) 122846258

PPRL:

129365299 129375306(afdna)

CVG:	107083520 107091588

CTUL:

119774925(afdna) 119792781

GMU:	124855985 124881916(afdna)

NFU:	107377737(mllt4) 107391780

KMR:	108239057 108244865(afdna)

ALIM:

106511082 106531073 106532193

NWH:	119418631(afdna) 119427247

AOCE:

111565480(afdna) 111578622

EJA:	138205092 138212104(afdna)

BFRE:

138632269 138633064(afdna)

MCEP:

125023816

CSEM:

103380787 103381106(mllt4)

POV:	109636285 109639962 109640840

SSEN:

122782852 122784252(afdna)

SSOE:

131443804(afdna) 131444905

HHIP:

117755562 117758053(afdna)

HSP:	118099103(afdna) 118116601

PPLT:

128450703 128460145(afdna)

SMAU:

118286801 118289903(afdna)

LCF:	108885264(afdna) 108886728

SDU:	111225712 111235862(afdn)

SLAL:

111665838 111672497(afdn)

XGL:	120789305(afdna) 120795482

HCQ:	109516743(afdn) 109517313

SSCV:

125981133 125990474(afdna)

SBIA:

133496334(afdna) 133513517

PEE:	133417290(afdna)

PTAO:

133468590

BPEC:

110155365(afdn)

MALB:

109968852 109973351

BSPL:

114848753 114849151

SJO:

128375846

SSCO:

133998005(afdna) 134001264

GMH:	115534674 115544277

SASA:

106571391 106603236 106607791(afdn)

STRU:

115172057 115174826 115193037(afdn)

OTW:	112217594 112250157 112262432

OMY:	110498692 110521052 110529594(afdna)

OGO:	123990738 123995073

ONE:	115107737 115139431(afdn) 115146758

OKI:	109885485(afdn) 109894797 109900730

OKE:	118361831 118386605 118397872

OMM:	135505991 135507450 135557576

OCLA:

139374444 139407142 139415114

SALP:

111954279 111968974 111973276

SNH:	120019714 120024176 120060078

CCLU:

121538941 121548942 121552194(afdna)

ELS:	105015458 105017961(afdn)

SFM:	108928525(afdn)

PKI:	111836150(afdn)

AANG:

118230233 118234553

AROT:

135254964 135257524(afdna)

CCOG:

133129352

LOC:	102695439(mllt4)

PSPA:

121315898 121317024(afdna)

ARUT:

117402228 117411391

PSEX:

120525817

LCM:	102354328(AFDN)

CMK:	103179304(afdna)

RTP:	109934259(afdna)

CPLA:

122552965(afdna)

HOC:	132819822(afdna)

LERI:

129699546(afdna)

PMRN:

116955521(AFDN)

LRJ:	133356951(AFDN) 133357018

BFO:

BBEL:

CIN:

SCLV:

SPU:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG42312(cno)

DER:

6552377

DSE:

6613905

DSI:	Dsimw501_GD19640(Dsim_GD19640)

DYA:	Dyak_GE14588 Dyak_GE25307

DAN:

6498867

DSR:	110183906 110188055

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10219

DAZ:

108621666

DNV:

108657063

DHE:

111604906

DVI:	6633102(cno)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957602(cno)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

109399005 115259774 115259816

ASUA:

134227373

CQU:	CpipJ_CPIJ007708 CpipJ_CPIJ007709

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139110394(Cno)

TLN:	139810642(Cno)

HST:

DQU:

CFO:

FEX:

PMEC:

138936196(Cno)

LHU:	105671319(cno)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:	103571974 103577985

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

138130116(cno)

DPA:

109540285

ESIM:

136419526(cno)

EFOR:

136344254(cno)

SOY:	115875142 115886425

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207588 KGM_207589

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137931288(cno)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:	110380554(cno)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106688410(cno)

NLU:

111053155

HVI:

124357597

MQU:	128987718 128988204

PHU:	Phum_PHUM605280

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_316993

DMK:

DPZ:

AFRA:

PVM:

PJA:	122243223 122248195 122257974

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:	136849101(cno)

PORN:

139755545(cno)

HAZT:

108664288

EAF:

111709291

LSM:	121132592(cno)

TCF:

131880764

PPOI:

119100282 119109048 119109053

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:	118181958 118199544

CEL:	CELE_W03F11.6(afd-1)

CBR:	CBG_03894(Cbr-afd-1)

CRQ:	GCK72_000803

LOA:	LOAG_18317

TSP:

Tsp_09428

HRO:	HELRODRAFT_184008

LGI:	LOTGIDRAFT_210615

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_164340

OVI:	T265_04653 T265_14559

EGL:	EGR_02758 EGR_06408

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_170

AQU:

105316712

» show all

Reference

PMID:10477764

Authors

Ikeda W, Nakanishi H, Miyoshi J, Mandai K, Ishizaki H, Tanaka M, Togawa A, Takahashi K, Nishioka H, Yoshida H, Mizoguchi A, Nishikawa S, Takai Y

Title

Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.

Journal

J Cell Biol 146:1117-32 (1999)
DOI:10.1083/jcb.146.5.1117

Sequence

[mmu:17356]

All links

Gene (2947)   
   MGENES (589)   
   RefGene (2354)   
   OC (4)   
All databases (2947)   

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