KEGG   ORTHOLOGY: K05708Help
Entry
K05708                      KO                                     

Name
hcaE, hcaA1
Definition
3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha [EC:1.14.12.19]
Pathway
ko00360  Phenylalanine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K05708  hcaE, hcaA1; 3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.19  3-phenylpropanoate dioxygenase
     K05708  hcaE, hcaA1; 3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha
BRITE hierarchy
Other DBs
RN: R06782 R06783
COG: COG4638
GO: 0008695
Genes
ECO: b2538(hcaE)
ECJ: JW2522(hcaE)
ECD: ECDH10B_2705(hcaE)
EBW: BWG_2302(hcaE)
ECOK: ECMDS42_2082(hcaE)
ECE: Z3809(hcaA1)
ECS: ECs3404
ETW: ECSP_3482(hcaE)
ELX: CDCO157_3171
EOJ: ECO26_3585(hcaE)
EOI: ECO111_3262(hcaE)
EOH: ECO103_3055(hcaE)
ECOO: ECRM13514_3370(hcaA1)
ECOH: ECRM13516_3226(hcaA1)
EOK: G2583_3068(hcaE)
ESO: O3O_18925
ESM: O3M_06770
ESL: O3K_06725
ELH: ETEC_2695
ECX: EcHS_A2690(hcaE)
ECM: EcSMS35_2691(hcaE)
ECY: ECSE_2825
ECR: ECIAI1_2590(hcaE)
ECK: EC55989_2824(hcaE)
ECT: ECIAI39_2739(hcaE)
EOC: CE10_2970(hcaE)
EUM: ECUMN_2858(hcaE)
ELO: EC042_2742(hcaE)
EBR: ECB_02430(hcaE)
EBD: ECBD_1146
EKF: KO11_10130(hcaE)
EDJ: ECDH1ME8569_2465(hcaE)
ELW: ECW_m2764(hcaE)
ELL: WFL_13535(hcaE)
ELP: P12B_c2638(hcaA)
EBL: ECD_02430(hcaE)
EBE: B21_02394(hcaE)
SFL: SF2585(hcaA1)
SFX: S2757(hcaA1)
SFV: SFV_2586(hcaA1)
SFE: SFxv_2841(hcaE)
SFN: SFy_3672
SFS: SFyv_3749
SFT: NCTC1_02841(hcaA1)
SSN: SSON_2620(hcaA1)
SBO: SBO_2562(hcaA1)
REE: electrica_01233(hcaE)
EBF: D782_1131
PLU: plu2204(hcaE)
PAY: PAU_02357(hcaE)
LRI: NCTC12151_03203(hcaE_1) NCTC12151_03204(hcaE_2)
ASJ: AsACE_CH00358(hcaE)
BCEN: DM39_1983
AFQ: AFA_13915
NAR: Saro_3840
SPHP: LH20_03925
SWI: Swit_0890
SPHD: HY78_22240
AAY: WYH_01869(hcaE)
MVA: Mvan_4415
MAB: MAB_4370c
CDR: CDHC03_1952(hcaE)
CMV: CMUST_15080(hcaE)
NFR: ERS450000_00303(hcaE_2)
REQ: REQ_35060
GOR: KTR9_1265
SCB: SCAB_2191(hcaE)
SMAL: SMALA_8449
TRO: trd_A0341
SAI: Saci_2059
SID: M164_0864
SII: LD85_0977
SIH: SiH_0732
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
  Sequence
[eco:b2538]

KEGG   ORTHOLOGY: K05709Help
Entry
K05709                      KO                                     

Name
hcaF, hcaA2
Definition
3-phenylpropionate/trans-cinnamate dioxygenase subunit beta [EC:1.14.12.19]
Pathway
ko00360  Phenylalanine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K05709  hcaF, hcaA2; 3-phenylpropionate/trans-cinnamate dioxygenase subunit beta
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.19  3-phenylpropanoate dioxygenase
     K05709  hcaF, hcaA2; 3-phenylpropionate/trans-cinnamate dioxygenase subunit beta
BRITE hierarchy
Other DBs
RN: R06782 R06783
COG: COG5517
GO: 0008695
Genes
ECO: b2539(hcaF)
ECJ: JW2523(hcaF)
ECD: ECDH10B_2706(hcaF)
EBW: BWG_2303(hcaF)
ECOK: ECMDS42_2083(hcaF)
ECE: Z3810(hcaA2)
ECS: ECs3405
ECF: ECH74115_3771(hcaF)
ETW: ECSP_3483(hcaF)
ELX: CDCO157_3172
EOJ: ECO26_3586(hcaF)
EOI: ECO111_3263(hcaF)
ECOO: ECRM13514_3371(hcaA2)
ECOH: ECRM13516_3227(hcaA2)
EOK: G2583_3069(hcaF)
ESO: O3O_18930
ESM: O3M_06765
ESL: O3K_06720
ECW: EcE24377A_2824(hcaF)
ELH: ETEC_2696
ECX: EcHS_A2691(hcaF)
ECM: EcSMS35_2692(hcaF)
ECY: ECSE_2826
ECR: ECIAI1_2591(hcaF)
ECK: EC55989_2825(hcaF)
ECT: ECIAI39_2740(hcaF)
EOC: CE10_2971(hcaF)
EUM: ECUMN_2859(hcaF)
ELO: EC042_2743(hcaF)
EBR: ECB_02431(hcaF)
EBD: ECBD_1145
EKF: KO11_10125(hcaF)
EDJ: ECDH1ME8569_2466(hcaF)
ELW: ECW_m2765(hcaF)
ELL: WFL_13540(hcaF)
ELP: P12B_c2639(hcaF)
EBL: ECD_02431(hcaF)
EBE: B21_02395(hcaF)
SFL: SF2586(hcaA2)
SFX: S2758(hcaA2)
SFV: SFV_2587(hcaA2)
SFE: SFxv_2842(hcaF)
SFN: SFy_3673
SFS: SFyv_3750
SFT: NCTC1_02842(hcaA2)
SSN: SSON_2621(hcaA2)
SBO: SBO_2563(hcaA2)
REE: electrica_01232(hcaF)
EBF: D782_1130
PLU: plu2205(hcaF)
PAY: PAU_02356(hcaF)
LRI: NCTC12151_03202(hcaF)
ASJ: AsACE_CH00359(hcaF)
AFQ: AFA_13920
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
  Sequence
[eco:b2539]

KEGG   ORTHOLOGY: K05710Help
Entry
K05710                      KO                                     

Name
hcaC
Definition
3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin component
Pathway
ko00360  Phenylalanine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K05710  hcaC; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin component
BRITE hierarchy
Other DBs
RN: R06782 R06783
COG: COG2146
Genes
ECO: b2540(hcaC)
ECJ: JW2524(hcaC)
ECD: ECDH10B_2707(hcaC)
EBW: BWG_2304(hcaC)
ECOK: ECMDS42_2084(hcaC)
ECE: Z3811(hcaC)
ECS: ECs3406
ECF: ECH74115_3772(hcaC)
ETW: ECSP_3484(hcaC)
ELX: CDCO157_3173
EOJ: ECO26_3587(hcaC)
EOI: ECO111_3264(hcaC)
EOH: ECO103_3060(hcaC)
ECOH: ECRM13516_3228(hcaC)
EOK: G2583_3070(hcaC)
ESO: O3O_18935
ESM: O3M_06760
ESL: O3K_06715
ECW: EcE24377A_2825(hcaC)
ELH: ETEC_2697
ECX: EcHS_A2692(hcaC)
ECM: EcSMS35_2693(hcaC)
ECY: ECSE_2827
ECR: ECIAI1_2592(hcaC)
ECK: EC55989_2826(hcaC)
ECT: ECIAI39_2741(hcaC)
EOC: CE10_2972(hcaC)
EUM: ECUMN_2860(hcaC)
ELO: EC042_2744(hcaC)
EBR: ECB_02432(hcaC)
EBD: ECBD_1144
EKF: KO11_10120(hcaC)
EDJ: ECDH1ME8569_2467(hcaC)
ELW: ECW_m2766(hcaC)
ELL: WFL_13545(hcaC)
ELP: P12B_c2640(hcaC)
EBL: ECD_02432(hcaC)
EBE: B21_02396(hcaC)
SFL: SF2587(hcaC)
SFX: S2759(hcaC)
SFV: SFV_2588(hcaC)
SFE: SFxv_2843(hcaC)
SFN: SFy_3674
SFS: SFyv_3751
SFT: NCTC1_02843(hcaC)
SSN: SSON_2622(hcaC)
SBO: SBO_2564(hcaC)
REE: electrica_01231(hcaC)
EBF: D782_1129
PLU: plu2206(hcaC)
PAY: PAU_02355(hcaC)
LRI: NCTC12151_03201(hcaC)
XFA: XF_1472
XFT: PD_0689(bedB)
XCC: XCC2771(bedB)
XCB: XC_1342
XCP: XCR_3136
XCV: XCV3084
XAX: XACM_2871
XAC: XAC2940(bedB)
XCI: XCAW_03218(hcaA1)
XOO: XOO1400(bedB)
XOM: XOO1283(XOO1283)
XOP: PXO_01974
XOR: XOC_1470
XAL: XALC_1025(hcaC)
XPH: XppCFBP6546_21210(XppCFBP6546P_21210)
SML: Smlt1150
SMT: Smal_0994
SMZ: SMD_1072
PSUW: WQ53_13610
PSD: DSC_05780
LAB: LA76x_1616(bnzC)
LAQ: GLA29479_659(bnzC)
LCP: LC55x_1397(bnzC)
LGU: LG3211_1294(bnzC)
LEZ: GLE_1254(bnzC)
LEM: LEN_3676(hcaC)
DKO: I596_1872
PPF: Pput_2672
PFS: PFLU_2391
PFB: VO64_5561
PMAN: OU5_5720
PKC: PKB_3013
PSET: THL1_2791
PSIL: PMA3_10385
ASJ: AsACE_CH00360(hcaC)
PIN: Ping_1502
MCA: MCA0987
METL: U737_08330
MAH: MEALZ_2007(bphF)
MMAI: sS8_2519
TKM: TK90_1586
TNI: TVNIR_1838(hcaC_[H])
TVR: TVD_05020
GAI: IMCC3135_07065(todB) IMCC3135_09340(ndoA)
SVA: SVA_1580
TBN: TBH_C1582
ENM: EBS_1534(hcaC)
RSN: RSPO_c02125(nagAb)
RSY: RSUY_16720(ndoA)
REH: H16_B0803(h16_B0803) H16_B1518(sufR)
BMA: BMAA1338
BMAL: DM55_4184
BMAE: DM78_3315
BMAQ: DM76_4884
BMAI: DM57_10360
BMAF: DM51_4991
BMAZ: BM44_4148
BMAB: BM45_3270
BPS: BPSS0894
BPM: BURPS1710b_A2492(hcaA12)
BPSE: BDL_4182
BPSM: BBQ_5243
BPSU: BBN_4353
BPSD: BBX_6022
BPK: BBK_3544
BPSH: DR55_4442
BPSA: BBU_5137
BPSO: X996_4130
BUT: X994_6231
BTQ: BTQ_4790
BTJ: BTJ_3422
BTZ: BTL_4270
BTD: BTI_5713
BTV: BTHA_3687
BTHE: BTN_3421
BTHM: BTRA_4172
BTHA: DR62_3494
BTHL: BG87_4246
BOK: DM82_5067
BOC: BG90_5528
BCEW: DM40_4682
BMJ: BMULJ_02644(hcaC)
BCT: GEM_3763
BUB: BW23_5507
BLAT: WK25_25845
BTEI: WS51_06805
BSEM: WJ12_29395
BPSL: WS57_04735
BSTG: WT74_28435
BGO: BM43_4773
BUL: BW21_5400
BXB: DR64_5519
PPNO: DA70_22080
PSPU: NA29_13005
BPE: BP0586
BPC: BPTD_0595
BPER: BN118_3481
BPET: B1917_3468
BPEU: Q425_35630
BPA: BPP0276
BPAR: BN117_0274
BBR: BB0279
BAV: BAV1581
AFQ: AFA_13925 AFA_15110(picB1)
POL: Bpro_4275
CTES: O987_17445
CFU: CFU_0344(mocE)
TBD: Tbd_0271
MMB: Mmol_1123
MEH: M301_0845
AZA: AZKH_1938 AZKH_2784(fdx)
MXA: MXAN_2758
CCX: COCOR_05289(hcaC)
HOH: Hoch_5508
AMIH: CO731_01987(nagAb) CO731_02243(ndoA)
SME: SM_b20819(mocE) SMc01993
SFH: SFHH103_04882(mocE) SFHH103_05516(mocE)
ARA: Arad_9583(mocEe)
RET: RHE_PE00445(mocEe)
REC: RHECIAT_PA0000368(mocEa)
RLE: pRL110621
RLG: Rleg_7184
RHL: LPU83_2620(CAO) LPU83_3869(mocE)
VGO: GJW-30_1_04001(andAb)
MET: M446_5690
MOR: MOC_3741
MAQU: Maq22A_c05965(nirD)
BID: Bind_2768
HDI: HDIA_1415(nagAb) HDIA_3413(ndoA)
JAN: Jann_1457
MALG: MALG_04164
SPKC: KC8_19515
TMO: TMO_b0116(bedB)
HTL: HPTL_1060
PMW: B2K_20075
AAC: Aaci_0991
AAD: TC41_1004(hcaC)
BTS: Btus_0578
STH: STH2039
TMR: Tmar_2043
SAY: TPY_3322(hcaC)
MVA: Mvan_1329
MPHL: MPHLCCUG_01330(todB)
MVQ: MYVA_1137
MAB: MAB_4369c
ASD: AS9A_0977(nirD) AS9A_1008
CDR: CDHC03_1953(hcaC)
NFR: ERS450000_00302(bphA3)
REQ: REQ_35070
RHB: NY08_3777
RFA: A3L23_02132(hcaC)
RHS: A3Q41_01251(hcaC)
RHU: A3Q40_00919(hcaC)
RRT: 4535765_00394(hcaC)
GOR: KTR9_1262
SCO: SCO1923(SCC22.05c)
SALB: XNR_4939
SMA: SAVERM_6327(hcaC1) SAVERM_6955(hcaC2)
SGR: SGR_5597
SGB: WQO_07360
SCB: SCAB_2181(hcaC) SCAB_70051 SCAB_7071(nirD)
SCT: SCAT_0381 SCAT_1085(hcaC)
SFA: Sfla_4900
SVE: SVEN_1554
STRP: F750_1782
SFI: SFUL_1482
STRM: M444_09820
SAMB: SAM23877_1994(bedB)
SPRI: SPRI_5611
SRW: TUE45_01806(hcaC_1) TUE45_02413(hcaC_2)
SLE: sle_52180(sle_52180)
SRN: A4G23_01135(bnzC)
STRD: NI25_29580
SLAU: SLA_1444
SALF: SMD44_01421(hcaC) SMD44_02077(hcaC)
SALJ: SMD11_5111(hcaC)
SLX: SLAV_27945(hcaC)
SGE: DWG14_06459(hcaC_1) DWG14_07313(hcaC_2)
KSK: KSE_55630
TWH: TWT_335
TWS: TW436
LXX: Lxx11670
CMI: CMM_1729
CMS: CMS1973
CMC: CMN_01709
MTS: MTES_3645
MOO: BWL13_01108(bnzC)
AMIN: AUMI_14210
AUW: AURUGA1_00974(hcaC)
ART: Arth_2105
ARM: ART_0722
ARX: ARZXY2_1873(hcaC)
AAU: AAur_2106
ACH: Achl_1847
AAI: AARI_27910(hcaC)
BCV: Bcav_2338
JDE: Jden_1142
LMOI: VV02_14650
XCE: Xcel_1359
IDO: I598_0893(todB)
CFL: Cfla_1673
CFI: Celf_1695
SERJ: SGUI_0265
DCO: SAMEA4475696_1776(bphA3)
PAC: PPA1547
PACC: PAC1_08130
PACH: PAGK_0633
CACN: RN83_08200
CGRN: 4412665_01073(ndoA)
PFRE: RM25_1416
PPC: HMPREF9154_1082(ndoA)
ACIJ: JS278_01237(hcaC)
MPH: MLP_14510
NDK: I601_3414(andAb)
KFL: Kfla_3280
PSIM: KR76_13935
TFU: Tfu_1985
NDA: Ndas_2961
NAL: B005_5504
STRR: EKD16_15180(ndoA) EKD16_17060(hcaC)
TCU: Tcur_2226
SRO: Sros_5985
FAL: FRAAL4561
GOB: Gobs_2066
BSD: BLASA_3219(sufE)
MMAR: MODMU_2893(hcaC) MODMU_3610(sufE)
KRA: Krad_4109
SEN: SACE_3146(hcaC2) SACE_4486(hcaC2)
AMD: AMED_7562(hcaC) AMED_7994(hcaC)
AMM: AMES_7450(hcaC) AMES_7875(hcaC)
AMZ: B737_7450(hcaC) B737_7875(hcaC)
AOI: AORI_6807(hcaC)
AMQ: AMETH_4494(hcaC2)
PDX: Psed_4208
PSEE: FRP1_20325
PSEH: XF36_06485
PAUT: Pdca_14140(hcaC)
AMI: Amir_5152
SESP: BN6_62310
AHG: AHOG_06305(hcaC) AHOG_11810(andAb)
ALO: CRK56354
MIL: ML5_3987
ASE: ACPL_1873(bedB)
ACTN: L083_2177
AFS: AFR_10675
ACTS: ACWT_1751
SNA: Snas_2444
AHE: Arch_0935
TPYO: X956_05225
TBW: NCTC13354_00016(bphA3)
TBI: Tbis_1970
CWO: Cwoe_5395
AFO: Afer_0562
HAU: Haur_0406
TRO: trd_A0838
STI: Sthe_3233
ATM: ANT_17920
DRA: DR_1950
DGE: Dgeo_0455
DFC: DFI_09235
TRA: Trad_0260
TTH: TT_C1490
TTJ: TTHA1841
TAQ: TO73_0290
MRB: Mrub_0780
MTAI: Mtai_v1c05020(hcaC)
TTR: Tter_1694
MIN: Minf_2462(nirD)
MKC: kam1_2161
PSL: Psta_2904
PIR: VN12_27040(ndoA)
PLS: VT03_26350(carAc) VT03_29855(hcaC)
PLH: VT85_08740(nagAb)
FMR: Fuma_05750(hcaC)
TTF: THTE_4297
GMR: GmarT_11770(hcaC_2)
MFF: MFFC18_29650(ndoA)
IPA: Isop_3231
PBOR: BSF38_04069(carAc)
AGV: OJF2_45800(ndoA)
LIL: LA_3561(nirD)
LIE: LIF_A2866(nirD)
LIC: LIC_10633(bedB)
LIS: LIL_10643(nirD)
LBJ: LBJ_2444(nirD)
LBL: LBL_0668(nirD)
LBF: LBF_1863(nirD)
LST: LSS_15531
GAU: GAU_3031
GBA: J421_2086
CPI: Cpin_0589
FLN: FLA_5411
SMIZ: 4412673_00125(andAb)
IAL: IALB_2268(hcaC)
NDE: NIDE2767
FAI: FAD_0012
MPY: Mpsy_1353
MPD: MCP_0385
SOL: Ssol_2796
SSOA: SULA_2818
SSOL: SULB_2819
SSOF: SULC_2816
SII: LD85_0660
PYR: P186_1883
POG: Pogu_1789
NMR: Nmar_0308
NID: NPIRD3C_0710(bedB)
NCT: NMSP_0657(sdx_1) NMSP_1400(sdx_3)
TAA: NMY3_01267(nagAb_2) NMY3_01309(nagAb_3)
NCV: NCAV_0226
NDV: NDEV_0450
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
Reference
  Authors
Vezina J, Barriault D, Sylvestre M
  Title
Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.
  Journal
J Bacteriol 189:779-88 (2007)
DOI:10.1128/JB.01267-06

KEGG   ORTHOLOGY: K00529Help
Entry
K00529                      KO                                     

Name
hcaD
Definition
3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
Pathway
ko00071  Fatty acid degradation
ko00360  Phenylalanine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K00529  hcaD; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K00529  hcaD; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.3  ferredoxin---NAD+ reductase
     K00529  hcaD; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component
BRITE hierarchy
Other DBs
RN: R02000 R06782 R06783
COG: COG0446
GO: 0008860
Genes
ECO: b2542(hcaD)
ECJ: JW2526(hcaD)
ECD: ECDH10B_2709(hcaD)
EBW: BWG_2306(hcaD)
ECOK: ECMDS42_2086(hcaD)
ECE: Z3814(hcaD)
ECS: ECs3408
ECF: ECH74115_3774(hcaD)
ETW: ECSP_3486(hcaD)
ELX: CDCO157_3175
EOJ: ECO26_3589(hcaD)
EOI: ECO111_3266(hcaD)
EOH: ECO103_3062(hcaD)
EOK: G2583_3072(hcaD)
ESO: O3O_18945
ESM: O3M_06750
ESL: O3K_06705
ECW: EcE24377A_2827(hcaD)
ELH: ETEC_2699
ECX: EcHS_A2694(hcaD)
ECM: EcSMS35_2695(hcaD)
ECY: ECSE_2829
ECK: EC55989_2828(hcaD)
ECT: ECIAI39_2743(hcaD)
EOC: CE10_2974(hcaD)
EUM: ECUMN_2862(hcaD)
ELO: EC042_2746(hcaD)
EBR: ECB_02434(hcaD)
EBD: ECBD_1142
EKF: KO11_10110(hcaD)
EDJ: ECDH1ME8569_2469(hcaD)
ELW: ECW_m2768(hcaD)
ELL: WFL_13555(hcaD)
ELP: P12B_c2642(hcaD)
EBL: ECD_02434(hcaD)
EBE: B21_02398(hcaD)
SFV: SFV_2590(hcaD)
SFE: SFxv_2845(hcaD)
SFN: SFy_3676
SFS: SFyv_3753
SFT: NCTC1_02845(hcaD_1) NCTC1_02846(hcaD_2)
SSN: SSON_2624(hcaD)
ENC: ECL_04260
ECLO: ENC_31820
ECLX: LI66_18670
ECLY: LI62_20130
ECLZ: LI64_17560
EEC: EcWSU1_03730(thcD)
KPN: KPN_03366
KPR: KPR_4631
KPJ: N559_0870
KPNU: LI86_04260
EAE: EAE_03025
EAR: CCG33376
RTG: NCTC13098_01028(andAa)
REE: electrica_01229(hcaD)
YRO: CH64_1873
SPE: Spro_3963
SRL: SOD_c39190(thcD)
SPLY: Q5A_021000(thcD)
SMAF: D781_3684
SMW: SMWW4_v1c40720(hcaD)
SMAR: SM39_3555
SERF: L085_08140
PLU: plu2209
PAY: PAU_02352(hcaD)
PSI: S70_19015
PSX: DR96_2720
PRG: RB151_039990(andAa)
LRI: NCTC12151_03199(hcaD)
XCV: XCV2179
XAX: XACM_2265
PSD: DSC_14560
PCQ: PcP3B5_42510(thcD_2)
PFS: PFLU_2392
PFE: PSF113_3383(ethA)
PFB: VO64_5562
ACB: A1S_0951
ABY: ABAYE2843
ABN: AB57_1026
ABX: ABK1_0936
ABH: M3Q_1249
ABAD: ABD1_09030
ABAZ: P795_12955
ABAU: IX87_00780
ABAA: IX88_06760
ACC: BDGL_000228(thcD)
ASJ: AsACE_CH00363(hcaD)
PAT: Patl_2303
PPHE: PP2015_459
PTN: PTRA_a0478(hcaD)
PART: PARC_a2206(hcaD)
PAGA: PAGA_a1709(hcaD)
MAQ: Maqu_0601
MHC: MARHY2840(ahpH)
MAD: HP15_27
MARJ: MARI_17960(camA)
GPS: C427_3050
GAI: IMCC3135_09320(thcD_1) IMCC3135_19405(thcD_2) IMCC3135_21415(thcD_3)
CSA: Csal_0136
HBE: BEI_0073(hcaD)
ABO: ABO_0203
ADI: B5T_02077
APAC: S7S_11265
AXE: P40_09940
SALN: SALB1_2724
RSL: RPSI07_2133(hcaD)
RSN: RSPO_c02130(nirB)
REH: H16_A1630(h16_A1630) H16_B0802(h16_B0802)
BMA: BMAA1326
BMAL: DM55_4196
BMAE: DM78_3327
BMAQ: DM76_4896
BMAI: DM57_10420
BMAF: DM51_4979
BMAZ: BM44_4160
BMAB: BM45_3282
BPS: BPSS0906
BPM: BURPS1710b_A2504(mopA)
BPSE: BDL_4194
BPSM: BBQ_5231
BPSU: BBN_4365
BPSD: BBX_6034
BPK: BBK_3532
BPSH: DR55_4430
BPSA: BBU_5125
BPSO: X996_4142
BTQ: BTQ_4778
BTJ: BTJ_3410
BTZ: BTL_4258
BTD: BTI_5725
BTV: BTHA_3699
BTHE: BTN_3433
BTHM: BTRA_4184
BTHA: DR62_3506
BTHL: BG87_4234
BOK: DM82_5079
BOC: BG90_5516
BCEW: DM40_4670
BMJ: BMULJ_02643(hcaD)
BUB: BW23_5495
BLAT: WK25_25785
BTEI: WS51_06745
BSEM: WJ12_29335
BPSL: WS57_04795
BSTG: WT74_28375
BGU: KS03_4077
BUL: BW21_5412
BFN: OI25_3033(thcD) OI25_3902(thcD) OI25_5519
PPNO: DA70_03300
PPNM: LV28_03030
PPUL: RO07_21920
PAPI: SG18_20970
BPE: BP0585
BPEU: Q425_35640
BHO: D560_1526 D560_1678(thcD)
BHM: D558_1517 D558_1666(thcD)
BHZ: ACR54_01067(camA) ACR54_01699(andAa) ACR54_04420(thcD)
BTRM: SAMEA390648702391(camA)
AXX: ERS451415_02891(thcD_2)
PUT: PT7_2669
AMIM: MIM_c31590
AFQ: AFA_13935 AFA_15115(picB2)
RFR: Rfer_0300
AJS: Ajs_0213
ACK: C380_15960(bphA4)
DAC: Daci_2353
HYR: BSY239_2683(thcD)
CBAA: SRAA_1072
CBAB: SMCB_0826
MPT: Mpe_B0597
CFU: CFU_0345(mocF)
LCH: Lcho_3288
AZO: azo2529(camA)
AOA: dqs_2686
AMIH: CO731_00487(thcD_1) CO731_02242(andAa)
PLA: Plav_0127
RBS: RHODOSMS8_03330(camA)
ATU: Atu1013
ARA: Arad_1563 Arad_9582(mocFe)
RET: RHE_CH01347 RHE_CH02643(mocFch) RHE_PE00444(mocFe)
RIR: BN877_I1000(thcD)
RHL: LPU83_1320 LPU83_2621(mocF1) LPU83_3868(mocF3)
RHT: NT26_0971(thcD)
BME: BMEII0557
BMEL: DK63_2689(thcD)
BMEE: DK62_2713(thcD)
BMF: BAB2_0511
BABO: DK55_2491(thcD)
BABR: DO74_2906(thcD)
BABT: DK49_2748(thcD)
BABB: DK48_2200(thcD)
BABU: DK53_2494(thcD)
BABS: DK51_3078(thcD)
BABC: DO78_2564(thcD)
BMS: BRA0729
BSZ: DK67_2693(thcD)
BOV: BOV_A0683
BCS: BCAN_B0736(thcD)
BCAR: DK60_2428(thcD)
BCAS: DA85_13955
BMR: BMI_II722
BPP: BPI_II782
BPV: DK65_2909(thcD)
OAN: Oant_3868
OAH: DR92_4393(thcD)
OCH: CES85_4051(thcD) CES85_5687(fdr)
BRS: S23_51680
BRAD: BF49_1851
RPA: RPA3782
RPB: RPB_3656
RPC: RPC_1647
RPD: RPD_1802
RPE: RPE_1676
RPT: Rpal_4303
NWI: Nwi_2287
NHA: Nham_2703
BOS: BSY19_593
VGO: GJW-30_1_00441(thcD)
XAU: Xaut_2616
SNO: Snov_0477
MEX: Mext_0977
MDI: METDI1124
MCH: Mchl_0941
MPO: Mpop_0917
MET: M446_2274
MNO: Mnod_0328
MOR: MOC_4083
META: Y590_03895
MAQU: Maq22A_c07385(hcaD)
MTUN: MTUNDRAET4_0896(camA)
FIL: BN1229_v1_2293(fdr)
FIY: BN1229_v1_2293(fdr)
BVR: BVIR_2618
BLAG: BLTE_22930
PLEO: OHA_2_00071(hcaD2)
MMED: Mame_03831(thcD)
HDI: HDIA_0861(thcD) HDIA_1414(andAa)
RBM: TEF_10365
CCR: CC_3525
PZU: PHZ_c0214
SIL: SPO3737
RSP: RSP_0900
RCP: RCAP_rcc03412(thcD)
JAN: Jann_0440
RDE: RD1_0947
DSH: Dshi_0114
KVU: EIO_0493
KVL: KVU_0054
KRO: BVG79_00317(hcaD)
PSF: PSE_0031
PGA: PGA1_c29270(thcD)
PGL: PGA2_c27200(thcD)
PGD: Gal_00503
PHP: PhaeoP97_00578(thcD)
PPIC: PhaeoP14_02699(thcD)
OTM: OSB_01410(fdr)
LAQU: R2C4_15210
PTP: RCA23_c03430(thcD)
MALG: MALG_03090
RSU: NHU_03901
RHC: RGUI_2695
RMM: ROSMUCSMR3_02975(thcD)
HNE: HNE_1888
GAK: X907_2626
SAL: Sala_1971
SMAZ: LH19_16785
SGI: SGRAN_1201(camA) SGRAN_1587(fdr) SGRAN_2775(camA2) SGRAN_3240(camA3)
SPHU: SPPYR_0680(fdr) SPPYR_0815(fdr) SPPYR_1398(fdr)
SPHM: G432_00945
STAX: MC45_14140
SSAN: NX02_11185
SPKC: KC8_02110
SPMI: K663_06390
SPHB: EP837_00486(hcaD)
SINB: SIDU_01545
SFLA: SPHFLASMR4Y_00997(fdr)
BLAS: BSY18_317
SMIC: SmB9_27880
ELI: ELI_12420
AAY: WYH_02138(fdr)
ANH: A6F65_00548(fdr)
ADO: A6F68_00373(fdr)
ALB: AEB_P0367
KEU: S101446_03116(hcaD)
ASZ: ASN_576
SHUM: STHU_47130
TMO: TMO_a0555(thcD) TMO_b0125(thcD) TMO_c0277(thcD)
MAGQ: MGMAQ_2659
MTU: Rv1869c
MTC: MT1918
MRA: MRA_1880
MTUR: CFBS_1961
MTD: UDA_1869c
MTUC: J113_12960
MTUE: J114_09960
MTUL: TBHG_01824
MTUT: HKBT1_1958
MTUU: HKBT2_1966
MBB: BCG_1905c
MBT: JTY_1889
MBX: BCGT_1702
MAF: MAF_18910
MMIC: RN08_2074
MPA: MAP_1579c
MAO: MAP4_2260
MAVI: RC58_11240
MAVU: RE97_11250
MAV: MAV_2849
MIA: OCU_26650
MID: MIP_03989
MYO: OEM_25310
MLP: MLM_2286
MMC: Mmcs_3219
MKM: Mkms_3281
MJL: Mjls_3230
MMI: MMAR_3153
MMM: W7S_13005
MHAD: B586_11635
MGI: Mflv_4591
MPHL: MPHLCCUG_01328(thcD)
MVQ: MYVA_1135
MSTE: MSTE_04054
MTER: 4434518_01908(andAa) 4434518_03871(camA)
CDR: CDHC03_1954(hcaD)
CVA: CVAR_0135
CTER: A606_11495
CMV: CMUST_15090(hcaD)
CAMG: CAMM_10640
NFA: NFA_12150
NFR: ERS450000_00301(thcD_1) ERS450000_00667(thcD_2) ERS450000_02785(thcD_3) ERS450000_02895(thcD_4)
RFA: A3L23_01169(thcD_1) A3L23_05141(camA)
RHS: A3Q41_00445(camA) A3Q41_02200(thcD_1)
RRT: 4535765_00396(thcD_1) 4535765_01806(andAa)
GRU: GCWB2_12280(camA1) GCWB2_21195(camA2) GCWB2_21445(camA3) GCWB2_23000(thcD4)
GOM: D7316_03163(andAa) D7316_03239(thcD_2) D7316_03417(thcD_3) D7316_05153(thcD_4)
SALB: XNR_4478
SGB: WQO_10105
SCT: SCAT_1535
SFA: Sfla_4382
SBH: SBI_00328 SBI_07356(fprD)
SHY: SHJG_3945
SVE: SVEN_2257
STRP: F750_2319
SFI: SFUL_2016
STRE: GZL_05962
SRW: TUE45_03065(camA)
SLE: sle_47430(sle_47430)
SRN: A4G23_01569(andAa)
SALJ: SMD11_4667
SLX: SLAV_25040(thcD2)
SGE: DWG14_05723(camA)
AMIN: AUMI_19500
AUW: AURUGA1_00408(thcD_1)
LMOI: VV02_12055
IDO: I598_2943(thcD)
CFI: Celf_2109
DCO: SAMEA4475696_0460(bedA)
ACIJ: JS278_00284(andAa)
NDK: I601_1173(thcD) I601_1935(camA_1) I601_3166(camA_2)
SRO: Sros_1897
FAL: FRAAL3171 FRAAL4010(fprC)
ACE: Acel_0803
NML: Namu_3641
SEN: SACE_2839(fprC) SACE_3145(fprC) SACE_3433 SACE_4511(fprC) SACE_5609(padAd2)
SACC: EYD13_07995(thcD1)
AMD: AMED_0391(hcaD) AMED_4383
AMM: AMES_0391(hcaD) AMES_4329
AMZ: B737_0392(hcaD) B737_4329
AOI: AORI_0410(hcaD) AORI_3258(hcaD) AORI_6047
AJA: AJAP_22905(andAa) AJAP_37605(thcD)
PSEA: WY02_20120
PAUT: Pdca_38410
SESP: BN6_12600
KAL: KALB_1398
ALO: CRK55028
AFS: AFR_27755
CAI: Caci_2641
RXY: Rxyl_2822
AVA: Ava_2874
FLM: MY04_2083
MARM: YQ22_01785
CBAL: M667_11695
CBAT: M666_11740
HMA: rrnAC0717
NPH: NP_4516A
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)

KEGG   ENZYME: 1.14.12.19Help
Entry
EC 1.14.12.19               Enzyme                                 

Name
3-phenylpropanoate dioxygenase;
HcaA1A2CD;
Hca dioxygenase;
3-phenylpropionate dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
BRITE hierarchy
Sysname
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
Reaction(IUBMB)
(1) 3-phenylpropanoate + NADH + H+ + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ [RN:R06782];
(2) (2E)-3-phenylprop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD+
Reaction(KEGG)
R06782;
(other) R06783
Show
Substrate
3-phenylpropanoate;
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007];
(2E)-3-phenylprop-2-enoate [CPD:C00423]
Product
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate.
History
EC 1.14.12.19 created 2005, modified 2011
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05708  3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha
K05709  3-phenylpropionate/trans-cinnamate dioxygenase subunit beta
Genes
ECO: b2538(hcaE) b2539(hcaF)
ECJ: JW2522(hcaE) JW2523(hcaF)
ECD: ECDH10B_2705(hcaE) ECDH10B_2706(hcaF)
EBW: BWG_2302(hcaE) BWG_2303(hcaF)
ECOK: ECMDS42_2082(hcaE) ECMDS42_2083(hcaF)
ECE: Z3809(hcaA1) Z3810(hcaA2)
ECS: ECs3404 ECs3405
ECF: ECH74115_3771(hcaF)
ETW: ECSP_3482(hcaE) ECSP_3483(hcaF)
ELX: CDCO157_3171 CDCO157_3172
EOJ: ECO26_3585(hcaE) ECO26_3586(hcaF)
EOI: ECO111_3262(hcaE) ECO111_3263(hcaF)
EOH: ECO103_3055(hcaE)
ECOO: ECRM13514_3370(hcaA1) ECRM13514_3371(hcaA2)
ECOH: ECRM13516_3226(hcaA1) ECRM13516_3227(hcaA2)
EOK: G2583_3068(hcaE) G2583_3069(hcaF)
ECW: EcE24377A_2824(hcaF)
ECX: EcHS_A2690(hcaE) EcHS_A2691(hcaF)
ECM: EcSMS35_2691(hcaE) EcSMS35_2692(hcaF)
ECR: ECIAI1_2590(hcaE) ECIAI1_2591(hcaF)
ECK: EC55989_2824(hcaE) EC55989_2825(hcaF)
ECT: ECIAI39_2739(hcaE) ECIAI39_2740(hcaF)
EOC: CE10_2970(hcaE) CE10_2971(hcaF)
EUM: ECUMN_2858(hcaE) ECUMN_2859(hcaF)
ELO: EC042_2742(hcaE) EC042_2743(hcaF)
EBR: ECB_02430(hcaE) ECB_02431(hcaF)
EKF: KO11_10125(hcaF) KO11_10130(hcaE)
ELW: ECW_m2764(hcaE) ECW_m2765(hcaF)
ELL: WFL_13535(hcaE) WFL_13540(hcaF)
ELP: P12B_c2638(hcaA) P12B_c2639(hcaF)
EBL: ECD_02430(hcaE) ECD_02431(hcaF)
EBE: B21_02394(hcaE) B21_02395(hcaF)
SFL: SF2585(hcaA1) SF2586(hcaA2)
SFX: S2757(hcaA1) S2758(hcaA2)
SFV: SFV_2586(hcaA1) SFV_2587(hcaA2)
SFE: SFxv_2841(hcaE) SFxv_2842(hcaF)
SFT: NCTC1_02841(hcaA1) NCTC1_02842(hcaA2)
SSN: SSON_2620(hcaA1) SSON_2621(hcaA2)
SBO: SBO_2562(hcaA1) SBO_2563(hcaA2)
PLU: plu2204(hcaE) plu2205(hcaF)
PAY: PAU_02356(hcaF) PAU_02357(hcaE)
LRI: NCTC12151_03202(hcaF) NCTC12151_03203(hcaE_1) NCTC12151_03204(hcaE_2)
ASJ: AsACE_CH00358(hcaE) AsACE_CH00359(hcaF)
BCEN: DM39_1983
NAR: Saro_3840
SPHP: LH20_03925
SWI: Swit_0890
SPHD: HY78_22240
AAY: WYH_01869(hcaE)
MVA: Mvan_4415
MAB: MAB_4370c
CDR: CDHC03_1952(hcaE)
CMV: CMUST_15080(hcaE)
NFR: ERS450000_00303(hcaE_2)
REQ: REQ_35060
GOR: KTR9_1265
SCB: SCAB_2191(hcaE)
SMAL: SMALA_8449
TRO: trd_A0341
SAI: Saci_2059
SID: M164_0864
SII: LD85_0977
SIH: SiH_0732
 » show all
Taxonomy
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
  Sequence
[eco:b2538 b2539]
Reference
2  [PMID:6345502]
  Authors
Burlingame R, Chapman PJ.
  Title
Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli.
  Journal
J Bacteriol 155:113-21 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.12.19
IUBMB Enzyme Nomenclature: 1.14.12.19
ExPASy - ENZYME nomenclature database: 1.14.12.19
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.19
BRENDA, the Enzyme Database: 1.14.12.19

KEGG   REACTION: R06782Help
Entry
R06782                      Reaction                               

Name
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
Definition
Phenylpropanoate + Oxygen + NADH + H+ <=> cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol + NAD+
Equation
Comment
HcaA1 HcaA2 HcaC HcaD
Reaction class
RC00001  C00003_C00004
RC00098  C05629_C11588
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K05708  3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha [EC:1.14.12.19]
K05709  3-phenylpropionate/trans-cinnamate dioxygenase subunit beta [EC:1.14.12.19]
K05710  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin component
Other DBs
RHEA: 20360

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