KEGG   ORTHOLOGY: K05718
Entry
K05718                      KO                                     

Name
ITGAL, CD11a
Definition
integrin alpha L
Pathway
ko04015  Rap1 signaling pathway
ko04514  Cell adhesion molecules
ko04613  Neutrophil extracellular trap formation
ko04650  Natural killer cell mediated cytotoxicity
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05144  Malaria
ko05150  Staphylococcus aureus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05323  Rheumatoid arthritis
ko05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05718  ITGAL, CD11a; integrin alpha L
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05718  ITGAL, CD11a; integrin alpha L
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K05718  ITGAL, CD11a; integrin alpha L
   04650 Natural killer cell mediated cytotoxicity
    K05718  ITGAL, CD11a; integrin alpha L
   04670 Leukocyte transendothelial migration
    K05718  ITGAL, CD11a; integrin alpha L
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05718  ITGAL, CD11a; integrin alpha L
   05169 Epstein-Barr virus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09174 Infectious disease: parasitic
   05144 Malaria
    K05718  ITGAL, CD11a; integrin alpha L
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05718  ITGAL, CD11a; integrin alpha L
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K05718  ITGAL, CD11a; integrin alpha L
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05718  ITGAL, CD11a; integrin alpha L
   04515 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
   04090 CD molecules
    K05718  ITGAL, CD11a; integrin alpha L
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K05718  ITGAL, CD11a; integrin alpha L
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K05718  ITGAL, CD11a; integrin alpha L
CD molecules [BR:ko04090]
 Proteins
  K05718  CD11a, ITGAL; integrin, alpha L
Genes
HSA: 3683(ITGAL)
PTR: 454045(ITGAL)
PPS: 100968171(ITGAL)
GGO: 101139540(ITGAL)
PON: 100451665(ITGAL)
NLE: 100600240(ITGAL)
MCC: 711945(ITGAL)
MCF: 102117706(ITGAL)
CSAB: 103231906(ITGAL)
RRO: 104681602(ITGAL)
RBB: 108535405(ITGAL)
CJC: 100390790(ITGAL)
SBQ: 101049788(ITGAL)
MMU: 16408(Itgal)
MCAL: 110299482(Itgal)
MPAH: 110338926(Itgal)
RNO: 308995(Itgal)
MUN: 110548001(Itgal)
CGE: 100770691(Itgal)
NGI: 103726419(Itgal)
HGL: 101723643(Itgal)
CCAN: 109683028(Itgal)
OCU: 100356927(ITGAL)
TUP: 102469543(ITGAL)
CFA: 489905(ITGAL)
VVP: 112929237(ITGAL)
AML: 100464009(ITGAL)
UMR: 103657863(ITGAL)
UAH: 113267681(ITGAL)
ORO: 101370679(ITGAL)
ELK: 111162178
FCA: 101085940(ITGAL)
PTG: 102951540(ITGAL)
PPAD: 109259024(ITGAL)
AJU: 106979092(ITGAL)
BTA: 281874(ITGAL)
BOM: 102281951(ITGAL)
BIU: 109578145(ITGAL)
BBUB: 102412430(ITGAL)
CHX: 102172115(ITGAL)
OAS: 641296(ITGAL)
SSC: 733681(ITGAL)
CFR: 102519794(ITGAL)
CDK: 105102736(ITGAL)
BACU: 103015686(ITGAL)
LVE: 103086254(ITGAL)
OOR: 101278885(ITGAL)
DLE: 111182142(ITGAL)
PCAD: 102973622
ECB: 100065508(ITGAL)
EPZ: 103547219(ITGAL)
EAI: 106831918(ITGAL)
MYB: 102245292(ITGAL)
MYD: 102754113(ITGAL)
MNA: 107541988(ITGAL)
HAI: 109374220(ITGAL)
DRO: 112304654(ITGAL)
PALE: 102879417(ITGAL)
RAY: 107515868(ITGAL)
MJV: 108399261(ITGAL)
LAV: 100658239(ITGAL)
TMU: 101355641
MDO: 100017790(ITGAL)
SHR: 100932849(ITGAL)
PCW: 110223126(ITGAL)
OAA: 100090742(ITGAL)
ASN: 102379989
AMJ: 102574904(ITGAL)
PSS: 102448841(ITGAL)
CMY: 102935120
CPIC: 101951426
ACS: 103280821(itgal)
PVT: 110090083(ITGAL)
PBI: 103063786
TSR: 106549614(ITGAL)
PMUA: 114581671(ITGAL)
GJA: 107111209(ITGAL)
XLA: 108701717
XTR: 100495488(itgal)
DRE: 557935(zmp:0000001082)
SRX: 107755319
SANH: 107690075
SGH: 107572597
CCAR: 109082665
IPU: 108258823
PHYP: 113524847
EEE: 113568533
NCC: 104956319
XMA: 102232813
XCO: 114143997
PRET: 103463430
CVG: 107085482
NFU: 107397049
KMR: 108251354(zmp:0000001082)
ALIM: 106526910
AOCE: 111575069
CSEM: 103384365
POV: 109627556
SLAL: 111660400
HCQ: 109521850(itgal)
MALB: 109956782
ELS: 105021449
SFM: 108933547
PKI: 111850807
 » show all
Reference
PMID:2537322
  Authors
Larson RS, Corbi AL, Berman L, Springer T
  Title
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
  Journal
J Cell Biol 108:703-12 (1989)
DOI:10.1083/jcb.108.2.703
  Sequence
[hsa:3683]
Reference
  Authors
Knight JM, Lee SH, Roberts L, Smith CW, Weiss ST, Kheradmand F, Corry DB
  Title
CD11a polymorphisms regulate TH2 cell homing and TH2-related disease.
  Journal
J Allergy Clin Immunol 133:189-97.e1-8 (2014)
DOI:10.1016/j.jaci.2013.03.049

KEGG   ORTHOLOGY: K06461
Entry
K06461                      KO                                     

Name
ITGAM, CD11b
Definition
integrin alpha M
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04514  Cell adhesion molecules
ko04610  Complement and coagulation cascades
ko04613  Neutrophil extracellular trap formation
ko04640  Hematopoietic cell lineage
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05146  Amoebiasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06461  ITGAM, CD11b; integrin alpha M
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06461  ITGAM, CD11b; integrin alpha M
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06461  ITGAM, CD11b; integrin alpha M
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06461  ITGAM, CD11b; integrin alpha M
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06461  ITGAM, CD11b; integrin alpha M
   04610 Complement and coagulation cascades
    K06461  ITGAM, CD11b; integrin alpha M
   04613 Neutrophil extracellular trap formation
    K06461  ITGAM, CD11b; integrin alpha M
   04670 Leukocyte transendothelial migration
    K06461  ITGAM, CD11b; integrin alpha M
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06461  ITGAM, CD11b; integrin alpha M
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K06461  ITGAM, CD11b; integrin alpha M
  09171 Infectious disease: bacterial
   05133 Pertussis
    K06461  ITGAM, CD11b; integrin alpha M
   05134 Legionellosis
    K06461  ITGAM, CD11b; integrin alpha M
   05150 Staphylococcus aureus infection
    K06461  ITGAM, CD11b; integrin alpha M
   05152 Tuberculosis
    K06461  ITGAM, CD11b; integrin alpha M
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K06461  ITGAM, CD11b; integrin alpha M
   05140 Leishmaniasis
    K06461  ITGAM, CD11b; integrin alpha M
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06461  ITGAM, CD11b; integrin alpha M
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06461  ITGAM, CD11b; integrin alpha M
   04515 Cell adhesion molecules
    K06461  ITGAM, CD11b; integrin alpha M
   04090 CD molecules
    K06461  ITGAM, CD11b; integrin alpha M
   00536 Glycosaminoglycan binding proteins
    K06461  ITGAM, CD11b; integrin alpha M
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06461  ITGAM, CD11b; integrin alpha M
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06461  ITGAM, CD11b; integrin alpha M
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06461  ITGAM, CD11b; integrin alpha M
CD molecules [BR:ko04090]
 Proteins
  K06461  CD11b, ITGAM; integrin, alpha M
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Adhesion molecules of cell surface
   K06461  ITGAM, CD11b; integrin alpha M
Genes
HSA: 3684(ITGAM)
PTR: 454069(ITGAM)
PPS: 100992002(ITGAM)
GGO: 101135400(ITGAM)
PON: 100439660(ITGAM)
NLE: 100603969(ITGAM)
MCC: 714832(ITGAM)
MCF: 101866035(ITGAM)
CSAB: 103231383(ITGAM)
RRO: 104661578(ITGAM)
RBB: 108528119(ITGAM)
CJC: 100389341(ITGAM)
SBQ: 101035688(ITGAM)
MMU: 16409(Itgam)
MCAL: 110298307(Itgam)
MPAH: 110327528(Itgam)
RNO: 25021(Itgam)
MUN: 110564544(Itgam)
CGE: 100758889(Itgam)
NGI: 103726316(Itgam)
HGL: 101719288(Itgam)
CCAN: 109696521
OCU: 100351865(ITGAM)
TUP: 102483623(ITGAM)
CFA: 489928(ITGAM)
VVP: 112929270(ITGAM)
AML: 100475340
UMR: 103657890(ITGAM)
UAH: 113267723(ITGAM)
ORO: 101374774(ITGAM)
ELK: 111162313
FCA: 101087957
PTG: 102966486(ITGAM)
PPAD: 109259037(ITGAM)
AJU: 106979120(ITGAM)
BTA: 407124(ITGAM)
BOM: 102270519(ITGAM)
BBUB: 102396526(ITGAM)
CHX: 102180100(ITGAM)
OAS: 443217(ITGAM)
SSC: 397459(ITGAM)
CFR: 102513083(ITGAM)
CDK: 105089721(ITGAM)
BACU: 103004729(ITGAM)
LVE: 103073578(ITGAM)
OOR: 101287801(ITGAM)
DLE: 111182295
PCAD: 102987095
ECB: 100064803(ITGAM)
EPZ: 103547251(ITGAM)
EAI: 106831877(ITGAM)
MYB: 102257478(ITGAM)
MNA: 107540812(ITGAM)
HAI: 109374167
DRO: 112304783(ITGAM)
PALE: 102889241(ITGAM)
RAY: 107506837(ITGAM)
MJV: 108400695(ITGAM)
TMU: 101357920
MDO: 100016833 100016871(ITGAM)
SHR: 100921679(ITGAM)
PCW: 110220501
OAA: 100085462
ACS: 100556984(itgam)
NPR: 108801695
DRE: 101882585(si:dkey-32n7.4)
SRX: 107708962
SANH: 107660450
SGH: 107562007
PHYP: 113527309
AMEX: 103046566
EEE: 113587515
PRET: 103481408
AOCE: 111581578
CSEM: 103381978
POV: 109644068
SDU: 111220319
SLAL: 111658703
HCQ: 109523946
SASA: 106579408
OTW: 112223837
SALP: 111977683
LCM: 102360838
RTP: 109923306
CIN: 100184061
 » show all
Reference
PMID:2457584
  Authors
Corbi AL, Kishimoto TK, Miller LJ, Springer TA
  Title
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
  Journal
J Biol Chem 263:12403-11 (1988)
  Sequence
[hsa:3684]
Reference
  Authors
Ding C, Ma Y, Chen X, Liu M, Cai Y, Hu X, Xiang D, Nath S, Zhang HG, Ye H, Powell D, Yan J
  Title
Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.
  Journal
Nat Commun 4:2813 (2013)
DOI:10.1038/ncomms3813

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