KEGG ORTHOLOGY: K05731

ORTHOLOGY: K05731

Entry

K05731                      KO

Symbol

TIAM1

Name

T-lymphoma invasion and metastasis-inducing protein 1

Pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04530

Tight junction

map04810

Regulation of actin cytoskeleton

map05205

Proteoglycans in cancer

Disease

H02459

Syndromic neurodevelopmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04015 Rap1 signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04024 cAMP signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
Pleckstrin homology (PH) domain-containing proteins
  Dbl-Like RhoGEF family proteins
   K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1

Genes

HSA:	7074(TIAM1)

PTR:	473949(TIAM1)

PPS:	100967869(TIAM1)

GGO:	101125464(TIAM1)

PON:	100431618(TIAM1)

PPYG:

129022373(TIAM1)

NLE:	100605316(TIAM1)

HMH:	116481786(TIAM1)

SSYN:

129482911(TIAM1)

MCC:	702288(TIAM1)

MCF:	101865530(TIAM1)

MTHB:

126951691

MNI:	105472738(TIAM1)

CSAB:

103217191(TIAM1)

CATY:

105575576(TIAM1)

PANU:

101011726(TIAM1)

TGE:	112620958(TIAM1)

MLEU:

105545976(TIAM1)

RRO:	104664652(TIAM1)

RBB:	108536834(TIAM1)

TFN:	117095685(TIAM1)

PTEH:

111524998(TIAM1)

CANG:

105520967(TIAM1)

CJC:	100390844(TIAM1)

SBQ:	101042162(TIAM1)

ANAN:

105713527(TIAM1)

CSYR:

103267759(TIAM1)

MMUR:

105880123(TIAM1)

LCAT:

123630677(TIAM1)

PCOQ:

105820791(TIAM1)

OGA:	100950232(TIAM1)

MMU:	21844(Tiam1)

MCAL:

110311394(Tiam1)

MPAH:

110330159(Tiam1)

RNO:	304109(Tiam1)

MCOC:

116086106(Tiam1)

ANU:	117717813(Tiam1)

MUN:	110557645(Tiam1)

CGE:	100756100(Tiam1)

MAUA:

101830242(Tiam1)

PROB:

127227463(Tiam1)

PLEU:

114698453(Tiam1)

MORG:

121465285(Tiam1)

MFOT:

126515247

AAMP:

119824846(Tiam1)

NGI:	103736475(Tiam1)

HGL:	101711984(Tiam1)

CPOC:

100735633(Tiam1)

CCAN:

109700897(Tiam1)

DORD:

105994106(Tiam1)

DSP:	122114257(Tiam1)

PLOP:

125351520(Tiam1)

NCAR:

124992547

MMMA:

107136135(Tiam1)

OCU:

100338333

OPI:	101526247(TIAM1)

TUP:	102500733(TIAM1)

GVR:	103585520(TIAM1)

CFA:	487731(TIAM1)

CLUD:

112661908(TIAM1)

VVP:	112909492(TIAM1)

VLG:	121479551(TIAM1)

NPO:	129501991(TIAM1)

AML:	105242089(TIAM1)

UMR:	103673212(TIAM1)

UAR:	123784191(TIAM1)

ELK:

111155650

LLV:

125095150

MPUF:

101693463(TIAM1)

MNP:	132012341(TIAM1)

MLK:	131825301(TIAM1)

NVS:	122908346(TIAM1)

ORO:	101365424(TIAM1)

EJU:	114217533(TIAM1)

ZCA:	113916973(TIAM1)

MLX:	118018814(TIAM1)

NSU:	110570117(TIAM1)

LWW:	102736196(TIAM1)

FCA:	101094530(TIAM1)

PYU:	121036015(TIAM1)

PCOO:

112849321(TIAM1)

PBG:	122491249(TIAM1)

PVIV:

125174832(TIAM1)

LRUF:

124526864

PTG:	102955456(TIAM1)

PPAD:

109249680(TIAM1)

PUC:

125920780

AJU:

106977842

HHV:	120229789(TIAM1)

BTA:	536517(TIAM1)

BOM:	102283572(TIAM1)

BIU:	109562052(TIAM1)

BBUB:

102413018(TIAM1)

BBIS:

105004638(TIAM1)

CHX:	102170463(TIAM1)

OAS:	101103280(TIAM1)

BTAX:

128047488(TIAM1)

ODA:	120854116(TIAM1)

CCAD:

122428727(TIAM1)

MBEZ:

129552725(TIAM1)

SSC:	100524587(TIAM1)

CBAI:

105070251(TIAM1)

CDK:	105086777(TIAM1)

VPC:	102527012(TIAM1)

BACU:

103016623(TIAM1)

BMUS:

118894209(TIAM1)

LVE:	103073449(TIAM1)

OOR:	101280455(TIAM1)

DLE:	111172246(TIAM1)

PCAD:

102980632(TIAM1)

PSIU:

116753482(TIAM1)

NASI:

112408564(TIAM1)

ECB:	100052764(TIAM1)

EPZ:	103550555(TIAM1)

EAI:	106847274(TIAM1)

MMYO:

118676321(TIAM1)

MDT:	132229824(TIAM1)

PKL:	118714137(TIAM1)

EFUS:

103289940(TIAM1)

MNA:	107533494(TIAM1)

DRO:	112304037(TIAM1)

SHON:

118983246(TIAM1)

AJM:	119061032(TIAM1)

PDIC:

114490037(TIAM1)

PHAS:

123827960(TIAM1)

MMF:	118617355(TIAM1)

PPAM:

129074137(TIAM1)

HAI:	109393508(TIAM1)

RFQ:	117030926(TIAM1)

PALE:

102883973(TIAM1)

PGIG:

120598497(TIAM1)

PVP:	105301274(TIAM1)

RAY:	107519567(TIAM1)

MJV:	108387898(TIAM1)

TOD:	119257245(TIAM1)

SARA:

101541293(TIAM1)

SETR:

126026136(TIAM1)

LAV:	100675466(TIAM1)

TMU:

101352570

ETF:	101647656(TIAM1)

DNM:	101417075(TIAM1)

MDO:	100015064(TIAM1)

GAS:	123239605(TIAM1)

SHR:	100920711(TIAM1)

AFZ:

127553845

PCW:	110214866(TIAM1)

TVP:	118838352(TIAM1)

OAA:	100088712(TIAM1)

GGA:	418491(TIAM1)

PCOC:

116242026(TIAM1)

MGP:	100540208(TIAM1)

CJO:	107322765(TIAM1)

TPAI:

128076423(TIAM1)

LMUT:

125688278(TIAM1)

NMEL:

110402256(TIAM1)

APLA:

101803496(TIAM1)

ACYG:

106043428(TIAM1)

CATA:

118247646(TIAM1)

AFUL:

116495393(TIAM1)

TGU:	100219509(TIAM1)

LSR:	110481491(TIAM1)

SCAN:

103818444

PMOA:

120496511(TIAM1)

OTC:	121333627(TIAM1)

PRUF:

121349718(TIAM1)

GFR:	102040520(TIAM1)

FAB:	101806275(TIAM1)

OMA:	130255987(TIAM1)

PHI:	102109961(TIAM1)

PMAJ:

107213264(TIAM1)

CCAE:

111942402(TIAM1)

CCW:	104684195(TIAM1)

CBRC:

103625244(TIAM1)

ETL:	114069404(TIAM1)

ZAB:	102071136(TIAM1)

ZLE:	135455556(TIAM1)

ACHL:

103803899(TIAM1)

SVG:	106860712(TIAM1)

MMEA:

130574764(TIAM1)

HRT:	120765479(TIAM1)

SATI:

136375309(TIAM1)

FPG:	101914291(TIAM1)

FCH:	102057263(TIAM1)

NNT:	104412000(TIAM1)

SHAB:

115604375(TIAM1)

ACUN:

113477782(TIAM1)

TALA:

104368695(TIAM1)

ACHC:

115343736(TIAM1)

HLE:	104842743(TIAM1)

AGEN:

126053215

GCL:

127015822

CSTI:

104561345

LDI:	104344247(TIAM1)

DPUB:

104306419(TIAM1)

AVIT:

104279051(TIAM1)

BRHI:

104489230(TIAM1)

EGZ:	104128218(TIAM1)

NNI:	104020113(TIAM1)

PCRI:

104031801(TIAM1)

PCAO:

104042980(TIAM1)

PADL:

103920307(TIAM1)

AFOR:

103901960(TIAM1)

FGA:

104083658

GSTE:

104260646

CLV:	102098791(TIAM1)

MUI:	104542486(TIAM1)

PGUU:

104465467

PLET:

104622806(TIAM1)

EHS:	104516923(TIAM1)

CMAC:

104476028(TIAM1)

CUCA:

104064769(TIAM1)

BREG:

104644146(TIAM1)

OHA:	104328358(TIAM1)

ACAR:

104522948

CPEA:

104392425(TIAM1)

CVF:	104295182(TIAM1)

RTD:	128904149(TIAM1)

AAM:	106494979(TIAM1)

AROW:

112971857(TIAM1)

NPD:	112942676(TIAM1)

TGT:	104577168(TIAM1)

DNE:	112985159(TIAM1)

SCAM:

104139464(TIAM1)

ASN:	102385589(TIAM1)

AMJ:	106737085(TIAM1)

CPOO:

109305758(TIAM1)

GGN:	109302781(TIAM1)

PSS:	102446695(TIAM1)

CMY:	102934808(TIAM1)

DCC:	119844412(TIAM1)

CPIC:

101936219(TIAM1)

TST:	117889410(TIAM1)

CABI:

116835433(TIAM1)

MRV:	120395919(TIAM1)

ACS:	100555790(tiam1)

ASAO:

132771902(TIAM1)

PVT:	110080375(TIAM1)

SUND:

121926585(TIAM1)

PBI:	103061969(TIAM1)

PMUR:

107290521(TIAM1)

CTIG:

120319732(TIAM1)

TSR:	106546455(TIAM1)

PGUT:

117673548(TIAM1)

APRI:

131199175(TIAM1)

PTEX:

113436287(TIAM1)

NSS:	113409866(TIAM1)

VKO:	123029550(TIAM1)

PMUA:

114596030(TIAM1)

PRAF:

128412960(TIAM1)

ZVI:	118085763(TIAM1)

HCG:	128350325(TIAM1)

GJA:	107109049(TIAM1)

STOW:

125430698(TIAM1)

EMC:	129326455(TIAM1)

XLA:	108707884(tiam1.L) 735176(tiam1.S)

XTR:	734013(tiam1)

NPR:	108787811(TIAM1)

RTEM:

120927888(TIAM1)

BBUF:

120994536(TIAM1)

BGAR:

122930801(TIAM1)

MUO:	115469457(TIAM1)

GSH:	117362700(TIAM1)

DRE:	567621(tiam1a)

SRX:	107718732 107720640

SANH:

107693916 107701134

SGH:	107555129 107557220

CCAR:

109097672

CAUA:

113054300 113071690 113109853

CGIB:

127966410 128021188

PTET:

122352917(tiam1a)

LROH:

127172545(tiam1a)

OMC:	131548058(tiam1a)

PPRM:

120476488(tiam1a)

RKG:	130082822(tiam1a)

MAMB:

125258771(tiam1a)

CIDE:

127521563

CERY:

137028743(tiam1a)

MASI:

127432814 127433843

TROS:

130545772(tiam1a)

TDW:	130411695(tiam1a)

MANU:

129446947(tiam1a)

IPU:	108277166(tiam1a)

IFU:	128620012(tiam1a)

PHYP:

113543504

SMEO:

124393292(tiam1a)

TFD:	113659148(tiam1a)

TVC:	132862932(tiam1a)

TRN:	134332167(tiam1a)

AMEX:

103029595(tiam1a)

CMAO:

118824487(tiam1a)

CHAR:

105907408(tiam1a)

TRU:	101072336 101079238

TFS:	130534580(tiam1b) 130537352(tiam1a)

TNG:	GSTEN00018899G001 GSTEN00035201G001

LCO:	104923304(tiam1) 104923828

NCC:	104963587(tiam1)

TBEN:

117468828 117490292

CGOB:

115018152(tiam1) 115018867

PGEO:

117457369(tiam1b) 117458261

GACU:

117535378 117540368

EMAC:

134872206 134880339

ELY:	117260009(tiam1b) 117266152(tiam1a)

EFO:	125889209(tiam1b) 125898995

PLEP:

121943546(tiam1b) 121952201

SLUC:

116036945 116048370(tiam1b)

ECRA:

117940235(tiam1b) 117955392

ESP:	116687057 116700092

PFLV:

114552649(tiam1)

GAT:	120821089 120821643(tiam1a)

PPUG:

119214483(tiam1b) 119215176(tiam1a)

AFB:	129091025(tiam1b) 129113538

CLUM:

117741392(tiam1b) 117742340

PSWI:

130191723 130210358(tiam1b)

MSAM:

119882272 119895291(tiam1a)

SCHU:

122879398 122887808

CUD:	121517469(tiam1b) 121519132(tiam1a)

ALAT:

119031161 119033217

MZE:	101474606(tiam1) 101482226

ONL:	100694077(tiam1) 100698758

OAU:

116331402

OLA:	101173083 101174366

OML:	112142610 112149543

CSAI:

133441930(tiam1b) 133460106(tiam1a)

XMA:	102234854 102238061

XCO:	114153357 114161546(tiam1)

XHE:	116728109 116737601(tiam1)

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

129358929(tiam1b) 129368620

CVG:	107087930 107095569

CTUL:

119783467 119789478

GMU:	124876295 124884248

NFU:	107380221 107386955

KMR:	108236015 108237009

ALIM:

106514129 106520557(tiam1)

NWH:

119410720

AOCE:

111563695 111575869

MCEP:

125013167 125021323(tiam1a)

CSEM:

103378218 103395510

POV:	109630293(tiam1) 109635848

SSEN:

122759969 122779704(tiam1a)

HHIP:

117772420(tiam1b) 117774159

HSP:	118106503(tiam1b) 118122346(tiam1a)

PPLT:

128440115 128457026

SMAU:

118294629(tiam1b) 118301007(tiam1a)

LCF:	108876057 108893269(tiam1a)

SDU:	111217098 111224422

SLAL:

111657801

XGL:	120792234(tiam1b) 120802632

HCQ:

109509727

SSCV:

125972482 125982271

SBIA:

133491655 133504384(tiam1b)

PEE:	133404788(tiam1b) 133416500(tiam1a)

PTAO:

133467396 133481824(tiam1b)

BPEC:

110158501 110175098

MALB:

109959263 109967522

BSPL:

114867736(tiam1b) 114869294(tiam1a)

SJO:	128360196(tiam1b) 128371236

STRU:

115163807 115206681(tiam1)

OTW:	112231461 112266214 112267642

OMY:	110503436 110508084 110509394(tiam1a)

OGO:	123993836 124004974 124006688(tiam1a)

OKI:	109879675 109883930 109885904

OKE:	118380856 118381030 127930603

SNH:	120028540(tiam1b)

CCLU:

121542031(tiam1a) 121566851 121567684

ELS:	105012849 105026051

SFM:

108936219

PKI:

111840433

AANG:

118209999 118235718

LOC:	102696827(tiam1)

PSPA:

121320410 121327843

ARUT:

117405862 117407339

PSEX:

120523519

CPLA:

122555057(tiam1a)

HOC:	132821023(tiam1a)

LERI:

129702639(tiam1a)

SCLV:

120345627

ARUN:

117296283

DME:	Dmel_CG34418(sif)

DER:

6544675

DSE:

6610901

DYA:	Dyak_GE21504

DAN:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12138

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ014866

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

PFUC:

VPS:

VCRB:

VVE:

TPRE:

LHT:

LBD:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110384088(sif)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

ACOO:

DVT:

DCI:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM606710

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

DPX:	DAPPUDRAFT_244635

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:	124499264 124500654

CVS:	136974998(sif)

PTEP:

107446947 107456951

ABRU:

129965787 129968455

UDV:	129216874 129221509

SDM:	118195621 118197475

LPOL:

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

MAEA:

LJP:

LLON:

Reference

PMID:14999151

Authors

Minard ME, Kim LS, Price JE, Gallick GE

Title

The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.

Journal

Breast Cancer Res Treat 84:21-32 (2004)
DOI:10.1023/B:BREA.0000018421.31632.e6

Reference

PMID:20361982

Authors

Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ

Title

The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

Journal

J Mol Biol 398:730-46 (2010)
DOI:10.1016/j.jmb.2010.03.047

Reference

PMID:7999144

Authors

Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG

Title

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

Journal

Cell 77:537-49 (1994)
DOI:10.1016/0092-8674(94)90216-X

Sequence

[mmu:21844]

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (2608)   
   KEGG GENES (662)   
   KEGG MGENES (614)   
   RefGene (1327)   
   OC (5)   
Literature (3)   
   PubMed (3)   
All databases (2628)   

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