KEGG   ORTHOLOGY: K05753
Entry
K05753                      KO                                     

Name
WASF1
Definition
WAS protein family, member 1
Pathway
ko04520  Adherens junction
ko04666  Fc gamma R-mediated phagocytosis
ko04810  Regulation of actin cytoskeleton
ko05100  Bacterial invasion of epithelial cells
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05231  Choline metabolism in cancer
Disease
H02459  Syndromic neurodevelopmental disorder
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05753  WASF1; WAS protein family, member 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05753  WASF1; WAS protein family, member 1
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K05753  WASF1; WAS protein family, member 1
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K05753  WASF1; WAS protein family, member 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05753  WASF1; WAS protein family, member 1
   05131 Shigellosis
    K05753  WASF1; WAS protein family, member 1
   05100 Bacterial invasion of epithelial cells
    K05753  WASF1; WAS protein family, member 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05753  WASF1; WAS protein family, member 1
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    WASP / WAVE
     K05753  WASF1; WAS protein family, member 1
Genes
HSA: 8936(WASF1)
PTR: 462935(WASF1)
PPS: 100967352(WASF1)
GGO: 101131112(WASF1)
PON: 100174148(WASF1)
NLE: 100607631(WASF1)
MCC: 699042(WASF1)
MCF: 102143377(WASF1)
CSAB: 103240591(WASF1)
RRO: 104664499(WASF1)
RBB: 108540547(WASF1)
CJC: 100403045(WASF1)
SBQ: 101046766(WASF1)
MMU: 83767(Wasf1)
MCAL: 110303189(Wasf1)
MPAH: 110326371(Wasf1)
RNO: 294568(Wasf1)
MUN: 110555444(Wasf1)
CGE: 100772707(Wasf1)
NGI: 103749551(Wasf1)
HGL: 101705685(Wasf1)
CCAN: 109685392(Wasf1)
OCU: 100348657(WASF1)
TUP: 102489813(WASF1)
CFA: 475024(WASF1)
VVP: 112925169(WASF1)
AML: 100478002(WASF1)
UMR: 103677004(WASF1)
UAH: 113264744(WASF1)
ORO: 101381480(WASF1)
ELK: 111158284
FCA: 101083083(WASF1)
PTG: 102959553(WASF1)
PPAD: 109263534(WASF1)
AJU: 106968896(WASF1)
BTA: 531488(WASF1)
BOM: 102264451(WASF1)
BIU: 109563830(WASF1)
BBUB: 102393671(WASF1)
CHX: 102183793(WASF1)
OAS: 101112488(WASF1)
SSC: 100154562(WASF1) 110256054
CFR: 102510461(WASF1)
CDK: 105097105(WASF1)
BACU: 103004278(WASF1)
LVE: 103078061(WASF1)
OOR: 101283798(WASF1)
DLE: 111164540(WASF1)
PCAD: 102980332(WASF1)
ECB: 100066751(WASF1)
EPZ: 103551718(WASF1)
EAI: 106829752(WASF1)
MYB: 102249211(WASF1)
MYD: 102756548(WASF1)
MNA: 107540702(WASF1)
HAI: 109384767(WASF1)
DRO: 112297330(WASF1)
PALE: 102893633(WASF1)
RAY: 107519372(WASF1)
MJV: 108401289(WASF1)
LAV: 100654554(WASF1)
TMU: 101358300
MDO: 100022094(WASF1)
SHR: 100921263(WASF1)
PCW: 110222862(WASF1)
OAA: 100075943(WASF1)
GGA: 421761(WASF1)
MGP: 100544489(WASF1)
CJO: 107311898(WASF1)
NMEL: 110396515(WASF1)
APLA: 101790467(WASF1)
ACYG: 106032593(WASF1)
TGU: 100189950(WASF1)
LSR: 110483707(WASF1)
SCAN: 103818668(WASF1)
GFR: 102036578(WASF1)
FAB: 101818376(WASF1)
PHI: 102101508(WASF1)
PMAJ: 107201988(WASF1)
CCAE: 111927262(WASF1)
CCW: 104691438(WASF1)
ETL: 114065529(WASF1)
FPG: 101911128(WASF1)
FCH: 102058978(WASF1)
CLV: 102096819(WASF1)
EGZ: 104131560(WASF1)
NNI: 104011156(WASF1)
ACUN: 113478707(WASF1)
PADL: 103918994(WASF1)
AAM: 106489747(WASF1)
ASN: 102368676(WASF1)
AMJ: 102567234(WASF1)
PSS: 102459711(WASF1)
CMY: 102933869(WASF1)
CPIC: 101935787(WASF1)
ACS: 100558519(wasf1)
PVT: 110083153(WASF1)
PBI: 103066762(WASF1)
PMUR: 107297819(WASF1)
TSR: 106545875(WASF1)
PMUA: 114594035(WASF1)
GJA: 107106878(WASF1)
XLA: 108716834(wasf1.L) 444717(wasf1.S)
XTR: 100124768(wasf1)
NPR: 108797683(WASF1)
DRE: 100001221(wasf1)
SRX: 107739187
IPU: 108261263(wasf1)
PHYP: 113528956(wasf1)
AMEX: 103042428(wasf1)
EEE: 113572041(wasf1)
TRU: 101078856(wasf1)
LCO: 104922002(wasf1)
NCC: 104961975(wasf1)
MZE: 101463877(wasf1)
ONL: 100693709(wasf1)
OLA: 101159716(wasf1)
XMA: 102236940(wasf1)
XCO: 114158737(wasf1)
PRET: 103457538(wasf1)
CVG: 107086049(wasf1)
NFU: 107377624(wasf1)
KMR: 108240115(wasf1)
ALIM: 106519773(wasf1)
AOCE: 111580905
CSEM: 103380861(wasf1)
POV: 109636179(wasf1)
LCF: 108895639(wasf1)
SDU: 111239134(wasf1)
SLAL: 111650572(wasf1)
HCQ: 109518133(wasf1)
BPEC: 110153709(wasf1)
MALB: 109953612(wasf1)
SASA: 106571806 106607959(wasf1)
SALP: 111954517(wasf1)
ELS: 105017470(wasf1)
SFM: 108920433(wasf1)
PKI: 111856702(wasf1)
CMK: 103178246(wasf1)
RTP: 109923603(wasf1)
 » show all
Reference
  Authors
Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK
  Title
Structure and control of the actin regulatory WAVE complex.
  Journal
Nature 468:533-8 (2010)
DOI:10.1038/nature09623
  Sequence
[hsa:8936]

KEGG   ORTHOLOGY: K05748
Entry
K05748                      KO                                     

Name
WASF2
Definition
WAS protein family, member 2
Pathway
ko04520  Adherens junction
ko04666  Fc gamma R-mediated phagocytosis
ko04810  Regulation of actin cytoskeleton
ko05100  Bacterial invasion of epithelial cells
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05135  Yersinia infection
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05748  WASF2; WAS protein family, member 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05748  WASF2; WAS protein family, member 2
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K05748  WASF2; WAS protein family, member 2
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K05748  WASF2; WAS protein family, member 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05748  WASF2; WAS protein family, member 2
   05131 Shigellosis
    K05748  WASF2; WAS protein family, member 2
   05135 Yersinia infection
    K05748  WASF2; WAS protein family, member 2
   05100 Bacterial invasion of epithelial cells
    K05748  WASF2; WAS protein family, member 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05748  WASF2; WAS protein family, member 2
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    WASP / WAVE
     K05748  WASF2; WAS protein family, member 2
Genes
HSA: 10163(WASF2)
PTR: 456675(WASF2) 473870
PPS: 100979214(WASF2) 100994236
GGO: 101139707 101154359(WASF2)
PON: 100437132 100447501(WASF2)
NLE: 100585497(WASF2)
MCC: 716082(WASF2)
MCF: 102120933(WASF2)
CSAB: 103225285(WASF2)
RRO: 104675723(WASF2)
RBB: 108518185(WASF2)
CJC: 100391469(WASF2)
SBQ: 101045414(WASF2)
MMU: 242687(Wasf2)
MCAL: 110292514(Wasf2)
MPAH: 110322998(Wasf2)
RNO: 313024(Wasf2)
MUN: 110552520(Wasf2)
CGE: 100759260(Wasf2)
NGI: 103737074(Wasf2)
HGL: 101701848(Wasf2)
CCAN: 109696055(Wasf2)
OCU: 100355636(WASF2)
TUP: 102501983(WASF2)
CFA: 487343(WASF2)
VVP: 112931646(WASF2)
AML: 100466792(WASF2)
UMR: 103666501(WASF2)
UAH: 113268437(WASF2)
ORO: 101367711(WASF2)
ELK: 111142836
FCA: 101082837(WASF2)
PTG: 102954999(WASF2)
PPAD: 109256761(WASF2)
AJU: 106977544(WASF2)
BTA: 504482(WASF2)
BOM: 102277401(WASF2)
BIU: 109573135(WASF2)
BBUB: 102405935(WASF2)
CHX: 102190345 106503491(WASF2)
OAS: 101107336(WASF2) 101120599
SSC: 100512789(WASF2)
CFR: 102519425(WASF2)
CDK: 105100710(WASF2)
BACU: 103016380(WASF2)
LVE: 103080596(WASF2)
OOR: 101270117(WASF2)
DLE: 111163450(WASF2)
PCAD: 102976265(WASF2)
EPZ: 103550524(WASF2)
EAI: 106839098(WASF2)
MYB: 102257954(WASF2)
MYD: 102752634(WASF2)
MNA: 107540073(WASF2)
HAI: 109386760(WASF2)
DRO: 112299263(WASF2)
PALE: 102886126(WASF2)
RAY: 107503537(WASF2)
MJV: 108406564(WASF2)
LAV: 100675212(WASF2)
TMU: 101340374
MDO: 100618879(WASF2)
SHR: 100927851(WASF2)
PCW: 110206152(WASF2)
OAA: 100681465(WASF2)
GGA: 426359(WASF2)
MGP: 100545294(WASF2)
CJO: 107324004(WASF2)
NMEL: 110387318(WASF2)
APLA: 101793411(WASF2)
ACYG: 106047916(WASF2)
TGU: 100226656(WASF2)
LSR: 110472852(WASF2)
SCAN: 103823598(WASF2)
GFR: 102032350(WASF2)
FAB: 101816860(WASF2)
PHI: 102102838(WASF2)
PMAJ: 107214034(WASF2)
CCAE: 111939071(WASF2)
ETL: 114071330(WASF2)
FPG: 101922545(WASF2)
FCH: 102052077(WASF2)
CLV: 102085911(WASF2)
EGZ: 104134876(WASF2)
NNI: 104017704(WASF2)
ACUN: 113488382(WASF2)
PADL: 103912774(WASF2)
AAM: 106494550(WASF2)
ASN: 102369808(WASF2)
AMJ: 102574052(WASF2)
PSS: 102459291(WASF2)
CMY: 102945284(WASF2)
CPIC: 101940754(WASF2)
ACS: 100551568(wasf2)
PVT: 110088416(WASF2)
PBI: 103055853(WASF2)
PMUR: 107286750(WASF2)
TSR: 106554053(WASF2)
PMUA: 114601496(WASF2)
GJA: 107116649(WASF2)
XLA: 108709524(wasf2.S) 733146(wasf2.L)
XTR: 100125121(wasf2)
NPR: 108786650(WASF2)
DRE: 394056(wasf2)
CCAR: 109112303
IPU: 108257242(wasf2)
PHYP: 113536082(wasf2)
AMEX: 103038132(wasf2)
EEE: 113588356(wasf2)
TRU: 101064106(wasf2)
LCO: 104922104(wasf2)
MZE: 101482993(wasf2)
ONL: 100697143(wasf2)
OLA: 101175491(wasf2)
XMA: 102217914(wasf2)
XCO: 114156204(wasf2)
PRET: 103472306(wasf2)
CVG: 107083297(wasf2)
NFU: 107394778(wasf2)
KMR: 108237969(wasf2)
ALIM: 106515749(wasf2)
AOCE: 111567761(wasf2)
CSEM: 103394337(wasf2)
POV: 109631777(wasf2)
LCF: 108897781(wasf2)
SDU: 111223491(wasf2)
SLAL: 111659362(wasf2)
HCQ: 109509859(wasf2)
BPEC: 110167344(wasf2)
MALB: 109963992(wasf2)
OTW: 112264497
ELS: 105012518(wasf2)
SFM: 108931771(wasf2)
PKI: 111839710(wasf2)
LCM: 102347776(WASF2)
CMK: 103179451(wasf2)
RTP: 109930140
BFO: 118422163
APLC: 110974450
CRG: 105337059
MYI: 110460262
LAK: 106174069
 » show all
Reference
  Authors
Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R
  Title
Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.
  Journal
Proc Natl Acad Sci U S A 102:16644-9 (2005)
DOI:10.1073/pnas.0507021102
  Sequence
[hsa:10163]

KEGG   ORTHOLOGY: K06083
Entry
K06083                      KO                                     

Name
WASF3
Definition
WAS protein family, member 3
Pathway
ko04520  Adherens junction
ko04666  Fc gamma R-mediated phagocytosis
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K06083  WASF3; WAS protein family, member 3
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K06083  WASF3; WAS protein family, member 3
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K06083  WASF3; WAS protein family, member 3
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K06083  WASF3; WAS protein family, member 3
   05132 Salmonella infection
    K06083  WASF3; WAS protein family, member 3
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K06083  WASF3; WAS protein family, member 3
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    WASP / WAVE
     K06083  WASF3; WAS protein family, member 3
Genes
HSA: 10810(WASF3)
PTR: 112204139(WASF3) 452502(WASF3)
PPS: 100983777(WASF3)
GGO: 101151762(WASF3)
PON: 100445243(WASF3)
NLE: 100587985(WASF3)
MCC: 709849(WASF3)
MCF: 102131834(WASF3)
CSAB: 103249043(WASF3)
RRO: 104671579(WASF3)
RBB: 108512939(WASF3)
CJC: 100388335(WASF3)
SBQ: 101041139(WASF3)
MMU: 245880(Wasf3)
MCAL: 110294629(Wasf3)
MPAH: 110312868(Wasf3)
RNO: 682937(Wasf3)
CGE: 100759001(Wasf3)
NGI: 103731011(Wasf3)
HGL: 101719051(Wasf3)
CCAN: 109678987(Wasf3)
OCU: 100353601(WASF3)
TUP: 102475767(WASF3)
CFA: 477331(WASF3)
VVP: 112918626(WASF3)
AML: 100467351(WASF3)
UMR: 103664308(WASF3)
UAH: 113251198(WASF3)
ORO: 101384867(WASF3)
ELK: 111159899
FCA: 101086527(WASF3)
PTG: 102958125(WASF3)
PPAD: 109266139(WASF3)
AJU: 106985548(WASF3)
BTA: 540674(WASF3)
BOM: 102277617(WASF3)
BIU: 109566837(WASF3)
BBUB: 102412434(WASF3)
CHX: 102190427(WASF3)
OAS: 101114880(WASF3)
SSC: 100155782(WASF3)
CFR: 102506363(WASF3)
CDK: 105106341(WASF3)
BACU: 103009919(WASF3)
LVE: 103083477(WASF3)
OOR: 101281198(WASF3)
DLE: 111175176(WASF3)
PCAD: 102978208(WASF3)
ECB: 100050895(WASF3)
EPZ: 103561699(WASF3)
EAI: 106832892(WASF3)
MYB: 102242858(WASF3)
MYD: 102753908(WASF3)
MNA: 107546408(WASF3)
HAI: 109387514(WASF3)
DRO: 112296215(WASF3)
PALE: 102893292(WASF3)
RAY: 107498593(WASF3)
MJV: 108394393(WASF3)
LAV: 100658868(WASF3)
TMU: 101345576
MDO: 100015800 100019501(WASF3)
SHR: 100924737(WASF3) 100934823
OAA: 100073372 100089353(WASF3)
GGA: 418934(WASF3) 422323(WASF3L)
MGP: 100545202(WASF3) 100548963
CJO: 107308308(WASF3) 107312862
NMEL: 110389036(WASF3) 110403383
APLA: 101797872 101802693(WASF3)
ACYG: 106038521 106041148(WASF3)
TGU: 100218623(WASF3) 100221700
LSR: 110467882 110476769(WASF3)
SCAN: 103816504 103827326(WASF3)
GFR: 102035199 102038946(WASF3)
FAB: 101809371(WASF3) 101821982
PHI: 102103986 102105898(WASF3)
PMAJ: 107204031 107212765(WASF3)
CCAE: 111923371(WASF3) 111929306
CCW: 104689884(WASF3) 104691720
ETL: 114068776 114070454(WASF3)
FPG: 101912273 101924043(WASF3)
FCH: 102050638 102056861(WASF3)
CLV: 102090076 102095877(WASF3)
EGZ: 104126072 104133704(WASF3)
NNI: 104023027(WASF3) 104023505
ACUN: 113479757(WASF3) 113479945
PADL: 103916354 103920100(WASF3)
AAM: 106489842 106500397(WASF3)
ASN: 102368224 102384701(WASF3)
AMJ: 102568457 106737150(WASF3)
PSS: 102449094 102453488(WASF3)
CMY: 102931297(WASF3) 102948125
CPIC: 101940193 101949887(WASF3)
ACS: 100552149(wasf3) 100564556
PVT: 110074267 110076468(WASF3)
PBI: 103060633(WASF3) 103060915
PMUR: 107282924 107288421(WASF3)
TSR: 106538639(WASF3) 106548636
PMUA: 114589133 114595746(WASF3)
GJA: 107112639(WASF3) 107124673
XLA: 108698377 108700078 108708712(wasf3.L) 108709964(wasf3.S)
XTR: 779716(wasf3)
NPR: 108790727(WASF3) 108791906
DRE: 553542(zgc:109889) 555437(si:ch73-362m14.4) 562750(wasf3a) 563632(wasf3b)
NCC: 104948808 104965996(wasf3)
LCM: 102362853 102363912(WASF3)
CMK: 103179519 103183261(wasf3)
CIN: 100181735
SKO: 102804925
DME: Dmel_CG4636(SCAR)
DER: 6541548
DSE: 6612093
DSI: Dsimw501_GD23746(Dsim_GD23746)
DAN: 6498643
DSR: 110183401
DPE: 6589603
DMN: 108162889
DWI: 6641923
DAZ: 108610688
DNV: 108649616
DHE: 111592606
DVI: 6627755
MDE: 101900962
LCQ: 111690420
AAG: 5576427
AALB: 109398704
AME: 410922
BIM: 100741655
BTER: 100644542
CCAL: 108629167
OBB: 114874969
SOC: 105198730
MPHA: 105836346
AEC: 105149697
ACEP: 105618988
PBAR: 105433230
VEM: 105570623
HST: 105183335
DQU: 106748649
CFO: 105252536
LHU: 105673100
PGC: 109856223
OBO: 105276095
PCF: 106783693
NVI: 100123693
CSOL: 105368559
MDL: 103571051
TCA: 662022
DPA: 109544590
ATD: 109598066
NVL: 108556683
BMOR: 101741866
BMAN: 114250379
PMAC: 106710212
PRAP: 110995427
TNL: 113492496
API: 100166500
DNX: 107161395
AGS: 114124549
RMD: 113555741
BTAB: 109038973
CLEC: 106668482
ZNE: 110831064
FCD: 110852889
PVM: 113824188
TUT: 107366957
DPTE: 113796917
CSCU: 111633988
CEL: CELE_R06C1.3(wve-1)
CBR: CBG18687(Cbr-wve-1)
BMY: Bm1_54690
PCAN: 112565636
OBI: 106870025
NVE: 5504730
EPA: 110231809
ADF: 107342986
AMIL: 114959636
PDAM: 113672015
SPIS: 111334243
DGT: 114535444
HMG: 100207708
 » show all
Reference
  Authors
Sossey-Alaoui K, Li X, Cowell JK
  Title
c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
  Journal
J Biol Chem 282:26257-65 (2007)
DOI:10.1074/jbc.M701484200
  Sequence
[hsa:10810]

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