KEGG   ORTHOLOGY: K05824
Entry
K05824                      KO                                     

Name
LYS12
Definition
homoisocitrate dehydrogenase [EC:1.1.1.87]
Pathway
ko00300  Lysine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K05824  LYS12; homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K05824  LYS12; homoisocitrate dehydrogenase
Other DBs
RN: R01934 R01936 R04862
COG: COG0473
GO: 0047046
Genes
QSU: 111984152 111991115
SCE: YIL094C(LYS12)
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
CGR: CAGL0G02585g
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
PIC: PICST_50442(LYS12)
CAL: CAALFM_CR01400WA(LYS12)
SLB: AWJ20_5129(LYS12)
BNN: FOA43_004130(LYS12)
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
MGR: MGG_01566
SSCK: SPSK_09424
MAW: MAC_01875
MAJ: MAA_00573
CMT: CCM_06018
MBE: MBM_09266
ANI: AN5206.2
ANG: ANI_1_398134(An15g02490)
ABE: ARB_06194
TVE: TRV_01663
PTE: PTT_19273
CNE: CND03850
CNB: CNBD2460
TASA: A1Q1_01965
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
MGL: MGL_3003
MRT: MRET_3610
PCQ: PcP3B5_09520(hicd)
PKC: PKB_4900(leub3)
PSET: THL1_4856
AMAH: DLM_3455
RCA: Rcas_3471
CAU: Caur_0331
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
DRA: DR_1674
DGE: Dgeo_1458
DFC: DFI_05685
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378
TSC: TSC_c20650(icd2)
TAQ: TO73_0559
MRB: Mrub_2738
 » show all
Reference
PMID:4395693
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]

KEGG   ORTHOLOGY: K10978
Entry
K10978                      KO                                     

Name
aksF
Definition
methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
Pathway
ko00300  Lysine biosynthesis
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
ko01240  Biosynthesis of cofactors
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K10978  aksF; methanogen homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K10978  aksF; methanogen homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K10978  aksF; methanogen homoisocitrate dehydrogenase
    1.1.1.-  
     K10978  aksF; methanogen homoisocitrate dehydrogenase
Other DBs
RN: R01934 R01936 R04862 R08214 R08215
COG: COG0473
Genes
MJA: MJ_1596
MFE: Mefer_0957
MVU: Metvu_0752
MFS: MFS40622_0058
MIF: Metin_0287
MJH: JH146_0764
MIG: Metig_0040
MMP: MMP0880(aksF)
MMQ: MmarC5_0688
MMX: MmarC6_1775
MMD: GYY_05110
MMAK: MMKA1_09750(aksF)
MMAO: MMOS7_09540(aksF)
MMAD: MMJJ_01120(hicd_1)
MAE: Maeo_1484
MVO: Mvol_0791
MTH: MTH_184
METC: MTCT_0151
MWO: MWSIV6_0600(leuB1)
METE: tca_00168(hicd_1)
MST: Msp_0674
MRU: mru_1033(aksF)
MSI: Msm_0373
MEB: Abm4_0999(aksF)
MMIL: sm9_0644(aksF)
MEYE: TL18_03130
MOL: YLM1_0578
METH: MBMB1_1404(leuB1)
MFC: BRM9_0639(aksF)
MFI: DSM1535_0612(leuB1)
MCUB: MCBB_1645(leuB1)
MFV: Mfer_1273
MKA: MK1215(leuB_2)
MBAR: MSBR2_2662
MBAK: MSBR3_2764
MAC: MA_3748(leuB)
MMA: MM_0642
MMAC: MSMAC_0669
METM: MSMTP_0734
MTHR: MSTHT_2378
MTHE: MSTHC_0902
MHOR: MSHOH_0789
MMET: MCMEM_2087
MMH: Mmah_0129
MPY: Mpsy_2352
MTP: Mthe_0855
MCJ: MCON_1920(aksF)
MHI: Mhar_2394
MHU: Mhun_1797
MLA: Mlab_0235
MBG: BN140_3039(leuB3)
MEMA: MMAB1_2207(leuB)
MPI: Mpet_2492
MBN: Mboo_0602
MPL: Mpal_2146
MPD: MCP_1963(aksF)
MEZ: Mtc_1557(aksF)
RCI: RCIX2644(leuB-2)
PTO: PTO0910
 » show all
Reference
  Authors
Howell DM, Graupner M, Xu H, White RH
  Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000
  Sequence
[mja:MJ_1596]

KEGG   ENZYME: 1.1.1.87
Entry
EC 1.1.1.87                 Enzyme                                 

Name
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
R01934;
(other) R01936 R04862
Substrate
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662];
NAD+ [CPD:C00003]
Product
2-oxoadipate [CPD:C00322];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Forms part of the lysine biosynthesis pathway in fungi [3].
History
EC 1.1.1.87 created 1972 (EC 1.1.1.155 created 1976, incorporated 2004)
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K05824  homoisocitrate dehydrogenase
K10978  methanogen homoisocitrate dehydrogenase
Genes
QSU: 111984152 111991115
SCE: YIL094C(LYS12)
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
CGR: CAGL0G02585g
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
PIC: PICST_50442(LYS12)
CAL: CAALFM_CR01400WA(LYS12)
SLB: AWJ20_5129(LYS12)
BNN: FOA43_004130(LYS12)
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
MGR: MGG_01566
SSCK: SPSK_09424
MAW: MAC_01875
MAJ: MAA_00573
CMT: CCM_06018
MBE: MBM_09266
ANI: AN5206.2
ANG: ANI_1_398134(An15g02490)
ABE: ARB_06194
TVE: TRV_01663
PTE: PTT_19273
CNE: CND03850
CNB: CNBD2460
TASA: A1Q1_01965
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
MGL: MGL_3003
MRT: MRET_3610
PCQ: PcP3B5_09520(hicd)
PKC: PKB_4900(leub3)
PSET: THL1_4856
AMAH: DLM_3455
RCA: Rcas_3471
CAU: Caur_0331
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
DRA: DR_1674
DGE: Dgeo_1458
DFC: DFI_05685
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378
TSC: TSC_c20650(icd2)
TAQ: TO73_0559
MRB: Mrub_2738
MJA: MJ_1596
MMP: MMP0880(aksF)
MMD: GYY_05110
MMAK: MMKA1_09750(aksF)
MMAO: MMOS7_09540(aksF)
MMAD: MMJJ_01120(hicd_1)
MAE: Maeo_1484
MVO: Mvol_0791
MTH: MTH_184
METC: MTCT_0151
MWO: MWSIV6_0600(leuB1)
METE: tca_00168(hicd_1)
MST: Msp_0674
MRU: mru_1033(aksF)
MSI: Msm_0373
MEB: Abm4_0999(aksF)
MMIL: sm9_0644(aksF)
MEYE: TL18_03130
MOL: YLM1_0578
METH: MBMB1_1404(leuB1)
MFC: BRM9_0639(aksF)
MFI: DSM1535_0612(leuB1)
MCUB: MCBB_1645(leuB1)
MFV: Mfer_1273
MKA: MK1215(leuB_2)
MBAR: MSBR2_2662
MBAK: MSBR3_2764
MAC: MA_3748(leuB)
MMA: MM_0642
MMAC: MSMAC_0669
METM: MSMTP_0734
MTHR: MSTHT_2378
MTHE: MSTHC_0902
MHOR: MSHOH_0789
MMET: MCMEM_2087
MMH: Mmah_0129
MPY: Mpsy_2352
MTP: Mthe_0855
MCJ: MCON_1920(aksF)
MHI: Mhar_2394
MHU: Mhun_1797
MLA: Mlab_0235
MBG: BN140_3039(leuB3)
MEMA: MMAB1_2207(leuB)
MPI: Mpet_2492
MBN: Mboo_0602
MPL: Mpal_2146
MPD: MCP_1963(aksF)
MEZ: Mtc_1557(aksF)
RCI: RCIX2644(leuB-2)
PTO: PTO0910
 » show all
Reference
1  [PMID:4284830]
  Authors
Strassman M, Ceci LN.
  Title
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
  Journal
J Biol Chem 240:4357-61 (1965)
Reference
2  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]
Reference
3  [PMID:10714900]
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
DOI:10.1039/A801345D
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.87
IUBMB Enzyme Nomenclature: 1.1.1.87
ExPASy - ENZYME nomenclature database: 1.1.1.87
BRENDA, the Enzyme Database: 1.1.1.87
CAS: 9067-90-7

KEGG   REACTION: R01934
Entry
R01934                      Reaction                               

Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
DOI:10.1021/bi00835a023
Other DBs
RHEA: 11903

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