KEGG ORTHOLOGY: K05842

ORTHOLOGY: K05842

Entry

K05842                      KO

Symbol

TRIF

Name

toll-like receptor adapter molecule 1

Pathway

map04064

NF-kappa B signaling pathway

map04217

Necroptosis

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04936

Alcoholic liver disease

map05133

Pertussis

map05135

Yersinia infection

map05142

Chagas disease

map05160

Hepatitis C

map05161

Hepatitis B

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

Disease

H02536

Infection-induced acute encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05842  TRIF; toll-like receptor adapter molecule 1
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K05842  TRIF; toll-like receptor adapter molecule 1
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05842  TRIF; toll-like receptor adapter molecule 1
   04621 NOD-like receptor signaling pathway
    K05842  TRIF; toll-like receptor adapter molecule 1
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05842  TRIF; toll-like receptor adapter molecule 1
  09172 Infectious disease: viral
   05161 Hepatitis B
    K05842  TRIF; toll-like receptor adapter molecule 1
   05160 Hepatitis C
    K05842  TRIF; toll-like receptor adapter molecule 1
   05164 Influenza A
    K05842  TRIF; toll-like receptor adapter molecule 1
   05168 Herpes simplex virus 1 infection
    K05842  TRIF; toll-like receptor adapter molecule 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05842  TRIF; toll-like receptor adapter molecule 1
   05165 Human papillomavirus infection
    K05842  TRIF; toll-like receptor adapter molecule 1
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05842  TRIF; toll-like receptor adapter molecule 1
   05133 Pertussis
    K05842  TRIF; toll-like receptor adapter molecule 1
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K05842  TRIF; toll-like receptor adapter molecule 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05842  TRIF; toll-like receptor adapter molecule 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05842  TRIF; toll-like receptor adapter molecule 1

Genes

HSA:	148022(TICAM1)

PTR:	468677(TICAM1)

PPS:	100974002(TICAM1)

GGO:	101143359(TICAM1)

PON:	100455734(TICAM1)

PPYG:

129021214(TICAM1)

NLE:	100588929(TICAM1)

HMH:	116457855 116483533(TICAM1)

SSYN:

129458821 129467053(TICAM1)

MCC:	574294(TICAM1)

MCF:	102122857(TICAM1)

MTHB:

126942532

MNI:	105485089(TICAM1)

CSAB:

103233731(TICAM1)

CATY:

105591822(TICAM1)

PANU:

101015106(TICAM1)

TGE:	112613598(TICAM1)

MLEU:

105530039(TICAM1)

RRO:	104665406(TICAM1)

RBB:	108512106(TICAM1)

TFN:	117076533(TICAM1)

PTEH:

111521961(TICAM1)

CANG:

105512851(TICAM1)

CJC:	100405343(TICAM1)

SBQ:	101041287(TICAM1)

CIMI:

108304274(TICAM1)

ANAN:

105706198(TICAM1)

MMUR:

105873915(TICAM1)

LCAT:

123636728(TICAM1)

PCOQ:

105811926(TICAM1)

OGA:	100961846(TICAM1)

MMU:	106759(Ticam1)

MCAL:

110283813(Ticam1)

MPAH:

110336092(Ticam1)

RNO:	363328(Ticam1)

MCOC:

116075485(Ticam1)

ANU:	117704938(Ticam1)

MUN:	110546236(Ticam1)

CGE:	100769672(Ticam1)

MAUA:

101834348(Ticam1)

PROB:

127216762(Ticam1)

PLEU:

114685101(Ticam1)

MORG:

121459211(Ticam1)

MFOT:

126490323

AAMP:

119804058(Ticam1)

NGI:	103737218(Ticam1)

HGL:	101721230(Ticam1)

CPOC:

100717594(Ticam1)

CCAN:

109687793(Ticam1)

DORD:

105990289(Ticam1)

DSP:	122099354(Ticam1)

PLOP:

125347643(Ticam1)

NCAR:

124969552

OPI:	101530235(TICAM1)

TUP:	102480594(TICAM1)

GVR:	103603246(TICAM1)

CFA:	611852(TICAM1)

CLUD:

112666319(TICAM1)

VVP:	112935599(TICAM1)

VLG:	121495956(TICAM1)

NPO:	129522440(TICAM1)

AML:	100463778(TICAM1)

UMR:	103681847(TICAM1)

UAH:	113242838(TICAM1)

UAR:	123796797(TICAM1)

ELK:

111161725

LLV:

125088060

MPUF:

101692322(TICAM1)

MNP:	132010819(TICAM1)

MLK:	131823341(TICAM1)

NVS:	122909849(TICAM1)

ORO:	101371542(TICAM1)

EJU:	114226305(TICAM1)

ZCA:	113918381(TICAM1)

MLX:	118005289(TICAM1)

NSU:	110593848(TICAM1)

LWW:	102737118(TICAM1)

FCA:	101082884(TICAM1)

PYU:	121021513(TICAM1)

PBG:	122486740(TICAM1)

PVIV:

125161093(TICAM1)

LRUF:

124524270

PTG:	102951327(TICAM1)

PPAD:

109255994(TICAM1)

PUC:

125928873

AJU:

113596324

HHV:	120242077(TICAM1)

BTA:	510427(TICAM1)

BOM:	102280458(TICAM1)

BIU:	109561728(TICAM1)

BBUB:

102402850(TICAM1)

BBIS:

104979701(TICAM1)

CHX:	102170774(TICAM1)

OAS:	101111016(TICAM1)

BTAX:

128050916(TICAM1)

ODA:	120864846(TICAM1)

CCAD:

122440258(TICAM1)

MBEZ:

129558739(TICAM1)

SSC:	100623776(TICAM1)

CFR:	102522409(TICAM1)

CBAI:

105078232(TICAM1)

CDK:	105091750(TICAM1)

VPC:	102531050(TICAM1)

BACU:

103012352(TICAM1)

BMUS:

118892933(TICAM1)

LVE:	103073041(TICAM1)

OOR:	101271374(TICAM1)

DLE:	111165914(TICAM1)

PCAD:

102975837(TICAM1)

PSIU:

116750848(TICAM1)

NASI:

112400342(TICAM1)

ECB:	100062414(TICAM1)

EPZ:	103545173(TICAM1)

EAI:	106832333(TICAM1)

MYB:	102242611(TICAM1)

MYD:	102754468(TICAM1)

MMYO:

118658886(TICAM1)

MLF:	102426981(TICAM1)

MDT:	132235157(TICAM1)

PKL:	118731340(TICAM1)

EFUS:

103294388(TICAM1)

MNA:	107525658(TICAM1)

DRO:	112312662(TICAM1)

SHON:

118984530(TICAM1)

AJM:	119063741(TICAM1)

PDIC:

114502817(TICAM1)

PHAS:

123814049(TICAM1)

MMF:	118615402(TICAM1)

PPAM:

129078173(TICAM1)

HAI:	109388568(TICAM1)

RFQ:	117037587(TICAM1)

PALE:

102896235(TICAM1)

PGIG:

120615407(TICAM1)

PVP:	105301058(TICAM1)

RAY:	107510780(TICAM1)

MJV:	108391396(TICAM1)

TOD:	119240600(TICAM1)

SARA:

101557102(TICAM1)

SETR:

126030121(TICAM1)

LAV:	100654083(TICAM1)

TMU:

101358234

ETF:	101649346(TICAM1) 115873309

DNM:	101433765(TICAM1)

MDO:	100023610(TICAM1)

GAS:	123232131(TICAM1)

SHR:	100921575(TICAM1)

AFZ:

127541566

PCW:	110197380(TICAM1)

TVP:	118852876(TICAM1)

OAA:	100086769(TICAM1)

GGA:	100008585(TICAM1)

PCOC:

116235677(TICAM1)

MGP:	100541581(TICAM1)

CJO:	107325399(TICAM1)

TPAI:

128088967(TICAM1)

LMUT:

125684885(TICAM1)

NMEL:

110389069

APLA:

101791305(TICAM1)

ACYG:

106044984(TICAM1)

CATA:

118258726(TICAM1)

AFUL:

116499013(TICAM1)

TGU:	100231928(TICAM1)

LSR:	110477892(TICAM1)

SCAN:

103821959(TICAM1)

PMOA:

120513937(TICAM1)

OTC:	121346613(TICAM1)

PRUF:

121349884(TICAM1)

GFR:	102043331(TICAM1)

FAB:	101819322(TICAM1)

OMA:	130264539(TICAM1)

PHI:	102099238(TICAM1)

PMAJ:

107215462(TICAM1)

CCAE:

111943530(TICAM1)

CCW:	104697360(TICAM1)

CBRC:

103621179(TICAM1)

ETL:	114067891(TICAM1)

ZAB:	102062494(TICAM1)

ZLE:	135458889(TICAM1)

ACHL:

103810789(TICAM1)

SVG:	106859681(TICAM1)

MMEA:

130585555(TICAM1)

HRT:	120763350(TICAM1)

SATI:

136371992(TICAM1)

FPG:	101912470(TICAM1)

FCH:	102046422(TICAM1)

CCRI:

104156082(TICAM1)

NNT:	104400449(TICAM1)

SHAB:

115618270(TICAM1)

ACUN:

113489409(TICAM1)

TALA:

104368783(TICAM1)

ACHC:

115349277(TICAM1)

HALD:

104312923(TICAM1)

HLE:	104828524(TICAM1)

AGEN:

126042192

GCL:

127025525

CSTI:

104559526(TICAM1)

LDI:	104341223(TICAM1)

MNB:	103780147(TICAM1)

DPUB:

104300422(TICAM1)

AVIT:

104276720(TICAM1)

BRHI:

104496118(TICAM1)

EGZ:	104124355(TICAM1)

NNI:	104018738(TICAM1)

PCRI:

104025637(TICAM1)

PCAO:

104052158(TICAM1)

PADL:

103912181(TICAM1)

AFOR:

103902934(TICAM1)

FGA:	104072675(TICAM1)

GSTE:

104255668(TICAM1)

CLV:	102092595(TICAM1)

MUI:	104534833(TICAM1)

PGUU:

104462170(TICAM1)

PLET:

104615203(TICAM1)

EHS:	104516475(TICAM1)

CMAC:

104474547(TICAM1)

CUCA:

104060978(TICAM1)

TEO:

104370730

BREG:

104633692(TICAM1)

OHA:	104331082(TICAM1)

ACAR:

104519210(TICAM1)

CVF:	104295424(TICAM1)

RTD:	128900568(TICAM1)

AAM:	106484486(TICAM1)

AROW:

112966772

NPD:	112943864(TICAM1)

TGT:	104575371(TICAM1)

DNE:	112986557(TICAM1)

SCAM:

104145946(TICAM1)

ASN:	102372528(TICAM1)

AMJ:	102559652(TICAM1)

CPOO:

109320451(TICAM1)

GGN:	109294885(TICAM1)

PSS:	102460229(TICAM1)

CMY:	102937845(TICAM1)

CCAY:

125626953(TICAM1)

DCC:	119848466(TICAM1)

CPIC:

101953839(TICAM1)

TST:	117868822(TICAM1)

CABI:

116820836(TICAM1)

MRV:	120391899(TICAM1)

ACS:	103281181(ticam1)

ASAO:

132781041(TICAM1)

PVT:	110079314(TICAM1)

SUND:

121936822(TICAM1)

PBI:	103050089(TICAM1)

PMUR:

107296141(TICAM1) 107301311

TSR:	106552723(TICAM1)

PGUT:

117668655(TICAM1)

APRI:

131188367(TICAM1)

PTEX:

113449297(TICAM1)

NSS:	113425931(TICAM1)

VKO:	123016881(TICAM1)

PMUA:

114588582(TICAM1)

PRAF:

128405893(TICAM1)

ZVI:	118086905(TICAM1)

HCG:	128342008(TICAM1)

GJA:	107118289(TICAM1)

STOW:

125432440(TICAM1)

EMC:	129330873(TICAM1)

XLA:

108712214

XTR:

101733659

RTEM:

120910613

BBUF:

120989547(TICAM1)

BGAR:

122929089

MUO:	115479746(TICAM1)

GSH:	117365204(TICAM1)

DRE:	403147(ticam1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122328199(ticam1)

LROH:

127153687(ticam1)

OMC:	131530314(ticam1)

PPRM:

120486782(ticam1)

MAMB:

125263270(ticam1)

CIDE:

127521475

CERY:

137028067(ticam1)

MASI:

127438497

TROS:

130548959(ticam1)

TDW:	130429416(ticam1)

MANU:

129452636(ticam1)

IPU:	100304977(ticam1)

IFU:	128614183(ticam1)

PHYP:

113534662

SMEO:

124391234(ticam1)

TFD:	113651026(ticam1)

TVC:	132854047(ticam1)

TRN:	134331718(ticam1)

AMEX:

103030647(ticam1)

CMAO:

118819127(ticam1)

EEE:

113592145

CHAR:

105898272(ticam1)

TRU:	100134852(ticam)

TFS:	130538549(ticam1)

LCO:

104924828

NCC:

104949583

TBEN:

117488933(ticam1)

CGOB:

115021951

PGEO:

117462890(ticam1)

GACU:

117532668(ticam1)

EMAC:

134866425(ticam1)

ELY:	117271461(ticam1)

EFO:	125902474(ticam1)

PLEP:

121951395(ticam1)

SLUC:

116037389(ticam1)

ECRA:

117954779(ticam1)

ESP:

116699508

PFLV:

114565342

GAT:	120816503(ticam1)

PPUG:

119209880(ticam1)

AFB:	129088914(ticam1)

PSWI:

130197884(ticam1)

MSAM:

119902884(ticam1)

SCHU:

122887165(ticam1)

CUD:	121519594(ticam1)

ALAT:

119011883(ticam1)

MZE:

101475302

ONL:

100701239

OAU:	116311363(ticam1)

OLA:

101154981

OML:	112147833(ticam1)

CSAI:

133451940(ticam1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122841016(ticam1)

PPRL:

129362356(ticam1)

CVG:

107092307

CTUL:

119772978(ticam1)

GMU:	124869539(ticam1)

NFU:

107384071

KMR:	108239449(ticam1)

ALIM:

106526942

NWH:	119415138(ticam1)

AOCE:

111567655

MCEP:

125011467(ticam1)

CSEM:

103395975

POV:

109637358

SSEN:

122786302(ticam1)

HHIP:

117778877(ticam1)

HSP:	118118329(ticam1)

PPLT:

128454048(ticam1)

SMAU:

118311368(ticam1)

LCF:	108883553(ticam1)

SDU:

111229163

SLAL:

111654777

XGL:	120798581(ticam1)

HCQ:

109507455

SSCV:

125984944

SBIA:

133510609(ticam1)

PEE:	133412157(ticam1)

PTAO:

133488455(ticam1)

BPEC:

110158200

MALB:

109969290

BSPL:

114845051(ticam1)

SJO:	128369302(ticam1)

SASA:

106584543

STRU:

115192721

OTW:	112221602(ticam1)

OMY:	110521348(ticam1)

OGO:	124037600(ticam1)

ONE:

115144798

OKI:

109897786

OKE:	118359301(ticam1)

SALP:

111971988

SNH:	120052385(ticam1)

CCLU:

121540557(ticam1)

ELS:

105018625

SFM:

108938967

PKI:

111860173

AANG:

118224595(ticam1)

LOC:	102691641(ticam1)

PSPA:

121300468 121301180

ARUT:

117401336 117966211

LCM:	102356907(TICAM1)

CMK:

103183547

CPLA:

122565199(ticam1)

HOC:	132828975(ticam1)

» show all

Reference

PMID:12471095

Authors

Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S

Title

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

Journal

J Immunol 169:6668-72 (2002)
DOI:10.4049/jimmunol.169.12.6668

Sequence

[hsa:148022]

Reference

PMID:14519765

Authors

Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T

Title

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

Journal

J Biol Chem 278:49751-62 (2003)
DOI:10.1074/jbc.M305820200

Sequence

[hsa:148022]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (32)   
   KEGG PATHWAY (32)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (397)   
   KEGG GENES (395)   
   RefGene (1)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (433)   

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