KEGG   ORTHOLOGY: K05884
Entry
K05884                      KO                                     

Name
comC
Definition
L-2-hydroxycarboxylate dehydrogenase (NAD+) [EC:1.1.1.337]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00358  Coenzyme M biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K05884  comC; L-2-hydroxycarboxylate dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.337  L-2-hydroxycarboxylate dehydrogenase (NAD+)
     K05884  comC; L-2-hydroxycarboxylate dehydrogenase (NAD+)
Other DBs
RN: R07136
COG: COG2055
Genes
VSH: BSZ05_08715
CNC: CNE_BB1p05710(comC)
CUH: BJN34_35490
PNR: AT302_16585
BFZ: BAU07_07535
PUS: CKA81_13830
PIG: EGT29_10430
LIM: L103DPR2_01654(yjmC)
HYN: F9K07_00765
BPRC: D521_0584
BEBA: BWI17_02740
SMK: Sinme_5353
SMQ: SinmeB_5546
SMX: SM11_pC1598
SMI: BN406_04935
SMEG: C770_GR4pC1290
SMEL: SM2011_a0265
SMER: DU99_24705
SFH: SFHH103_06683(mdh)
SIX: BSY16_5575
REL: REMIM1_PF00544
REI: IE4771_PD00374
RLB: RLEG3_08205
RLU: RLEG12_11130
RIR: BN877_p0363
RGA: RGR602_PC00441
RJG: CCGE525_30300
SHZ: shn_26825
DEQ: XM25_09010
DEI: C4375_14185
RHZ: RHPLAN_59280
YTI: FNA67_12740
MMED: Mame_04860(yjmC_2)
PSIN: CAK95_00810
OTM: OSB_08100(yjmC)
DAA: AKL17_3266
SUAM: BOO69_02845
SEDI: EBB79_05045
LIT: FPZ52_15805
PALW: PSAL_017020(allD)
LRU: HMPREF0538_21967
LRT: LRI_1196
LRR: N134_04225
LMU: LBLM1_05130
LOR: AYI71_01210
LHW: BSQ49_10025
LMAL: LM596_10330
LCY: LC20004_10680
LHO: LOOC260_100690
THL: TEH_05010(mdh)
TOO: C7K38_02045
TKR: C7K43_11960
OEN: DSM07_06615
CRN: CAR_c14810(mdh)
CAC: CA_C0566
CAE: SMB_G0579(mdh)
CAY: CEA_G0580
CKL: CKL_2769(mdh)
CKR: CKR_2460
CLJ: CLJU_c05920(mdh)
CLS: CXIVA_05030
CPAS: Clopa_1152
CPAT: CLPA_c31190(mdh)
CPAE: CPAST_c31190(mdh)
CAH: CAETHG_2689
CTYK: CTK_C26970(mdh)
CARG: RSJ17_10995
CFER: D4Z93_02490
RUM: CK1_23260 CK1_39560
CCT: CC1_29650
ROB: CK5_14170
BYL: A4V09_10375
BHAN: CGC63_01920
BPRO: PMF13cell1_03197(yjmC_2)
BLAB: EYS05_03090
CSH: Closa_3084
EAC: EAL2_808p02730(mdh)
AWO: Awo_c16770(mdh)
MDV: C5Q96_04090
CBAR: PATL70BA_1096(mdh)
TWI: Thewi_0372
TEP: TepRe1_1808
TAE: TepiRe1_1949(mdh)
VNK: VEIT17_15940
ERM: EYR00_09930
MTY: MTOK_02180
SLE: sle_01170(sle_01170)
SGE: DWG14_06080(dpkA)
FRP: AX769_07390
DDT: AAY81_05455
OLS: Olsu_0270
ERZ: ER308_02550
LCRE: Pla8534_16970(yjmC)
SDYN: Mal52_06970(yjmC)
TAZ: TREAZ_1631
TPI: TREPR_3329
SPER: EW093_13865
SBU: SpiBuddy_0633
SCC: Spico_1555
SGP: SpiGrapes_1364
OCK: EXM22_12545
ACO: Amico_1325 Amico_1663
CBAE: COR50_00710
CHIT: FW415_08115
NKO: Niako_5052
NSO: NIASO_00405
FGG: FSB75_01485
AGI: FSB73_14960
PGIN: FRZ67_22035
LACS: H4075_07420
PSN: Pedsa_2198
CAMU: CA2015_1167
BBD: Belba_1791
EVI: Echvi_0162
EST: DN752_07350
ECHI: FKX85_00785
SPIK: EXU85_28470
SPIB: G8759_30960
RSI: Runsl_0559
RUN: DR864_22800
RUP: DTQ70_27545
HSW: Hsw_3558
HYM: N008_11585
HYP: A0257_10070
HYZ: AXW84_17735
HRS: HER32_07605
RUF: TH63_01270
RTI: DC20_19730
RUD: TH61_09780
ADD: HUW48_20385
ASWU: HUW51_03165
FPF: DCC35_04490
FLM: MY04_2484 MY04_2897
CHK: D4L85_06045
CACI: CLOAM1159(mdh)
KPF: IX53_06400
MPG: Theba_0594
MINF: MESINF_0035(mdh) MESINF_1540(mdh)
BANA: BARAN1_1319(mdh)
MJA: MJ_1425
MFE: Mefer_1396
MVU: Metvu_0738
MFS: MFS40622_0628
MIF: Metin_0176
MJH: JH146_0548
MIG: Metig_0716
MMP: MMP1133(comC)
MMQ: MmarC5_0451
MMX: MmarC6_1534
MMZ: MmarC7_0385
MMD: GYY_06515
MMAK: MMKA1_13120(comC)
MMAO: MMOS7_12420(comC)
MMAD: MMJJ_17120(yjmC)
MAE: Maeo_1015
MVN: Mevan_0455
MVO: Mvol_0905
MOK: Metok_0546
METF: CFE53_04010
MTH: MTH_1205
MMG: MTBMA_c15830(comC)
METC: MTCT_1098
MWO: MWSIV6_1598(comC)
METE: tca_01162(yjmC)
METZ: METMT2_1207
METK: FVF72_05595
MTHM: FZP57_07660
MST: Msp_0279(comC)
METB: AW729_05750
MRU: mru_1980(comC)
MSI: Msm_1040
MEB: Abm4_1552(comC)
MMIL: sm9_2052(comC)
MEYE: TL18_09445
MOL: YLM1_1417
MEL: Metbo_0320
MEW: MSWAN_2101
METH: MBMB1_1726(comC)
MFC: BRM9_0342(comC)
MFI: DSM1535_0956(comC)
MCUB: MCBB_2038(comC)
MSUB: BK009_07660
METN: BK008_03315
METT: CIT01_03895
METO: CIT02_09230
MFV: Mfer_0389
MKA: MK0392(comC)
STO: STK_20900
SOH: D1869_11455
AMAN: B6F84_09265
ABRI: DFR85_02480 DFR85_02750
ASUL: DFR86_07970
AAMB: D1866_00065 D1866_09410
SACD: HS1genome_1813
SAZO: D1868_06535
STEP: IC006_0144
LOKI: Lokiarch_23620(mdh_3) Lokiarch_23630(mdh_4)
PSYT: DSAG12_01758(mdh)
 » show all
Reference
  Authors
Graupner M, Xu H, White RH
  Title
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:3688-92 (2000)
DOI:10.1128/JB.182.13.3688-3692.2000
  Sequence
[mja:MJ_1425]

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (319)   
   KEGG GENES (205)   
   KEGG MGENES (81)   
   RefGene (27)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (333)   

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KEGG   ENZYME: 1.1.1.337
Entry
EC 1.1.1.337                Enzyme                                 

Name
L-2-hydroxycarboxylate dehydrogenase (NAD+);
(R)-sulfolactate:NAD+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
L-2-hydroxyacid dehydrogenase (NAD+);
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ [RN:R10189]
Reaction(KEGG)
R10189 > R07136
Substrate
(2S)-2-hydroxycarboxylate [CPD:C15565];
NAD+ [CPD:C00003]
Product
2-oxocarboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
History
EC 1.1.1.337 created 2012
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K05884  L-2-hydroxycarboxylate dehydrogenase (NAD+)
Genes
VSH: BSZ05_08715
CNC: CNE_BB1p05710(comC)
CUH: BJN34_35490
PNR: AT302_16585
BFZ: BAU07_07535
PUS: CKA81_13830
PIG: EGT29_10430
LIM: L103DPR2_01654(yjmC)
HYN: F9K07_00765
BPRC: D521_0584
BEBA: BWI17_02740
SMK: Sinme_5353
SMQ: SinmeB_5546
SMX: SM11_pC1598
SMI: BN406_04935
SMEG: C770_GR4pC1290
SMEL: SM2011_a0265
SMER: DU99_24705
SFH: SFHH103_06683(mdh)
SIX: BSY16_5575
REL: REMIM1_PF00544
REI: IE4771_PD00374
RLB: RLEG3_08205
RLU: RLEG12_11130
RIR: BN877_p0363
RGA: RGR602_PC00441
RJG: CCGE525_30300
SHZ: shn_26825
DEQ: XM25_09010
DEI: C4375_14185
RHZ: RHPLAN_59280
YTI: FNA67_12740
MMED: Mame_04860(yjmC_2)
PSIN: CAK95_00810
OTM: OSB_08100(yjmC)
DAA: AKL17_3266
SUAM: BOO69_02845
SEDI: EBB79_05045
LIT: FPZ52_15805
PALW: PSAL_017020(allD)
LRU: HMPREF0538_21967
LRT: LRI_1196
LRR: N134_04225
LMU: LBLM1_05130
LOR: AYI71_01210
LHW: BSQ49_10025
LMAL: LM596_10330
LCY: LC20004_10680
LHO: LOOC260_100690
THL: TEH_05010(mdh)
TOO: C7K38_02045
TKR: C7K43_11960
OEN: DSM07_06615
CRN: CAR_c14810(mdh)
CAC: CA_C0566
CAE: SMB_G0579(mdh)
CAY: CEA_G0580
CKL: CKL_2769(mdh)
CKR: CKR_2460
CLJ: CLJU_c05920(mdh)
CLS: CXIVA_05030
CPAS: Clopa_1152
CPAT: CLPA_c31190(mdh)
CPAE: CPAST_c31190(mdh)
CAH: CAETHG_2689
CTYK: CTK_C26970(mdh)
CARG: RSJ17_10995
CFER: D4Z93_02490
RUM: CK1_23260 CK1_39560
CCT: CC1_29650
ROB: CK5_14170
BYL: A4V09_10375
BHAN: CGC63_01920
BPRO: PMF13cell1_03197(yjmC_2)
BLAB: EYS05_03090
CSH: Closa_3084
EAC: EAL2_808p02730(mdh)
AWO: Awo_c16770(mdh)
MDV: C5Q96_04090
CBAR: PATL70BA_1096(mdh)
TWI: Thewi_0372
TEP: TepRe1_1808
TAE: TepiRe1_1949(mdh)
VNK: VEIT17_15940
ERM: EYR00_09930
MTY: MTOK_02180
SLE: sle_01170(sle_01170)
SGE: DWG14_06080(dpkA)
FRP: AX769_07390
DDT: AAY81_05455
OLS: Olsu_0270
ERZ: ER308_02550
LCRE: Pla8534_16970(yjmC)
SDYN: Mal52_06970(yjmC)
TAZ: TREAZ_1631
TPI: TREPR_3329
SPER: EW093_13865
SBU: SpiBuddy_0633
SCC: Spico_1555
SGP: SpiGrapes_1364
OCK: EXM22_12545
ACO: Amico_1325 Amico_1663
CBAE: COR50_00710
CHIT: FW415_08115
NKO: Niako_5052
NSO: NIASO_00405
FGG: FSB75_01485
AGI: FSB73_14960
PGIN: FRZ67_22035
LACS: H4075_07420
PSN: Pedsa_2198
CAMU: CA2015_1167
BBD: Belba_1791
EVI: Echvi_0162
EST: DN752_07350
ECHI: FKX85_00785
SPIK: EXU85_28470
SPIB: G8759_30960
RSI: Runsl_0559
RUN: DR864_22800
RUP: DTQ70_27545
HSW: Hsw_3558
HYM: N008_11585
HYP: A0257_10070
HYZ: AXW84_17735
HRS: HER32_07605
RUF: TH63_01270
RTI: DC20_19730
RUD: TH61_09780
ADD: HUW48_20385
ASWU: HUW51_03165
FPF: DCC35_04490
FLM: MY04_2484 MY04_2897
CHK: D4L85_06045
CACI: CLOAM1159(mdh)
KPF: IX53_06400
MPG: Theba_0594
MINF: MESINF_0035(mdh) MESINF_1540(mdh)
BANA: BARAN1_1319(mdh)
MJA: MJ_1425
MFE: Mefer_1396
MVU: Metvu_0738
MFS: MFS40622_0628
MIF: Metin_0176
MJH: JH146_0548
MIG: Metig_0716
MMP: MMP1133(comC)
MMQ: MmarC5_0451
MMX: MmarC6_1534
MMZ: MmarC7_0385
MMD: GYY_06515
MMAK: MMKA1_13120(comC)
MMAO: MMOS7_12420(comC)
MMAD: MMJJ_17120(yjmC)
MAE: Maeo_1015
MVN: Mevan_0455
MVO: Mvol_0905
MOK: Metok_0546
METF: CFE53_04010
MTH: MTH_1205
MMG: MTBMA_c15830(comC)
METC: MTCT_1098
MWO: MWSIV6_1598(comC)
METE: tca_01162(yjmC)
METZ: METMT2_1207
METK: FVF72_05595
MTHM: FZP57_07660
MST: Msp_0279(comC)
METB: AW729_05750
MRU: mru_1980(comC)
MSI: Msm_1040
MEB: Abm4_1552(comC)
MMIL: sm9_2052(comC)
MEYE: TL18_09445
MOL: YLM1_1417
MEL: Metbo_0320
MEW: MSWAN_2101
METH: MBMB1_1726(comC)
MFC: BRM9_0342(comC)
MFI: DSM1535_0956(comC)
MCUB: MCBB_2038(comC)
MSUB: BK009_07660
METN: BK008_03315
METT: CIT01_03895
METO: CIT02_09230
MFV: Mfer_0389
MKA: MK0392(comC)
STO: STK_20900
SOH: D1869_11455
AMAN: B6F84_09265
ABRI: DFR85_02480 DFR85_02750
ASUL: DFR86_07970
AAMB: D1866_00065 D1866_09410
SACD: HS1genome_1813
SAZO: D1868_06535
STEP: IC006_0144
LOKI: Lokiarch_23620(mdh_3) Lokiarch_23630(mdh_4)
PSYT: DSAG12_01758(mdh)
 » show all
Reference
1  [PMID:10850983]
  Authors
Graupner M, Xu H, White RH
  Title
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:3688-92 (2000)
DOI:10.1128/JB.182.13.3688-3692.2000
  Sequence
[mja:MJ_1425]
Reference
2  [PMID:11451450]
  Authors
Graupner M, White RH.
  Title
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.
  Journal
Biochim Biophys Acta 1548:169-73 (2001)
DOI:10.1016/S0167-4838(01)00220-5
  Sequence
[mja:MJ_1425]
Reference
3  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p
Reference
4  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.337
IUBMB Enzyme Nomenclature: 1.1.1.337
ExPASy - ENZYME nomenclature database: 1.1.1.337
BRENDA, the Enzyme Database: 1.1.1.337
CAS: 81210-65-3

  All links  
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (314)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (205)   
   KEGG MGENES (81)   
   RefGene (27)   
Protein sequence (12)   
   UniProt (10)   
   SWISS-PROT (2)   
DNA sequence (10)   
   GenBank (5)   
   EMBL (5)   
Protein domain (4)   
   InterPro (4)   
All databases (356)   

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KEGG   REACTION: R07136
Entry
R07136                      Reaction                               

Name
(2R)-3-sulfolactate:NAD+ oxidoreductase
Definition
(2R)-3-Sulfolactate + NAD+ <=> 3-Sulfopyruvate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00031  C05528_C11537
Enzyme
1.1.1.37        1.1.1.337
Pathway
rn00270  Cysteine and methionine metabolism
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00358  Coenzyme M biosynthesis
Orthology
K00024  malate dehydrogenase [EC:1.1.1.37]
K00025  malate dehydrogenase [EC:1.1.1.37]
K00026  malate dehydrogenase [EC:1.1.1.37]
K05884  L-2-hydroxycarboxylate dehydrogenase (NAD+) [EC:1.1.1.337]
Other DBs
RHEA: 15536

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (11)   
   KEGG PATHWAY (10)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
Gene (6891)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (6887)   
All databases (6913)   

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