KEGG   ORTHOLOGY: K05898
Entry
K05898                      KO                                     

Name
kstD
Definition
3-oxosteroid 1-dehydrogenase [EC:1.3.99.4]
Pathway
ko00984  Steroid degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K05898  kstD; 3-oxosteroid 1-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.4  3-oxosteroid 1-dehydrogenase
     K05898  kstD; 3-oxosteroid 1-dehydrogenase
Other DBs
RN: R09884
COG: COG1053
GO: 0047571
Genes
SOD: Sant_0955
EBI: EbC_17210
PAO: Pat9b_1567
VAF: D1115_23240
PRE: PCA10_12340(kstD)
PPUT: L483_14095
PPUN: PP4_27200(kstD3)
PVR: PverR02_11670
PPUU: PputUW4_01674
PKC: PKB_4330
PSET: THL1_1313
PSIL: PMA3_11570
SPL: Spea_2125
SHL: Shal_2097
PHA: PSHAa2133(tesH)
PTN: PTRA_a2586(kstD)
PNG: PNIG_a2780(kstD)
REH: H16_B0639(h16_B0639)
CNC: CNE_2c05840(kstD) CNE_BB1p03860(ksdD1) CNE_BB1p04140(kstD)
BCJ: BCAM1646
BCEO: I35_5506
BMUL: NP80_3988
BCED: DM42_6312(kstD)
BCON: NL30_03955
BTEI: WS51_05855
BMEC: WJ16_26970
BXB: DR64_7938
BPH: Bphy_7441
BFN: OI25_4615
CABA: SBC2_48750(kstD)
BPE: BP3500
BPC: BPTD_3450
BPA: BPP0873
BBR: BB0967
CTES: O987_07760
EBA: p2A2 p2A323
GME: Gmet_2225
PLA: Plav_1792
RHT: NT26_3059
NEN: NCHU2750_12250(kstD) NCHU2750_48230(kstD)
KVL: KVU_PA0184(kstD3)
KVU: EIO_3010
RID: RIdsm_01865(ifcA_2)
SGI: SGRAN_3515(kstD)
SSAN: NX02_07685
SPHB: EP837_02950(urdA) EP837_03338(kstD)
ERF: FIU90_01650(kstD)
LSP: Bsph_0520
KZO: NCTC404_01577(ksdD) NCTC404_01892(kstD)
MTU: Rv3537(kstD)
MTV: RVBD_3537
MTC: MT3641
MRA: MRA_3576
MTUR: CFBS_3753
MTD: UDA_3537
MTUB: MT7199_3599(kstD)
MTUC: J113_24750
MTUE: J114_18915
MTUH: I917_24820
MTUL: TBHG_03477
MTUT: HKBT1_3738
MTUU: HKBT2_3747
MBO: BQ2027_MB3567(kstd)
MBB: BCG_3601
MBT: JTY_3602
MBX: BCGT_3403
MAF: MAF_35490
MMIC: RN08_3913
MCQ: BN44_110029(kstD)
MCV: BN43_90035(kstD)
MCX: BN42_90032(kstD)
MCZ: BN45_100032(kstD)
MLP: MLM_0768
MHAD: B586_04625
MPHL: MPHLCCUG_00564(ksdD_1) MPHLCCUG_02603(kstD_1) MPHLCCUG_02624(kstD_2) MPHLCCUG_03809(kstD_3) MPHLCCUG_03814(kstD_4) MPHLCCUG_05061(ksdD_2)
MTHN: 4412656_00940(kstD_1) 4412656_00942(kstD_2) 4412656_02901(kstD_3) 4412656_03103(kstD_4) 4412656_04053(ksdD)
MHAS: MHAS_00710(kstD_1) MHAS_02480(kstD_2) MHAS_02630(kstD_3) MHAS_02635(ksdD) MHAS_03730(kstD_4)
MAB: MAB_0622c
MSTE: MSTE_00581
MSAL: DSM43276_00540(kstD_1) DSM43276_00767(kstD_2)
MTER: 4434518_03655(kstD)
ASD: AS9A_0160 AS9A_0923(kstD3)
CAMG: CAMM_03990
NFR: ERS450000_01853(ksdD) ERS450000_03774(kstD_1) ERS450000_05822(kstD_2)
RHA: RHA1_ro04532(kstD) RHA1_ro09040(kstD)
RER: RER_07370(kstD3) RER_12410(kstD2) RER_29470 RER_51050(kstD1)
RRT: 4535765_00579(kstD_1) 4535765_04009(kstD_2) 4535765_04044(kstD_3)
GBR: Gbro_0895
GPO: GPOL_c41290(kstD1) GPOL_c41370(kstD2)
GOR: KTR9_0802(kstD)
GRU: GCWB2_04100(kstD)
GOM: D7316_02535(ksdD) D7316_02574(kstD_1) D7316_02576(kstD_2) D7316_02586(kstD_3)
TPR: Tpau_3848
SDV: BN159_3882(kstD)
SALU: DC74_7450
SALL: SAZ_38455
STRM: M444_05900
SLX: SLAV_27450(kstD1) SLAV_33045(kstD2)
SGE: DWG14_03584(ksdD)
IDO: I598_0510(ksdD)
ACIJ: JS278_02361(ksdD)
NCA: Noca_2780
NDK: I601_0580(kstD_1) I601_0607(kstD_2) I601_3473(ksdD)
FAL: FRAAL4374
NML: Namu_2896
SACC: EYD13_11975(kstD)
AMYY: YIM_07935(ksdD) YIM_14440(kstD1) YIM_36690(kstD2)
PAUT: Pdca_05130
KAL: KALB_5140
AFS: AFR_27765
CAI: Caci_5094
CWO: Cwoe_1511
GPA: GPA_27460
AEQ: AEQU_0919
CBAC: JI75_04740
CAU: Caur_0376
TRO: trd_1806
HTU: Htur_3820
 » show all
Reference
  Authors
Knol J, Bodewits K, Hessels GI, Dijkhuizen L, van der Geize R
  Title
3-Keto-5alpha-steroid Delta(1)-dehydrogenase from Rhodococcus erythropolis SQ1 and its orthologue in Mycobacterium tuberculosis H37Rv are highly specific enzymes that function in cholesterol catabolism.
  Journal
Biochem J 410:339-46 (2008)
DOI:10.1042/BJ20071130
  Sequence
[rer:RER_07370]
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
  Sequence
[mtu:Rv3537]

KEGG   ENZYME: 1.3.99.4
Entry
EC 1.3.99.4                 Enzyme                                 

Name
3-oxosteroid 1-dehydrogenase;
3-oxosteroid Delta1-dehydrogenase;
Delta1-dehydrogenase;
3-ketosteroid-1-en-dehydrogenase;
3-ketosteroid-Delta1-dehydrogenase;
1-ene-dehydrogenase;
3-oxosteroid:(2,6-dichlorphenolindophenol) Delta1-oxidoreductase;
4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase;
Delta1-steroid reductase;
3-oxosteroid:(acceptor) Delta1-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
Sysname
3-oxosteroid:acceptor Delta1-oxidoreductase
Reaction(IUBMB)
a 3-oxosteroid + acceptor = a 3-oxo-Delta1-steroid + reduced acceptor [RN:R03748]
Reaction(KEGG)
R03748 > R09884
Substrate
3-oxosteroid [CPD:C01876];
acceptor [CPD:C00028]
Product
3-oxo-Delta1-steroid [CPD:C02941];
reduced acceptor [CPD:C00030]
History
EC 1.3.99.4 created 1965
Pathway
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05898  3-oxosteroid 1-dehydrogenase
Genes
SOD: Sant_0955
EBI: EbC_17210
PAO: Pat9b_1567
VAF: D1115_23240
PRE: PCA10_12340(kstD)
PPUT: L483_14095
PPUN: PP4_27200(kstD3)
PVR: PverR02_11670
PPUU: PputUW4_01674
PKC: PKB_4330
PSET: THL1_1313
PSIL: PMA3_11570
SPL: Spea_2125
SHL: Shal_2097
PHA: PSHAa2133(tesH)
PTN: PTRA_a2586(kstD)
PNG: PNIG_a2780(kstD)
REH: H16_B0639(h16_B0639)
CNC: CNE_2c05840(kstD) CNE_BB1p03860(ksdD1) CNE_BB1p04140(kstD)
BCJ: BCAM1646
BCEO: I35_5506
BMUL: NP80_3988
BCED: DM42_6312(kstD)
BCON: NL30_03955
BTEI: WS51_05855
BMEC: WJ16_26970
BXB: DR64_7938
BPH: Bphy_7441
BFN: OI25_4615
CABA: SBC2_48750(kstD)
BPE: BP3500
BPC: BPTD_3450
BPA: BPP0873
BBR: BB0967
CTES: O987_07760
EBA: p2A2 p2A323
GME: Gmet_2225
PLA: Plav_1792
RHT: NT26_3059
NEN: NCHU2750_12250(kstD) NCHU2750_48230(kstD)
KVL: KVU_PA0184(kstD3)
KVU: EIO_3010
RID: RIdsm_01865(ifcA_2)
SGI: SGRAN_3515(kstD)
SSAN: NX02_07685
SPHB: EP837_02950(urdA) EP837_03338(kstD)
ERF: FIU90_01650(kstD)
LSP: Bsph_0520
KZO: NCTC404_01577(ksdD) NCTC404_01892(kstD)
MTU: Rv3537(kstD)
MTV: RVBD_3537
MTC: MT3641
MRA: MRA_3576
MTUR: CFBS_3753
MTD: UDA_3537
MTUB: MT7199_3599(kstD)
MTUC: J113_24750
MTUE: J114_18915
MTUH: I917_24820
MTUL: TBHG_03477
MTUT: HKBT1_3738
MTUU: HKBT2_3747
MBO: BQ2027_MB3567(kstd)
MBB: BCG_3601
MBT: JTY_3602
MBX: BCGT_3403
MAF: MAF_35490
MMIC: RN08_3913
MCQ: BN44_110029(kstD)
MCV: BN43_90035(kstD)
MCX: BN42_90032(kstD)
MCZ: BN45_100032(kstD)
MLP: MLM_0768
MHAD: B586_04625
MPHL: MPHLCCUG_00564(ksdD_1) MPHLCCUG_02603(kstD_1) MPHLCCUG_02624(kstD_2) MPHLCCUG_03809(kstD_3) MPHLCCUG_03814(kstD_4) MPHLCCUG_05061(ksdD_2)
MTHN: 4412656_00940(kstD_1) 4412656_00942(kstD_2) 4412656_02901(kstD_3) 4412656_03103(kstD_4) 4412656_04053(ksdD)
MHAS: MHAS_00710(kstD_1) MHAS_02480(kstD_2) MHAS_02630(kstD_3) MHAS_02635(ksdD) MHAS_03730(kstD_4)
MAB: MAB_0622c
MSTE: MSTE_00581
MSAL: DSM43276_00540(kstD_1) DSM43276_00767(kstD_2)
MTER: 4434518_03655(kstD)
ASD: AS9A_0160 AS9A_0923(kstD3)
CAMG: CAMM_03990
NFR: ERS450000_01853(ksdD) ERS450000_03774(kstD_1) ERS450000_05822(kstD_2)
RHA: RHA1_ro04532(kstD) RHA1_ro09040(kstD)
RER: RER_07370(kstD3) RER_12410(kstD2) RER_29470 RER_51050(kstD1)
RRT: 4535765_00579(kstD_1) 4535765_04009(kstD_2) 4535765_04044(kstD_3)
GBR: Gbro_0895
GPO: GPOL_c41290(kstD1) GPOL_c41370(kstD2)
GOR: KTR9_0802(kstD)
GRU: GCWB2_04100(kstD)
GOM: D7316_02535(ksdD) D7316_02574(kstD_1) D7316_02576(kstD_2) D7316_02586(kstD_3)
TPR: Tpau_3848
SDV: BN159_3882(kstD)
SALU: DC74_7450
SALL: SAZ_38455
STRM: M444_05900
SLX: SLAV_27450(kstD1) SLAV_33045(kstD2)
SGE: DWG14_03584(ksdD)
IDO: I598_0510(ksdD)
ACIJ: JS278_02361(ksdD)
NCA: Noca_2780
NDK: I601_0580(kstD_1) I601_0607(kstD_2) I601_3473(ksdD)
FAL: FRAAL4374
NML: Namu_2896
SACC: EYD13_11975(kstD)
AMYY: YIM_07935(ksdD) YIM_14440(kstD1) YIM_36690(kstD2)
PAUT: Pdca_05130
KAL: KALB_5140
AFS: AFR_27765
CAI: Caci_5094
CWO: Cwoe_1511
GPA: GPA_27460
AEQ: AEQU_0919
CBAC: JI75_04740
CAU: Caur_0376
TRO: trd_1806
HTU: Htur_3820
 » show all
Reference
1  [PMID:13673006]
  Authors
LEVY HR, TALALAY P.
  Title
Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation.
  Journal
J Biol Chem 234:2014-21 (1959)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.4
IUBMB Enzyme Nomenclature: 1.3.99.4
ExPASy - ENZYME nomenclature database: 1.3.99.4
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.4
BRENDA, the Enzyme Database: 1.3.99.4
CAS: 9029-04-3

KEGG   REACTION: R09884
Entry
R09884                      Reaction                               

Name
androstenedione:acceptor Delta1-oxidoreductase
Definition
Androstenedione + Acceptor <=> Androsta-1,4-diene-3,17-dione + Reduced acceptor
Equation
Reaction class
RC00991  C00280_C20144
Enzyme
Pathway
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K05898  3-oxosteroid 1-dehydrogenase [EC:1.3.99.4]
Other DBs
RHEA: 51059

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