KEGG   ORTHOLOGY: K05907
Entry
K05907                      KO                                     

Name
APR
Definition
adenylyl-sulfate reductase (glutathione) [EC:1.8.4.9]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K05907  APR; adenylyl-sulfate reductase (glutathione)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.4  With a disulfide as acceptor
    1.8.4.9  adenylyl-sulfate reductase (glutathione)
     K05907  APR; adenylyl-sulfate reductase (glutathione)
Other DBs
RN: R05717
GO: 0033741
Genes
ATH: AT1G62180(APR2) AT4G04610(APR1) AT4G21990(APR3)
ALY: 9303872 9310871 9322553
CRB: 17880982 17883322 17896630
CSAT: 104703816 104707608 104714551 104716805 104718119 104722840 104731320 104737308 104752870
EUS: EUTSA_v10023459mg EUTSA_v10025134mg EUTSA_v10028642mg
BRP: 103839826 103848153 103859677 103861274
BNA: 106346634 106347879 106366895 106396567 106418321 106418329 106420885 106435512 106440433 106442702 111212167
BOE: 106306507 106310441 106319498 106342464
RSZ: 108824435 108828637 108829478 108829485 108842087 108842851 108848746 108851680
THJ: 104806307 104809496 104818752
TCC: 18597168
EGR: 104441413
CAM: 101505158
LJA: Lj4g3v0149340.1(Lj4g3v0149340.1) Lj6g3v1872560.1(Lj6g3v1872560.1)
FVE: 101296464
RCN: 112165291
RCU: 8284186
JCU: 105649322
BVG: 104900978
SOE: 110792539
OSA: 4343348
DOSA: Os07t0509800-01(Os07g0509800)
OBR: 102709478
BDI: 100828269
ATS: 109738044(LOC109738044)
SBI: 8080734
ZMA: 103647705(aprl2) 606419(aprl1)
SITA: 101776145
MUS: 103975596
DCT: 110111790
PEQ: 110030804
ATR: 18445736
PPP: 112281535
CRE: CHLREDRAFT_131444(MET16)
APRO: F751_6755
OLU: OSTLU_13445(APR1)
EHX: EMIHUDRAFT_455311(PAPR)
 » show all
Reference
PMID:8917599
  Authors
Gutierrez-Marcos JF, Roberts MA, Campbell EI, Wray JL
  Title
Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity.
  Journal
Proc Natl Acad Sci U S A 93:13377-82 (1996)
DOI:10.1073/pnas.93.23.13377
  Sequence
Reference
PMID:8917600
  Authors
Setya A, Murillo M, Leustek T
  Title
Sulfate reduction in higher plants: molecular evidence for a novel 5'-adenylylsulfate reductase.
  Journal
Proc Natl Acad Sci U S A 93:13383-8 (1996)
DOI:10.1073/pnas.93.23.13383

KEGG   ENZYME: 1.8.4.9
Entry
EC 1.8.4.9                  Enzyme                                 

Name
adenylyl-sulfate reductase (glutathione);
5'-adenylylsulfate reductase (also used for EC 1.8.99.2);
AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming);
plant-type 5'-adenylylsulfate reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)
Reaction(IUBMB)
AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione [RN:R05717]
Reaction(KEGG)
R05717
Substrate
AMP [CPD:C00020];
sulfite [CPD:C00094];
glutathione disulfide [CPD:C00127]
Product
adenylyl sulfate [CPD:C00224];
glutathione [CPD:C00051]
Comment
This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by gamma-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or mercaptoethanol. The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Enteromorpha intestinalis.
History
EC 1.8.4.9 created 2000, modified 2002
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05907  adenylyl-sulfate reductase (glutathione)
Genes
ATH: AT1G62180(APR2) AT4G04610(APR1) AT4G21990(APR3)
ALY: 9303872 9310871 9322553
CRB: 17880982 17883322 17896630
CSAT: 104703816 104707608 104714551 104716805 104718119 104722840 104731320 104737308 104752870
EUS: EUTSA_v10023459mg EUTSA_v10025134mg EUTSA_v10028642mg
BRP: 103839826 103848153 103859677 103861274
BNA: 106346634 106347879 106366895 106396567 106418321 106418329 106420885 106435512 106440433 106442702 111212167
BOE: 106306507 106310441 106319498 106342464
RSZ: 108824435 108828637 108829478 108829485 108842087 108842851 108848746 108851680
THJ: 104806307 104809496 104818752
TCC: 18597168
EGR: 104441413
CAM: 101505158
LJA: Lj4g3v0149340.1(Lj4g3v0149340.1) Lj6g3v1872560.1(Lj6g3v1872560.1)
FVE: 101296464
RCN: 112165291
RCU: 8284186
JCU: 105649322
BVG: 104900978
SOE: 110792539
OSA: 4343348
DOSA: Os07t0509800-01(Os07g0509800)
OBR: 102709478
BDI: 100828269
ATS: 109738044(LOC109738044)
SBI: 8080734
ZMA: 103647705(aprl2) 606419(aprl1)
SITA: 101776145
MUS: 103975596
DCT: 110111790
PEQ: 110030804
ATR: 18445736
PPP: 112281535
CRE: CHLREDRAFT_131444(MET16)
APRO: F751_6755
OLU: OSTLU_13445(APR1)
EHX: EMIHUDRAFT_455311(PAPR)
 » show all
Reference
1  [PMID:8917599]
  Authors
Gutierrez-Marcos JF, Roberts MA, Campbell EI, Wray JL
  Title
Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity.
  Journal
Proc Natl Acad Sci U S A 93:13377-82 (1996)
DOI:10.1073/pnas.93.23.13377
  Sequence
Reference
2  [PMID:8917600]
  Authors
Setya A, Murillo M, Leustek T
  Title
Sulfate reduction in higher plants: molecular evidence for a novel 5'-adenylylsulfate reductase.
  Journal
Proc Natl Acad Sci U S A 93:13383-8 (1996)
DOI:10.1073/pnas.93.23.13383
  Sequence
[ath:AT4G04610]
Reference
3  [PMID:9653199]
  Authors
Bick JA, Aslund F, Chen Y, Leustek T.
  Title
Glutaredoxin function for the carboxyl-terminal domain of the plant-type 5'-adenylylsulfate reductase.
  Journal
Proc Natl Acad Sci U S A 95:8404-9 (1998)
DOI:10.1073/pnas.95.14.8404
  Sequence
[ath:AT4G04610]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.9
IUBMB Enzyme Nomenclature: 1.8.4.9
ExPASy - ENZYME nomenclature database: 1.8.4.9
BRENDA, the Enzyme Database: 1.8.4.9
CAS: 355840-27-6

KEGG   REACTION: R05717
Entry
R05717                      Reaction                               

Name
AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)
Definition
AMP + Sulfite + Glutathione disulfide <=> Adenylyl sulfate + 2 Glutathione
Equation
Reaction class
RC00007  C00020_C00224
RC00011  C00051_C00127
RC02862  C00094_C00224
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K05907  adenylyl-sulfate reductase (glutathione) [EC:1.8.4.9]
Other DBs
RHEA: 14144

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