KEGG   ORTHOLOGY: K05928
Entry
K05928                      KO                                     

Name
E2.1.1.95
Definition
tocopherol O-methyltransferase [EC:2.1.1.95]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K05928  E2.1.1.95; tocopherol O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.95  tocopherol C-methyltransferase
     K05928  E2.1.1.95; tocopherol O-methyltransferase
Other DBs
RN: R07236 R07504 R10491 R10492
COG: COG0500
GO: 0050342
Genes
ATH: AT1G64970(G-TMT)
ALY: 9322850
CRB: 17896175
CSAT: 104722834 104725296 104751124 104760795
EUS: EUTSA_v10018768mg
BRP: 103852208 103853294
BNA: 106388189 106390439 106406285
BOE: 106318945 106322543
RSZ: 108816273
THJ: 104805718 104821707
CPAP: 110815941
CIT: 102628754
TCC: 18599602
EGR: 104424262
GMX: 100778509 100792443(GAMMA-TMT) 732543
CAM: 101513488
LJA: Lj3g3v3639870.1(Lj3g3v3639870.1) Lj3g3v3639870.2(Lj3g3v3639870.2)
LANG: 109348558
FVE: 101307130
RCN: 112192792
PPER: 18769165
PMUM: 103339737
PAVI: 110753538
CSV: 101205148
CMO: 103501078
MCHA: 111017272
CMAX: 111484262
CMOS: 111449074
CPEP: 111777902
RCU: 8284310
JCU: 105632484
HBR: 110659616
MESC: 110619928
POP: 7465624
PEU: 105139626
JRE: 109003796
VVI: 100242641
SLY: 778248(TMT)
SPEN: 107028652
SOT: 102577815(GAMMA-TMT)
CANN: 107870898
NTO: 104111647
NAU: 109211043
INI: 109179117
SIND: 105174312
OEU: 111381589
DCR: 108210384
BVG: 104888087
SOE: 110793113
CQI: 110693052
OSA: 4330437
DOSA: Os02t0701600-01(Os02g0701600)
OBR: 102706446
BDI: 100836877
ATS: 109744847(LOC109744847)
ZMA: 732837(cl364_1)
SITA: 101778567
PDA: 103716652
EGU: 105033221
MUS: 104000155
DCT: 110115783
PEQ: 110031053
PPP: 112288826
CRE: CHLREDRAFT_129990(VTE4)
MNG: MNEG_4528
APRO: F751_6137
NCR: NCU04129
NTE: NEUTE1DRAFT75477(NEUTE1DRAFT_75477)
MGR: MGG_04901
SSCK: SPSK_06415
MBE: MBM_01895
PTI: PHATRDRAFT_20470(TMT)
FCY: FRACYDRAFT_238951(VTE4)
TMC: LMI_3088
EBA: c1A84
MXA: MXAN_0151
RVA: Rvan_2344
RUT: FIU92_06015(rebM1)
SSAN: NX02_23295
SPMI: K663_17016
SPHT: K426_22279
ART: Arth_1026
SESP: BN6_50360
ALO: CRK55118
CAI: Caci_3249
SYN: slr0089(erg6)
SYZ: MYO_126250(erg6)
SYY: SYNGTS_2600(slr0089)
SYT: SYNGTI_2599(slr0089)
SYS: SYNPCCN_2598(slr0089)
SYQ: SYNPCCP_2598(slr0089)
SYJ: D082_21800(erg6)
CYA: CYA_2254
CYB: CYB_2403
LET: O77CONTIG1_00395(rebM_1)
AMR: AM1_4540
MAR: MAE_24880
MPK: VL20_4041
CYT: cce_3547
TER: Tery_3884
GVI: glr3090
GLJ: GKIL_0804(ubiE)
ANA: alr1803
NSH: GXM_00587
AVA: Ava_4806
NAZ: Aazo_3463
CALH: IJ00_11010
CTHE: Chro_0307
TRA: Trad_1513
PIR: VN12_16875(rebM_2)
RUL: UC8_29360(rebM_3)
GMR: GmarT_17950(rebM_1)
 » show all

KEGG   ENZYME: 2.1.1.95
Entry
EC 2.1.1.95                 Enzyme                                 

Name
tocopherol C-methyltransferase;
gamma-tocopherol methyltransferase;
VTE4 (gene name);
S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase (incorrect);
tocopherol O-methyltransferase (incorrect)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:gamma-tocopherol 5-C-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol  [RN:R07236];
(2) S-adenosyl-L-methionine + delta-tocopherol = S-adenosyl-L-homocysteine + beta-tocopherol  [RN:R07504];
(3) S-adenosyl-L-methionine + gamma-tocotrienol = S-adenosyl-L-homocysteine + alpha-tocotrienol  [RN:R10491];
(4) S-adenosyl-L-methionine + delta-tocotrienol = S-adenosyl-L-homocysteine + beta-tocotrienol [RN:R10492]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
gamma-tocopherol [CPD:C02483];
delta-tocopherol [CPD:C14151];
gamma-tocotrienol [CPD:C14155];
delta-tocotrienol [CPD:C14156]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
alpha-tocopherol [CPD:C02477];
beta-tocopherol [CPD:C14152];
alpha-tocotrienol [CPD:C14153];
beta-tocotrienol [CPD:C14154]
Comment
The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols.
History
EC 2.1.1.95 created 1989, modified 2013, modified 2019
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05928  tocopherol O-methyltransferase
Genes
ATH: AT1G64970(G-TMT)
ALY: 9322850
CRB: 17896175
CSAT: 104722834 104725296 104751124 104760795
EUS: EUTSA_v10018768mg
BRP: 103852208 103853294
BNA: 106388189 106390439 106406285
BOE: 106318945 106322543
RSZ: 108816273
THJ: 104805718 104821707
CPAP: 110815941
CIT: 102628754
TCC: 18599602
EGR: 104424262
GMX: 100778509 100792443(GAMMA-TMT) 732543
CAM: 101513488
LJA: Lj3g3v3639870.1(Lj3g3v3639870.1) Lj3g3v3639870.2(Lj3g3v3639870.2)
LANG: 109348558
FVE: 101307130
RCN: 112192792
PPER: 18769165
PMUM: 103339737
PAVI: 110753538
CSV: 101205148
CMO: 103501078
MCHA: 111017272
CMAX: 111484262
CMOS: 111449074
CPEP: 111777902
RCU: 8284310
JCU: 105632484
HBR: 110659616
MESC: 110619928
POP: 7465624
PEU: 105139626
JRE: 109003796
VVI: 100242641
SLY: 778248(TMT)
SPEN: 107028652
SOT: 102577815(GAMMA-TMT)
CANN: 107870898
NTO: 104111647
NAU: 109211043
INI: 109179117
SIND: 105174312
OEU: 111381589
DCR: 108210384
BVG: 104888087
SOE: 110793113
CQI: 110693052
OSA: 4330437
DOSA: Os02t0701600-01(Os02g0701600)
OBR: 102706446
BDI: 100836877
ATS: 109744847(LOC109744847)
ZMA: 732837(cl364_1)
SITA: 101778567
PDA: 103716652
EGU: 105033221
MUS: 104000155
DCT: 110115783
PEQ: 110031053
PPP: 112288826
CRE: CHLREDRAFT_129990(VTE4)
MNG: MNEG_4528
APRO: F751_6137
NCR: NCU04129
NTE: NEUTE1DRAFT75477(NEUTE1DRAFT_75477)
MGR: MGG_04901
SSCK: SPSK_06415
MBE: MBM_01895
PTI: PHATRDRAFT_20470(TMT)
FCY: FRACYDRAFT_238951(VTE4)
TMC: LMI_3088
EBA: c1A84
MXA: MXAN_0151
RVA: Rvan_2344
RUT: FIU92_06015(rebM1)
SSAN: NX02_23295
SPMI: K663_17016
SPHT: K426_22279
ART: Arth_1026
SESP: BN6_50360
ALO: CRK55118
CAI: Caci_3249
SYN: slr0089(erg6)
SYZ: MYO_126250(erg6)
SYY: SYNGTS_2600(slr0089)
SYT: SYNGTI_2599(slr0089)
SYS: SYNPCCN_2598(slr0089)
SYQ: SYNPCCP_2598(slr0089)
SYJ: D082_21800(erg6)
CYA: CYA_2254
CYB: CYB_2403
LET: O77CONTIG1_00395(rebM_1)
AMR: AM1_4540
MAR: MAE_24880
MPK: VL20_4041
CYT: cce_3547
TER: Tery_3884
GVI: glr3090
GLJ: GKIL_0804(ubiE)
ANA: alr1803
NSH: GXM_00587
AVA: Ava_4806
NAZ: Aazo_3463
CALH: IJ00_11010
CTHE: Chro_0307
TRA: Trad_1513
PIR: VN12_16875(rebM_2)
RUL: UC8_29360(rebM_3)
GMR: GmarT_17950(rebM_1)
 » show all
Reference
1  [PMID:24253640]
  Authors
Camara B, d'Harlingue A
  Title
Demonstration and solubilization of S-adenosylmethionine: gamma-tocopherol methyltransferase from Capsicum chromoplasts.
  Journal
Plant Cell Rep 4:31-2 (1985)
DOI:10.1007/BF00285499
Reference
2  [PMID:12492478]
  Authors
Koch M, Lemke R, Heise KP, Mock HP
  Title
Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana.
  Journal
Eur J Biochem 270:84-92 (2003)
DOI:10.1046/j.1432-1033.2003.03364.x
Reference
3  [PMID:22763462]
  Authors
Zhang GY, Liu RR, Xu G, Zhang P, Li Y, Tang KX, Liang GH, Liu QQ
  Title
Increased alpha-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis gamma-tocopherol methyltransferase.
  Journal
Transgenic Res 22:89-99 (2013)
DOI:10.1007/s11248-012-9630-2
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.95
IUBMB Enzyme Nomenclature: 2.1.1.95
ExPASy - ENZYME nomenclature database: 2.1.1.95
BRENDA, the Enzyme Database: 2.1.1.95
CAS: 84788-82-9

KEGG   REACTION: R10492
Entry
R10492                      Reaction                               

Name
S-adenosyl-L-methionine:delta-tocotrienol 5-O-methyltransferase
Definition
S-Adenosyl-L-methionine + delta-Tocotrienol <=> S-Adenosyl-L-homocysteine + beta-Tocotrienol
Equation
Reaction class
RC00003  C00019_C00021
RC01662  C14154_C14156
Enzyme
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Orthology
K05928  tocopherol O-methyltransferase [EC:2.1.1.95]

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