KEGG   ORTHOLOGY: K05947
Entry
K05947                      KO                                     

Name
E2.4.1.217
Definition
mannosyl-3-phosphoglycerate synthase [EC:2.4.1.217]
Pathway
ko00051  Fructose and mannose metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.217  mannosyl-3-phosphoglycerate synthase
     K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
Glycosyltransferases [BR:ko01003]
 Others
  Glycosylglycerate
   K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
Other DBs
RN: R05768
GO: 0050504
Genes
NCR: NCU05700
NTE: NEUTE1DRAFT100267(NEUTE1DRAFT_100267)
SMP: SMAC_02065
PAN: PODANSg2537
TTT: THITE_2120465
MTM: MYCTH_2303166
CTHR: CTHT_0072260
TMN: UCRPA7_732
CFJ: CFIO01_04083
ELA: UCREL1_10936
PTE: PTT_11203
ACTN: L083_6965
AFS: AFR_36880
DET: DET1363(mpgSP)
DEH: cbdbA1314
DMC: btf_1241
DMD: dcmb_1222
DMG: GY50_1201(mngA)
TTH: TT_C0588
TTJ: TTHA0954
RMR: Rmar_0502
MFV: Mfer_0544
PFU: PF0591
PFI: PFC_02085
PHO: PH0927(PH0927)
PAB: PAB0816
PYN: PNA2_1454
PYS: Py04_0855
TGA: TGAM_0817
TSI: TSIB_0251
THA: TAM4_785
TLT: OCC_09696
THS: TES1_0131
TNU: BD01_0152
PPAC: PAP_01435
APE: APE_0889.1(mpgs)
ACJ: ACAM_0578(mpgs)
SMR: Smar_0498
NGA: Ngar_c16030(mngA1) Ngar_c27190(mngA2)
NVN: NVIE_006110(mngA)
NEV: NTE_01978
NFN: NFRAN_0350(mngA) NFRAN_1965(mngA)
NCV: NCAV_1295(mngA)
 » show all
Reference
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J Biol Chem 276:43580-8 (2001)
DOI:10.1074/jbc.M108054200
  Sequence
[pho:PH0927]

KEGG   ENZYME: 2.4.1.217
Entry
EC 2.4.1.217                Enzyme                                 

Name
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
Reaction(KEGG)
R05768
Substrate
GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]
Product
GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]
Comment
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
History
EC 2.4.1.217 created 2002
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K05947  mannosyl-3-phosphoglycerate synthase
Genes
NCR: NCU05700
NTE: NEUTE1DRAFT100267(NEUTE1DRAFT_100267)
SMP: SMAC_02065
PAN: PODANSg2537
TTT: THITE_2120465
MTM: MYCTH_2303166
CTHR: CTHT_0072260
TMN: UCRPA7_732
CFJ: CFIO01_04083
ELA: UCREL1_10936
PTE: PTT_11203
ACTN: L083_6965
AFS: AFR_36880
DET: DET1363(mpgSP)
DEH: cbdbA1314
DMC: btf_1241
DMD: dcmb_1222
DMG: GY50_1201(mngA)
TTH: TT_C0588
TTJ: TTHA0954
RMR: Rmar_0502
MFV: Mfer_0544
PFU: PF0591
PFI: PFC_02085
PHO: PH0927(PH0927)
PAB: PAB0816
PYN: PNA2_1454
PYS: Py04_0855
TGA: TGAM_0817
TSI: TSIB_0251
THA: TAM4_785
TLT: OCC_09696
THS: TES1_0131
TNU: BD01_0152
PPAC: PAP_01435
APE: APE_0889.1(mpgs)
ACJ: ACAM_0578(mpgs)
SMR: Smar_0498
NGA: Ngar_c16030(mngA1) Ngar_c27190(mngA2)
NVN: NVIE_006110(mngA)
NEV: NTE_01978
NFN: NFRAN_0350(mngA) NFRAN_1965(mngA)
NCV: NCAV_1295(mngA)
 » show all
Reference
1  [PMID:11562374]
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS.
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J Biol Chem 276:43580-8 (2001)
DOI:10.1074/jbc.M108054200
  Sequence
[pho:PH0927]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.217
IUBMB Enzyme Nomenclature: 2.4.1.217
ExPASy - ENZYME nomenclature database: 2.4.1.217
BRENDA, the Enzyme Database: 2.4.1.217
CAS: 393512-63-5

KEGG   REACTION: R05768
Entry
R05768                      Reaction                               

Name
GDP-mannose:3-phosphoglycerate 3-a-D-mannosyltransferase
Definition
GDP-mannose + 3-Phospho-D-glycerate <=> GDP + 2-(alpha-D-Mannosyl)-3-phosphoglycerate
Equation
Reaction class
RC00005  C00035_C00096
RC00397  C00197_C11516
RC02748  C00096_C11516
Enzyme
Pathway
rn00051  Fructose and mannose metabolism
rn01100  Metabolic pathways
Orthology
K05947  mannosyl-3-phosphoglycerate synthase [EC:2.4.1.217]
Other DBs
RHEA: 13540

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