KEGG ORTHOLOGY: K06225

ORTHOLOGY: K06225

Entry

K06225                      KO

Symbol

PTCH1

Name

patched 1

Pathway

map04024

cAMP signaling pathway

map04340

Hedgehog signaling pathway

map04341

Hedgehog signaling pathway - fly

map04360

Axon guidance

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05217

Basal cell carcinoma

Disease

H00039

Basal cell carcinoma

H00267

Holoprosencephaly

H00895

Basal cell nevus syndrome

H01667

Medulloblastoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K06225  PTCH1; patched 1
   04341 Hedgehog signaling pathway - fly
    K06225  PTCH1; patched 1
   04024 cAMP signaling pathway
    K06225  PTCH1; patched 1
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K06225  PTCH1; patched 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06225  PTCH1; patched 1
   05205 Proteoglycans in cancer
    K06225  PTCH1; patched 1
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K06225  PTCH1; patched 1

Other DBs

GO:	0005119 0008158

TC:	2.A.6.6.2 2.A.6.6.13

Genes

HSA:	5727(PTCH1)

PTR:	465254(PTCH1)

PPS:	100970040(PTCH1)

GGO:	101138988(PTCH1)

PON:	100432417(PTCH1)

PPYG:

129043980(PTCH1)

NLE:	100581789(PTCH1)

HMH:	116475280(PTCH1)

SSYN:

129479162(PTCH1)

MCC:	718751(PTCH1)

MCF:	102121818(PTCH1)

MTHB:

126937986

MNI:	105498937(PTCH1)

CSAB:

103219825(PTCH1)

CATY:

105579525(PTCH1)

PANU:

101018770(PTCH1)

TGE:	112608438(PTCH1)

MLEU:

105536603(PTCH1)

RRO:	104669119(PTCH1)

RBB:	108529288(PTCH1)

TFN:	117098271(PTCH1)

PTEH:

111521696(PTCH1)

CANG:

105501521(PTCH1)

CJC:	100410387(PTCH1)

SBQ:	101048276(PTCH1)

CIMI:

108317034(PTCH1)

ANAN:

105723763(PTCH1)

CSYR:

103260565(PTCH1)

MMUR:

105862135(PTCH1)

LCAT:

123645901(PTCH1)

PCOQ:

105806844(PTCH1)

OGA:	100961156(PTCH1)

MMU:	19206(Ptch1)

MCAL:

110307775(Ptch1)

MPAH:

110333595(Ptch1)

RNO:	89830(Ptch1)

MCOC:

116081424(Ptch1)

ANU:	117713602(Ptch1)

ASYL:

127665159

MUN:	110551759(Ptch1)

CGE:	100763926(Ptch1)

MAUA:

101823482(Ptch1)

PROB:

127229131(Ptch1)

PLEU:

114708424(Ptch1)

MORG:

121443344 121453284

MFOT:

126502661

AAMP:

119817589(Ptch1)

NGI:

103751618

HGL:	101711146(Ptch1)

CPOC:

100729719(Ptch1)

CCAN:

109683424(Ptch1)

DORD:

105999815(Ptch1)

DSP:	122113824(Ptch1)

DMER:

138834899(Ptch1)

PLOP:

125339795(Ptch1)

NCAR:

124965298

MMMA:

107157623(Ptch1)

ITI:	101970388(Ptch1)

OCU:

100345046

OPI:	101521576(PTCH1)

TUP:	102471693(PTCH1)

GVR:	103586051(PTCH1)

CFA:	484137(PTCH1)

CLUD:

112644598(PTCH1)

VVP:	112908731(PTCH1)

VLG:	121484106(PTCH1)

NPO:	129499614(PTCH1)

AML:	100475966(PTCH1)

UMR:	103682234(PTCH1)

UAH:	113269779(PTCH1)

UAR:	123781394(PTCH1)

ELK:

111139086

LLV:

125083161

MPUF:

101680366(PTCH1)

MNP:	132024752(PTCH1)

MLK:	131812048(PTCH1)

NVS:	122917630(PTCH1)

ORO:	101379447(PTCH1)

EJU:	114223388(PTCH1)

ZCA:	113934486(PTCH1)

MLX:	118023339(PTCH1)

NSU:	110569938(PTCH1)

LWW:	102738196(PTCH1)

FCA:	101085077(PTCH1)

PYU:

121014183

PCOO:

112868509(PTCH1)

PBG:	122475073(PTCH1)

PVIV:

125150324(PTCH1)

LRUF:

124529241

LGF:	123593695(PTCH1)

AJU:

106971452

PTG:	102972008(PTCH1)

PPAD:

109251660

PUC:

125925310

PLEZ:

122204940(PTCH1)

HHV:	120240837(PTCH1)

BTA:	520994(PTCH1)

BOM:	102283867(PTCH1)

BIU:	109563237(PTCH1)

BBUB:

102389314(PTCH1)

BBIS:

104985743(PTCH1)

CHX:	102187048(PTCH1)

OAS:	101112193(PTCH1)

BTAX:

128052308(PTCH1)

CSUM:

138081053(PTCH1)

ODA:	120867037(PTCH1)

CCAD:

122432119(PTCH1)

MREE:

136176535(PTCH1)

OVR:	110137698(PTCH1)

MBEZ:

129556988(PTCH1)

SSC:	100627504(PTCH1)

CFR:	102517641(PTCH1)

CBAI:

105078863(PTCH1)

CDK:	105084688(PTCH1)

VPC:	102525054(PTCH1)

BACU:

103004681(PTCH1)

BMUS:

118897335(PTCH1)

LVE:	103086592(PTCH1)

OOR:	101284461(PTCH1)

LALB:

132523775(PTCH1)

GMF:	115840246(PTCH1)

DDP:	132427482(PTCH1)

DLE:	111166803(PTCH1)

PCAD:

102973233(PTCH1)

PSIU:

116755916(PTCH1)

PPHC:

136124978(PTCH1)

NASI:

112405448(PTCH1)

ECB:	100033936(PTCH1)

EPZ:	103551335(PTCH1)

EAI:	106841108(PTCH1)

MYB:	102254605(PTCH1)

MYD:	102770033(PTCH1)

MMYO:

118667639(PTCH1)

MLF:	102424447(PTCH1)

MDT:	132211815(PTCH1)

MYUM:

138998889(PTCH1)

PKL:	118732205(PTCH1)

EFUS:

103297886(PTCH1)

MNA:	107532314(PTCH1)

DRO:	112302742(PTCH1)

SHON:

118993710(PTCH1)

AJM:	119046072(PTCH1)

PDIC:

114512586(PTCH1)

PHAS:

123819437(PTCH1)

MMF:	118629803(PTCH1)

PPAM:

129082371(PTCH1)

HAI:	109396730(PTCH1)

RFQ:	117032144(PTCH1)

PALE:

102884350(PTCH1)

PGIG:

120616899(PTCH1)

PVP:	105306915(PTCH1)

RAY:	107518086(PTCH1)

MJV:	108383415(PTCH1)

TOD:	119232087(PTCH1)

SARA:

101552783(PTCH1)

SFUM:

130034983

SETR:

126006690(PTCH1)

LAV:	100676123(PTCH1)

TMU:

101346502

ETF:	101661574(PTCH1)

DNM:

101422669

MDO:	100014019(PTCH1)

GAS:	123231296(PTCH1)

SHR:	100934585(PTCH1)

AFZ:

127561700

PCW:	110197646(PTCH1)

TVP:	118834828(PTCH1)

PBRV:

138161156(PTCH1)

MLAO:

141501261(PTCH1)

OAA:	100079214(PTCH1)

TACU:

119946724(PTCH1)

GGA:	395806(PTCH1)

PCOC:

116238484(PTCH1)

CJO:	107306269(PTCH1)

TPAI:

128089577(PTCH1)

LMUT:

125687227(PTCH1)

NMEL:

110389731(PTCH1)

APLA:

101802613(PTCH1)

ACYG:

106047348(PTCH1)

CATA:

118257382(PTCH1)

AFUL:

116500683(PTCH1)

TGU:	100224767(PTCH1)

LSR:	110471014(PTCH1)

SCAN:

103822966(PTCH1)

PMOA:

120511975(PTCH1)

OTC:	121333264(PTCH1)

PRUF:

121360712(PTCH1)

ATRC:

139588952(PTCH1)

GFR:	102033626(PTCH1)

FAB:	101813866(PTCH1)

OMA:	130265215(PTCH1)

PHI:	102104157(PTCH1)

PMAJ:

107198215(PTCH1)

CCAE:

111941810(PTCH1)

CCW:	104692014(PTCH1)

CBRC:

103619855(PTCH1)

ACOE:

138102783 138103325(PTCH1)

ETL:	114055235(PTCH1) 114071695

ZAB:	102060815(PTCH1)

ZLE:	135459325(PTCH1)

ACHL:

103801192(PTCH1)

SVG:	106848909(PTCH1)

MMEA:

130575821(PTCH1)

HRT:	120765624(PTCH1)

CCIC:

134056325(PTCH1)

FPG:	101915344(PTCH1)

FCH:	102054107(PTCH1)

CCRI:

104168152(PTCH1)

NNT:	104413540(PTCH1)

SHAB:

115619911(PTCH1)

ACUN:

113490118(PTCH1)

TALA:

104359315(PTCH1)

ACHC:

115336793(PTCH1) 121232936

HALD:

104312912(PTCH1)

HLE:	104832469(PTCH1)

AGEN:

126035435 126036458

HHAR:

128136072 128136857(PTCH1)

GCL:	127027678 127027961

CSTI:

104562852

LDI:	104344265(PTCH1)

MNB:	103776680(PTCH1)

DPUB:

104298786(PTCH1)

PPUS:

135193095(PTCH1)

AVIT:

104267036(PTCH1)

BRHI:

104497422(PTCH1)

EGZ:	104125901(PTCH1)

NNI:	104011757(PTCH1) 104022796

PCRI:

104038460(PTCH1)

PCAO:

104049532(PTCH1)

PADL:

103920407(PTCH1)

AFOR:

103893793(PTCH1)

FGA:	104084285(PTCH1)

CBOY:

140650726(PTCH1) 140650831

CLV:	102096921(PTCH1)

CNIC:

136001479(PTCH1)

MUI:	104533453(PTCH1)

PGUU:

104463424(PTCH1)

PLET:

104628516

EHS:	104507849(PTCH1)

CMAC:

104483781(PTCH1)

CUCA:

104059905(PTCH1)

TEO:	104377161(PTCH1)

BREG:

104639091(PTCH1)

OHA:	104331154(PTCH1)

ACAR:

104525590(PTCH1)

CPEA:

104389116(PTCH1)

CVF:	104287166(PTCH1) 104292237

RTD:	128901901 128902375(PTCH1)

CRID:

134508386(PTCH1)

AAM:	106489077(PTCH1) 106492944

AROW:

112976814(PTCH1)

NPD:	112946422(PTCH1)

TGT:	104566507(PTCH1) 104572409

DNE:	112978825(PTCH1)

SCAM:

104146473 104152422

ASN:	102382615(PTCH1)

AMJ:	102570023(PTCH1)

CPOO:

109323424(PTCH1)

GGN:	109297535(PTCH1)

PSS:	102445339(PTCH1)

CMY:	102936563(PTCH1)

CCAY:

125636995(PTCH1)

DCC:	119856055(PTCH1)

CPIC:

101942144(PTCH1)

TST:	117878979(PTCH1)

CABI:

116821162(PTCH1)

MRV:	120408524(PTCH1)

ACS:	100561354(ptch1)

ASAO:

132767298(PTCH1)

PVT:	110084178(PTCH1)

SUND:

121922494(PTCH1)

PBI:	103057988(PTCH1)

PMUR:

107294604(PTCH1)

CTIG:

120308183(PTCH1)

TSR:	106537500(PTCH1)

PGUT:

117661370(PTCH1)

PCAE:

139311244(PTCH1)

APRI:

131190886(PTCH1)

PTEX:

113438495(PTCH1)

NSS:	113416529(PTCH1)

VKO:	123031396(PTCH1)

PMUA:

114606550(PTCH1)

PRAF:

128423718(PTCH1)

ZVI:	118076713(PTCH1)

HCG:	128346780(PTCH1)

GJA:	107111660(PTCH1)

STOW:

125436183(PTCH1)

EMC:	129334733(PTCH1)

XLA:	108714691(ptch1.L) 398215(ptch1.S)

XTR:	100492061(ptch1)

NPR:	108788147(PTCH1)

RTEM:

120941850(PTCH1)

ACAT:

141146686(PTCH1)

BBUF:

120989096(PTCH1)

BGAR:

122922751(PTCH1)

DTC:	141049477(PTCH1)

PWL:	138287486(PTCH1)

MUO:	115463278(PTCH1)

GSH:	117352069(PTCH1)

DRE:	30189(ptch1)

SRX:	107711868 107724865

SANH:

107669660 107689274

SGH:	107594528 107602819(ptch1)

CCAR:

109048512(ptch1) 109095008

CAUA:

113096379 113107504

CGIB:

127963772 128018538

PTET:

122350898(ptch1)

LROH:

127169827(ptch1)

GRF:	141287080(ptch1)

OMC:	131545314(ptch1)

PPRM:

120484655(ptch1)

RKG:	130072459(ptch1)

MAMB:

125279705(ptch1)

CIDE:

127517759

CERY:

137027089(ptch1)

MASI:

127414914 127424328

TROS:

130568269(ptch1)

TDW:	130439905(ptch1)

MANU:

129414094(ptch1)

PDAB:

135729504(ptch1)

IPU:

108265905

IFU:	128607840(ptch1)

PHYP:

113526490(ptch1)

SMEO:

124399875(ptch1)

TFD:	113656148(ptch1)

TVC:	132853484(ptch1)

CGAR:

128530294(ptch1)

NGRA:

132893120(ptch1)

TRN:	134317615(ptch1)

AMEX:

103030480(ptch1)

CMAO:

118813172(ptch1)

EEE:	113591305(ptch1)

CHAR:

105894152 116224733(ptch1)

SPIL:

134060038(ptch1)

TRU:	101065775(ptch1)

TFS:	130525821(ptch1)

TNG:	GSTEN00008859G001

LCO:	104920679(ptch1)

NCC:

104961260

TBEN:

117472824(ptch1)

CGOB:

115013236(ptch1)

PGEO:

117453154(ptch1)

GACU:

117558558(ptch1)

EMAC:

134874090(ptch1)

ELY:	117252668(ptch1)

EFO:	125890475(ptch1)

PLEP:

121944402(ptch1)

SLUC:

116054025(ptch1)

ECRA:

117944979(ptch1)

ESP:	116688885(ptch1)

PFLV:

114555949(ptch1)

GAT:	120830892(ptch1)

PPUG:

119225375(ptch1)

AFB:	129101209(ptch1)

CLUM:

117736350(ptch1)

PSWI:

130197089(ptch1)

CANA:

137805281(ptch1)

CVE:	137867166(ptch1)

MSAM:

119891957(ptch1)

SCHU:

122876156(ptch1)

CUD:	121509987(ptch1)

SPUL:

138610135(ptch1)

LMIX:

132974606(ptch1)

ALAT:

119019829(ptch1)

ASTR:

137592802(ptch1)

MZE:	101469910(ptch1)

ONL:	100700194(ptch1)

OAU:	116311163(ptch1)

OLA:	101166055(ptch1)

OML:	112148505(ptch1)

CSAI:

133450601(ptch1)

XMA:	102216370(ptch1)

XCO:	114154713(ptch1)

XHE:	116729898(ptch1)

PRET:

103470155(ptch1)

PFOR:

103135448(ptch1)

PLAI:

106948666(ptch1)

PMEI:

106917880(ptch1)

GAF:	122828383(ptch1)

PPRL:

129366156(ptch1)

CVG:	107098237(ptch1)

CTUL:

119781110(ptch1)

GMU:	124878031(ptch1)

NFU:	107394090(ptch1)

KMR:	108244808(ptch1)

ALIM:

106534574(ptch1)

AOCE:

111576662(ptch1)

EJA:	138191509(ptch1)

BFRE:

138621461(ptch1)

MCEP:

125012392(ptch1)

CSEM:

103397246 103398858

POV:	109639307(ptch1)

SSEN:

122769693(ptch1)

SSOE:

131463716(ptch1)

HHIP:

117768058(ptch1)

HSP:	118115454(ptch1)

PPLT:

128438904(ptch1)

SMAU:

118314237(ptch1)

LCF:

108882648

SDU:	111236154(ptch1)

SLAL:

111644627(ptch1)

XGL:	120805768(ptch1)

HCQ:	109520682(ptch1)

SSCV:

125994286(ptch1)

SBIA:

133499518(ptch1)

PEE:	133399906(ptch1)

PTAO:

133475246(ptch1)

BPEC:

110167016(ptch1)

ENY:	140347572(ptch1)

MALB:

109956558(ptch1)

BSPL:

114862104(ptch1)

SJO:	128365391(ptch1)

SSCO:

133978826(ptch1)

GMH:	115545602(ptch1)

SASA:

106580561 106585152(ptch1)

STRU:

115164238(ptch1) 115200404

OTW:	112249515(ptch1) 112262641

OMY:	110525920(ptch1) 110535101

OGO:	124034123(ptch1) 124036525

ONE:	115111823(ptch1) 115140695

OKI:	109894934 116357717(ptch1)

OKE:	118374258(ptch1) 118394092

OMM:	135544268(ptch1)

OCLA:

139389486 139398024 139398201

SALP:

111957566 111974363(ptch1)

SNH:	120044320(ptch1) 120062919

CCLU:

121559464 121585073(ptch1)

ELS:	105014106(ptch1)

SFM:	108938420(ptch1)

PKI:	111836962(ptch2) 111839228(ptch1)

AANG:

118206641(ptch1)

AROT:

135264504(ptch1)

CCOG:

133140640(ptch1)

LOC:	102685711(ptch1)

PSPA:

121303042 121314947

ARUT:

117411705 117973031

PSEX:

120532650(ptch1)

LCM:	102356323(PTCH1)

CMK:	103182828(ptch1)

RTP:	109910728(ptch1)

CPLA:

122561596(ptch1)

HOC:	132824157(ptch1)

LERI:

129695718(ptch1)

HAKA:

140741302(ptch1)

PMRN:

116950944

LRJ:	133358969(PTCH1)

CIN:

SCLV:

SPU:

AJJ:

APLC:

ARUN:

AAMU:

AJC:

SKO:

DME:	Dmel_CG2411(ptc)

DER:

6542563

DSE:

6608211

DSI:	Dsimw501_GD15378(Dsim_GD15378)

DYA:	Dyak_GE19216

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18803

DAZ:

108616937

DNV:

115564864

DHE:

111597108

DVI:	6625655(ptc)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119674486 119677537

MDE:	101891704 131800407

SCAC:

106082355

LCQ:

111683638

LSQ:

119613586

CVJ:	135962355(ptc)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003243

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108724287(ptc)

CCOA:

108771220 108772416

PBAR:

105425643

VEM:

105560263

COBS:

139102537(Ptc)

TLN:	139809584(Ptc)

HST:

DQU:

CFO:

FEX:

PMEC:

138936366(Ptc)

LHU:	105677457(ptc)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100120760(Ptc)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141530808(Ptc)

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124224712(ptc)

NFB:

NLO:

NVG:

AROA:

TCA:	656155(Ptc)

TMOL:

138140034(ptc)

DPA:

109537974

ESIM:

136409490(ptc)

EFOR:

136347071(ptc)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

MSEX:

DPL:	KGM_215640

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137926586(ptc)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141438263(ptc) 141438264

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106692953(ptc)

NLU:

111063259

HVI:

124354611

MQU:	128996885 128997054

PHU:	Phum_PHUM390440

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138693037(ptc)

BROR:

134540309

HAMR:

139700360(ptc)

FCD:

110846444

DPX:	DAPPUDRAFT_40041(PTC)

DMK:

DPZ:

AFRA:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123745177(ptc)

CQD:	128685265(ptc)

PTRU:

123519432

ESN:	127003491 127003511

MNZ:

135210768

MRJ:	136854517(ptc)

PORN:

139759606(ptc)

HAZT:

108677627

EAF:

111713880

LSM:	121119746(ptc)

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:	111242949 111245110 111252634

VJA:	111261749 111266823 111270737

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136984851 136985521

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_Y110A2AL.8(ptc-3) CELE_ZK675.1(ptc-1)

CBR:	CBG_03294 CBG_19582(Cbr-ptc-3)

CRQ:	GCK72_005683 GCK72_006798

NAI:	NECAME_13111

BMY:	BM_BM12292(Bma-ptc-3) BM_BM3500(Bm3500)

LOA:	LOAG_05826 LOAG_06459

TSP:

Tsp_05634

LGI:	LOTGIDRAFT_71238

PCAN:

LSAX:

BGT:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111120798 111120833

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_131940

OVI:	T265_04436

EGL:

LLON:

NVE:

EPA:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AAF:	AURANDRAFT_67307

» show all

Reference

PMID:8647801

Authors

Hahn H, Christiansen J, Wicking C, Zaphiropoulos PG, Chidambaram A, Gerrard B, Vorechovsky I, Bale AE, Toftgard R, Dean M, Wainwright B

Title

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities.

Journal

J Biol Chem 271:12125-8 (1996)
DOI:10.1074/jbc.271.21.12125

Sequence

[hsa:5727] [mmu:19206]

All links

Ontology (4)   
   GO (2)   
   TC (2)   
Gene (2690)   
   MGENES (590)   
   RefGene (2096)   
   OC (4)   
All databases (2694)   

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