KEGG   ORTHOLOGY: K06255
Entry
K06255                      KO                                     
Symbol
HSPG2
Name
basement membrane-specific heparan sulfate proteoglycan core protein
Pathway
map04512  ECM-receptor interaction
map05161  Hepatitis B
map05205  Proteoglycans in cancer
Disease
H00493  Heparan sulfate proteoglycan gene defects
H01777  Schwartz-Jampel syndrome
H02155  Dyssegmental dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
  09172 Infectious disease: viral
   05161 Hepatitis B
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
   00535 Proteoglycans
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
Proteoglycans [BR:ko00535]
 Extracellular matrix (ECM) proteoglycans
  Basement membrane proteoglycans
   K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Genes
HSA: 3339(HSPG2)
PTR: 100613114(HSPG2)
PPS: 100969025(HSPG2)
GGO: 101138254(HSPG2)
PON: 100446648(HSPG2)
NLE: 100603335(HSPG2)
MCC: 707213(HSPG2)
MCF: 102145976(HSPG2)
CSAB: 103225428(HSPG2)
CATY: 105595111(HSPG2)
PANU: 101006455(HSPG2)
TGE: 112621465(HSPG2)
RRO: 104663240(HSPG2)
RBB: 108538399(HSPG2)
TFN: 117093163(HSPG2)
PTEH: 111547535(HSPG2)
CJC: 100413695(HSPG2)
SBQ: 101035920(HSPG2)
CSYR: 103265029(HSPG2)
MMUR: 105873615(HSPG2)
LCAT: 123635874(HSPG2)
OGA: 100951313(HSPG2)
MMU: 15530(Hspg2)
MCAL: 110292307(Hspg2)
MPAH: 110323502(Hspg2)
RNO: 313641(Hspg2)
MCOC: 116096880(Hspg2)
MUN: 110545004(Hspg2)
CGE: 100689041(Hspg2)
MAUA: 101826207(Hspg2)
PLEU: 114697205(Hspg2)
MORG: 121448110(Hspg2)
AAMP: 119816879(Hspg2)
HGL: 101700294(Hspg2)
CPOC: 100718406(Hspg2)
CCAN: 109694908(Hspg2)
DORD: 105997956(Hspg2)
DSP: 122115166(Hspg2)
NCAR: 124980329
OCU: 100340334(HSPG2)
OPI: 101520034(HSPG2)
TUP: 102493755(HSPG2)
CFA: 403440(HSPG2)
CLUD: 112660444(HSPG2)
VVP: 112929713(HSPG2)
VLG: 121497853(HSPG2)
AML: 100467831(HSPG2)
UMR: 103666798(HSPG2)
UAH: 113268545(HSPG2)
UAR: 123782114(HSPG2)
ELK: 111154824
LLV: 125096806
MPUF: 101681560
ORO: 101366326(HSPG2)
EJU: 114199066(HSPG2)
ZCA: 113928887(HSPG2)
MLX: 118019916(HSPG2)
FCA: 101094520(HSPG2)
PYU: 121022703(HSPG2)
PBG: 122480058(HSPG2)
PTG: 102954270(HSPG2)
PPAD: 109274267(HSPG2)
AJU: 106977608(HSPG2)
HHV: 120221389(HSPG2)
BTA: 444872(HSPG2)
BOM: 102271087(HSPG2)
BBUB: 102395253(HSPG2)
CHX: 102188640(HSPG2)
OAS: 101122677(HSPG2)
ODA: 120855013(HSPG2)
CCAD: 122426805(HSPG2)
SSC: 100517288(HSPG2)
CFR: 102522322(HSPG2)
CBAI: 105071124(HSPG2)
CDK: 105088891(HSPG2)
VPC: 102545237(HSPG2)
BACU: 103016583(HSPG2)
LVE: 103071665(HSPG2)
OOR: 101272353(HSPG2)
DLE: 111163281(HSPG2)
PCAD: 102979982(HSPG2)
PSIU: 116744715(HSPG2)
ECB: 100071701(HSPG2)
EPZ: 103558488(HSPG2)
EAI: 106840047(HSPG2)
MYB: 102241192(HSPG2)
MYD: 102756550(HSPG2)
MMYO: 118675506(HSPG2)
MLF: 102429510(HSPG2)
MNA: 107538321(HSPG2)
PKL: 118722689(HSPG2)
HAI: 109396746(HSPG2)
DRO: 112299193(HSPG2)
SHON: 118977847(HSPG2)
AJM: 119042186(HSPG2)
PDIC: 114496875(HSPG2)
PHAS: 123831989(HSPG2)
MMF: 118626818(HSPG2)
RFQ: 117026763(HSPG2)
PALE: 102887886(HSPG2)
PGIG: 120596197(HSPG2)
PVP: 105290659(HSPG2)
RAY: 107513054(HSPG2)
MJV: 108391519(HSPG2)
TOD: 119235363(HSPG2)
SARA: 101548643(HSPG2)
LAV: 100668646(HSPG2)
TMU: 101349957
DNM: 101425366(HSPG2)
MDO: 100617792(HSPG2)
GAS: 123241006(HSPG2)
SHR: 100926296(HSPG2)
PCW: 110206031(HSPG2)
OAA: 100093007(HSPG2)
GGA: 429806(HSPG2)
PCOC: 116238347(HSPG2)
MGP: 100549236
CJO: 107323300(HSPG2)
NMEL: 110386991
AFUL: 116497495(HSPG2)
TGU: 115497983(HSPG2)
LSR: 110474430(HSPG2)
SCAN: 103820959(HSPG2)
PMOA: 120496722(HSPG2)
OTC: 121343882(HSPG2)
PRUF: 121351325(HSPG2)
GFR: 102033967(HSPG2)
FAB: 101809010(HSPG2)
PHI: 102108967(HSPG2)
PMAJ: 107213501
CCW: 104698588(HSPG2)
CBRC: 103614554
CLV: 106145640(HSPG2)
TALA: 116959522(HSPG2)
ACHC: 115343089(HSPG2)
AROW: 112961666(HSPG2)
ASN: 102377486(HSPG2)
CPOO: 109314507(HSPG2)
GGN: 109293865(HSPG2)
CMY: 102942490(HSPG2)
CPIC: 101931520(HSPG2)
TST: 117868084(HSPG2)
MRV: 120387792(HSPG2)
PVT: 110073100(HSPG2)
SUND: 121936072(HSPG2)
PBI: 103053870(HSPG2)
PMUR: 107298504(HSPG2)
TSR: 106543154(HSPG2)
PGUT: 117656552(HSPG2)
VKO: 123018832(HSPG2)
PMUA: 114602821(HSPG2)
ZVI: 118086846(HSPG2)
GJA: 107111588(HSPG2)
STOW: 125445556(HSPG2)
XLA: 108696836(hspg2.L)
XTR: 100494785(hspg2)
NPR: 108802213(HSPG2)
RTEM: 120916186(HSPG2)
BBUF: 120994841(HSPG2)
BGAR: 122929027(HSPG2)
DRE: 565429(hspg2)
CCAR: 109055269
PPRM: 120462949(hspg2)
MAMB: 125259607(hspg2)
IPU: 108275596(hspg2)
PHYP: 113530313(hspg2)
SMEO: 124398805(hspg2)
TFD: 113641658(hspg2)
AMEX: 103021689(hspg2)
EEE: 113578609(hspg2)
TRU: 101065556(hspg2)
LCO: 104928635(hspg2)
ELY: 117258249(hspg2)
EFO: 125891897(hspg2)
PLEP: 121946944(hspg2)
SLUC: 116043712(hspg2)
ECRA: 117947108(hspg2)
PFLV: 114558686(hspg2)
GAT: 120828747(hspg2)
PPUG: 119221920(hspg2)
MSAM: 119905157(hspg2)
CUD: 121517704(hspg2)
ALAT: 119022790(hspg2)
MZE: 101473055(hspg2)
ONL: 100709308(hspg2)
OAU: 116322036(hspg2)
OLA: 101159991(hspg2)
OML: 112158594(hspg2)
XMA: 102217130(hspg2)
XCO: 114140465(hspg2)
XHE: 116716915(hspg2)
PRET: 103467813(hspg2)
PFOR: 103156803(hspg2)
PLAI: 106950833(hspg2)
PMEI: 106921820(hspg2)
GAF: 122833920(hspg2)
CVG: 107091679(hspg2)
CTUL: 119785000(hspg2)
GMU: 124876718(hspg2)
NFU: 107390415(hspg2)
KMR: 108237624(hspg2)
ALIM: 106529069(hspg2)
NWH: 119417454(hspg2)
AOCE: 111562749(hspg2)
MCEP: 124995713(hspg2)
CSEM: 103385274(hspg2)
POV: 109640818(hspg2)
SSEN: 122777353(hspg2)
HHIP: 117764252(hspg2)
HSP: 118110680(hspg2)
LCF: 108888875(hspg2)
SDU: 111234870(hspg2)
SLAL: 111661952(hspg2)
XGL: 120803450(hspg2)
HCQ: 109520187(hspg2)
BPEC: 110159404(hspg2)
MALB: 109951229(hspg2)
BSPL: 114859263(hspg2)
OTW: 112216269(hspg2) 112221519
OMY: 110491067 110532581(hspg2)
OGO: 124032177(hspg2) 124045995
SNH: 120059625(hspg2) 120061201
CCLU: 121537999(hspg2) 121545748
ELS: 105028690(hspg2)
SFM: 108939266(hspg2)
PKI: 111855723(hspg2)
LOC: 102691374(hspg2)
ARUT: 117432294
LCM: 102366028(HSPG2)
CMK: 103181437(hspg2)
BFO: 118431007
BBEL: 109479630
CIN: 445626
SCLV: 120335853
SPU: 589644
HAME: 121868776
NVE: 5507167
ATEN: 116300084
HMG: 101240275
 » show all
Reference
PMID:1569102
  Authors
Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV
  Title
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
  Journal
J Biol Chem 267:8544-57 (1992)
  Sequence
[hsa:3339]
Reference
  Authors
Whitelock JM, Melrose J, Iozzo RV
  Title
Diverse cell signaling events modulated by perlecan.
  Journal
Biochemistry 47:11174-83 (2008)
DOI:10.1021/bi8013938

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