KEGG   ORTHOLOGY: K06270
Entry
K06270                      KO                                     
Symbol
PPP1R12A, MYPT1
Name
protein phosphatase 1 regulatory subunit 12A
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04270  Vascular smooth muscle contraction
map04510  Focal adhesion
map04611  Platelet activation
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map05205  Proteoglycans in cancer
Disease
H02523  Genitourinary and/or brain malformation syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
   04022 cGMP-PKG signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Genes
HSA: 4659(PPP1R12A)
PTR: 452095(PPP1R12A)
PPS: 100989468(PPP1R12A)
GGO: 101139376(PPP1R12A)
PON: 100172617(PPP1R12A)
NLE: 100602476(PPP1R12A)
MCC: 695735(PPP1R12A)
MCF: 101864805(PPP1R12A)
CSAB: 103238782(PPP1R12A)
CATY: 105581076(PPP1R12A)
PANU: 101021299(PPP1R12A)
TGE: 112633984(PPP1R12A)
RRO: 104675773(PPP1R12A)
RBB: 108528527(PPP1R12A)
TFN: 117089688(PPP1R12A)
PTEH: 111547177(PPP1R12A)
CJC: 100393191(PPP1R12A)
SBQ: 101034840(PPP1R12A)
CSYR: 103258562(PPP1R12A)
MMUR: 105863369(PPP1R12A)
OGA: 100955707(PPP1R12A)
MMU: 17931(Ppp1r12a)
MCAL: 110302933(Ppp1r12a)
MPAH: 110326185(Ppp1r12a)
RNO: 116670(Ppp1r12a)
MCOC: 116076104(Ppp1r12a)
MUN: 110558205(Ppp1r12a)
CGE: 100754718(Ppp1r12a)
PLEU: 114695636(Ppp1r12a)
NGI: 103749250(Ppp1r12a)
HGL: 101700150(Ppp1r12a)
CPOC: 100727982(Ppp1r12a)
CCAN: 109697808(Ppp1r12a)
DORD: 105987486(Ppp1r12a)
DSP: 122124417(Ppp1r12a)
NCAR: 124982345
OCU: 100350558(PPP1R12A)
OPI: 101529033(PPP1R12A)
TUP: 102473894(PPP1R12A)
CFA: 475411(PPP1R12A)
VVP: 112914878(PPP1R12A)
VLG: 121480949(PPP1R12A)
AML: 100483995(PPP1R12A)
UMR: 103680852(PPP1R12A)
UAH: 113256222(PPP1R12A)
UAR: 123780848(PPP1R12A)
ELK: 111141992
LLV: 125106141
MPUF: 101684983(PPP1R12A)
ORO: 101384536(PPP1R12A)
EJU: 114211055(PPP1R12A)
ZCA: 113921641(PPP1R12A)
MLX: 118008531(PPP1R12A)
FCA: 101089624(PPP1R12A)
PYU: 121040701(PPP1R12A)
PBG: 122472249(PPP1R12A)
PTG: 102951696(PPP1R12A)
PPAD: 109270552(PPP1R12A)
AJU: 106967400(PPP1R12A)
HHV: 120233963(PPP1R12A)
BTA: 538606(PPP1R12A)
BOM: 102268036(PPP1R12A)
BIU: 109558936(PPP1R12A)
BBUB: 102395084(PPP1R12A)
CHX: 102183294(PPP1R12A)
OAS: 641303(PPP1R12A)
ODA: 120858445(PPP1R12A)
CCAD: 122427569(PPP1R12A)
SSC: 397190(PPP1R12A)
CFR: 102511361(PPP1R12A)
CBAI: 105072021(PPP1R12A)
CDK: 105084895(PPP1R12A)
VPC: 102539445(PPP1R12A)
BACU: 103020020(PPP1R12A)
LVE: 103071997(PPP1R12A)
OOR: 101279306(PPP1R12A)
DLE: 111167253(PPP1R12A)
PCAD: 102992707(PPP1R12A)
PSIU: 116760401(PPP1R12A)
ECB: 100060501(PPP1R12A)
EPZ: 103549928(PPP1R12A)
EAI: 106831522(PPP1R12A)
MYB: 102251394(PPP1R12A)
MYD: 102765262(PPP1R12A)
MMYO: 118650077(PPP1R12A)
MLF: 102429955(PPP1R12A)
MNA: 107526828(PPP1R12A)
PKL: 118730887(PPP1R12A)
HAI: 109375211(PPP1R12A)
DRO: 112322163(PPP1R12A)
SHON: 118984712(PPP1R12A)
AJM: 119058981(PPP1R12A)
PDIC: 114513386(PPP1R12A)
PHAS: 123822821(PPP1R12A)
MMF: 118623369(PPP1R12A)
RFQ: 117028313(PPP1R12A)
PALE: 102898474(PPP1R12A)
PGIG: 120583373(PPP1R12A)
PVP: 105301889(PPP1R12A)
RAY: 107503696(PPP1R12A)
MJV: 108408094(PPP1R12A)
TOD: 119247473(PPP1R12A)
SARA: 101556321(PPP1R12A)
LAV: 100673922(PPP1R12A)
TMU: 101341352
DNM: 101447857(PPP1R12A)
MDO: 100019488(PPP1R12A)
GAS: 123250694(PPP1R12A)
SHR: 100926931(PPP1R12A)
PCW: 110213174(PPP1R12A)
OAA: 100077235(PPP1R12A)
GGA: 396020(PPP1R12A)
PCOC: 116226728(PPP1R12A)
MGP: 100539276(PPP1R12A)
CJO: 107311018(PPP1R12A)
NMEL: 110392872(PPP1R12A)
APLA: 101800288(PPP1R12A)
ACYG: 106046454(PPP1R12A)
AFUL: 116497380(PPP1R12A)
TGU: 100220857(PPP1R12A)
LSR: 110469380(PPP1R12A)
SCAN: 103813426(PPP1R12A)
PMOA: 120499763(PPP1R12A)
OTC: 121338585(PPP1R12A)
PRUF: 121352505(PPP1R12A)
GFR: 102037308(PPP1R12A)
FAB: 101822232(PPP1R12A)
PHI: 102107346(PPP1R12A)
PMAJ: 107204392(PPP1R12A)
CCAE: 111933170(PPP1R12A)
CCW: 104698411(PPP1R12A)
ETL: 114063665(PPP1R12A)
ZAB: 102071992(PPP1R12A)
FPG: 101914871(PPP1R12A)
FCH: 102052384(PPP1R12A)
CLV: 102098984(PPP1R12A)
EGZ: 104132935(PPP1R12A)
NNI: 104010975(PPP1R12A)
ACUN: 113488441(PPP1R12A)
TALA: 104368605(PPP1R12A)
PADL: 103919928(PPP1R12A)
ACHC: 115336095(PPP1R12A)
AAM: 106488611(PPP1R12A)
AROW: 112963277(PPP1R12A)
NPD: 112956239(PPP1R12A)
DNE: 112983349(PPP1R12A)
ASN: 102381466(PPP1R12A)
AMJ: 102562278(PPP1R12A)
CPOO: 109315966(PPP1R12A)
GGN: 109295752(PPP1R12A)
PSS: 102460329(PPP1R12A)
CMY: 102930708(PPP1R12A)
CPIC: 101949705(PPP1R12A)
TST: 117878110(PPP1R12A)
CABI: 116835801(PPP1R12A)
MRV: 120380171(PPP1R12A)
ACS: 100560455(ppp1r12a)
PVT: 110084990(PPP1R12A)
SUND: 121930949(PPP1R12A)
PBI: 103053749(PPP1R12A)
PMUR: 107284036(PPP1R12A)
TSR: 106547769(PPP1R12A)
PGUT: 117655359(PPP1R12A)
VKO: 123036395(PPP1R12A)
ZVI: 118091493(PPP1R12A)
GJA: 107113829(PPP1R12A)
XLA: 108711109(ppp1r12a.L) 108713841 108715193 733200(ppp1r12a.S)
XTR: 100487727 100493563(ppp1r12a)
NPR: 108799788(PPP1R12A)
RTEM: 120917244 120931940(PPP1R12A)
BBUF: 120980976(PPP1R12A) 120981057
BGAR: 122920592 122927987(PPP1R12A)
DRE: 445393(ppp1r12a) 571837(zmp:0000001167)
SGH: 107560300(ppp1r12a) 107561184 107591124
CCAR: 109076480
PPRM: 120473478(ppp1r12a) 120474043(zmp:0000001167)
IPU: 108279475(ppp1r12a)
SMEO: 124392160(zmp:0000001167)
TFD: 113648169 113654009(zmp:0000001167) 125139542
AMEX: 103046804(ppp1r12a)
TRU: 101079088(ppp1r12a)
LCO: 104924035(ppp1r12a) 104928858
NCC: 104949170(ppp1r12a) 104956193
ELY: 117262461(zmp:0000001167)
PLEP: 121950090(zmp:0000001167)
SLUC: 116038311(zmp:0000001167)
GAT: 120808673(zmp:0000001167)
PPUG: 119195724(zmp:0000001167)
MSAM: 119893300(zmp:0000001167) 119918120(ppp1r12a)
CUD: 121515748(zmp:0000001167)
MZE: 101469187
ONL: 100691168 100701481(ppp1r12a)
OAU: 116325451(ppp1r12a) 116326292(zmp:0000001167)
XCO: 114160902(ppp1r12a)
PRET: 103459134(ppp1r12a)
KMR: 108233296(ppp1r12a)
AOCE: 111568454(ppp1r12a) 111577267
CSEM: 103380280 103382552(ppp1r12a)
POV: 109641125(ppp1r12a)
SSEN: 122776008(zmp:0000001167)
HHIP: 117763329(zmp:0000001167)
LCF: 108873647(ppp1r12a) 108886890
SDU: 111229837
SLAL: 111660032(ppp1r12a) 111666970
XGL: 120793526(zmp:0000001167) 120801257(ppp1r12a)
HCQ: 109507600 109530079(ppp1r12a)
BPEC: 110161521(ppp1r12a) 110169303
MALB: 109967812(ppp1r12a) 109972924
SASA: 106584787
OTW: 112219159(zmp:0000001167) 112238870
OGO: 124037460(zmp:0000001167) 124038538
ELS: 105018059
AANG: 118218693
BFO: 118407388
BBEL: 109463543
CIN: 100187107
SCLV: 120330795
DGR: 6556574
ACOZ: 120952109
AARA: 120896407
AAG: 5576767
AALB: 109416470
CPII: 120424884
CNS: 116338909
AME: 726541
ACER: 108002538
ALAB: 122712797
BIM: 100749351
BBIF: 117204474
BVK: 117235158
BVAN: 117153585
BTER: 100646538
BPYO: 122569581
CCAL: 108628490
OBB: 114871136
MGEN: 117228672
NMEA: 116425033
CGIG: 122395116
SOC: 105198893
MPHA: 105827753
AEC: 105145669
ACEP: 105617107
PBAR: 105426810
VEM: 105565091
HST: 105192635
DQU: 106741992
CFO: 105251152
FEX: 115239072
LHU: 105677120
PGC: 109854374
PCF: 106791741
PFUC: 122524385
VPS: 122634018
NVI: 100114433
TPRE: 106648966
MDL: 103580139
CGLO: 123260605
FAS: 105270029
DAM: 107035755
AGIF: 122848681
CCIN: 107269253
TCA: 659634
SOY: 115890036
CSET: 123322743
OTU: 111427104
SLIU: 111360984
HHAL: 106689635
NLU: 111050492
ZNE: 110827706
CSEC: 111868082
PVM: 113822392
PJA: 122249215
PCHN: 125030928
HAME: 121874079
PCLA: 123755300
PTRU: 123510981
HAZT: 108664356
EAF: 111700938
DSV: 119463364
RSAN: 119401456
RMP: 119164099
VDE: 111255382
VJA: 111261193
CEL: CELE_C06C3.1(mel-11)
CBR: CBG_00870(Cbr-mel-11)
BGT: 106067201
GAE: 121370381
HRF: 124110875
HRJ: 124263368
CRG: 105330003
PMAX: 117327866
OSN: 115229173
NVE: 5515674
ATEN: 116303719
XEN: 124439617
 » show all
Reference
PMID:7982954
  Authors
Shimizu H, Ito M, Miyahara M, Ichikawa K, Okubo S, Konishi T, Naka M, Tanaka T, Hirano K, Hartshorne DJ, et al.
  Title
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.
  Journal
J Biol Chem 269:30407-11 (1994)
  Sequence
[gga:396020]
Reference
  Authors
Grassie ME, Moffat LD, Walsh MP, MacDonald JA
  Title
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.
  Journal
Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018

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