ORTHOLOGY: K06270 Help
Entry
Symbol
PPP1R12A, MYPT1
Name
protein phosphatase 1 regulatory subunit 12A
Pathway
map04270 Vascular smooth muscle contraction
map04810 Regulation of actin cytoskeleton
Disease
H02523 Genitourinary and/or brain malformation syndrome
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
04022 cGMP-PKG signaling pathway
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09142 Cell motility
04810 Regulation of actin cytoskeleton
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09152 Endocrine system
04921 Oxytocin signaling pathway
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09153 Circulatory system
04270 Vascular smooth muscle contraction
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Protein phosphatases and associated proteins [BR:ko01009 ]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
K06270 PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
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Genes
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Taxonomy UniProt
Reference
Authors
Shimizu H, Ito M, Miyahara M, Ichikawa K, Okubo S, Konishi T, Naka M, Tanaka T, Hirano K, Hartshorne DJ, et al.
Title
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.
Journal
J Biol Chem 269:30407-11 (1994)
Sequence
Reference
Authors
Grassie ME, Moffat LD, Walsh MP, MacDonald JA
Title
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.
Journal