KEGG ORTHOLOGY: K06277

ORTHOLOGY: K06277

Entry

K06277                      KO

Symbol

RAPGEF1, GRF2

Name

Rap guanine nucleotide exchange factor 1

Pathway

map04015

Rap1 signaling pathway

map04510

Focal adhesion

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map05211

Renal cell carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1

Genes

HSA:	2889(RAPGEF1)

PTR:	464812(RAPGEF1)

PPS:	100972192(RAPGEF1)

GGO:	101140063(RAPGEF1)

PON:	100444262(RAPGEF1)

PPYG:

129043426(RAPGEF1)

NLE:	100603139(RAPGEF1)

HMH:	116475789(RAPGEF1)

SSYN:

129478762(RAPGEF1)

MCC:	715272(RAPGEF1)

MCF:	102137533(RAPGEF1)

MTHB:

126936885

MNI:	105464055(RAPGEF1)

CSAB:

103239727(RAPGEF1)

CATY:

105594162(RAPGEF1)

PANU:

100999166(RAPGEF1)

TGE:	112607857(RAPGEF1)

MLEU:

105554935(RAPGEF1)

RRO:	104669757(RAPGEF1)

RBB:	108513945(RAPGEF1)

TFN:	117073498(RAPGEF1)

PTEH:

111545822(RAPGEF1)

CANG:

105504005(RAPGEF1)

CJC:	100402777(RAPGEF1)

SBQ:	101052399(RAPGEF1)

CIMI:

108282973(RAPGEF1)

ANAN:

105721100(RAPGEF1)

CSYR:

103256191

MMUR:

105859859(RAPGEF1)

LCAT:

123646573(RAPGEF1)

PCOQ:

105806663(RAPGEF1)

OGA:	100965849(RAPGEF1)

MMU:	107746(Rapgef1)

MCAL:

110309132(Rapgef1)

MPAH:

110317565(Rapgef1)

RNO:	63881(Rapgef1)

MCOC:

116089919(Rapgef1)

ANU:	117703002(Rapgef1)

MUN:	110552091(Rapgef1)

CGE:	100764804(Rapgef1)

MAUA:

101836494(Rapgef1)

PROB:

127222690(Rapgef1)

PLEU:

114702763(Rapgef1)

MORG:

121462617(Rapgef1)

MFOT:

126509219

AAMP:

119818619(Rapgef1)

NGI:	103742879(Rapgef1)

HGL:	101714387(Rapgef1)

CPOC:

100727953(Rapgef1)

CCAN:

109691895(Rapgef1)

DORD:

105989398(Rapgef1)

DSP:	122108897(Rapgef1)

PLOP:

125350572(Rapgef1)

NCAR:

124964735

MMMA:

107152161(Rapgef1)

OCU:

100358044

OPI:	101522659(RAPGEF1)

TUP:	102490444(RAPGEF1)

GVR:	103581226 103605897 103608102(RAPGEF1)

CFA:	491286(RAPGEF1)

CLUD:

112677353(RAPGEF1)

VVP:	112927996(RAPGEF1)

VLG:	121473724(RAPGEF1)

NPO:	129504730(RAPGEF1)

AML:	100478465(RAPGEF1)

UMR:	103670406(RAPGEF1)

UAH:	113266537(RAPGEF1)

UAR:	123775730(RAPGEF1)

ELK:

111145866

LLV:

125084098

MPUF:

101682299(RAPGEF1)

MNP:	132024311(RAPGEF1)

MLK:	131812612(RAPGEF1)

NVS:	122917147(RAPGEF1)

ORO:	101367883(RAPGEF1)

EJU:	114198850(RAPGEF1)

ZCA:	113935084(RAPGEF1)

MLX:	118017569(RAPGEF1)

NSU:	110581425(RAPGEF1)

LWW:	102733374(RAPGEF1)

FCA:	101099507(RAPGEF1)

PYU:	121035131(RAPGEF1)

PCOO:

112849767(RAPGEF1)

PBG:	122474705(RAPGEF1)

PVIV:

125150689(RAPGEF1)

LRUF:

124525635

PTG:	102962616(RAPGEF1)

PPAD:

109249998(RAPGEF1)

PUC:

125927720

AJU:

106985330

HHV:	120230122(RAPGEF1)

BTA:	520454(RAPGEF1)

BOM:	102286409(RAPGEF1)

BIU:	109566561(RAPGEF1)

BBUB:

102392822(RAPGEF1)

BBIS:

105000874(RAPGEF1)

CHX:	102176334(RAPGEF1)

OAS:	101121164(RAPGEF1)

BTAX:

128056845(RAPGEF1)

ODA:	120852113(RAPGEF1)

CCAD:

122442291(RAPGEF1)

MBEZ:

129539680(RAPGEF1)

SSC:	100511735(RAPGEF1)

CFR:	102521802(RAPGEF1)

CBAI:

105069710(RAPGEF1)

CDK:	105085169(RAPGEF1)

VPC:	102526154(RAPGEF1)

BACU:

103016774(RAPGEF1)

BMUS:

118896559(RAPGEF1)

LVE:	103068519(RAPGEF1)

OOR:	101281077(RAPGEF1)

DLE:	111177101(RAPGEF1)

PCAD:

102992323(RAPGEF1)

PSIU:

116755221(RAPGEF1)

NASI:

112411538(RAPGEF1)

ECB:	100069527(RAPGEF1)

EPZ:	103553650(RAPGEF1)

EAI:	106845379(RAPGEF1)

MYB:	102249993(RAPGEF1)

MYD:	102755223(RAPGEF1)

MMYO:

118666938(RAPGEF1)

MLF:	102417583(RAPGEF1)

MDT:	132212498(RAPGEF1)

PKL:	118708912(RAPGEF1)

EFUS:

103296165(RAPGEF1)

MNA:	107524638(RAPGEF1)

DRO:	112306444(RAPGEF1)

SHON:

118980055(RAPGEF1)

AJM:	119059006(RAPGEF1)

PDIC:

114504642(RAPGEF1)

PHAS:

123823357(RAPGEF1)

MMF:	118629452(RAPGEF1)

PPAM:

129079197(RAPGEF1)

HAI:	109380820(RAPGEF1)

RFQ:	117031873(RAPGEF1)

PALE:

102882490(RAPGEF1)

PGIG:

120602724(RAPGEF1)

PVP:	105298681(RAPGEF1)

RAY:	107504562(RAPGEF1)

MJV:	108406801(RAPGEF1)

TOD:	119231259(RAPGEF1)

SARA:

101559332(RAPGEF1)

SETR:

126009589(RAPGEF1)

LAV:	100668712(RAPGEF1)

TMU:

101344782

ETF:	101657149(RAPGEF1)

DNM:	101429999(RAPGEF1)

MDO:	100016537(RAPGEF1)

GAS:	123233623(RAPGEF1)

SHR:	100914252(RAPGEF1)

AFZ:

127550912

PCW:	110198895(RAPGEF1)

TVP:	118841628(RAPGEF1)

OAA:	100075047(RAPGEF1)

GGA:	417173(RAPGEF1)

PCOC:

116234264(RAPGEF1)

MGP:	100538909(RAPGEF1)

CJO:	107321760(RAPGEF1)

TPAI:

128073957(RAPGEF1)

LMUT:

125702417(RAPGEF1)

NMEL:

110406774(RAPGEF1)

APLA:

101796594(RAPGEF1)

ACYG:

106044103(RAPGEF1)

CATA:

118252179(RAPGEF1)

AFUL:

116496876(RAPGEF1)

TGU:	100223502(RAPGEF1)

LSR:	110477603(RAPGEF1)

SCAN:

103818988(RAPGEF1)

PMOA:

120507339(RAPGEF1)

OTC:	121336856(RAPGEF1)

PRUF:

121357576(RAPGEF1)

GFR:	102041561(RAPGEF1)

FAB:	101819251(RAPGEF1)

OMA:	130260194(RAPGEF1)

PHI:	102101609(RAPGEF1)

PMAJ:

107211975(RAPGEF1)

CCAE:

111937012(RAPGEF1)

CCW:	104688313(RAPGEF1)

CBRC:

103623146(RAPGEF1)

ETL:	114073801(RAPGEF1)

ZAB:	102066748(RAPGEF1)

ZLE:	135455055(RAPGEF1)

ACHL:

103811599(RAPGEF1)

SVG:	106851283(RAPGEF1)

MMEA:

130576724(RAPGEF1)

HRT:	120761610(RAPGEF1)

SATI:

136369752(RAPGEF1)

FPG:	101920279(RAPGEF1)

FCH:	102051437(RAPGEF1)

CCRI:

104155290 104166620

NNT:	104413078(RAPGEF1)

SHAB:

115616995(RAPGEF1)

ACUN:

113486529(RAPGEF1)

TALA:

104363194(RAPGEF1)

ACHC:

115334989(RAPGEF1)

HALD:

104319562(RAPGEF1)

HLE:	104833890(RAPGEF1)

AGEN:

126052055

GCL:

127023601

CSTI:

104561283(RAPGEF1)

LDI:	104347082(RAPGEF1)

MNB:	103780587(RAPGEF1)

DPUB:

104296395(RAPGEF1)

AVIT:

104280077(RAPGEF1)

BRHI:

104490349(RAPGEF1)

EGZ:	104129824(RAPGEF1)

NNI:	104023176(RAPGEF1)

PCRI:

104038180

PCAO:

104053278(RAPGEF1)

PADL:

103915278(RAPGEF1)

AFOR:

103905317(RAPGEF1)

FGA:	104080328(RAPGEF1)

GSTE:

104255499(RAPGEF1)

CLV:	102093050(RAPGEF1)

MUI:	104544615(RAPGEF1)

PGUU:

104462839(RAPGEF1)

PLET:

104621415(RAPGEF1)

EHS:	104515466(RAPGEF1)

CMAC:

104486590(RAPGEF1)

CUCA:

104066815(RAPGEF1)

TEO:	104381716(RAPGEF1)

BREG:

104644190(RAPGEF1)

OHA:	104329168(RAPGEF1)

ACAR:

104532085(RAPGEF1)

CPEA:

104389831(RAPGEF1)

CVF:	104292808(RAPGEF1)

RTD:	128917404(RAPGEF1)

AAM:	106490324(RAPGEF1)

AROW:

112964279(RAPGEF1)

NPD:	112955918(RAPGEF1)

TGT:	104570866(RAPGEF1)

DNE:	112984153(RAPGEF1)

SCAM:

104138259(RAPGEF1)

ASN:	102376116(RAPGEF1)

AMJ:	102567356(RAPGEF1)

CPOO:

109313957(RAPGEF1)

GGN:	109292741(RAPGEF1)

PSS:	102462283(RAPGEF1)

CMY:	102941951(RAPGEF1)

CCAY:

125623397(RAPGEF1)

DCC:	119844178(RAPGEF1)

CPIC:

101952144(RAPGEF1)

TST:	117889411(RAPGEF1)

CABI:

116835113(RAPGEF1)

MRV:	120386929(RAPGEF1)

ACS:

100558908

ASAO:

132763563(RAPGEF1)

PVT:	110079600(RAPGEF1)

SUND:

121936317(RAPGEF1)

PBI:	103062364(RAPGEF1)

PMUR:

107291046(RAPGEF1)

CTIG:

120298842(RAPGEF1)

PGUT:

117656847(RAPGEF1)

APRI:

131186076(RAPGEF1)

PTEX:

113443884(RAPGEF1)

VKO:	123028258(RAPGEF1)

PMUA:

114588828(RAPGEF1)

PRAF:

128407006(RAPGEF1)

ZVI:	118083789(RAPGEF1)

HCG:	128338852(RAPGEF1)

GJA:	107113979(RAPGEF1)

STOW:

125441665(RAPGEF1)

EMC:	129341999(RAPGEF1)

XLA:	108698866(rapgef1.L) 444199(rapgef1.S)

XTR:	733953(rapgef1)

NPR:	108795307(RAPGEF1)

RTEM:

120913998(RAPGEF1)

BBUF:

120977804(RAPGEF1)

BGAR:

122919953 122946078(RAPGEF1)

MUO:	115473118(RAPGEF1)

GSH:	117367567(RAPGEF1)

DRE:	394101(rapgef1b) 558635(rapgef1a)

SRX:	107705978 107725290 107737187 107757300

SANH:

107661562 107664972 107674295

SGH:	107557186 107585645 107598978 107599366

CCAR:

109048431 109065214 109083858 109094744

CAUA:

113039015 113064437 113071767 113107170

CGIB:

127941799 127963568 127985854 128018908

PTET:

122332573(rapgef1b) 122350575(rapgef1a)

LROH:

127152696(rapgef1b) 127169554(rapgef1a)

OMC:	131528880(rapgef1b) 131545683(rapgef1a)

PPRM:

120471241(rapgef1b) 120474505(rapgef1a)

RKG:	130091684(rapgef1a) 130100621(rapgef1b)

MAMB:

125252103(rapgef1b) 125279383(rapgef1a)

CIDE:

127503544 127517366

CERY:

137012080(rapgef1b) 137026896(rapgef1a)

MASI:

127415147 127423918 127429233 127431146

TROS:

130568193(rapgef1a) 130570093(rapgef1b)

TDW:	130407801(rapgef1b) 130440363(rapgef1a)

MANU:

129414123(rapgef1a) 129423633(rapgef1b)

IPU:	108265900(rapgef1a) 108279164(rapgef1b)

IFU:	128608116(rapgef1a) 128622650(rapgef1b)

PHYP:

113535223 113535681

SMEO:

124397978(rapgef1b) 124400050(rapgef1a)

TFD:	113634287(rapgef1a) 113664067(rapgef1b)

TVC:	132853417(rapgef1a) 132859606(rapgef1b)

TRN:	134318270(rapgef1a) 134330364(rapgef1b)

AMEX:

103035014(rapgef1a) 103043049(rapgef1b)

CMAO:

118813834(rapgef1a) 118820428(rapgef1b)

EEE:	113577358(rapgef1) 113588027

CHAR:

105891596(rapgef1a) 105902468(rapgef1b)

TRU:	101073444(rapgef1)

TFS:	130517601(rapgef1b)

TNG:	GSTEN00014400G001 GSTEN00014401G001

LCO:	104924499(rapgef1) 104934753

NCC:	104967939(rapgef1)

TBEN:

117475715 117476613(rapgef1b)

CGOB:

115005563 115016717(rapgef1)

PGEO:

117455835(rapgef1b)

GACU:

117560203(rapgef1b)

EMAC:

134868251(rapgef1b) 134873710(rapgef1a)

ELY:	117252148 117269588(rapgef1b)

EFO:	125890857 125906344(rapgef1b)

PLEP:

121959531(rapgef1b)

SLUC:

116056991 116062783(rapgef1b)

ECRA:

117959849(rapgef1b)

ESP:	116704339(rapgef1)

PFLV:

114556397 114570984(rapgef1)

GAT:	120831380(rapgef1a) 120831509(rapgef1b)

PPUG:

119226265(rapgef1b)

AFB:	129101445(rapgef1a) 129102734(rapgef1b)

CLUM:

117736307(rapgef1a)

PSWI:

130196758 130204878(rapgef1b)

MSAM:

119891532 119914123(rapgef1b)

SCHU:

122865682(rapgef1b) 122875993

CUD:	121510527 121525344(rapgef1b)

ALAT:

119020317 119029769(rapgef1b)

MZE:	101486972 106675478

ONL:	100693176(rapgef1) 100712315

OAU:	116316397 116331865(rapgef1b)

OLA:	101157374(rapgef1) 101158464

OML:	112147904 112162969(rapgef1b)

CSAI:

133450760 133454982(rapgef1b)

XMA:	102230952(rapgef1) 102235637

XCO:	114150223(rapgef1) 114154767

XHE:	116725018 116730235(rapgef1)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122828599 122846789(rapgef1b)

PPRL:

129365718(rapgef1a) 129374072(rapgef1b)

CVG:	107089763(rapgef1) 107104265

CTUL:

119776579(rapgef1b)

GMU:	124872361(rapgef1b) 124877125

NFU:	107374772 107386212(rapgef1)

KMR:	108230997(rapgef1b) 108248096

ALIM:

106516284(rapgef1) 106532135

NWH:	119413739 119424703(rapgef1b)

AOCE:

111564078(rapgef1) 111586833

MCEP:

124996400(rapgef1b) 125012308

CSEM:

103390102 103397946(rapgef1)

POV:	109626210(rapgef1)

SSEN:

122758050(rapgef1b) 122769701

HHIP:

117771524(rapgef1b)

HSP:	118125467(rapgef1b)

PPLT:

128462290(rapgef1b)

SMAU:

118285393(rapgef1b) 118314322(rapgef1a)

LCF:	108873981(rapgef1b) 108894420

SDU:	111237355(rapgef1) 111237440

SLAL:

111668040(rapgef1)

XGL:	120787511 120806202(rapgef1b)

HCQ:	109517154(rapgef1)

SSCV:

125979930

SBIA:

133515294(rapgef1b)

PEE:	133413682(rapgef1b)

PTAO:

133490019(rapgef1b)

BPEC:

110157298(rapgef1)

MALB:

109957411(rapgef1) 109972316

BSPL:

114863034(rapgef1a) 114866487(rapgef1b)

SJO:	128364100 128380528(rapgef1b)

SASA:

106562868 106569917 106580123(rapgef1) 106585645

STRU:

115159930 115164879 115199785 115203741

OTW:	112220256(rapgef1b) 112230757 112248224 112263306

OMY:	110509502 110523299(rapgef1b) 110525335 110535740

OGO:	123989375(rapgef1b) 124016614 124034575 124036026

ONE:	115111320 115118651 115140648 115147105

OKI:	109874014 109876092 109877927 109895644

OKE:	118358045 118385597 118388060(rapgef1b) 118392915

SALP:

111957802 111960909 111964466 111974844

SNH:	120021185 120026253(rapgef1b) 120049178(rapgef1a) 120063060

CCLU:

121541430 121550195 121582093(rapgef1b) 121584508

ELS:	105014664(rapgef1) 105028395

SFM:	108920197 108934417(rapgef1)

PKI:	111841868(rapgef1)

AANG:

118212082(rapgef1b)

LOC:	102697581(rapgef1)

PSPA:

121309747(rapgef1a)

ARUT:

117396940 117422459

PSEX:

120535056

LCM:	102362033(RAPGEF1)

CMK:	103184630(rapgef1b)

RTP:

109935633

CPLA:

122564907

HOC:	132825882(rapgef1a)

LERI:

129711967

PMRN:

116938950 116953089(RAPGEF1)

LRJ:	133348464 133354714

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

SKO:

DME:	Dmel_CG42328(C3G)

DER:

6551687

DSE:

6612208

DSI:	Dsimw501_GD16179(Dsim_GD16179)

DYA:	Dyak_GE16444(Dyak_C3G)

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21607

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AAG:	110680616 5578702

AALB:

109415177 109428492 109428493

ASUA:

134207675

CQU:	CpipJ_CPIJ019106

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204405

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:	110370762(C3g)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:	113561052 113561339

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106679504(C3G)

NLU:

111050783

HVI:

124360607

MQU:

128993630

PHU:	Phum_PHUM211010

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:	122251804 122261855

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:	124494883 124496932

CSCU:

111612386

CVS:	136984008(C3G)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_Y34B4A.4(Y34B4A.4)

CBR:

CBG_14649

CRQ:	GCK72_024395

NAI:	NECAME_02439

BMY:	BM_BM6361(Bm6361)

LOA:	LOAG_17875

TSP:

Tsp_03304

LGI:	LOTGIDRAFT_137628

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106157520 106180728

SMM:	Smp_144600

OVI:	T265_04006

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AQU:

DDI:	DDB_G0277913(gefJ)

DPP:	DICPUDRAFT_46357

» show all

Reference

PMID:7806500

Authors

Knudsen BS, Feller SM, Hanafusa H

Title

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.

Journal

J Biol Chem 269:32781-7 (1994)

Sequence

[hsa:2889]

Reference

PMID:9266971

Authors

van den Berghe N, Cool RH, Horn G, Wittinghofer A

Title

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

Journal

Oncogene 15:845-50 (1997)
DOI:10.1038/sj.onc.1201407

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Gene (2087)   
   KEGG GENES (780)   
   KEGG MGENES (375)   
   RefGene (926)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (2100)   

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