KEGG ORTHOLOGY: K06454

ORTHOLOGY: K06454

Entry

K06454                      KO

Symbol

CD4

Name

T-cell surface glycoprotein CD4

Pathway

map03250

Viral life cycle - HIV-1

map03260

Virion - Human immunodeficiency virus

map04060

Cytokine-cytokine receptor interaction

map04514

Cell adhesion molecules

map04612

Antigen processing and presentation

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05135

Yersinia infection

map05166

Human T-cell leukemia virus 1 infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K06454  CD4; T-cell surface glycoprotein CD4
   03260 Virion - Human immunodeficiency virus
    K06454  CD4; T-cell surface glycoprotein CD4
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K06454  CD4; T-cell surface glycoprotein CD4
   04514 Cell adhesion molecules
    K06454  CD4; T-cell surface glycoprotein CD4
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06454  CD4; T-cell surface glycoprotein CD4
   04612 Antigen processing and presentation
    K06454  CD4; T-cell surface glycoprotein CD4
   04660 T cell receptor signaling pathway
    K06454  CD4; T-cell surface glycoprotein CD4
   04658 Th1 and Th2 cell differentiation
    K06454  CD4; T-cell surface glycoprotein CD4
   04659 Th17 cell differentiation
    K06454  CD4; T-cell surface glycoprotein CD4
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06454  CD4; T-cell surface glycoprotein CD4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06454  CD4; T-cell surface glycoprotein CD4
   05170 Human immunodeficiency virus 1 infection
    K06454  CD4; T-cell surface glycoprotein CD4
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K06454  CD4; T-cell surface glycoprotein CD4
  09163 Immune disease
   05340 Primary immunodeficiency
    K06454  CD4; T-cell surface glycoprotein CD4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06454  CD4; T-cell surface glycoprotein CD4
CD molecules [BR:ko04090]
Proteins
  K06454  CD4; CD4 antigen (p55)

Genes

HSA:

920(CD4)

PTR:	450124(CD4)

PPS:	100970574(CD4)

GGO:	101130322(CD4)

PON:	100452381(CD4)

PPYG:

129010352(CD4)

NLE:	100591806(CD4)

HMH:	116472598(CD4)

SSYN:

129481919(CD4)

MCC:	713807(CD4)

MCF:	101864991(CD4)

MTHB:

126930442

MNI:	105484203(CD4)

CSAB:

103218480(CD4)

CATY:

105583039(CD4)

PANU:

100303658(CD4)

TGE:	112634139(CD4)

MLEU:

105541800(CD4)

RRO:	104680099(CD4)

RBB:	108542050(CD4)

TFN:	117090614(CD4)

PTEH:

111555927(CD4)

CANG:

105518929(CD4)

CJC:	100385000(CD4)

SBQ:	101028824(CD4)

CIMI:

108295007(CD4)

ANAN:

105731187(CD4)

CSYR:

103252157(CD4)

MMUR:

105869095(CD4)

LCAT:

123640106(CD4)

PCOQ:

105805024(CD4)

OGA:	100953378(CD4)

MMU:	12504(Cd4)

MCAL:

110296921(Cd4)

MPAH:

110317139(Cd4)

RNO:	24932(Cd4)

MCOC:

116099586(Cd4)

ANU:	117715411(Cd4)

MUN:	110548574(Cd4)

CGE:	100766761(Cd4)

MAUA:

101836856(Cd4)

PROB:

127213006(Cd4)

PLEU:

114708820(Cd4)

MORG:

121440366(Cd4)

MFOT:

126514916

AAMP:

119807903(Cd4)

NGI:	103727506(Cd4)

HGL:	101716842(Cd4)

CPOC:

100734494(Cd4)

CCAN:

109682769(Cd4)

DORD:

105991025(Cd4)

DSP:	122101946(Cd4)

NCAR:

124983047

MMMA:

107154945(Cd4)

OCU:	100009152(CD4)

OPI:	101536290(CD4)

TUP:	102469339(CD4)

GVR:	103586411(CD4)

CFA:	403931(CD4)

CLUD:

112675354(CD4)

VVP:	112917336(CD4)

VLG:	121479658(CD4)

NPO:	129503501(CD4)

AML:	100482689(CD4)

UMR:	103656225(CD4)

UAH:	113257962(CD4)

UAR:	123781683(CD4)

ELK:

111159821

LLV:

125107477

MPUF:

101684487(CD4)

MNP:	132019914(CD4)

MLK:	131838466(CD4)

NVS:	122891290(CD4)

ORO:	101370279(CD4)

EJU:	114222546(CD4)

ZCA:	113922007(CD4)

MLX:	118025728(CD4)

NSU:	110580959(CD4)

LWW:	102731984(CD4)

FCA:	493775(CD4)

PYU:	121021965(CD4)

PCOO:

112867903(CD4)

PBG:	122473566(CD4)

PVIV:

125169796(CD4)

LRUF:

124501369

PTG:	102954103(CD4)

PPAD:

109276110(CD4) 109276152

PUC:

125917982

AJU:

106965350

HHV:	120220463(CD4)

BTA:	407098(CD4)

BOM:	102281198(CD4)

BIU:	109558922(CD4)

BBUB:

102413723(CD4)

BBIS:

104992179(CD4)

CHX:	102170124(CD4)

OAS:	443509(CD4)

BTAX:

128048680(CD4)

ODA:	120858732(CD4)

CCAD:

122423969(CD4)

MBEZ:

129536212(CD4)

SSC:	404704(CD4)

CFR:	102506854(CD4)

CBAI:

105071091(CD4)

CDK:	105098206(CD4)

VPC:	102530125(CD4)

BACU:

103010726(CD4)

BMUS:

118901712(CD4)

LVE:	103090277(CD4)

OOR:	101285114(CD4)

DLE:	111176687(CD4)

PSIU:

116761015(CD4)

NASI:

112391862(CD4)

ECB:	100052502(CD4)

EPZ:	103547015(CD4)

EAI:	106847327(CD4)

MYB:	102262721(CD4)

MYD:	102760024(CD4)

MMYO:

118651657(CD4)

MLF:	102427698(CD4)

MDT:	132227208(CD4)

PKL:	118729334(CD4)

EFUS:

103289023(CD4)

MNA:	107544013(CD4)

DRO:	112322003(CD4)

SHON:

119002350(CD4)

AJM:	119060419(CD4)

PDIC:

114513512(CD4)

PHAS:

123810628(CD4)

MMF:	118623896(CD4)

PPAM:

129071444 129071445(CD4)

HAI:	109373637(CD4)

RFQ:	117028935(CD4)

PGIG:

120611664(CD4)

PVP:	105295953(CD4)

MJV:	108403555(CD4)

TOD:	119247775(CD4)

SARA:

101544961(CD4)

SETR:

126006959(CD4)

LAV:	100675007(CD4)

TMU:

101343648

ETF:	101661201(CD4)

DNM:	101411381(CD4)

MDO:	100016045(CD4)

GAS:	123250035(CD4)

SHR:	100923185(CD4)

AFZ:

127564449

PCW:	110213788(CD4)

TVP:	118851692(CD4)

OAA:	103165339(CD4)

GGA:	395362(CD4)

PCOC:

116239941

MGP:	100126554(CD4)

CJO:

107318700

TPAI:

128089886

LMUT:

125685280

NMEL:

110398410(CD4)

APLA:

101790140(CD4)

ACYG:

106047858(CD4)

CATA:

118247575(CD4)

AFUL:

116491037(CD4)

TGU:	100227917(CD4)

LSR:	110480811(CD4)

SCAN:

103812453(CD4)

PMOA:

120506408(CD4)

OTC:	121339345(CD4)

PRUF:

121351620(CD4)

GFR:	102039868(CD4)

FAB:	101811036(CD4)

OMA:	130248364(CD4)

PHI:	102112871(CD4)

PMAJ:

107203925(CD4)

CCAE:

111938276(CD4)

CCW:	104687125(CD4)

CBRC:

103614061(CD4)

ETL:

114058187

ZAB:	102073639(CD4)

ZLE:	135442737(CD4)

ACHL:

103810992

SVG:	106857890(CD4)

MMEA:

130574787(CD4)

HRT:	120748906(CD4)

SATI:

136375555

FPG:	101918856(CD4)

FCH:

CCRI:

NNT:

SHAB:

ACUN:

113476745(CD4)

TALA:

104360758(CD4)

ACHC:

115344140(CD4)

HALD:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:	103768050(CD4)

DPUB:

104299502

AVIT:

104273496

BRHI:

104492176

EGZ:	104126598(CD4)

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CLV:	102084034(CD4)

MUI:	104543498(CD4)

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

104519383(CD4)

CPEA:

104389907(CD4)

CVF:

104293427

RTD:	128904246(CD4)

AAM:

106497174

AROW:

112963141(CD4)

NPD:	112960135(CD4)

TGT:

104565681

DNE:	112991055(CD4)

SCAM:

104150715

ASN:	102380067(CD4)

AMJ:	102572958(CD4)

CPOO:

109319394(CD4)

GGN:	109304868(CD4)

PSS:	102461725(CD4)

CMY:	102933832(CD4)

CCAY:

125622609(CD4)

DCC:	119845987(CD4)

CPIC:

101943745(CD4)

TST:	117885813(CD4)

CABI:

116837532(CD4)

MRV:	120395998(CD4)

ACS:	100567219(cd4)

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

125437022(CD4)

XLA:	100653504(cd4.S) 108696056(cd4.L)

XTR:

NPR:

RTEM:

BBUF:

BGAR:

MUO:	115457814(CD4)

GSH:

117350309

DRE:	799982(cd4-1)

SRX:	107717420 107755530

SANH:

107671215 107700156

SGH:	107578959 107598455

CCAR:

109070695

CAUA:

113059967 113116393

CGIB:

127974323 128031132

PTET:

122359874(cd4-1)

LROH:

127178071(cd4-1)

OMC:	131521872(cd4-1)

PPRM:

120484373(cd4-1)

RKG:	130103629(cd4-1)

MAMB:

125243632 125244174 125244178

CIDE:

127496790

CERY:

137032024 137032086

MASI:

127453273 127453958

TROS:

130558465(cd4-1)

TDW:	130433490(cd4-1)

MANU:

129448423 129448425

IPU:	100304978(cd4-1)

IFU:	128608038(cd4-1)

PHYP:

113542643

SMEO:

124385209(cd4-1)

TFD:	113643587(cd4-1)

TVC:	132846110(cd4-1)

TRN:	134310088(cd4-1)

AMEX:

103041570(cd4-1)

CMAO:

118824754(cd4-1)

EEE:

113570626

CHAR:

105894549(cd4-1)

TRU:	778001(cd4)

TFS:	130532967(cd4-1)

LCO:

104922282

TBEN:

117494722(cd4-1)

CGOB:

115021281

PGEO:

117461231(cd4-1)

GACU:

117549561(cd4-1)

EMAC:

134861266(cd4-1)

ELY:	117265662(cd4-1)

EFO:	125893133(cd4-1)

PLEP:

121945264(cd4-1)

SLUC:

116049734(cd4-1)

ECRA:

117946240(cd4-1)

ESP:

116691255

PFLV:

114557493

GAT:	120810838(cd4-1)

PPUG:

119197243(cd4-1)

AFB:

129109537

CLUM:

117745461(cd4-1)

MSAM:

119897409

SCHU:

122882046(cd4-1)

CUD:	121513840(cd4-1)

ALAT:

119006345(cd4-1)

MZE:

101464216

ONL:

100709183

OAU:	116323777(cd4-1)

OLA:

100125525

OML:	112143674(cd4-1)

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122830983(cd4-1)

PPRL:

129371161(cd4-1)

CVG:

107082188

CTUL:

119783101(cd4-1)

GMU:

124865839

NFU:

107379481

KMR:	108235418(cd4-1)

ALIM:

106521019

NWH:	119409696(cd4-1)

AOCE:

111569482

MCEP:

125016771(cd4-1)

CSEM:

103388025

POV:

109633355

SSEN:

122765142 122774511(cd4-1)

HHIP:

117776805(cd4-2.2)

HSP:	118113203(cd4-2.2)

PPLT:

128449611

SMAU:

118315132(cd4-1)

LCF:	108880732(cd4-1)

SDU:

111230068

SLAL:

111669902

XGL:	120784094(cd4-1)

HCQ:

109515260

SBIA:

133500402(cd4-1)

PEE:	133402072(cd4-1)

PTAO:

133480137(cd4-1)

MALB:

109966202

BSPL:

114842934(cd4-1)

SJO:	128365862(cd4-1)

SASA:

100136501 100136502(CD4)

STRU:

115176380 115177282

OTW:	112223122(cd4-1) 112246591

OMY:	100136285(cd4-1) 110501538

OGO:	123997554 124005545

ONE:	115141342 115141355

OKI:	109902185 109910298

OKE:	118364237 118366528

SALP:

111965239 111965255

SNH:	120031194 120048302

ELS:

105028237

SFM:

108922084

PKI:

111834638

AANG:

118213758(cd4-1)

LOC:

PSPA:

ARUT:

Reference

PMID:2990730

Authors

Maddon PJ, Littman DR, Godfrey M, Maddon DE, Chess L, Axel R

Title

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

Journal

Cell 42:93-104 (1985)
DOI:10.1016/S0092-8674(85)80105-7

Sequence

[hsa:920]

Reference

PMID:2214026

Authors

Crise B, Buonocore L, Rose JK

Title

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.

Journal

J Virol 64:5585-93 (1990)
DOI:10.1128/JVI.64.11.5585-5593.1990

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (28)   
   KEGG PATHWAY (28)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (6)   
   KEGG DRUG (6)   
Gene (409)   
   KEGG GENES (407)   
   KEGG MGENES (1)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (448)   

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