KEGG   ORTHOLOGY: K06463
Entry
K06463                      KO                                     

Name
FCGR3, CD16
Definition
low affinity immunoglobulin gamma Fc receptor III
Pathway
ko04145  Phagosome
ko04380  Osteoclast differentiation
ko04613  Neutrophil extracellular trap formation
ko04650  Natural killer cell mediated cytotoxicity
ko04666  Fc gamma R-mediated phagocytosis
ko05140  Leishmaniasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00090  NK cell defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04650 Natural killer cell mediated cytotoxicity
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04666 Fc gamma R-mediated phagocytosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   05152 Tuberculosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
CD molecules [BR:ko04090]
 Proteins
  K06463  CD16a, FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  K06463  CD16b, FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Receptors
  K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Other DBs
GO: 0019770
Genes
HSA: 2214(FCGR3A) 2215(FCGR3B)
PTR: 457457 745350
GGO: 101129837 101143892
PON: 100453994
NLE: 101176357
MCC: 720006(FCGR3)
MCF: 102140945(FCGR3)
CSAB: 103223675
RRO: 104671953
RBB: 108542585
CJC: 100387926
SBQ: 101040447
MMU: 246256(Fcgr4)
MCAL: 110299183
MPAH: 110322271
RNO: 116591(Fcgr2a) 304966(Fcgr3a)
MUN: 110554430
CGE: 103161892
NGI: 103746771
HGL: 101701607
CCAN: 109693505
TUP: 102499391(FCGR3B)
CFA: 478984
VVP: 112914295
AML: 100481923
UMR: 103658250
UAH: 113268656
ORO: 101363133
ELK: 111151151
FCA: 493677(FCGR3A)
PTG: 102959153
PPAD: 109276673(FCGR3A)
AJU: 106986773
BTA: 281766(FCGR3A)
BOM: 102273538
BIU: 109578151
BBUB: 102410092
CHX: 102185698
OAS: 100192433(FCGR3A)
SSC: 397684(FCGR3B)
CFR: 102516303
CDK: 105105185
BACU: 103008795
LVE: 103068717
OOR: 101270000
DLE: 111170413
PCAD: 102990877(FCGR3A)
ECB: 100051526
EPZ: 103540860(FCGR3A)
MYB: 102247789(FCGR3B)
MYD: 102754425(FCGR3A)
MNA: 107535119
HAI: 109392302
DRO: 112297203
PALE: 102893884
RAY: 107502476
LAV: 104846346
MDO: 100015157
SHR: 100924138(FCGR3B)
PCW: 110209910
XTR: 116406731
XMA: 111611195
XCO: 114156970
KMR: 112450140
AOCE: 111567090
ELS: 105009337
RTP: 109932873
 » show all
Reference
PMID:2526846
  Authors
Ravetch JV, Perussia B
  Title
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
  Journal
J Exp Med 170:481-97 (1989)
DOI:10.1084/jem.170.2.481
  Sequence
[hsa:2214 2215]
Reference
  Authors
Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B
  Title
Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.
  Journal
PLoS One 10:e0121788 (2015)
DOI:10.1371/journal.pone.0121788

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