KEGG   ORTHOLOGY: K06464
Entry
K06464                      KO                                     

Name
ITGB2, CD18
Definition
integrin beta 2
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04390  Hippo signaling pathway
ko04514  Cell adhesion molecules
ko04610  Complement and coagulation cascades
ko04613  Neutrophil extracellular trap formation
ko04650  Natural killer cell mediated cytotoxicity
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05144  Malaria
ko05146  Amoebiasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05166  Human T-cell leukemia virus 1 infection
ko05323  Rheumatoid arthritis
ko05416  Viral myocarditis
Disease
H00099  Leukocyte adhesion deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06464  ITGB2, CD18; integrin beta 2
   04390 Hippo signaling pathway
    K06464  ITGB2, CD18; integrin beta 2
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06464  ITGB2, CD18; integrin beta 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06464  ITGB2, CD18; integrin beta 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06464  ITGB2, CD18; integrin beta 2
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K06464  ITGB2, CD18; integrin beta 2
   04613 Neutrophil extracellular trap formation
    K06464  ITGB2, CD18; integrin beta 2
   04650 Natural killer cell mediated cytotoxicity
    K06464  ITGB2, CD18; integrin beta 2
   04670 Leukocyte transendothelial migration
    K06464  ITGB2, CD18; integrin beta 2
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06464  ITGB2, CD18; integrin beta 2
  09171 Infectious disease: bacterial
   05133 Pertussis
    K06464  ITGB2, CD18; integrin beta 2
   05134 Legionellosis
    K06464  ITGB2, CD18; integrin beta 2
   05150 Staphylococcus aureus infection
    K06464  ITGB2, CD18; integrin beta 2
   05152 Tuberculosis
    K06464  ITGB2, CD18; integrin beta 2
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K06464  ITGB2, CD18; integrin beta 2
   05144 Malaria
    K06464  ITGB2, CD18; integrin beta 2
   05140 Leishmaniasis
    K06464  ITGB2, CD18; integrin beta 2
  09163 Immune disease
   05323 Rheumatoid arthritis
    K06464  ITGB2, CD18; integrin beta 2
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06464  ITGB2, CD18; integrin beta 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06464  ITGB2, CD18; integrin beta 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06464  ITGB2, CD18; integrin beta 2
   04515 Cell adhesion molecules
    K06464  ITGB2, CD18; integrin beta 2
   04090 CD molecules
    K06464  ITGB2, CD18; integrin beta 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06464  ITGB2, CD18; integrin beta 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06464  ITGB2, CD18; integrin beta 2
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin beta subunits
   K06464  ITGB2, CD18; integrin beta 2
CD molecules [BR:ko04090]
 Proteins
  K06464  CD18, ITGB2; integrin, beta 2
Other DBs
GO: 0030369
Genes
HSA: 3689(ITGB2)
PTR: 458607(ITGB2)
PPS: 100985940(ITGB2)
GGO: 101142773(ITGB2)
PON: 100451938(ITGB2)
NLE: 100600337(ITGB2)
MCC: 710577(ITGB2)
MCF: 101925124(ITGB2)
CSAB: 103220048(ITGB2)
RRO: 104659958(ITGB2)
RBB: 108539787(ITGB2)
CJC: 100402685(ITGB2)
SBQ: 101053620(ITGB2)
MMU: 16414(Itgb2) 16415(Itgb2l)
MCAL: 110303281(Itgb2) 110311769
MPAH: 110326926(Itgb2) 110330040
RNO: 309684(Itgb2)
MUN: 110545086(Itgb2)
CGE: 100756135(Itgb2)
NGI: 103739950(Itgb2)
HGL: 101703921(Itgb2)
CCAN: 109694990(Itgb2) 109702039
OCU: 100339049(ITGB2)
TUP: 102497567 102501274(ITGB2)
CFA: 403770(ITGB2)
VVP: 112909536(ITGB2)
AML: 100484264(ITGB2)
UMR: 103680739(ITGB2)
UAH: 113250821(ITGB2)
ORO: 101383612(ITGB2)
ELK: 111155758
FCA: 101087258(ITGB2)
PTG: 102962262(ITGB2)
PPAD: 109258109(ITGB2)
AJU: 106985666(ITGB2)
BTA: 281877(ITGB2)
BOM: 102285348(ITGB2)
BIU: 109560786(ITGB2)
BBUB: 102400120(ITGB2)
CHX: 100861185(ITGB2)
OAS: 494433(ITGB2)
SSC: 396943(ITGB2)
CFR: 102512225(ITGB2)
CDK: 105101515(ITGB2)
BACU: 103008120(ITGB2)
LVE: 103079755(ITGB2)
OOR: 101285903(ITGB2)
DLE: 111186435(ITGB2)
PCAD: 102983789(ITGB2)
ECB: 100056049 100056128(ITGB2)
EPZ: 103543384
EAI: 106827902 106842975(ITGB2)
MYB: 102248879(ITGB2)
MYD: 102760033(ITGB2)
MNA: 107543669(ITGB2)
HAI: 109372101(ITGB2)
DRO: 112304402(ITGB2)
PALE: 102896231(ITGB2)
RAY: 107510212(ITGB2)
MJV: 108388833(ITGB2)
LAV: 100665256(ITGB2)
TMU: 101349050
MDO: 100024596(ITGB2)
SHR: 100925715(ITGB2)
PCW: 110198845(ITGB2)
OAA: 100092394(ITGB2)
GGA: 396181(ITGB2)
MGP: 100543565(ITGB2)
CJO: 107316393(ITGB2)
NMEL: 110399666(ITGB2)
APLA: 101796803(ITGB2)
ACYG: 106030119(ITGB2)
TGU: 100229042(ITGB2)
LSR: 110471688(ITGB2)
SCAN: 103814562(ITGB2)
GFR: 102035991(ITGB2)
FAB: 101806243(ITGB2)
PHI: 102111289(ITGB2)
PMAJ: 107207766(ITGB2)
CCAE: 111931900(ITGB2)
CCW: 104698247(ITGB2)
ETL: 114068111(ITGB2)
FPG: 101919496(ITGB2)
FCH: 102051822(ITGB2)
CLV: 102087554(ITGB2)
EGZ: 104132401(ITGB2)
NNI: 104013641(ITGB2)
ACUN: 113482437(ITGB2)
PADL: 103914154(ITGB2)
AAM: 106492316(ITGB2)
ASN: 102383861(ITGB2)
AMJ: 102563942(ITGB2)
PSS: 102455278(ITGB2)
CMY: 102947116(ITGB2)
CPIC: 101951111(ITGB2)
ACS: 100564287(itgb2)
PVT: 110087486(ITGB2)
PBI: 103050081(ITGB2)
PMUR: 107284294(ITGB2)
TSR: 106553055(ITGB2)
PMUA: 114582534(ITGB2)
GJA: 107117606(ITGB2)
XLA: 379708(itgb2.S)
XTR: 100492659(itgb2)
DRE: 557797(itgb2)
IPU: 100304487
PHYP: 113525914
AMEX: 103028506
EEE: 113577217
TRU: 101071641
LCO: 104938242
NCC: 104946113
MZE: 101476106
XMA: 102231373
XCO: 114148797
PRET: 103482508
CVG: 107102807(itgb2) 107102808
NFU: 107390286
KMR: 108238776(itgb2)
ALIM: 106530485
AOCE: 111588445
CSEM: 103392358(itgb2)
POV: 109637398
SDU: 111228090
SLAL: 111663463
HCQ: 109519258
BPEC: 110165161
MALB: 109963778
SASA: 100306785(itb2) 106581859
ELS: 105016184
LCM: 102365824(ITGB2)
CMK: 103176852(itgb2)
RTP: 109915473
 » show all
Reference
PMID:3028646
  Authors
Kishimoto TK, O'Connor K, Lee A, Roberts TM, Springer TA
  Title
Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family.
  Journal
Cell 48:681-90 (1987)
DOI:10.1016/0092-8674(87)90246-7
  Sequence
[hsa:3689]
Reference
  Authors
Xu J, Gao XP, Ramchandran R, Zhao YY, Vogel SM, Malik AB
  Title
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
  Journal
Nat Immunol 9:880-6 (2008)
DOI:10.1038/ni.1628

KEGG   ORTHOLOGY: K06461
Entry
K06461                      KO                                     

Name
ITGAM, CD11b
Definition
integrin alpha M
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04514  Cell adhesion molecules
ko04610  Complement and coagulation cascades
ko04613  Neutrophil extracellular trap formation
ko04640  Hematopoietic cell lineage
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05146  Amoebiasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06461  ITGAM, CD11b; integrin alpha M
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06461  ITGAM, CD11b; integrin alpha M
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06461  ITGAM, CD11b; integrin alpha M
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06461  ITGAM, CD11b; integrin alpha M
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06461  ITGAM, CD11b; integrin alpha M
   04610 Complement and coagulation cascades
    K06461  ITGAM, CD11b; integrin alpha M
   04613 Neutrophil extracellular trap formation
    K06461  ITGAM, CD11b; integrin alpha M
   04670 Leukocyte transendothelial migration
    K06461  ITGAM, CD11b; integrin alpha M
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06461  ITGAM, CD11b; integrin alpha M
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K06461  ITGAM, CD11b; integrin alpha M
  09171 Infectious disease: bacterial
   05133 Pertussis
    K06461  ITGAM, CD11b; integrin alpha M
   05134 Legionellosis
    K06461  ITGAM, CD11b; integrin alpha M
   05150 Staphylococcus aureus infection
    K06461  ITGAM, CD11b; integrin alpha M
   05152 Tuberculosis
    K06461  ITGAM, CD11b; integrin alpha M
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K06461  ITGAM, CD11b; integrin alpha M
   05140 Leishmaniasis
    K06461  ITGAM, CD11b; integrin alpha M
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06461  ITGAM, CD11b; integrin alpha M
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06461  ITGAM, CD11b; integrin alpha M
   04515 Cell adhesion molecules
    K06461  ITGAM, CD11b; integrin alpha M
   04090 CD molecules
    K06461  ITGAM, CD11b; integrin alpha M
   00536 Glycosaminoglycan binding proteins
    K06461  ITGAM, CD11b; integrin alpha M
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06461  ITGAM, CD11b; integrin alpha M
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06461  ITGAM, CD11b; integrin alpha M
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06461  ITGAM, CD11b; integrin alpha M
CD molecules [BR:ko04090]
 Proteins
  K06461  CD11b, ITGAM; integrin, alpha M
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Adhesion molecules of cell surface
   K06461  ITGAM, CD11b; integrin alpha M
Genes
HSA: 3684(ITGAM)
PTR: 454069(ITGAM)
PPS: 100992002(ITGAM)
GGO: 101135400(ITGAM)
PON: 100439660(ITGAM)
NLE: 100603969(ITGAM)
MCC: 714832(ITGAM)
MCF: 101866035(ITGAM)
CSAB: 103231383(ITGAM)
RRO: 104661578(ITGAM)
RBB: 108528119(ITGAM)
CJC: 100389341(ITGAM)
SBQ: 101035688(ITGAM)
MMU: 16409(Itgam)
MCAL: 110298307(Itgam)
MPAH: 110327528(Itgam)
RNO: 25021(Itgam)
MUN: 110564544(Itgam)
CGE: 100758889(Itgam)
NGI: 103726316(Itgam)
HGL: 101719288(Itgam)
CCAN: 109696521
OCU: 100351865(ITGAM)
TUP: 102483623(ITGAM)
CFA: 489928(ITGAM)
VVP: 112929270(ITGAM)
AML: 100475340
UMR: 103657890(ITGAM)
UAH: 113267723(ITGAM)
ORO: 101374774(ITGAM)
ELK: 111162313
FCA: 101087957
PTG: 102966486(ITGAM)
PPAD: 109259037(ITGAM)
AJU: 106979120(ITGAM)
BTA: 407124(ITGAM)
BOM: 102270519(ITGAM)
BBUB: 102396526(ITGAM)
CHX: 102180100(ITGAM)
OAS: 443217(ITGAM)
SSC: 397459(ITGAM)
CFR: 102513083(ITGAM)
CDK: 105089721(ITGAM)
BACU: 103004729(ITGAM)
LVE: 103073578(ITGAM)
OOR: 101287801(ITGAM)
DLE: 111182295
PCAD: 102987095
ECB: 100064803(ITGAM)
EPZ: 103547251(ITGAM)
EAI: 106831877(ITGAM)
MYB: 102257478(ITGAM)
MNA: 107540812(ITGAM)
HAI: 109374167
DRO: 112304783(ITGAM)
PALE: 102889241(ITGAM)
RAY: 107506837(ITGAM)
MJV: 108400695(ITGAM)
TMU: 101357920
MDO: 100016833 100016871(ITGAM)
SHR: 100921679(ITGAM)
PCW: 110220501
OAA: 100085462
ACS: 100556984(itgam)
NPR: 108801695
DRE: 101882585(si:dkey-32n7.4)
SRX: 107708962
SANH: 107660450
SGH: 107562007
PHYP: 113527309
AMEX: 103046566
EEE: 113587515
PRET: 103481408
AOCE: 111581578
CSEM: 103381978
POV: 109644068
SDU: 111220319
SLAL: 111658703
HCQ: 109523946
SASA: 106579408
OTW: 112223837
SALP: 111977683
LCM: 102360838
RTP: 109923306
CIN: 100184061
 » show all
Reference
PMID:2457584
  Authors
Corbi AL, Kishimoto TK, Miller LJ, Springer TA
  Title
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
  Journal
J Biol Chem 263:12403-11 (1988)
  Sequence
[hsa:3684]
Reference
  Authors
Ding C, Ma Y, Chen X, Liu M, Cai Y, Hu X, Xiang D, Nath S, Zhang HG, Ye H, Powell D, Yan J
  Title
Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.
  Journal
Nat Commun 4:2813 (2013)
DOI:10.1038/ncomms3813

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