KEGG   ORTHOLOGY: K06498
Entry
K06498                      KO                                     

Name
FCGR1A, CD64
Definition
high affinity immunoglobulin gamma Fc receptor I
Pathway
ko04145  Phagosome
ko04380  Osteoclast differentiation
ko04640  Hematopoietic cell lineage
ko04666  Fc gamma R-mediated phagocytosis
ko05140  Leishmaniasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
ko05322  Systemic lupus erythematosus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
   04666 Fc gamma R-mediated phagocytosis
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
   05152 Tuberculosis
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
CD molecules [BR:ko04090]
 Proteins
  K06498  CD64, FCGR1A; Fc fragment of IgG, high affinity Ia, receptor for (CD64)
Other DBs
GO: 0019770
Genes
HSA: 2209(FCGR1A)
PTR: 457259
PPS: 100984157
GGO: 101151244
PON: 100431914
NLE: 100591598(FCGR1A)
MCC: 714664(FCGR1A)
MCF: 102147198(FCGR1A)
CSAB: 103247163
RRO: 104670100
RBB: 108538696
CJC: 100393738(FCGR1A)
SBQ: 101027415
MMU: 14129(Fcgr1)
MCAL: 110291166
MPAH: 110320097
RNO: 295279(Fcgr1a)
MUN: 110543586
CGE: 100774550(Fcgr1a)
NGI: 103742641(Fcgr1a)
HGL: 101725560
CCAN: 109677124
OCU: 100358696
TUP: 102492164(FCGR1A)
CFA: 403462(FCGR1A)
VVP: 112907678(FCGR1A)
AML: 100471819(FCGR1A)
UMR: 103667577(FCGR1A)
UAH: 113246145
ORO: 101381082
ELK: 111162063
FCA: 101087936
PTG: 102955538
PPAD: 109257074
AJU: 106982107
BTA: 282227(FCGR1A)
BOM: 102280754
BIU: 109555819
BBUB: 102410120
CHX: 102173987
OAS: 100192431(FCGR1A)
SSC: 613130(FCGR1A)
CFR: 102521148(FCGR1A)
CDK: 105103159
EPZ: 103540002
EAI: 106848287
MYB: 102249630
MYD: 102764315
MNA: 107545392
HAI: 109378026
DRO: 112314050
PALE: 102889680(FCGR1A)
RAY: 107504605(FCGR1A)
MJV: 108409964
LAV: 100654406(FCGR1B) 100654974(FCGR1A)
TMU: 101342556
MDO: 103093099(FCRL6)
OAA: 100093395
XLA: 108699133
NPR: 108802144
CCAR: 109113072
PHYP: 113543113
AMEX: 103021574
TRU: 101062846(fcer1a)
NCC: 104954275(fcer1a)
OLA: 101158714
XMA: 102220103
XCO: 114133593
KMR: 108240830
ALIM: 106519409
POV: 109630247
SDU: 111239819(fcer1a)
SLAL: 111654383
HCQ: 109518428
BPEC: 110163648
SASA: 106580961(FCGR1) 106612904(FCGR1) 106614022
ELS: 105027167
SFM: 108922389
 » show all
Reference
PMID:2974947
  Authors
Allen JM, Seed B
  Title
Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).
  Journal
Nucleic Acids Res 16:11824 (1988)
DOI:10.1093/nar/16.24.11824
  Sequence
[hsa:2209]
Reference
  Authors
Fossati G, Bucknall RC, Edwards SW
  Title
Fcgamma receptors in autoimmune diseases.
  Journal
Eur J Clin Invest 31:821-31 (2001)
DOI:10.1046/j.1365-2362.2001.00881.x

KEGG   ORTHOLOGY: K06472
Entry
K06472                      KO                                     

Name
FCGR2A, CD32
Definition
low affinity immunoglobulin gamma Fc receptor II-a
Pathway
ko04145  Phagosome
ko04380  Osteoclast differentiation
ko04611  Platelet activation
ko04666  Fc gamma R-mediated phagocytosis
ko05130  Pathogenic Escherichia coli infection
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H01360  Allergic rhinitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   04666 Fc gamma R-mediated phagocytosis
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   05135 Yersinia infection
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   05150 Staphylococcus aureus infection
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   05152 Tuberculosis
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
CD molecules [BR:ko04090]
 Proteins
  K06472  CD32a, FCGR2A; Fc fragment of IgG, low affinity IIa, receptor for (CD32)
Other DBs
GO: 0019770
Genes
HSA: 2212(FCGR2A)
PTR: 107973075 450194(FCGR2A)
PPS: 100991644(FCGR2A)
GGO: 101130688(FCGR2A)
PON: 100455333(FCGR2A)
NLE: 101176530(FCGR2A)
MCC: 719996(FCGR2A)
MCF: 102143568(FCGR2A)
CSAB: 103223676(FCGR2A)
RRO: 104669518(FCGR2A)
RBB: 108542586(FCGR2A)
CJC: 100387574(FCGR2A)
SBQ: 101040113(FCGR2A)
MCAL: 110288995
MPAH: 110321588
RNO: 498276
MUN: 110554429(Fcgr2a)
CGE: 103161891
NGI: 103746769(Fcgr2a)
HGL: 101700630(Fcgr2a)
CCAN: 109693506(Fcgr2a)
OCU: 100338413(FCGR2A)
BOM: 102274112
BIU: 109578180
OAS: 101106730
PCAD: 112062432
EPZ: 103540857 103540858(FCGR2A)
EAI: 106831113 106831115(FCGR2A)
MYB: 102263991
PALE: 102879478
RAY: 107502475
LAV: 104846329(FCGR2A)
TMU: 101350744
SANH: 107686749
TRU: 101072820
OLA: 105356322
XMA: 111611255
KMR: 112449806
SDU: 111239865
BPEC: 110172767
SASA: 106571983
ELS: 109615278
 » show all
Reference
PMID:2824655
  Authors
Stuart SG, Trounstine ML, Vaux DJ, Koch T, Martens CL, Mellman I, Moore KW
  Title
Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).
  Journal
J Exp Med 166:1668-84 (1987)
DOI:10.1084/jem.166.6.1668
  Sequence
[hsa:2212]
Reference
  Authors
Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, Sun PD
  Title
Structural recognition and functional activation of FcgammaR by innate pentraxins.
  Journal
Nature 456:989-92 (2008)
DOI:10.1038/nature07468

KEGG   ORTHOLOGY: K06463
Entry
K06463                      KO                                     

Name
FCGR3, CD16
Definition
low affinity immunoglobulin gamma Fc receptor III
Pathway
ko04145  Phagosome
ko04380  Osteoclast differentiation
ko04650  Natural killer cell mediated cytotoxicity
ko04666  Fc gamma R-mediated phagocytosis
ko05140  Leishmaniasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00090  NK cell defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04666 Fc gamma R-mediated phagocytosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   05152 Tuberculosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
CD molecules [BR:ko04090]
 Proteins
  K06463  CD16a, FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  K06463  CD16b, FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Receptors
  K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Other DBs
GO: 0019770
Genes
HSA: 2214(FCGR3A) 2215(FCGR3B)
PTR: 457457 745350
GGO: 101129837 101143892
PON: 100453994
NLE: 101176357
MCC: 720006(FCGR3)
MCF: 102140945(FCGR3)
CSAB: 103223675
RRO: 104671953
RBB: 108542585
CJC: 100387926
SBQ: 101040447
MMU: 246256(Fcgr4)
MCAL: 110299183
MPAH: 110322271
RNO: 116591(Fcgr2a) 304966(Fcgr3a)
MUN: 110554430
CGE: 103161892
NGI: 103746771
HGL: 101701607
CCAN: 109693505
TUP: 102499391(FCGR3B)
CFA: 478984
VVP: 112914295
AML: 100481923
UMR: 103658250
UAH: 113268656
ORO: 101363133
ELK: 111151151
FCA: 493677(FCGR3A)
PTG: 102959153
PPAD: 109276673(FCGR3A)
AJU: 106986773
BTA: 281766(FCGR3A)
BOM: 102273538
BIU: 109578151
BBUB: 102410092
CHX: 102185698
OAS: 100192433(FCGR3A)
SSC: 397684(FCGR3B)
CFR: 102516303
CDK: 105105185
BACU: 103008795
LVE: 103068717
OOR: 101270000
DLE: 111170413
PCAD: 102990877(FCGR3A)
ECB: 100051526
EPZ: 103540860(FCGR3A)
MYB: 102247789(FCGR3B)
MYD: 102754425(FCGR3A)
MNA: 107535119
HAI: 109392302
DRO: 112297203
PALE: 102893884
RAY: 107502476
LAV: 104846346
MDO: 100015157
SHR: 100924138(FCGR3B)
PCW: 110209910
XTR: 116406731
XMA: 111611195
XCO: 114156970
KMR: 112450140
AOCE: 111567090
ELS: 105009337
RTP: 109932873
 » show all
Reference
PMID:2526846
  Authors
Ravetch JV, Perussia B
  Title
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
  Journal
J Exp Med 170:481-97 (1989)
DOI:10.1084/jem.170.2.481
  Sequence
[hsa:2214 2215]
Reference
  Authors
Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B
  Title
Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.
  Journal
PLoS One 10:e0121788 (2015)
DOI:10.1371/journal.pone.0121788

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