KEGG   ORTHOLOGY: K06625
Entry
K06625                      KO                                     
Symbol
CDKN1A, P21, CIP1
Name
cyclin-dependent kinase inhibitor 1A
Pathway
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04012  ErbB signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04110  Cell cycle
map04115  p53 signaling pathway
map04151  PI3K-Akt signaling pathway
map04218  Cellular senescence
map04630  JAK-STAT signaling pathway
map04921  Oxytocin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H00030  Cervical cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04630 JAK-STAT signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04066 HIF-1 signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04068 FoxO signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04151 PI3K-Akt signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04115 p53 signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04218 Cellular senescence
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04928 Parathyroid hormone synthesis, secretion and action
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05202 Transcriptional misregulation in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05206 MicroRNAs in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05205 Proteoglycans in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05203 Viral carcinogenesis
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09162 Cancer: specific types
   05210 Colorectal cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05212 Pancreatic cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05225 Hepatocellular carcinoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05226 Gastric cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05214 Glioma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05216 Thyroid cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05220 Chronic myeloid leukemia
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05217 Basal cell carcinoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05218 Melanoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05211 Renal cell carcinoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05219 Bladder cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05215 Prostate cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05213 Endometrial cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05224 Breast cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05222 Small cell lung cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05223 Non-small cell lung cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05161 Hepatitis B
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05160 Hepatitis C
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05163 Human cytomegalovirus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05169 Epstein-Barr virus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05165 Human papillomavirus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   01522 Endocrine resistance
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
Other DBs
GO: 0004861
Genes
HSA: 1026(CDKN1A)
PTR: 104001067(CDKN1A)
PPS: 100977916(CDKN1A)
GGO: 101126640(CDKN1A)
PON: 100453682(CDKN1A)
NLE: 100599083(CDKN1A)
HMH: 116460475(CDKN1A)
MCC: 719199(CDKN1A)
MCF: 102136063(CDKN1A)
MTHB: 126952813
MNI: 105474528(CDKN1A)
CSAB: 103221583(CDKN1A)
CATY: 105592567(CDKN1A)
PANU: 100999911(CDKN1A)
TGE: 112623750(CDKN1A)
MLEU: 105544234(CDKN1A)
RRO: 104682880(CDKN1A)
RBB: 108528336(CDKN1A)
TFN: 117087134(CDKN1A)
PTEH: 111542983(CDKN1A)
CANG: 105514162(CDKN1A)
CJC: 100894215(CDKN1A)
SBQ: 101041919(CDKN1A)
CIMI: 108299987(CDKN1A)
CSYR: 103266974(CDKN1A)
MMUR: 105861439(CDKN1A)
LCAT: 123632883(CDKN1A)
PCOQ: 105812249(CDKN1A)
OGA: 100946725(CDKN1A)
MMU: 12575(Cdkn1a)
MCAL: 110283679(Cdkn1a)
MPAH: 110338236(Cdkn1a)
RNO: 114851(Cdkn1a)
MCOC: 116075178(Cdkn1a)
ANU: 117724897(Cdkn1a)
MUN: 110546586(Cdkn1a)
CGE: 103160601(Cdkn1a)
MAUA: 101826412(Cdkn1a)
PROB: 127224199(Cdkn1a)
PLEU: 114706157(Cdkn1a)
MORG: 121435589(Cdkn1a)
MFOT: 126502125
AAMP: 119823049(Cdkn1a)
NGI: 103739652(Cdkn1a)
HGL: 101710552(Cdkn1a)
CPOC: 100720449(Cdkn1a)
CCAN: 109696503(Cdkn1a)
DORD: 105995758(Cdkn1a)
DSP: 122111380(Cdkn1a)
PLOP: 125352645(Cdkn1a)
NCAR: 124989493
MMMA: 107143854(Cdkn1a)
OCU: 100348489
OPI: 101522490(CDKN1A)
TUP: 102490159(CDKN1A)
GVR: 103607313(CDKN1A)
CFA: 474890(CDKN1A)
CLUD: 112641497(CDKN1A)
VVP: 112913942(CDKN1A)
VLG: 121473591(CDKN1A)
NPO: 129512989(CDKN1A)
AML: 100484923(CDKN1A)
UMR: 103665536(CDKN1A)
UAH: 113243864(CDKN1A)
UAR: 123779575(CDKN1A)
ELK: 111147618
LLV: 125102743
MPUF: 101671066(CDKN1A)
MNP: 132018107(CDKN1A)
MLK: 131833891(CDKN1A)
NVS: 122907321(CDKN1A)
ORO: 101375107(CDKN1A)
EJU: 114222230(CDKN1A)
ZCA: 113927327(CDKN1A)
MLX: 118000822(CDKN1A)
NSU: 110575681(CDKN1A)
LWW: 102737261(CDKN1A)
FCA: 493943(CDKN1A)
PYU: 121029363(CDKN1A)
PCOO: 112862831(CDKN1A)
PBG: 122489448(CDKN1A)
PVIV: 125166021(CDKN1A)
LRUF: 124528296
PTG: 102964051(CDKN1A)
PPAD: 109271531(CDKN1A)
PUC: 125938307
AJU: 106972797
HHV: 120233834(CDKN1A)
BTA: 513497(CDKN1A)
BOM: 102268672(CDKN1A)
BIU: 109577247(CDKN1A)
BBUB: 102403077(CDKN1A)
BBIS: 104994949(CDKN1A)
CHX: 102179898(CDKN1A)
OAS: 100302083(CDKN1A)
BTAX: 128056953(CDKN1A)
ODA: 120870199(CDKN1A)
CCAD: 122429747(CDKN1A)
MBEZ: 129543530(CDKN1A)
SSC: 100152215(CDKN1A)
CFR: 102509404(CDKN1A)
CBAI: 105064166(CDKN1A)
CDK: 105101330(CDKN1A)
VPC: 102538980(CDKN1A)
BACU: 103005082(CDKN1A)
BMUS: 118903446(CDKN1A)
LVE: 103080733(CDKN1A)
OOR: 101288384(CDKN1A)
DLE: 111178743(CDKN1A)
PCAD: 102995437(CDKN1A)
PSIU: 116762584(CDKN1A)
NASI: 112414074(CDKN1A)
ECB: 100064022(CDKN1A)
EPZ: 103564535(CDKN1A)
EAI: 106824579(CDKN1A)
MYB: 102245891(CDKN1A)
MYD: 102773038(CDKN1A)
MMYO: 118659964(CDKN1A)
MLF: 102439094(CDKN1A)
PKL: 118705573(CDKN1A)
EFUS: 103295571(CDKN1A)
MNA: 107545578(CDKN1A)
DRO: 112302262(CDKN1A)
SHON: 118998962(CDKN1A)
AJM: 119050063(CDKN1A)
PDIC: 114494317(CDKN1A)
PHAS: 123822234(CDKN1A)
MMF: 118621843(CDKN1A)
PPAM: 129067419(CDKN1A)
HAI: 109395991(CDKN1A)
RFQ: 117020319(CDKN1A)
PALE: 102894049(CDKN1A)
PGIG: 120597553(CDKN1A)
PVP: 105288383(CDKN1A)
RAY: 107514682(CDKN1A)
TOD: 119252397(CDKN1A)
SARA: 101543917(CDKN1A)
LAV: 100671706(CDKN1A)
TMU: 101342008
ETF: 101660587(CDKN1A)
DNM: 101423941(CDKN1A)
MDO: 100029103(CDKN1A)
GAS: 123243800(CDKN1A)
SHR: 100926666(CDKN1A)
AFZ: 127561515
PCW: 110217257(CDKN1A)
OAA: 114813305(CDKN1A)
GGA: 101751545(CDKN1AL) 378914(CDKN1A)
PCOC: 116235198 116236924(CDKN1A)
MGP: 104912467 104914505(CDKN1A)
CJO: 107324690(CDKN1A)
TPAI: 128084456 128088168(CDKN1A)
LMUT: 125684119(CDKN1A) 125697108
NMEL: 110388091(CDKN1A)
APLA: 101796138 119713915(CDKN1A)
ACYG: 106031068 106048467(CDKN1A)
CATA: 118250064 118260390(CDKN1A)
AFUL: 116488021 116498917(CDKN1A)
TGU: 105759380(CDKN1A)
LSR: 110473068(CDKN1A)
SCAN: 103822335(CDKN1A)
PMOA: 120497652(CDKN1A)
OTC: 121345675(CDKN1A)
PRUF: 121349774(CDKN1A)
GFR: 102041135(CDKN1A)
FAB: 101811025(CDKN1A)
OMA: 130263778(CDKN1A)
PHI: 102112135(CDKN1A)
PMAJ: 107214716(CDKN1A)
CCAE: 111944648(CDKN1A)
CCW: 104692419(CDKN1A)
CBRC: 103619064(CDKN1A)
ETL: 114064409(CDKN1A)
ZAB: 102066168(CDKN1A)
ACHL: 103806291(CDKN1A)
SVG: 106851078(CDKN1A)
MMEA: 130578867(CDKN1A)
HRT: 120762768(CDKN1A)
FCH: 114014226(CDKN1A)
CLV: 102096820(CDKN1A)
NNI: 104010373(CDKN1A) 104012649
EHS: 104515602
ACUN: 113488931(CDKN1A) 113491306(CDKN1B)
TALA: 104367221(CDKN1A)
PADL: 103917239 103925936(CDKN1A)
AFOR: 103906559 103908252(CDKN1A)
ACHC: 115335243(CDKN1A) 115352787
HLE: 104836625 104842341(CDKN1A)
CSTI: 104561665
MUI: 104547174(CDKN1A) 104548622(CDKN1B)
LDI: 104351310(CDKN1A) 104351847
MNB: 103767892(CDKN1A)
OHA: 104328113(CDKN1A) 104334557
NNT: 104401887
SHAB: 115602356(CDKN1A)
DPUB: 104302162(CDKN1A)
ACAR: 104523170
CPEA: 104392040(CDKN1A)
CVF: 104281747 104292373(CDKN1A)
RTD: 128900424(CDKN1A) 128904447
CUCA: 104062281(CDKN1A) 104066609
BRHI: 104491112
AAM: 106484396(CDKN1A) 106488969
AROW: 112961449(CDKN1A) 112976484
NPD: 112942339 112944638(CDKN1A)
TGT: 104564318(CDKN1A) 104568068
DNE: 112990262(CDKN1A) 112991556
SCAM: 104142556(CDKN1A) 104146605
ASN: 102368723(CDKN1B) 102379358(CDKN1A)
AMJ: 102567302(CDKN1D) 102568235(CDKN1A)
CPOO: 109316307 109317512(CDKN1A)
GGN: 109295209(CDKN1A) 109296542
PSS: 102450716(CDKN1A) 102453637
CMY: 102939737(CDKN1A) 102940507
CCAY: 125624087 125624994(CDKN1A)
DCC: 119846253(CDKN1A) 119858218
CPIC: 101938764(CDKN1A)
TST: 117875921(CDKN1A) 117884239
CABI: 116838036 116839143(CDKN1A)
MRV: 120403691(CDKN1A) 120406125
ACS: 100555337(cdkn1a) 103281026
ASAO: 132773722(CDKN1A) 132776448
PVT: 110075002 110079972(CDKN1A)
SUND: 121928569(CDKN1A)
PBI: 103052025(CDKN1A) 103053360
PMUR: 107286965 107287054(CDKN1A)
CTIG: 120298948(CDKN1A) 120313065
TSR: 106541210(CDKN1A)
APRI: 131194735(CDKN1A) 131202097
VKO: 123017180 123030233(CDKN1A)
PMUA: 114596769 114599215(CDKN1A)
PRAF: 128413509 128416001(CDKN1A)
ZVI: 118088627(CDKN1A)
HCG: 128322404(CDKN1A) 128328365
GJA: 107111179 107117358(CDKN1A)
STOW: 125432942(CDKN1A) 125443880
EMC: 129330747(CDKN1A)
XLA: 108709405(cdkn1a.S) 492305(cdkn1a.L)
XTR: 100038054(cdkn1a)
BGAR: 122930287(CDKN1A)
MUO: 115478187 115481415(CDKN1A)
GSH: 117347696(CDKN1A) 117363998
DRE: 100151416(cdkn1a) 100151464(cdkn1d)
PTET: 122328011(cdkn1a) 122342555(cdkn1d)
LROH: 127153631(cdkn1a) 127164043(cdkn1d)
OMC: 131529620(cdkn1a) 131538564(cdkn1d)
RKG: 130072760(cdkn1a) 130092497(cdkn1d)
MAMB: 125244770(cdkn1d) 125263043(cdkn1a)
TROS: 130548969(cdkn1a) 130551066(cdkn1d)
TDW: 130420357(cdkn1d) 130430006(cdkn1a)
MANU: 129432155(cdkn1d) 129453256(cdkn1a)
IPU: 108281086
IFU: 128624820(cdkn1a)
SMEO: 124401027(cdkn1d) 124402343(cdkn1a)
TFD: 113645801(cdkn1d) 113648726(cdkn1a)
TVC: 132838038(cdkn1a) 132859128(cdkn1d)
AMEX: 103041774 103047217(cdkn1a)
CMAO: 118799630(cdkn1a) 118812411(cdkn1d)
EEE: 113573558 113586971(cdkn1a)
CHAR: 105897856(cdkn1a)
TFS: 130518885(cdkn1d) 130524552(cdkn1a)
TBEN: 117483300(cdkn1d) 117490010(cdkn1a)
PGEO: 117439119(cdkn1d) 117446925(cdkn1a)
GACU: 117551026(cdkn1a) 117558263(cdkn1d)
EMAC: 134879422(cdkn1d) 134883598(cdkn1a)
ELY: 117249374(cdkn1d) 117256340(cdkn1a)
EFO: 125882802(cdkn1d) 125896012(cdkn1a)
PLEP: 121951189(cdkn1a) 121961391(cdkn1d)
SLUC: 116039798(cdkn1d) 116041628(cdkn1a)
ECRA: 117938774(cdkn1d) 117943283(cdkn1a)
GAT: 120817084(cdkn1d) 120834939(cdkn1a)
PPUG: 119210451(cdkn1d) 119229970(cdkn1a)
AFB: 129106138(cdkn1a) 129112406(cdkn1d)
CLUM: 117725992(cdkn1d) 117731143(cdkn1a)
PSWI: 130200673(cdkn1d) 130208340(cdkn1a)
MSAM: 119886232(cdkn1a) 119918434(cdkn1d)
SCHU: 122861465(cdkn1a) 122871065(cdkn1d)
CUD: 121505410(cdkn1d) 121529301(cdkn1a)
ALAT: 119021974(cdkn1a) 119032388(cdkn1d)
OAU: 116328712(cdkn1d) 116333861(cdkn1a)
OML: 112144588(cdkn1a) 112158072
CSAI: 133423997(cdkn1d) 133449348(cdkn1a)
GAF: 122826725(cdkn1d) 122834621(cdkn1a)
PPRL: 129355840(cdkn1a) 129376091
CTUL: 119776254(cdkn1d) 119779949(cdkn1a)
GMU: 124857035(cdkn1a) 124882752(cdkn1d)
KMR: 108241005(cdkn1d) 112450491(cdkn1a)
NWH: 119412508(cdkn1a) 119427997(cdkn1d)
MCEP: 124999875(cdkn1d) 125007346(cdkn1a)
CSEM: 103385882
SSEN: 122766651(cdkn1d) 122767616(cdkn1a)
HHIP: 117757274(cdkn1d) 117761857(cdkn1a)
HSP: 118101413(cdkn1d) 118105387(cdkn1a)
SMAU: 118309289(cdkn1a) 118319569(cdkn1d)
LCF: 108886473 108890605(cdkn1d)
XGL: 120800817(cdkn1d) 120806924(cdkn1a)
SBIA: 133493513 133508026(cdkn1a)
PEE: 133397246 133408755(cdkn1a)
PTAO: 133471923 133483272(cdkn1a)
BPEC: 110168634
MALB: 109971122
BSPL: 114856254(cdkn1a) 114862126(cdkn1d)
SJO: 128353371(cdkn1d) 128356198(cdkn1a)
OMY: 110490248(cdkn1d) 110494354(cdkn1a) 110500225 110528083
AANG: 118210628(cdkn1a) 118232094(cdkn1d)
LOC: 102697870(cdkn1a)
ARUT: 117419487(cdkn1d) 117964374(cdkn1a)
PSEX: 120526216(cdkn1a)
LCM: 102361382(CDKN1A)
CMK: 103179079 103179335(cdkn1d)
LERI: 129708793(cdkn1a)
PMRN: 116939934
LRJ: 133350294
HVI: 124357969
ABRU: 129989154
RPHI: 132724436
 » show all
Reference
  Authors
Abbas T, Dutta A
  Title
p21 in cancer: intricate networks and multiple activities.
  Journal
Nat Rev Cancer 9:400-14 (2009)
DOI:10.1038/nrc2657
Reference
PMID:8242751
  Authors
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ
  Title
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
  Journal
Cell 75:805-16 (1993)
DOI:10.1016/0092-8674(93)90499-G
  Sequence
[hsa:1026]

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