| Entry |
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| Name |
diaminobutyrate acetyltransferase;
L-2,4-diaminobutyrate acetyltransferase;
L-2,4-diaminobutanoate acetyltransferase;
EctA;
diaminobutyric acid acetyltransferase;
DABA acetyltransferase;
2,4-diaminobutanoate acetyltransferase;
DAB acetyltransferase;
DABAcT;
acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + L-2,4-diaminobutanoate = CoA + (2S)-4-acetamido-2-aminobutanoate [RN: R06978]
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| Reaction(KEGG) |
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| Substrate |
acetyl-CoA [CPD: C00024];
L-2,4-diaminobutanoate [CPD: C03283]
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| Product |
CoA [CPD: C00010];
(2S)-4-acetamido-2-aminobutanoate [CPD: C06442]
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| Comment |
Requires Na+ or K+ for maximal activity [3]. Ornithine, lysine, aspartate, and alpha-, beta- and gamma-aminobutanoate cannot act as substrates [3]. However, acetyl-CoA can be replaced by propanoyl-CoA, although the reaction proceeds more slowly [3]. Forms part of the ectoine-biosynthesis pathway.
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| History |
EC 2.3.1.178 created 2006
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| Pathway |
| ec00260 | Glycine, serine and threonine metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K06718 | L-2,4-diaminobutyric acid acetyltransferase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Peters, P., Galinski, E.A. and Truper, H.G. |
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| Title |
The biosynthesis of ectoine. |
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| Journal |
FEMS Microbiol Lett 71:157-162 (1990) |
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| Reference |
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| Authors |
Ono H, Sawada K, Khunajakr N, Tao T, Yamamoto M, Hiramoto M, Shinmyo A, Takano M, Murooka Y. |
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| Title |
Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Reshetnikov AS, Mustakhimov II, Khmelenina VN, Trotsenko YA. |
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| Title |
Cloning, purification, and characterization of diaminobutyrate acetyltransferase from the halotolerant methanotroph Methylomicrobium alcaliphilum 20Z. |
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| Journal |
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| Reference |
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| Authors |
Kuhlmann AU, Bremer E. |
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| Title |
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Louis P, Galinski EA. |
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| Title |
Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.178 |
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