KEGG   ORTHOLOGY: K06751
Entry
K06751                      KO                                     
Symbol
MHC1
Name
MHC class I antigen
Pathway
map04144  Endocytosis
map04145  Phagosome
map04218  Cellular senescence
map04514  Cell adhesion molecules
map04612  Antigen processing and presentation
map04940  Type I diabetes mellitus
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05203  Viral carcinogenesis
map05320  Autoimmune thyroid disease
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05416  Viral myocarditis
Disease
H00079  Asthma
H01507  Seronegative arthritis
H01563  HIV infection
H01656  Psoriasis
H01674  Ankylosing spondylitis
H01694  Stevens-Johnson syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06751  MHC1; MHC class I antigen
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K06751  MHC1; MHC class I antigen
   04145 Phagosome
    K06751  MHC1; MHC class I antigen
  09143 Cell growth and death
   04218 Cellular senescence
    K06751  MHC1; MHC class I antigen
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06751  MHC1; MHC class I antigen
   04612 Antigen processing and presentation
    K06751  MHC1; MHC class I antigen
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K06751  MHC1; MHC class I antigen
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06751  MHC1; MHC class I antigen
   05170 Human immunodeficiency virus 1 infection
    K06751  MHC1; MHC class I antigen
   05168 Herpes simplex virus 1 infection
    K06751  MHC1; MHC class I antigen
   05163 Human cytomegalovirus infection
    K06751  MHC1; MHC class I antigen
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06751  MHC1; MHC class I antigen
   05169 Epstein-Barr virus infection
    K06751  MHC1; MHC class I antigen
   05165 Human papillomavirus infection
    K06751  MHC1; MHC class I antigen
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K06751  MHC1; MHC class I antigen
   05330 Allograft rejection
    K06751  MHC1; MHC class I antigen
   05332 Graft-versus-host disease
    K06751  MHC1; MHC class I antigen
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06751  MHC1; MHC class I antigen
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K06751  MHC1; MHC class I antigen
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06751  MHC1; MHC class I antigen
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06751  MHC1; MHC class I antigen
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K06751  MHC1; MHC class I antigen
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Antigens
  K06751  MHC1; MHC class I antigen
Genes
HSA: 3105(HLA-A) 3106(HLA-B) 3107(HLA-C) 3133(HLA-E) 3134(HLA-F) 3135(HLA-G)
PTR: 100169977(PATR-F) 450202(PATR-B) 462540(PATR-E) 471948 471962(PATR-C) 494187(PATR-G) 750725(PATR-A)
PPS: 100977055 100978112(Papa-A) 100978457 100978774 100979338 100982294 100982859 100993452
GGO: 101141279 101142134 101142998 101143108 101143843(MHC-G) 101143844 101144465 101153360 115930068
PON: 100173719(DKFZP469M1914) 100189734(DKFZP469I0912) 100432875 100435133 100435866 100438533 100440558 100449631 100450716 100456603
PPYG: 129037895 129038112 129038113 129038117 129038150 129039297 129039300 129039301 129039302 129039303 134739790
NLE: 100579523 100587765 100588639 100591000 100592911 100602874 115830427
HMH: 116459773 116460053 116460055 116460058 116460103
SSYN: 129473036 129473817 129473821 129473822 129473824 129473827
MCC: 100187576(MAMU-AG) 100424348 100426197 106995452 106996627 106996676 106997893 114676051 114677644 694372 699243(MAMU-A3) 709076(MAMU-F) 711532(MAMU-E) 711832(MAMU-A) 714964 719250 719702 720132 723473
MMU: 100529082(H2-T27) 110557(H2-Q6) 110558(H2-Q9) 110696(H2-M10.3) 14963(H2-Bl) 14964(H2-D1) 14972(H2-K1) 14980(H2-L) 14985(H2-M10.1) 14990(H2-M2) 14991(H2-M3) 14997(H2-M9) 15006(H2-Q1) 15007(H2-Q10) 15013(H2-Q2) 15015(H2-Q4) 15018(H2-Q7) 15024(H2-T10) 15039(H2-T22) 15040(H2-T23) 15042(H2-T24) 15043(H2-T3) 224753(H2-M10.4) 224754(H2-M11) 224756(H2-M1) 224761(H2-M10.5) 240095(H2-M5) 333715(H2-M10.2) 399549(H2-M10.6) 547349(H2-K1) 630294(H2-T25) 667977(H2-T26) 69717(Gm10499)
RNO: 102546590(H2-M10.6l) 24747(RT1-M3-1) 24750(RT1-N3) 24751(RT1-O1) 24973(RT1-A1) 24974(RT1-A2) 24988(RT1-M2) 294213(RT1-M1-4) 294228(RT1-S3) 309584(RT1-M4) 309600(RT1-CE12) 309603(RT1-CE1) 309607(RT1-CE5) 309627(RT1-A3) 360323(RT1-N2) 361787(RT1-T24-1) 365527(RT1-M6-2) 368153(RT1-CE7) 406194(RT1-T18) 414779(RT1-CE2) 414783(RT1-CE4) 414784(RT1-T24-4) 414785(RT1-M6-1) 414786(RT1-M1-2) 414788(RT1-T24-3) 414789(RT1-CE15) 414790(RT1-CE13) 414791(RT1-CE11) 414792(RT1-CE10) 414793(RT1-CE3) 414819(RT1-CE16) 499400(RT1-M5) 680842(RT1-M1-5)
HGL: 101721592
CFA: 100685196 474836(DLA88) 474838(DLA-64) 483594(DLA-79) 541592(DLA-12)
AML: 100465524 100466374 100470568(AIME-128) 100476691(AIME-152) 100483904(AIME-1906) 105241843 109488766
BTA: 407173(JSP.1) 507917 510417(BOLA-NC1) 512672 515712(BOLA) 533050(BoLA) 616942 767904(MGC126945)
SSC: 100037288(SLA-3) 100037293(SLA-1) 100135029(SLA-5) 100135031(SLA-2) 100135036(SLA-8) 100135037(SLA-6) 396650(SLA-7)
MDO: 100009719(MHC-I) 100024719(Mhc-1) 100026156(MODO-UM) 100026178(MODO-UE) 100026665(MODO-UJ) 100026781(MODO-UI) 100026802(Modo-UA) 100026822(MODO-UK) 103092123(Modo-UT5) 103092429(Modo-UT6) 103093835 103093918(Modo-UT9) 103094094(Modo-UT10) 103094634 103095253 103096009(Modo-UT15) 103103471 103106169 103106351(Modo-UT3) 107651120 107651418 751097(MHC-1) 780946(MODO-UG) 790902(MODO-UB) 790903(MODO-UC)
GGA: 100859134(HLA-F10AL4) 100859374(MHCIA2) 107049124 107050538 417057(MHCIA6) 417067(MICA) 425389(BF2) 427746(YF5) 430600(MHCIA7) 693260(BF1)
CJO: 107321563
CATA: 118260299
TGU: 100231469
LSR: 110483779
OTC: 121343095
PRUF: 121359110
GFR: 102034923(FCGRT) 102039800
CCW: 120412176
CBRC: 103617075
FPG: 101924893
NNT: 104406923
ACUN: 113490617
AGEN: 126034962
BRHI: 104490707
NNI: 104009142
PCRI: 104025148
PADL: 103914226
CLV: 102084942
MUI: 104535842
TEO: 104372145
CPEA: 104385235
CVF: 104292679
NPD: 112954975
SCAM: 104152267
DRE: 393377(mhc1uja) 393557(mhc1uxa2) 64885(mhc1uea) 767703(mhc1uha) 791453(mhc1zba)
PTET: 122335310
CERY: 137037831
CSEM: 103393860
SASA: 106569843 106569935 106569936(Sasa-ZCA) 106569938(Sasa-ZBA) 106569947(Sasa-UGA) 106582436(Sasa-UHA) 106588377(HA1L) 106588378 106588380(Sasa-ZE) 106588381(Sasa-ZAA) 106588401(Sasa-UBA) 106588402(Sasa-UBA) 106592784 106597015 106597513 106599071
LCM: 102345098(Lach-UX-02) 102345904(Lach-UB-05) 102348044 102348567(Lach-UC-01) 102351815(Lach-UB-02) 102354307 102356466 102356482 102360930 102365553(Lach-UD-01) 102365812 102365873 106706643(Lach-UB-05)
CMK: 103189724
 » show all
Reference
  Authors
Belicha-Villanueva A, Blickwedehl J, McEvoy S, Golding M, Gollnick SO, Bangia N
  Title
What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?
  Journal
Immunol Res 46:32-44 (2010)
DOI:10.1007/s12026-009-8123-8
Reference
  Authors
Sleiman M, Brons NH, Kaoma T, Dogu F, Villa-Forte A, Lenoble P, Hentges F, Kotsch K, Gadola SD, Vilches C, Zimmer J
  Title
NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.
  Journal
J Immunol 192:2602-10 (2014)
DOI:10.4049/jimmunol.1302843
  Sequence
[hsa:3105 3106 3107]
Reference
PMID:2715640
  Authors
Parham P, Lawlor DA, Lomen CE, Ennis PD
  Title
Diversity and diversification of HLA-A,B,C alleles.
  Journal
J Immunol 142:3937-50 (1989)
  Sequence
[hsa:3105 3106 3107]

KEGG   ORTHOLOGY: K06752
Entry
K06752                      KO                                     
Symbol
MHC2
Name
MHC class II antigen
Pathway
map04145  Phagosome
map04514  Cell adhesion molecules
map04612  Antigen processing and presentation
map04640  Hematopoietic cell lineage
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04672  Intestinal immune network for IgA production
map04940  Type I diabetes mellitus
map05140  Leishmaniasis
map05145  Toxoplasmosis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05164  Influenza A
map05166  Human T-cell leukemia virus 1 infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05310  Asthma
map05320  Autoimmune thyroid disease
map05321  Inflammatory bowel disease
map05322  Systemic lupus erythematosus
map05323  Rheumatoid arthritis
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05416  Viral myocarditis
Disease
H00079  Asthma
H00080  Systemic lupus erythematosus
H00083  Allograft rejection
H00294  Dilated cardiomyopathy
H00342  Tuberculosis
H00408  Type 1 diabetes mellitus
H00630  Rheumatoid arthritis
H01362  Dermatitis herpetiformis
H01490  Multiple sclerosis
H01504  Vogt-Koyanagi-Harada syndrome
H02123  Celiac disease
H02424  Primary central nervous system lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06752  MHC2; MHC class II antigen
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06752  MHC2; MHC class II antigen
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06752  MHC2; MHC class II antigen
   04612 Antigen processing and presentation
    K06752  MHC2; MHC class II antigen
   04658 Th1 and Th2 cell differentiation
    K06752  MHC2; MHC class II antigen
   04659 Th17 cell differentiation
    K06752  MHC2; MHC class II antigen
   04672 Intestinal immune network for IgA production
    K06752  MHC2; MHC class II antigen
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06752  MHC2; MHC class II antigen
   05164 Influenza A
    K06752  MHC2; MHC class II antigen
   05168 Herpes simplex virus 1 infection
    K06752  MHC2; MHC class II antigen
   05169 Epstein-Barr virus infection
    K06752  MHC2; MHC class II antigen
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06752  MHC2; MHC class II antigen
   05152 Tuberculosis
    K06752  MHC2; MHC class II antigen
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K06752  MHC2; MHC class II antigen
   05140 Leishmaniasis
    K06752  MHC2; MHC class II antigen
  09163 Immune disease
   05310 Asthma
    K06752  MHC2; MHC class II antigen
   05322 Systemic lupus erythematosus
    K06752  MHC2; MHC class II antigen
   05323 Rheumatoid arthritis
    K06752  MHC2; MHC class II antigen
   05320 Autoimmune thyroid disease
    K06752  MHC2; MHC class II antigen
   05321 Inflammatory bowel disease
    K06752  MHC2; MHC class II antigen
   05330 Allograft rejection
    K06752  MHC2; MHC class II antigen
   05332 Graft-versus-host disease
    K06752  MHC2; MHC class II antigen
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06752  MHC2; MHC class II antigen
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K06752  MHC2; MHC class II antigen
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06752  MHC2; MHC class II antigen
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06752  MHC2; MHC class II antigen
  Exosomal proteins of epithelial cells
   K06752  MHC2; MHC class II antigen
  Exosomal proteins of breast milk
   K06752  MHC2; MHC class II antigen
Genes
HSA: 3108(HLA-DMA) 3109(HLA-DMB) 3111(HLA-DOA) 3112(HLA-DOB) 3113(HLA-DPA1) 3115(HLA-DPB1) 3117(HLA-DQA1) 3118(HLA-DQA2) 3119(HLA-DQB1) 3122(HLA-DRA) 3123(HLA-DRB1) 3125(HLA-DRB3) 3126(HLA-DRB4) 3127(HLA-DRB5)
PTR: 100608816(MAMU-DMA) 100610904 100616520 104006793 449592(PATR-DMB) 462591(PATR-DRA) 462592(PATR-DRB5) 462594(PATR-DQB1) 462598(PATR-DPA1) 462599(PATR-DPB1) 471974(PATR-DQA1) 471976(PATR-DQA2) 471977(PATR-DOB)
PPS: 100967723 100968410(MHC-DMB) 100968989 100970847 100972641 100972994 100973583 100979649 100986750 100987081 100995226 100995577 134730587
GGO: 101128237 101131235 101132303 101133052 101133995 101134815 101137108 101139685 101140024(MHC-DMB) 101140641 101141025 101141395 109027175 115935014 134758703
PON: 100438181 100442586 100442956 100443317 100444477 100448112 100448477 100452885 100453254 100456477 100457574 100458290 100460187
PPYG: 129038027 129038028 129038029 129038031 129038032 129038210 129038211 129038212 129039023 129039456 129039458 129039459 129039460 129039609 129039611
NLE: 100579397 100581510 100584042 100601771 100602317 100602659 100602736 100602990 100603340 100603684 100606472 100606816 100607501 100607843
HMH: 116460144 116460248 116460249 116460315 116460316 116460317 116460318 116460319 116460327 116460328 116460329 116460331 116460420
SSYN: 129472866 129472868 129472884 129472885 129472887 129472888 129473012 129473013 129473271 129473394 129473399 129473414 129473425 134735693
MCC: 100187587(MAMU-DRA) 100428228(MAMU-DRB5) 100428435 100429857(MAMU-DMB) 106997902 114669810 114675357 692100(MAMU-DRB1) 716823(MAMU-DQB1) 717702(MAMU-DOB) 717870(MAMU-DMA) 717947(MAMU-DOA) 717969(MAMU-DPB) 717992(MAMU-DPA) 720582(MAMU-DQA1)
CSAB: 103221682(MHC-DPB1) 103221683(MHC-DPA1) 103221684(MHC-DOA) 103221688(MHC-DMA) 103221689(MHC-DMB) 103221695(MHC-DOB) 103221696(MHC-DQB1) 103221698(MHC-DQA1) 103221700 103221702 103221704(MHC-DRA) 103247136 103247138 103247148
CJC: 100385427(CAJA-DRA) 100386155(CAJA-DRB1) 100386865 100387227 100397732 100405222 100407771(CAJA-DMA) 100408132(CAJA-DOA) 100408503(CAJA-DPB1) 100411388 100412691(CAJA-DMB) 100413648(CAJA-DPA1) 128931734
MMU: 100504404(H2-Ea) 14960(H2-Aa) 14961(H2-Ab1) 14969(H2-Eb1) 14998(H2-DMa) 14999(H2-DMb1) 15000(H2-DMb2) 15001(H2-Oa) 15002(H2-Ob) 381091(H2-Eb2)
RNO: 24981(RT1-Db2) 24984(RT1-DOa) 24986(RT1-Ha) 294269(RT1-Da) 294270(RT1-Db1) 294273(RT1-DMb) 294274(RT1-DMa) 309621(RT1-Ba) 309622(RT1-Bb) 365542(RT1-DOb)
CFA: 100856137 474860(HLA-DRB1) 474869(DLA-DOA) 481731(DLA-DRA) 481732(DLA-DMA) 607786(DLA-DOB) 607827(DLA-DMB)
BTA: 100848815 282490(BOLA-DMA) 282491(BOLA-DMB) 282493(BOLA-DOB) 282494(BOLA-DQA5) 282495(BOLA-DQB) 282497(BOLA-DYA) 282498(BOLA-DYB) 282530(BOLA-DRB3) 282535(BOLA-DQA2) 506214(BOLA-DRA) 525727(BOLA-DOA) 538700(BOLA-DRB2) 539241(BLA-DQB) 618722(DSB)
SSC: 100037921(SLA-DQB1) 100135040(SLA-DRA) 100135049(SLA-DOB) 100135050(SLA-DMB) 100153386(SLA-DRB1) 100153387(SLA-DQA1) 100157996(SLA-DOA) 106504372 445528(SLA-DMA)
GGA: 101747454(BLB2) 101748499(MHCBL2) 107057103 417050(MHCDMA) 417051(DMB2) 425256(BLB3) 430189(BLA) 693256(BLB1)
CCW: 120412174
ACHL: 103803394
FPG: 101911209(Fape-DAB) 101911566 101920105
CCRI: 104169148
HALD: 104323948
GCL: 127027075
CSTI: 104554940
LDI: 104354370
BRHI: 104500978
GSTE: 104259360
CUCA: 104054230
TEO: 104382030
CPOO: 109306820
GGN: 109303386
XLA: 100037177 108698550(XB5827395.L) 108698551 373671(eladab-a) 373678(hla-dqa2.L) 399001(mhc2a.S) 495464
XTR: 100127727(hla-dqa1) 100145508 100495183 100495336(mhc2a)
DRE: 103911540(mhc2dhb) 30762(mhc2dab) 30763(mhc2dcb) 30783(mhc2a) 368614(mhc2dga) 368615(mhc2dgb) 368816(si:busm1-194e12.8) 368877(si:busm1-266f07.1) 368878(mhc2daa) 571282 64691(mhc2a1) 795595(si:dkey-33b17.1)
MANU: 129414229 129414280 129414285 129448765(si:ch73-31d8.2)
PGEO: 117451690
LERI: 129694455
ATEN: 116305295
 » show all
Reference
  Authors
Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC
  Title
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.
  Journal
Genes Immun 11:99-112 (2010)
DOI:10.1038/gene.2009.83
Reference
PMID:8849454
  Authors
Weber DA, Evavold BD, Jensen PE
  Title
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
  Journal
Science 274:618-20 (1996)
DOI:10.1126/science.274.5287.618
  Sequence
[hsa:3109]
Reference
PMID:1922365
  Authors
Kelly AP, Monaco JJ, Cho SG, Trowsdale J
  Title
A new human HLA class II-related locus, DM.
  Journal
Nature 353:571-3 (1991)
DOI:10.1038/353571a0
  Sequence
[hsa:3108]

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