KEGG   ORTHOLOGY: K07205
Entry
K07205                      KO                                     

Name
EIF4EBP1
Definition
eukaryotic translation initiation factor 4E binding protein 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko03013  RNA transport
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04910  Insulin signaling pathway
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05168  Herpes simplex virus 1 infection
ko05221  Acute myeloid leukemia
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 RNA transport
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04066 HIF-1 signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04151 PI3K-Akt signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04152 AMPK signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04150 mTOR signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  09149 Aging
   04211 Longevity regulating pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   05163 Human cytomegalovirus infection
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   05165 Human papillomavirus infection
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
Other DBs
GO: 0008190
Genes
HSA: 1978(EIF4EBP1)
PTR: 464114(EIF4EBP1)
PPS: 100972246(EIF4EBP1)
GGO: 101145454(EIF4EBP1)
PON: 100455169(EIF4EBP1)
NLE: 105740136(EIF4EBP1)
MCC: 703628(EIF4EBP1)
MCF: 102132583(EIF4EBP1)
CSAB: 103215636(EIF4EBP1)
RRO: 104679650(EIF4EBP1)
RBB: 108513587(EIF4EBP1)
CJC: 100386453(EIF4EBP1)
SBQ: 101029508(EIF4EBP1) 101030055
MMU: 13685(Eif4ebp1)
MCAL: 110300284(Eif4ebp1) 110305658
MPAH: 110336761(Eif4ebp1)
RNO: 116636(Eif4ebp1)
MUN: 110550200(Eif4ebp1)
CGE: 100769654(Eif4ebp1)
HGL: 101710614(Eif4ebp1)
CCAN: 109688934(Eif4ebp1)
OCU: 100338850(EIF4EBP1)
TUP: 102494657(EIF4EBP1)
CFA: 475590(EIF4EBP1)
VVP: 112916127(EIF4EBP1)
AML: 100469745(EIF4EBP1)
UMR: 103659121(EIF4EBP1)
UAH: 113262099(EIF4EBP1)
ORO: 101386736(EIF4EBP1)
ELK: 111144538
FCA: 101088571(EIF4EBP1)
PTG: 102961839(EIF4EBP1)
PPAD: 109262313(EIF4EBP1)
AJU: 106978406(EIF4EBP1)
BTA: 509613(EIF4EBP1)
BOM: 102278368(EIF4EBP1)
BIU: 109553533(EIF4EBP1)
BBUB: 112582961(EIF4EBP1)
CHX: 100861234(EIF4EBP1)
OAS: 101111426(EIF4EBP1)
SSC: 100627508(EIF4EBP1)
CFR: 102520195(EIF4EBP1)
CDK: 105089940(EIF4EBP1)
BACU: 103018352(EIF4EBP1)
LVE: 103074746(EIF4EBP1)
OOR: 101277165(EIF4EBP1)
DLE: 111173509(EIF4EBP1)
PCAD: 102995068(EIF4EBP1)
ECB: 100057875(EIF4EBP1)
EPZ: 103543726(EIF4EBP1)
EAI: 106837686(EIF4EBP1)
MYB: 102250463(EIF4EBP1)
MYD: 102758662(EIF4EBP1)
MNA: 107535229(EIF4EBP1)
HAI: 109393572(EIF4EBP1)
DRO: 112306701(EIF4EBP1)
PALE: 102881655(EIF4EBP1)
RAY: 107515968(EIF4EBP1)
MJV: 108409141(EIF4EBP1)
LAV: 100665518(EIF4EBP1)
TMU: 101361891
MDO: 100029774(EIF4EBP1)
SHR: 100918487 111718631(EIF4EBP1)
PCW: 110207589(EIF4EBP1)
OAA: 100084037(EIF4EBP1)
GGA: 426773(EIF4EBP1)
MGP: 100546275(EIF4EBP1)
CJO: 107323781(EIF4EBP1)
NMEL: 110387062(EIF4EBP1)
APLA: 101798286(EIF4EBP1)
ACYG: 106044378(EIF4EBP1)
TGU: 100230789(EIF4EBP1)
LSR: 110473370(EIF4EBP1)
SCAN: 103822697(EIF4EBP1)
PHI: 102105579(EIF4EBP1)
PMAJ: 107213862(EIF4EBP1)
CCW: 104694846(EIF4EBP1)
ETL: 114066482(EIF4EBP1)
FCH: 102047520(EIF4EBP1)
CLV: 102083572(EIF4EBP1)
EGZ: 104127858(EIF4EBP1)
NNI: 104016060(EIF4EBP1)
PADL: 103912368(EIF4EBP1)
AMJ: 102575532(EIF4EBP1)
PSS: 102459901(EIF4EBP1)
CMY: 102944935(EIF4EBP1)
CPIC: 101935335(EIF4EBP1)
ACS: 100553993(eif4ebp1)
PVT: 110075184(EIF4EBP1)
PBI: 103063177(EIF4EBP1)
TSR: 106547504(EIF4EBP1)
PMUA: 114585885(EIF4EBP1)
GJA: 107108168(EIF4EBP1)
DRE: 799566(eif4ebp1)
SRX: 107708518
SANH: 107703566
IPU: 108279290
PHYP: 113543397
AMEX: 103026948
NCC: 104941580(eif4ebp1)
OLA: 101162296(eif4ebp1) 101165490
KMR: 108232646 108234456(eif4ebp1)
ALIM: 106513527 106521658(eif4ebp1)
LCF: 108878192(eif4ebp1) 108886048
SDU: 111230852(eif4ebp1) 111239317
SASA: 106580340(4EBP2) 106585258(4EBP2)
ELS: 105027007
PKI: 111860034
LCM: 102357265(EIF4EBP1)
CMK: 103190311(eif4ebp1)
CIN: 100183767
SPU: 752411(4e-bp)
CSCU: 111633095
PCAN: 112573394
CRG: 105341698
OBI: 106879899
EGL: EGR_08339
NVE: 5502361
SLB: AWJ20_944
DDI: DDB_G0291990(febA)
DFA: DFA_02929(febA)
 » show all
Reference
  Authors
Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N
  Title
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
  Journal
Nat Med 7:1128-32 (2001)
DOI:10.1038/nm1001-1128
  Sequence
[mmu:13685]
Reference
  Authors
Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N
  Title
Translational homeostasis via the mRNA cap-binding protein, eIF4E.
  Journal
Mol Cell 46:847-58 (2012)
DOI:10.1016/j.molcel.2012.04.004
  Sequence
[hsa:1978]
Reference
PMID:7629182
  Authors
Lin TA, Kong X, Saltiel AR, Blackshear PJ, Lawrence JC Jr
  Title
Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway.
  Journal
J Biol Chem 270:18531-8 (1995)
DOI:10.1074/jbc.270.31.18531
  Sequence
[mmu:13685]

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